| Bipolar disorder (47) |  |
Other psychotic disorders, notably bipolar disorder and depression, can have similar manifestations. There could also be physical causes.
Multiple possibilities Other potential developments include upgrading the test to include bipolar disorder and depression. The aim would be to create a test that can cover the three disorders in one go not ustto establish
and psychiatric diseases including bipolar disorder and schizophrenia. Four technical partners based in Archamps (FR), Paris (FR), Bristol (UK),
because they hope it will yield a biological marker to prioritize bipolar disorder care to those who need it most urgently to stabilize their moodsspecially in regions of the world with scarce mental health services.
Bipolar disorder affects tens of millions of people worldwide, and can have devastating effects, including suicide. hese pilot study results give us preliminary proof of the concept that we can detect mood states in regular phone calls by analyzing broad features and properties of speech,
the same technology framework developed for bipolar disorder could prove useful in everything from schizophrenia and posttraumatic stress disorder to Parkinson disease,
RESULTS SO FAR The first six patients all have a rapid-cycling form of Type 1 bipolar disorder
The researchers study patients as they experience all aspects of bipolar disorder mood changes from mild depressions and hypomania (mild mania) to full-blown depressed and manic states.
#To study bipolar disorder, start with skin Scientists investigating what makes a person vulnerable to bipolar disorder took skin cells from people with the condition
and ultimately turned them into neurons. The team then compared those neurons to cells taken from people without bipolar.
and identified striking differences in how the neurons respond to lithium, the most common treatment for bipolar disorder.
Already, we see that cells from people with bipolar disorder are different in how often they express certain genes,
But wee only just beginning to understand what we can do with these cells to help answer the many unanswered questions in bipolar disorder origins
Mcinnis, who sees firsthand the impact that bipolar disorder has on patients and the frustration they and their families feel about the lack of treatment options,
says the new research could take treatment of bipolar disorder into the era of personalized medicine. Not only could stem cell research help find new treatments,
very specific differences emerged between the cells derived from bipolar disorder patients and those without the condition.
the new findings support the idea that genetic differences expressed early during brain development may have a lot to do with the development of bipolar disorder symptomsnd other mental health conditions that arise later in life, especially in the teen and young adult years.
and receivednd the new cell lines will make it possible to study this effect specifically in bipolar disorder-specific cells.
the neurons made from bipolar disorder patients also differed in how they were ddressedduring development for delivery to certain areas of the brain.
This supports the emerging concept that bipolar disorder arises from a combination of genetic vulnerabilities. The researchers are already developing stem cell lines from other trial participants with bipolar disorder,
though it takes months to derive each line and obtain mature neurons that can be studied.
The biological causes of mental illnesses such as schizophrenia and bipolar disorder have mystified scientists for decades; in the last five years however understanding has accelerated dramatically driven by advances in human genomics.
and bipolar disorder represent the best way to gain molecular insights into these disorders. The discovery of specific genes associated with these disorders provides significant clues to their biological basis and points to possible molecular targets for novel therapies.
Since 2004 Ted Stanley and his late wife Vada Stanley have been instrumental to the progress made thus far in identifying the genetic risk factors for schizophrenia and bipolar disorder and the initiation of therapeutic efforts based on those discoveries.
Biomedical researchers have struggled for years to understand the molecular causes of serious ailments such as schizophrenia and bipolar disorder.
Yet in the past few years scientists have begun to find genes that shape the risk of schizophrenia bipolar disorder and other illnesses thanks in large part to Stanley s support.
and assembled the world s largest collection of DNA samples in psychiatric research currently more than 175000 samples including schizophrenia bipolar disorder autism attention deficit hyperactivity disorder and healthy control samples.
Significant efforts are ramping up in bipolar disorder autism and other conditions. We are going to illuminate the biology behind these conditions says Eric Lander founding director and president of the Broad Institute and a professor of biology at MIT.
when his son Jonathan was stricken with severe bipolar disorder while in college. The first few years were difficult
Complete the list of all genes that play roles in severe psychiatric disorders including schizophrenia bipolar disorder autism and others.
Stanley Center researchers focus on schizophrenia bipolar disorder autism attention deficit hyperactivity disorder and other neuropsychiatric disorders.
when mutated, can give rise to a number of mental health conditions including schizophrenia, bipolar disorder, major clinical depression and autism.
Many psychiatric disorders such as autism, schizophrenia and bipolar disorder are characterised by poor social functioning. Oxytocin is a hormone that influences social behaviour
#High-res MRI links cerebellum to bipolar disorder A different type of MRI has given researchers an unprecedented look at previously unrecognized differences in the brains of people with bipolar disorder, a new study reports.
The cerebellar differences were not present in patients taking lithium, the most commonly used treatment for bipolar disorder.
Despite being relatively commonipolar disorder affects about one percent of the populationcientists don have a good understanding of what causes bipolar disorder,
Researchers examined 15 patients with bipolar disorder and 25 control subjects matched for age and gender.
ELEVATED MRI SIGNAL Compared to the brains of people without bipolar disorder, the MRI signal was elevated in the cerebral white matter
and the cerebellar region of patients affected by bipolar disorder. The elevated signal may be due to either a reduction in ph or a reduction in glucose concentrationoth factors influenced by cell metabolism.
Previous research has suggested that abnormal cell metabolism may play a role in bipolar disorder. However, investigating metabolic abnormalities in the brain has been hindered by lack of a good imaging tools.
One reason researchers didn know that the cerebellum might be important in bipolar disorder, is because no one chose to look there, says Casey Johnson,
The majority of bipolar disorder research has found differences in the frontal region of the brain.
the researchers conducted an extensive search of the scientific literature on bipolar disorder and began to find pieces of evidence that suggested that the cerebellum may function abnormally in bipolar disorder
and that lithium might potentially target the cerebellum and alter glucose levels in this brain region. ur paper,
While lithium can be an effective mood stabilizer for people with bipolar disorder, it causes numerous unpleasant side effects for patients. f lithium effect on the cerebellum is the key to its effectiveness as a mood stabilizer,
then a more targeted treatment that causes the same change in the cerebellum without affecting other systems might be a better treatment for patients with bipolar disorder,
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