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| Microarray (14) | |
| Molecular biology (89) | |
| Polymerase chain reaction (18) | |
| Programmed cell death (45) | |
| Biochip (8) | |
| Biomolecular (175) | |
| Microarray (14) | |
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| Polymerase chain reaction (18) | |
| Programmed cell death (45) | |
proliferation, apoptosis, and migration. The discovery that they are receptors for tumor-producing phorbol esters, plant-derived compounds that bind to and activate PKC,
In collaboration with the Clinical and Translational Science Institute (CTSI) at Boston University the researchers performed genome-wide microarray profiling
and Jonathan Karn, director of the Center for Aids Research and professor and chair of the Department of Molecular biology and Microbiology at Case Western Reserve's medical school.
Karn, the Reinberger Professor of Molecular biology.""It surprised us to find they all work as an aggregate."
and flow-cell cytometry systems--all applications where molecular biology is delivering tools and techniques, but imaging methods have struggled to keep up.
a professor of chemical and biomolecular engineering at the Georgia Institute of technology who was involved not in the research. t very well-controlled
The team also decided that with this new concept it would not be necessary to use a'biopolymer',such as collagen,
Also known as polysaccharides, these complex sugars are by far the most abundant biomolecules on the planet. Produced biologically in plants, animals and microorganisms,
##The power of microneedles for treating eye conditions is the ability to target delivery of the drug within the eye##says Mark Prausnitz professor in the School of Chemical and Biomolecular engineering at the Georgia Institute of technology.##
##The shoebox-sized prototype diagnostic device known as the single particle interferometric reflectance imaging sensor (SP-IRIS) detects pathogens by shining light from multicolor LED sources on viral nanoparticles bound to the sensor
"This is a particular disadvantage for biocomputer components that serve as sensors for specific biomolecules and transmit the relevant signal.
or apoptosis which reduces the likelihood that they will go on to form tumors.####As luck would have it that was the first gene
But she says it seemed natural given her collaboration on the study with Gregory Ziegler who has expertise in biopolymers such as carrageenan
and induce apoptosis. The cancer cell growth slowed by day 17 and all cells were dead by day 21.
The new material is described in a paper published in the journal Biomacromolecules. emi-smartmaterial came up with the idea a few years ago,
The researchers showed that they were able to easily attach biomolecules to the gas vesicle surface to enable targeting.
This is a particular disadvantage for biocomputer components that serve as sensors for specific biomolecules and transmit the relevant signal.
The dream of the researchers is to one day apply the technology to shed light on the spatial structure of biomolecules such as proteins.
Christoph Benning professor of biochemistry and molecular biology at Michigan State university and his colleagues unearthed the protein's potential
which makes it easier to detect even smaller changes for tiny traces of explosives in the air. he sensor could have applications beyond chemical and explosive detection such as use in biomolecular research.
and biomolecular engineering to come up with a viscous blend of strontium ferrite. It s not the first time a consumer electronic device was printed in Lipson s lab. Back in 2009 Malone
researcher's microscope slides or microarrays where the liquids are placed. Also as can be seen from oil spills in the Gulf of mexico oil can stick
The sensors make use of microfluidic technologyâ##developed by Abraham Stroock associate professor of chemical and biomolecular engineeringâ##that places a tiny cavity inside the chip.
of molecular biology and genetics at Cornell University. Using mouse studies only about 100 genes with imprinted expression had been identified.
chitin is the second-most common biopolymer on earth, occurring not only in crab and lobster shells,
Then simple polymerase chain reaction (PCR) technology can identify the code and reveal the origin of the product in about an hour right down to
An expert on sustainable agriculture and the potential environmental risks of biotechnology Mellon holds a doctorate in molecular biology and a law degree.
and because molecular biology techniques can be used to help proteins"evolve"to have desired properties, Romesberg said.
To measure gene activity the researchers used a powerful tool known as a DNA MICROARRAY which yields a quantitative measurement of the activity of every gene in the human genome simultaneously about 20000 genes in total.
or experimental artefacts, says Erik Sontheimer, a molecular biologist at Northwestern University in Evanston, Illinois. Instead,
Last year, Julia Salzman, a molecular biologist at Stanford university School of medicine in California, and her colleagues sent the first missive from the circular universe.
"I can t think of another form we might have missed, laughs Phillip Sharp, a molecular biologist at the Massachusetts institute of technology in Cambridge."
The molecule, TIC10, activates the gene for a protein called TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand),
which apoptosis#or cell death#is induced in cancer cells immediately next to healthy ones. Healthy cells are stimulated also to increase the amount of TRAIL receptors on their cell surface.
Their findings are reported in the journal Nature Structural & Molecular biology. Dr Samuel Cohen a Research Fellow at St john College, Cambridge,
molecular biologist Ling Zhao may have done just that. Her team came up with the eye drop idea after finding that children with a genetically inherited form of cataracts shared a mutation that stopped the production of lanosterol, an important steroid in the body.
a molecular biologist at Massachusetts institute of technology in Cambridge not affiliated with the study. He has been investigating cataract proteins
and molecular biologist at UC San diego, is looking forward to seeing what the lanosterol drops can dissolve next. think the natural next step is looking to translate it into humans,
if you have imaging probes that can sense specific biomolecules Johnson says. Dual actionjohnson and his colleagues designed the particles
Molecular biologists microbiologists and cell biologists seek to understand microbe/microbe and microbe/host cell function and communication he says.
They also found higher rates of apoptosis or programmed cell death in tumor cells near the capsules.
The other key component of Sikes system is a biochip a glass slide coated with hundreds of DNA PROBES that are complementary to sequences from the gene being studied.
When a DNA sample is exposed to this chip any strands that match the target sequences are trapped on the biochip.
The MIT team is now adapting the device to detect methylation of other cancer-linked genes by changing the DNA sequences of the biochip probes.
or polymerase chain reactions (PCR, which copies DNA) may be efficient in one area, but lacking in the other two.
If DNA damage is too extensive p53 forces the cell to undergo programmed cell death or apoptosis. Tumors that lack p53 can avoid this fate.
Usually p53 is the main driver of cell death and if cells lose this pathway they become very resistant to different treatments that cause cell death Morandell says.
If enough of these blockages form the cell undergoes a type of programmed cell suicide called apoptosis
Because mitochondria are involved in apoptosis the researchers wanted to see whether they could induce cell death by targeting MITOCHONDRIAL DNA particularly in cells that are already resistant to regular cisplatin.
The researchers also showed that the cells were dying through apoptosis and not some less-controlled form of cell death.
There are other ways for a cell to die besides apoptosis. You want a therapeutic agent to induce programmed cell death
because they can interact with so many different biomolecules Radford says. By targeting specific cellular organelles with the same therapeutic molecules we can learn a lot about how the cells respond to a given compound
Fang says, of biomolecules placed on the hybrid material surface. Sheng Shen, an assistant professor of mechanical engineering at Carnegie mellon University who was involved not in this research,
and atoms in contact with one another, sliding along like biomolecular motors, as a result of friction or lack of friction, Gangloff says. o this intuition for how to arrange atoms so as to minimize
You can attach biomolecules like proteins or DNA to them and make them change properties
The technique known as density gradient ultracentrifugation is a decades-old process used to separate biomolecules.
#Single unlabelled biomolecules can be detected through light Being able to track individual biomolecules and observe them at work is every biochemist's dream.
Their optical biosensor for single unlabelled molecules could also be a breakthrough in the development of biochips:
Our understanding of fundamental life processes was made first possible by knowledge of how individual biomolecules interact with each other.
Although light can be used to detect unlabelled biomolecules, the approach cannot be used to detect single DNA molecules,
The gain in signal is then sufficient to detect single biomolecules, such as DNA fragments. The Erlangen-based researchers did precisely that.
Saraf, a professor of chemical and biomolecular engineering said he envisions a stethoscope-like device that a doctor would press across a patient's chest to image the buried palpable structure.
and Biochemistry and Molecular biology at Penn State. In a paper first published online on Sept. 9 in the journal Nature Chemistry, Mallouk and colleagues at Penn State and the Research center for Exotic Nanocarbons at Shinshu University, Japan, describe a method called intercalation,
and the current in the channel is modulated by the binding between embedded receptor molecules and the charged target biomolecules to
Moreover the channel length of Mos2 FET biosensor can be scaled down to the dimensions similar to those of small biomolecules such as DNA
which can lead to high sensitivity even for detection of single quanta of these biomolecular species she added.
if the biomolecules are close to the hot spots Therefore, the molecules have to be trapped to be detected.
When University of Illinois Associate professor of Chemical and Biomolecular engineering Hyunjoon Kong graduate student Cartney Smith and colleagues set out to improve MR imaging (MRI) they turned current contrast agent technology on its head
Kong Smith and colleagues tackled these challenges by using interactions between naturally occurring biomolecules as a guide.
and analyzing changes in their physical properties said Rimer Ernest J. and Barbara M. Henley Assistant professor of Chemical and Biomolecular engineering at UH.
and precisely controlled micromirrors to shine light on a selected area of a solution containing photosensitive biopolymers and cells.
#New technology could speed up lifesaving drug discoveries A team of researchers from our University has developed a revolutionary new biochip device that will lead to a faster
In a research paper published in the Journal of Cell biology, Alessandro Vindigni, Ph d.,professor in the Edward A. Doisy Department of Biochemistry and Molecular biology at Saint louis University
an associate professor of chemical and biomolecular engineering at Nanyang Technological University in Singapore, who was involved not in this work. o me,
and then produce transcription factors that would activate the cellsown programmed cell death pathways. Research tool The researchers are now adapting this system to detect latent HIV proviruses,
since completing his Phd in Molecular biology in 1997. uring my post-doc at the Max-Planck Institute in Germany,
and then produce transcription factors that would activate the cells'own programmed cell death pathways s
#Paraplegic man walks using only his brain power A brain-to-computer echnology that can translate thoughts into leg movements has enab ed a man paralysed from the waist down by a spinal cord injury to become the first such
The current gold standard for Ebola virus detection relies on a method called polymerase chain reaction (PCR) to amplify the virus's genetic material for detection.
nontarget biomolecules were washed off, and the bound targets were released then by heating, labelled with fluorescent markers,
the team adapted two more techniques from nature's biomolecular toolkit: the way proteins use shape complementarity to simplify docking with other molecules,
and Extract Biomolecules from Fluid Mixtures Employing an ingenious microfluidic design that combines chemical and mechanical properties,
and extracting biomolecules from fluid mixtures. The approach requires fewer steps, uses less energy, and achieves better performance than several techniques currently in use
and extracting biomolecules from fluid mixtures. Illustration courtesy of Peter Mallen, Harvard Medical school. The biomolecule sorting technique was developed in the laboratory of Joanna Aizenberg, Amy Smith Berylson Professor of Materials science at Harvard School of engineering and Applied sciences (SEAS) and Professor in the Department of chemistry and Chemical Biology.
Aizenberg is also co-director of the Kavli Institute for Bionano Science and Technology and a core faculty member at Harvard Wyss Institute for Biologically Inspired Engineering, leading the Adaptive Materials Technologies platform there.
Modulating the ph levels of the solutions in those environments triggers the aptamers to atchor eleasethe target biomolecule.
Their research suggests that the technique could be applicable to other biomolecules, or used to determine chemical purity
Conventional biomolecule sorting systems rely on external electric fields infrared radiation, and magnetic fields, and often require chemical modifications of the biomolecules of interest.
That means setups can be used only once or require a series of sequential steps. In contrast, said Ankita Shastri, a graduate student in Chemistry and Chemical Biology at Harvard and a member of Aizenberg group,
and effectivechieving recovery of almost all of the target biomolecule through its continuous reusability. The authors say that the system could provide a means of removing contaminants from waternd even be tailored to enable energy-efficient desalination of seawater.
or diagnose substances at a molecular level. ur system can do chemistry, biology, biochemistry, molecular biology, clinical diagnosis,
an associate professor of chemical and biomolecular engineering at Nanyang Technological University in Singapore, who was involved not in this work. o me,
The cell wall of a plant is layered a nanostructure made up of biopolymers such as cellulose. Researchers are looking to convert these biopolymers to free the functional sugars and discharge energy.
An instrument constructed previously at ORNL was capable of imaging poplar cell wall structures from which exceptional topological data could be procured,
in a mixture containing other biomolecules, thus beating most of the currently used detectors. This novel technique enables sensitive DNA detection in compound biological samples e g.,
such as disposable cutlery, to natural biopolymers like DNA and proteins-fundamental to human life. Using insecticides is one of the few ways farmers currently have to treat their groves for greening, also known as Huanglongbing or HLB.
The current gold standard for Ebola virus detection relies on a method called polymerase chain reaction (PCR) to amplify the virus's genetic material for detection.
nontarget biomolecules are washed off, and the bound targets are released then by heating, labeled with fluorescent markers,
and then produce transcription factors that would activate the cellsown programmed cell death pathways. Research tool The researchers are now adapting this system to detect latent HIV proviruses,
To overcome this, the scientists used a technique called'mutation tracking'a polymerase chain reaction (PCR) test
which integrats the ultrafast laser with molecular biology and cell biology. Professor Lu has applied the tool to understand the molecular mechanisms that cause cancer at the very moment
Previously, scientists believed that allosteric regulation of glucokinase depended on strict structural transitions of the biomolecule.
"said Chase Beisel, co-senior author of the paper and an assistant professor in the department of chemical and biomolecular engineering at NC State."
Researchers at Johns hopkins university School of medicine, Johns hopkins university Department of Chemical and Biomolecular engineering and Federal University of Rio de janeiro in Brazil conducted a proof-of-concept study that found DNA-loaded nanoparticles could successfully pass through the hard-to-breach mucus barrier
and then produce transcription factors that would activate the cellsown programmed cell death pathways. Research tool The researchers are now adapting this system to detect latent HIV proviruses,
explains Christian Kastrup, an assistant professor in the Department of Biochemistry and Molecular biology and the Michael Smith Laboratories at the University of British columbia.
It uses microarrays of electrodes that can be implanted into the brains of volunteers to pick up tiny electrical pulses from the neurons.
#A new gene-editing breakthrough A FEW years ago, molecular biologists made a breakthrough. By borrowing an antiviral mechanism called CRISPR-Cas9 from bacteria,
"said senior author Dr. Zhijian"James"Chen, Professor of Molecular biology and a Howard Hughes Medical Institute (HHMI) investigator at UT Southwestern.
who is also an American Cancer Society Professor of Molecular biology.""This molecule Epha2 is having a huge effect on restraining cancer growth
Another avenue for application is functional 3d printing and microarray devices, especially in printing highly viscous and sticky biological and polymeric materials where friction and contamination are major obstacles.
Imagine a diabetics biochip detecting blood glucose levels within personalized parameters, and then initiating appropriate, immediate,
Imagine a diabetics biochip detecting blood glucose levels within personalized parameters, and then initiating appropriate, immediate,
and Alexander Mankin, director of the University of Illinois at Chicago College of Pharmacy Center for Biomolecular Sciences.
Jewett says. ur new protein-making factory holds promise to expand the genetic code in a unique and transformative way, providing exciting opportunities for synthetic biology and biomolecular engineering,
The ability to precisely tune enzymatic reactions with small biomolecules holds enormous potential for industrial manufacturing, analytical science,
since completing his doctorate in molecular biology in 1997.""During my post-doc at the Max-Planck Institute in Germany,
molecular biologist James Paulson at the Scripps Research Institute in the US told this publication. he authors exploit Siglec function by attaching sialic acids to nanoparticles that exploit the function of Siglecs and control inflammation,
Building blocks of life After molecular biologists James Watson and Francis Crick first published a paper on the structure of DNA in 1953, the double helix became the iconic symbol of the code of life.
an ARC Australian Laureate Fellow in the Department of Chemical and Biomolecular engineering at the University of Melbourne, was published today in the leading journal Advanced Materials.
an associate professor of chemical and biomolecular engineering at Nanyang Technological University in Singapore, who was involved not in this work. o me,
These sensors can detect biomolecule adsorption even at a few trillionth of a gram per millimeter square.
Higher binding capacity for biomolecules increases the signal levels and accuracy of analysis. The last several years
and interaction with a wide range of biomolecules. Stebunov and the team from the Laboratory of Nanooptics and Plasmonics at MIPT created
Thereafter a layer of streptavidin protein was developed on GO FOR selective immobilization of biomolecules. Scientists conducted a series of experiments with the GO chip
"said Orlin Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the corresponding author of the paper."
research assistant professor of chemical and biomolecular engineering at NC State and first author of the paper.
The plant cell wall is layered a nanostructure of biopolymers such as cellulose. Scientists want to convert such biopolymers to free the useful sugars and release energy An earlier instrument,
also invented at ORNL, provided imaging of poplar cell wall structures that yielded unprecedented topological information, advancing fundamental research in sustainable biofuels.
#Milestone single-biomolecule imaging technique may advance drug design Knowing the detailed shape of biomolecules such as proteins is essential for biological studies and drug discovery.
X-ray crystallography and cryo-electron microscopy to discover the tiny structural details of biomolecules. All these methods,
and thus structural details of an individual biomolecule are lost often. Now researchers from the University of Zurich, Switzerland have made a breakthrough by obtaining the first nanometer (one billionth of a meter) resolved image of individual tobacco mosaic virions
Second, low energy electrons are harmless to biomolecules, "Longchamp said. In many conventional techniques such as transmission electron microscopy, the possible resolution is limited by high-energy electrons'radiation damage to biological samples.
Individual biomolecules are destroyed long before an image of high enough quality can be acquired. In other words, the low permissible electron dose in conventional microscopies is not sufficient to obtain high-resolution images from a single biomolecule.
However in low energy electron holography, the employed electron doses can be much higher--even after exposing fragile molecules like DNA or proteins to a electron dose more than five orders of magnitude higher
Sufficient electron dose in low energy electron holography makes imaging individual biomolecules at a nanometer resolution possible.
and tunable number of photons per tagged biomolecule. They are expected also to be used for precise color matching in light-emitting devices and displays,
Lysozyme protein has been selected as the target biomolecule in this research. The excess secretion of this protein can be a sign of malfunction in kidney performance
the physicists applied their ultrashort electron pulses to a biomolecule in a diffraction experiment. It is planned to use those electron beams for pump-probe experiments:
"explains Dr. Charron, Director of the Molecular biology of Neural development research unit at the IRCM. Over the past few decades, the scientific community has struggled to understand why more than one guidance cue would be necessary for axons to reach the proper target.
Recently, a team from the Department of Chemical and Biomolecular engineering in the School of engineering and Applied science has shown how to do just that.
and Biomolecular engineering at Korea Advanced Institute of Science and Technology (KAIST) have developed a novel photolithographic technology enabling control over the functional shapes of micropatterns using oxygen diffusion.
The research was dedicated also to the late Professor Seung-Man Yang of the Department of Chemical and Biomolecular engineering at KAIST.
Nagoya, Japan-Yutaro Saito, Yasutomo Segawa and Professor Kenichiro Itami at the Institute of Transformative Biomolecules (ITBM
"says Kenichiro Itami, the Director of the Institute of Transformative Biomolecules.""Since starting this research in 2009,
an ARC Australian Laureate Fellow in the Department of Chemical and Biomolecular engineering at the University of Melbourne, was published today in Advanced Materials("Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets").
and then produce transcription factors that would activate the cellsown programmed cell death pathways. Research tool The researchers are now adapting this system to detect latent HIV proviruses,
These sensors can detect biomolecule adsorption even at a few trillionth of a gram per millimeter square.
Higher binding capacity for biomolecules increases the signal levels and accuracy of analysis. The last several years
and interaction with a wide range of biomolecules. Stebunov and the team from the Laboratory of Nanooptics and Plasmonics at MIPT created
Thereafter a layer of streptavidin protein was developed on GO FOR selective immobilization of biomolecules. Scientists conducted a series of experiments with the GO chip
#3d-printed scaffolds could enable the release biomolecules into the body with exceptional control (w/video) Tissue development is guided by gradients of biomolecules that direct the growth, migration,
Now, researchers are one step closer to this goal thanks to the creation of new 3d-printed scaffolds that enable researchers to release biomolecules into the body with exceptional control.
this time filled with blue food dye to represent a different type of biomolecule. The layering pattern continues until the gel achieves a predetermined height.
when different types of biomolecules are released from the gel by varying the shell coatings of the capsules
They can also be filled with a wide variety of biomolecules. ne can imagine filling the capsules with molecules such as medications
Now, researchers report in Biomacromolecules("Biodegradable ph-Sensitive Poly (ethylene glycol) Nanocarriers for Allergen Encapsulation and Controlled Release")the development of a potentially better allergy shot that uses nanocarriers to address these unwanted issues.
The current gold standard for Ebola virus detection relies on a method called polymerase chain reaction (PCR) to amplify the virus's genetic material for detection.
nontarget biomolecules are washed off, and the bound targets are released then by heating, labeled with fluorescent markers,
and tunable number of photons per tagged biomolecule. They are expected also to be used for precise color matching in light-emitting devices and displays,
Another avenue for application is functional 3d printing and microarray devices, especially in printing highly viscous and sticky biological and polymeric materials where friction and contamination are major obstacles.
The images and implications are described in a paper published online by the journal Nature Structural & Molecular biology("The architecture of a eukaryotic replisome"."
Brain-like structures were constructed using a bio-ink consisting of a novel peptide-modified biopolymer,
Talking to the Immune system Previous studies have shown RIPK3 controls the induction of a type of programmed cell death, called necroptosis,
#Single molecule detector reveals biomolecule secrets Supersensitive detection systems are an important element of today's life sciences.
and determining the amount of biomolecules, in order to be able to diagnose diseases earlier, to find new active ingredients faster and more reliably,
but it can also generate a wide range of information about the type and behavior of the marked biomolecules.
"says the molecular biologist Prof. Dr. Susanne Schoch from the department of Neuropathology at the University of Bonn.
Kit could one day Be led by widely available Professor Jeffrey Bode of the Institute of Transformative Biomolecules at Nagoya University in Japan,
This web of biomolecules that supports and controls gene activity is known as the epigenome. The researchers say having the ability to steer the epigenome will help them explore the roles that particular promoters
which cause apoptosis, where cells are prompted to die through natural mechanisms that can result in treatment resistance.
inhibition of apoptosis (programmed cell death) normally eliminates transformed cells; acceleration of uncontrolled division of cancer cells; formation of new blood vessels (angiogenesis),
which are problematic for conventional gel electrophoresis, a frequently used technique in biochemistry and molecular biology to size DNA and RNA fragments.
these results are published on 3rd of August in the journal Nature Structural & Molecular biology. Just after fertilization,
Researchers at the Center for Molecular biology of Heidelberg University, the German Cancer Research center and the Heidelberg Institute for Theoretical Studies collaborated on the project,
Dr. Bernd Bukau, Director of the Center for Molecular biology of Heidelberg University (ZMBH), who is also a researcher at the German Cancer Research center (DKFZ.
the Phd in biochemistry and molecular biology Gabriel Cabrera Betanzos designed a microencapsulation process from pomegranate juice
Additionally, the NAPA platform has shown the capabilities to analyze a wide variety of biomolecules and xenobiotics in a broad class of samples, making it the foundation for matrix-free laser desorption ionization.
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