#Self-assembling nanoparticle could improve MRI scanning for cancer diagnosis Scientists have designed a new self-assembling nanoparticle that targets tumours,
The new nanoparticle, developed by researchers at Imperial College London, boosts the effectiveness of Magnetic resonance imaging (MRI) scanning by specifically seeking out receptors that are found in cancerous cells.
The nanoparticle is coated with a special protein, which looks for specific signals given off by tumours,
causing the nanoparticle to self-assemble into a much larger particle so that it is more visible on the scan.
used cancer cells and mouse models to compare the effects of the self-assembling nanoparticle in MRI scanning against commonly used imaging agents
and found that the nanoparticle produced a more powerful signal and created a clearer MRI image of the tumour.
The scientists say the nanoparticle increases the sensitivity of MRI scanning and will ultimately improve doctor's ability to detect cancerous cells at much earlier stages of development.
The newly designed nanoparticle provides a tool to improve the sensitivity of MRI scanning, and the scientists are now working to enhance its effectiveness.
so that the nanoparticle would light up with a luminescent probe once it had found its target,
"Before testing and injecting the nontoxic nanoparticle into mice, the scientists had to make sure that it would not become so big
They injected the nanoparticle into a saline solution inside a petri dish and monitored its growth over a four hour period.
The nanoparticle grew from 100 to 800 nanometres still small enough to not cause any harm.
The scientists are now improving the nanoparticle and hope to test their design in a human trial within the next three to five years.
"We're now looking at fine tuning the size of the final nanoparticle so that it is even smaller
"On a fundamental level, our work demonstrates electron-beam based manipulation of nanoparticles an order of magnitude larger than previously possible,
If these molecules are close to nanoparticles, the plasmons in the nanoparticles enhance the Raman signal coming from the molecules that have to be detected with several orders of magnitude.
The nanoantennas developed in this project only enhance the emitted Raman signal if the biomolecules are close to the hot spots Therefore,
The catalysts, tungsten-based bimetallic alloy nanoparticles of non-cubic symmetry, have high melting points and consequently are able to maintain their crystal structure during the chemical vapor deposition (CVD) process,
or emboss the raised numerals on credit cardsould process nanoparticles more subtly than the most advanced chemistry.
when applied to nanoparticle arrays, forms new nanostructures with tunable properties.""There is a great potential market for this technology,
A coating of nanoparticles that can build into another structure has a certain functionality we don't have right now.
For example, under pressure, the dimensions of ordered three-dimensional nanoparticle arrays shrink. By fabricating a structure in
the nanoparticle array will remain at a constant state, able to transmit light and electricity with specific characteristics.
At even higher pressures, nanoparticles are forced to sinter, or bond, forming new classes of chemically
composition and phase orientation of the initial nanoparticle arrays, a variety of nanostructures or nanocomposites and 3-D interconnected networks are achievable.
#Scientists develop a'nanosubmarine'that delivers complementary molecules inside cells With the continuing need for very small devices in therapeutic applications there is a growing demand for the development of nanoparticles that can transport
Recently researchers created nanoparticles that under the right conditions self-assemble trapping complementary guest molecules within their structure.
Although the transport of molecules inside cells with nanoparticles has been achieved previously using various methods researchers have developed nanoparticles capable of delivering
if the nanoparticles can actually travel through the bloodstream. That would be the dream but we have no evidence that they can actually do so Raymo says.
The size of these nanoparticles their dynamic character and the fact that the reactions take place under normal biological conditions (at ambient temperature
and neutral environment) makes these nanoparticles an ideal vehicle for the controlled activation of therapeutics directly inside the cells Raymo says.
#Nanoparticles could provide easier route for cell therapy UT Arlington physics researchers may have developed a way to use laser technology to deliver drug and gene therapy at the cellular level without damaging surrounding tissue.
the team paired crystalline magnetic carbon nanoparticles and continuous wave near-infrared laser beams for in
and Mohanty used a 50 to 100 milliwatt laser and the same carbon nanoparticle, which absorbs the beam,
continuous wave near-infrared laser and the nanoparticle to permeate the cell membrane without killing the cells.
whose lab created the study's crystalline magnetic carbon nanoparticle using an electric plasma discharge inside a toulene solution.
A significant advantage of the new method is that the near-infrared light absorption of the nanoparticle can be used to selectively amplify interaction of low power laser with targeted tissue
The magnetic properties of the nanoparticles also mean they can be localized with an external magnetic field;
"Carbon nanoparticles produced for the cancer study varied from five to 20 nanometers wide. A human hair is about 100,000 nanometers wide.
The magnetic carbon nanoparticles also are fluorescent. So, they can be used to enhance contrast of optical imaging of tumors along with that of MRI I
#DNA-linked nanoparticles form switchable'thin films'on a liquid surface Scientists seeking ways to engineer the assembly of tiny particles measuring just billionths of a meter have achieved a new firsthe formation of a single
layer of nanoparticles on a liquid surface where the properties of the layer can be switched easily.
In addition, because the scientists used tiny synthetic strands of DNA to hold the nanoparticles together
the study also offers insight into the mechanism of interactions of nanoparticles and DNA molecules near a lipid membrane.
This understanding could inform the emerging use of nanoparticles as vehicles for delivering genes across cellular membranes."
"Our work reveals how DNA-coated nanoparticles interact and reorganize at a lipid interface, and how that process affects the properties of a"thin film"made of DNA-linked nanoparticles,
"said physicist Oleg Gang who led the study at the Center for Functional Nanomaterials (CFN) at the U s. Department of energy's Brookhaven National Laboratory.
the synthetic DNA strands used as"glue"to bind nanoparticles in this study have a natural tendency to pair up
Scientists at Brookhaven have made great use of the specificity of this attractive force to get nanoparticles coated with single synthetic DNA strands to pair up
"Many of the applications we envision for nanoparticles, such as optical coatings and photovoltaic and magnetic storage devices, require planar geometry,
Other groups of scientists have assembled such planes of nanoparticles, essentially floating them on a liquid surface,
"Using DNA linker molecules gives us a way to control the interactions between the nanoparticles."
a lipid, has a strong positive charge it attracts the negatively charged DNA strands that coat the nanoparticles.
That electrostatic attraction and the repulsion between the negatively charged DNA molecules surrounding adjacent nanoparticles overpower the attractive force between COMPLEMENTARY DNA bases.
and link the nanoparticles together more closely, first forming string-like arrays, and with more salt, a more solid yet elastic mesh-like layer."
As part of the study, the scientists examined the different configurations of the nanoparticles on top of the liquid layer using x-ray scattering at Brookhaven's National Synchrotron Light source (NSLS.
Because of the nanoscale size-regime, we might envision using such membranes for filtering proteins or other nanoparticles,
Understanding how synthetic DNA-coated nanoparticles interact with a lipid surface may also offer insight into how such particles coated with actual genes might interact with cell membraneshich are composed largely of lipidsnd with one another in a lipid environment."
"Other groups have considered using DNA-coated nanoparticles to detect genes within cells, or even for delivering genes to cells for gene therapy
#Technology using microwave heating may impact electronics manufacture Engineers at Oregon State university have shown successfully that a continuous flow reactor can produce high-quality nanoparticles by using microwave-assisted heating essentially the same forces
are essentially a"proof of concept"that a new type of nanoparticle production system should actually work at a commercial level."
"Nanoparticles are extraordinarily small particles at the forefront of advances in many biomedical, optical and electronic fields,
researchers worked with lead selenide nanoparticles, which are particularly good for the taggant technologies. Other materials can be synthesized using this reactor for different applications,
#New class of nanoparticle brings cheaper lighter solar cells outdoors Think those flat glassy solar panels on your neighbour's roof are the pinnacle of solar technology?
and tested a new class of solar-sensitive nanoparticle that outshines the current state of the art employing this new class of technology.
This new form of solid stable light-sensitive nanoparticles called colloidal quantum dots could lead to cheaper and more flexible solar cells as well as better gas sensors infrared lasers infrared light emitting diodes and more.
As the team describes in their paper published in the journal Scientific Reports the new system is based on adding certain types of nanoparticles to materials as part of the manufacturing process that can be read later using a special device.
Mixing the nanoparticles together allows for creating unique thermal signatures. To use the nanoparticles manufacturers would simply add them into the mix
when creating metals papers and even fluids. The researchers say the addition of the nanoparticles doesn't change how a material looks doesn't react with anything in it
or impact how a finished product performs. Reading the new type of bar code requires a device capable of performing differential scanning calorimetry (DSC) a technique based on assessing the difference in the amount of heat required to heat different parts of a sample material.
For criminals to circumvent the process they would have to somehow find out which nanomaterials were added to a product to create its unique thermal signature then add the right mix of nanoparticles to their own counterfeit product to recreate it no easy feat.
The researchers claim their nanoparticle bar codes could be used with paper metals fluids and even drugs.
Taox-capped Pt nanoparticles as efficient catalysts for polymer electrolyte fuel cells More information: Covert thermal barcodes based on phase change nanoparticles Scientific Reports 4 Article number:
5170 DOI: 10.1038/srep05170abstractan unmet need is to develop covert barcodes that can be used to track-trace objects
This paper describes a new nanoparticle-based covert barcode system in which a selected panel of solid-to-liquid phase change nanoparticles with discrete and sharp melting peaks is added in a variety of objects such as
This method has high labeling capacity owing to the small sizes of nanoparticles sharp melting peaks
#Nanoparticles on track to distinguish tumour tissue Gold nanoparticles could be used to help detect the margins between tumours and normal tissue,
whether the nanoparticles would work as effective optical contrast agents to provide an estimate of the size and shape of tumour margins during surgery.
Mr Duczynski used silica nanoparticles coated with a gold shell (silica-gold core-shell nanoparticles) in his research."
"Ultraviolet spectroscopy was used on the silica-gold core-shell nanoparticles made by Mr Duczynski to better understand their optical properties, such as extinction, scattering and absorption.
The research also involved the development of iron oxide-gold core shell nanoparticles.""This particle system was attempted because
"I was able to see some scattering of the iron oxide-gold core-shell nanoparticles,
Recently biomedical researchers have found ways to increase the effectiveness of certain contrast agents by associating them with nanoparticles.
Researchers are now exploring the multipurpose use of nanoparticles. If particles could be loaded with several types of contrast agents
though compounds packaged together into a nanoparticle cannot always play well together. For example contrast agents may bind to other chemicals reducing their effectiveness.
In addition when contrast agents are enclosed inside a nanoparticle they may not work as well. Attempts to attach agents to the outer surface of nanoparticles via covalent formation are also problematic as they can negatively affect the activity of the nanoparticles or the compounds that they carry.
Kong Smith and colleagues tackled these challenges by using interactions between naturally occurring biomolecules as a guide.
The group hypothesized that the same types of forces could be used to attach a contrast agent to the surface of a type of nanoparticle called a liposome
Gadolinium stably associated with the modified nanoparticles in solution and experiments in animal models showed that these nanoparticles produced clear diagnostic images.
The strategy works like Velcro on a molecular level to adhere functional units to the outer leaflet of a liposome said Smith who was first author on the study.
10.1021/la500412r) Kong and Smith developed a process for chemically cross-linking the components of the nanoparticle that prolonged the life of the nanoparticles in biological conditions.
Nanoparticle pinpoints blood vessel plaque e
#Liberating devices from their power cords: New structural'supercaps'take a lickin'keep on workin'Imagine a future in which our electrical gadgets are limited no longer by plugs and external power sources.
Gold nanoparticles lie on the surface of the chip and are programed chemically with an antibody receptor in such a way that they are capable of specifically attracting the protein markers circulating in blood.
and if cancer markers are present in the blood they will stick to the nanoparticles located on the micro-channels as they pass by setting off changes in
"When researching nanoparticles, you normally use samples. For us, we set the challenge to coat 2 meters long stainless steel tubes,
#Researchers find definitive evidence of how zeolites grow Researchers have found the first definitive evidence of how silicalite-1 (MFI type) zeolites grow showing that growth is concerted a process involving both the attachment of nanoparticles and the addition of molecules.
For more than two decades researchers have theorized that nanoparticles which are known to be present in zeolite growth solutions played a role in the growth
or molecules to the crystal the presence and gradual consumption of nanoparticles suggested a nonclassical pathway for zeolite crystallization.
The device which is designed to be used outside the body much like dialysis uses nanoparticles to trap pore-forming toxins that can damage cellular membranes
Nanoparticles have already been shown to be effective at neutralizing pore-forming toxins in the blood
but if those nanoparticles cannot be digested effectively they can accumulate in the liver creating a risk of secondary poisoning especially among patients who are already at risk of liver failure.
To solve this problem a research team led by nanoengineering professor Shaochen Chen created a 3-D-printed hydrogel matrix to house nanoparticles forming a device that mimics the function of the liver by sensing attracting
The concept of using 3-D printing to encapsulate functional nanoparticles in a biocompatible hydrogel is said novel Chen.
This field magnetised the nanoparticles leading to a particle re-arrangement in form of parallel lines.
potentially offering an easy way to monitor the assembly of nanoparticles, or to study how mass is distributed within a cell.
and morphology of the alloy nanoparticles on surfaces,"said Dr. Grant Johnson, a PNNL physical chemist who led the study.
The team created the nanoparticles using magnetron sputtering and gas aggregation. They placed them on a surface using ion soft landing techniques devised at PNNL.
The result is a layer of bare nanoparticles made from two different metals that is free of capping layers, residual reactants,
rather than homogeneous nanoparticles with the desired shape. Further, the particles lack a capping layer.
At relatively short time frames on flat surfaces, the nanoparticles bind randomly. Leave the process running longer and a continuous film forms.
Stepped surfaces result in the nanoparticles forming linear chains on the step edges at low coverage.
While this work focuses on single nanoparticles, the final result is extended an array with implications that stretch from the atomic scale to the mesoscale."
"Soft Landing of Bare Nanoparticles with Controlled Size, Composition, and Morphology.""Nanoscale 7: 3491-3503.
creating an electrode made of nanoparticles with a solid shell, and a olkinside that can change size again and again without affecting the shell.
The use of nanoparticles with an aluminum yolk and a titanium dioxide shell has proven to be he high-rate champion among high-capacity anodes
That where the idea of using confined aluminum in the form of a yolk-shell nanoparticle came in.
#Bioadhesive Nanoparticles Help Protect Your Skin From the Sun Dermatologists from Yale university have developed a new sunscreen made with bioadhesive nanoparticles that doesn penetrate the skin,
made with bioadhesive nanoparticles, that stays on the surface of the skin. Results of the research will appear in the September 28 online edition of the journal Nature Materials. e found that
and our nanoparticles are so adhesive that they don even go into hair follicles, which are relatively open.
the researchers developed a nanoparticle with a surface coating rich in aldehyde groups, which stick tenaciously to the outer skin layer.
The nanoparticle hydrophilic layer essentially locks in the active ingredient, a hydrophobic chemical called padimate O. Some sunscreen solutions that use larger particles of inorganic compounds, such as titanium dioxide or zinc oxide,
By using a nanoparticle to encase padimate O, an organic chemical used in many commercial sunscreens,
#Peering Into Nanoparticles One at a time Reveals Hidden World Imagine you could single out individuals in a large group
This is essentially what researchers at Chalmers University in Sweden have been able to achieve with a new microscopy technique that is capable of looking at a single nanoparticle rather than just a mass of them all clumped together. e were able to show that you gain deeper insights into the physics
of how nanomaterials interact with molecules in their environment by looking at the individual nanoparticle as opposed to looking at many of them at the same time,
The researchers applied the experimental spectroscopy technique to examine hydrogen absorption in single palladium nanoparticles.
despite various nanoparticles having the same size and shape, they would absorb hydrogen at pressures as different as 40 millibars.
While others have been able to image single nanoparticles previously, those efforts came at a rather high cost of heating the nanoparticles up,
or impacting them in some other way that eliminates the ability to observe them accurately. hen studying individual nanoparticles you have to send some kind of probe to ask the particle hat are you doing?
said Langhammer. his usually means focusing a beam of high-energy electrons or photons or a mechanical probe onto a very tiny volume.
so that it is possible to study nanoparticles one at a time in their actual environments. This ability to observe nanoparticles outside the lab could prove to be a key development for studies on the impact of nanoparticles in the environment e
#An Electric car Heater Can't Be Too Thin or Too Economical Just about every electrical device seems to want to slim down to a thin filmf possible,
The nanoengineering team was then able to modify the microfish body with various nanoparticles, using platinum in the tail section to interact with the hydrogen peroxide used to propel the fish forward,
Chen and Wang have conducted demonstrations to show the great potential of combining 3d printing with nanoengineering, installing polydiacetylene (PDA) nanoparticles within the microfish.
when nanoparticles are introduced to the particular toxins. This project offers boundless potential for the way that we locate
nanoparticles and biocompatible matrices for biotechnological applications. Moreover, they are pioneers in the application of silica-based ordered mesoporous materials,
#Microbubble Technology for Delivery of Nanoparticles to Tumours Biomedical researchers led by Dr. Gang Zheng at Princess Margaret Cancer Centre have converted successfully microbubble technology already used in diagnostic imaging into nanoparticles that stay
and observed that they fragmented into nanoparticles. Most importantly the nanoparticles stayed within the tumour and could be tracked using imaging."
"Our work provides the first evidence that the microbubble reforms into nanoparticles after bursting and that it also retains its intrinsic imaging properties.
We have identified a new mechanism for the delivery of nanoparticles to tumours, potentially overcoming one of the biggest translational challenges of cancer nanotechnology.
In addition, we have demonstrated that imaging can be used to validate and track the delivery mechanism, "says Dr. Zheng, Senior Scientist at the Princess Margaret and also Professor of Medical Biophysics at the University of Toronto.
"So for clinicians, harnessing microbubble to nanoparticle conversion may be a powerful new tool that enhances drug delivery to tumours,
#Electroluminescence with Phosphor Nanoparticles Holds Promise for Modern Lighting Light-emitting diodes (LEDS) are the modern lighting devices used in lamps, signals, signs or displays.
Special nanoparticles, so-called phosphors, are excited in an electric field to emit light. Researchers at the INM Leibniz Institute for New Materials have developed now a new method that enables electroluminescence on large
On application of an AC voltage, light is emitted from the electroluminescent layer. e embed luminous particles in the form of functionalized zinc sulphide nanoparticles as phosphors into the binder layer,
The researchers are currently working on further functionalization of the phosphor nanoparticles. ur goal is to generate white light by means of an altered doping
"Spatially strictly limited silicon nanoparticles display fundamentally different properties to conventional silicon wafers, "explains Matthias Wagner.
thus opens up the possibility of studying the fundamental electronic properties of cage-like Si nanoparticles compared to crystalline semiconductor silicon.
#Packaging Cancer drug into Nanoparticles Double Tumor Destroying Efficacy Researchers have packaged a widely used cancer drug into nanoparticles,
forming a water-soluble nanoparticle with the drug hidden in its core. These nanoparticles are highly soluble in blood
and are the perfect size to penetrate and accumulate in tumors where they take advantage of a tumor's acidic environment."
creating an electrode made of nanoparticles with a solid shell, and a olkinside that can change size again and again without affecting the shell.
The use of nanoparticles with an aluminum yolk and a titanium dioxide shell has proven to be he high-rate champion among high-capacity anodes
That where the idea of using confined aluminum in the form of a yolk-shell nanoparticle came in.
and nanoparticles to naturally occurring plant cells, biological polymers and tissues. The first application in which this microscope was deployed in the DOE Bioenergy Science Center was for analyzing plant cell walls,
Adhering nanoparticles of iron oxide to nylon fiber is done in three ways: electrospraying, which facilitates uniform nanoparticle placement in the fibers;
layer-by-layer assembly, where particles are coated on the fiber electrostatically; or chemical bonding. or the membrane, it important to evaluate particle retention and stability,
Trejo explained. ou would want the nanoparticles to stay on the Nylon 6 membranes so the material can have function throughout the life use.
#MRI SCANNERS can Non-Invasively Steer Cells with Nanoparticles to Tumour Sites Magnetic resonance imaging (MRI SCANNERS have been used since the 1980s to take detailed images inside the body-helping doctors to make a medical diagnosis
Amorphous Nanoparticles from Wide Material Range Before Ibuprofen can relieve your headache, it has to dissolve in your bloodstream.
Researchers from Harvard John A. Paulson School of engineering and Applied science (SEAS) have developed a new system that can produce stable, amorphous nanoparticles in large quantities that dissolve quickly.
But that not All the system is so effective that it can produce amorphous nanoparticles from a wide range of materials,
Mallinckrodt Professor of Physics and Applied Physics and an associate faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard, describes the research in a paper published today in Science. his is a surprisingly simple way to make amorphous nanoparticles from almost any material,
The droplets are dried completely between one to three microseconds from the time they are sprayed, leaving behind the amorphous nanoparticle.
At first, the amorphous structure of the nanoparticles was said perplexing Esther Amstad, a former postdoctoral fellow in Weitzlab and current assistant professor at EPFL in Switzerland.
These factors prevent crystallization in nanoparticles, even in materials that are highly prone to crystallization, such as table salt.
The amorphous nanoparticles are exceptionally stable against crystallization lasting at least seven months at room temperature. The next step, Amstad said,
is to characterize the properties of these new inorganic amorphous nanoparticles and explore potential applications. his system offers exceptionally good control over the composition,
This molecule was brominated at either side so that, upon addition of iron nanoparticles, the bromine would be abstracted and a diradical formed.
#Researchers Demonstrate Breakthrough Method for Getting Nanoparticles to Self-Assemble The medium is the message.
An innovative method they have demonstrated now for getting nanoparticles to self-assemble focuses on the medium in
This approach is an elegant alternative to present methods that require nanoparticles to be coated with light-sensitive molecules;
uncoated nanoparticles into a light-sensitive medium would be simpler, and the resulting system more efficient and durable than existing ones.
The nanoparticles then react to the change in acidity in their environment: It is this reaction that causes the particles to aggregate in the dark
This means that any nanoparticles that respond to acid a much larger group than those that respond to light can now potentially be manipulated into self-assembly.
By using light a favored means of generating nanoparticle self-assembly to control the reaction,
when and where the nanoparticles will aggregate. And since nanoparticles tend to have different properties
if they are floating freely or clustered together, the possibilities for creating new applications are nearly limitless.
For one, the particles do not seem to degrade over time a problem that plagues the coated nanoparticles. e ran one hundred cycles of writing
and rewriting with the nanoparticles in a gel-like medium what we call reversible information storage
In addition to durable ewritable paper, Klajn suggests that future applications of this method might include removing pollutants from water certain nanoparticles can aggregate around contaminants
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