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Scientists identify this certain bio-marker that is specific to a certain tumor then conjugates this bio-marker on the surface of the nanocarrier that only has the expression for that specific kind of cancer cell.
By using one nanocarrier to contain two different drugs we can potentially reduce their dose
The nanocarriers are made from a polymer called polyethylene glycol (PEG) to which researchers attach the cancer-killing drug camptothecin (CPT) like bunches of grapes on a vine.
The resulting nanocarrier is shaped like a flower#hence the term nanodaisy. The idea came from thinking actively about folding proteins in nature noted Gu referring to the way amino acids can assemble themselves into thousands of different shapes.
Using EGCG IBN researchers have engineered successfully nanocarriers that can deliver drugs and kill cancer cells more efficiently.
Our green tea nanocarrier not only delivered protein drugs more effectively to the cancer cells, the combination of carrier and drug also dramatically reduced tumor growth compared with the drug alone.
To solve this problem IBN has designed a therapeutic nanocarrier for drug delivery using novel compounds derived from EGCG.
Using the new nanocarrier twice as much drug accumulated in the cancer cells indicating an improved tumor targeting ability.
IBN has filed a patent on their green tea nanocarrier and is developing this technology for clinical applications.
Like tiny submarines these versatile nanocarriers can navigate in the watery environment surrounding cells and transport their guest molecules through the membrane of living cells to sequentially deliver their cargo.
For practical applications these nanocarriers are highly desirable explains Francisco Raymo professor of chemistry in the University of Miami College of Arts and Sciences and lead investigator of this project.
The new nanocarriers are15 nanometers in diameter. They are made supramolecular constructs up of building blocks called amphiphilic polymers.
These nanocarriers hold the guest molecules within the confines of their water-insoluble interior and use their water-soluble exterior to travel through an aqueous environment.
when the mab was used as a targeting device on Genisphere's 3dna nanocarrier loaded with doxorubicin.
and 3dna nanocarriers can deliver a variety of drug cargoes, we can easily generate targeted drugs for many of these indications."
scientists from the Helmholtz Zentrum Mnchen (HMGU) and the Ludwig-Maximilians-Universitt (LMU) in Munich have developed nanocarriers that site-selectively release medicines/drugs at the tumor site in human and mouse lungs.
Selective drug transport verified in human tissue for the first time The Munich scientists have developed nanocarriers that only release the carried drugs in lung tumour areas.
Tumour specific proteins were used to release drugs from the nanocarriers Tumour tissue in the lung contains high concentrations of certain proteases,
The scientists took advantage of this by modifying the nanocarriers with a protective layer that only these proteases can break down,
and so the medicines stay protected in the nanocarrier.""Using these nanocarriers we can very selectively release a drug such as a chemotherapeutic agent specifically at the lung tumour,"reports research group leader Meiners."
"We observed that the drug's effectiveness in the tumour tissue was 10 to 25 times greater compared to
"Further studies will now be directed to examine the safety of the nanocarriers in vivo and verify the clinical efficacy in an advanced lung tumour mouse model l
Now, researchers report in Biomacromolecules("Biodegradable ph-Sensitive Poly (ethylene glycol) Nanocarriers for Allergen Encapsulation and Controlled Release")the development of a potentially better allergy shot that uses nanocarriers to address these unwanted issues.
The researchers designed a new type of nanocarrier based on the biocompatible molecule poly (ethylene glycol or PEG, that releases its cargo only in targeted immune cells.
The nanocarrier degrades when it encounters the acidic part of these cells, simultaneously releasing the allergen
Non-aqueous solvent supports DNA NANOTECHNOLOGY May 27th, 2015controlled Release of Anticorrosive Materials in Spot by Nanocarriers May 27th, 2015production of Copper Cobaltite Nanocomposites with Photocatalytic Properties in Iran
Non-aqueous solvent supports DNA NANOTECHNOLOGY May 27th, 2015controlled Release of Anticorrosive Materials in Spot by Nanocarriers May 27th, 2015production of Copper Cobaltite Nanocomposites with Photocatalytic Properties in Iran
Non-aqueous solvent supports DNA NANOTECHNOLOGY May 27th, 2015controlled Release of Anticorrosive Materials in Spot by Nanocarriers May 27th, 2015production of Copper Cobaltite Nanocomposites with Photocatalytic Properties in Iran
News and information June 29th, 2015efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising Results June 29th, 2015making new materials with micro-explosions:
A novel microscope for nanosystems June 25th, 2015iranian Researchers Synthesize Nanostructures with Controlled Shape, Structure June 25th, 2015discoveries June 29th, 2015efforts to Use Smart Nanocarriers to Cure Leukemia Yield
New technique combines electron microscopy and synchrotron X-rays to track chemical reactions under real operating conditions June 29th, 2015announcements June 29th, 2015efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising
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