Tumors appeared accelerate the tissue aging process by 36 years and healthy breast tissue near breast tumors were an average of 12 years older than tissue elsewhere in the body.
In contrast transforming adult human cells into#pluripotent stem cells which reprograms them to act like embryonic stem cells effectively resets the cells'clock to zero Horvath says.#
#To make it happen the team removed parts of skull from three patients experiencing frequent drug-resistant epileptic seizures then attached a packet of electrodes to their exposed brains.
#Fruit flies Boost STI Immunity Before Sex Among the promiscuous common fruit fly sexually-transmitted infections run rampant.
and stress response genes when they hear the courtship song of a male. This helps them fight off sexually-transmitted infection from the fungus Metarhizium robertsii.
One of these genes#Turandot M#(Totm)# specifically protected the flies against STIS. When the flies were exposed to#a topical infection of the same fungus the#expression of Totm didn't help at all.
The researchers suggest that this immune anticipation is likely to be far more common than currently appreciated in insects#as they write in Proceedings of the Royal Society B. T he courtship-induced preemptive upregulation of Totm might be representative of a general pattern of immune anticipation
#Wii Fit Plus Helps Diabetics Control Blood sugar As you might already know playing Wii Fit is a funny thing.
In a randomized controlled trial older adults with type 2 diabetes had better controlled blood sugar after playing Wii Fit Plus for half an hour a day every day for 12 weeks.
Their blood sugar#level#reductions were on par with study participants who received the â##standard careâ#doctors normally give people with diabetes the U k. s National Health service reports.
This is encouraging because getting set up to play Wii Fit Plus is cheaper than other forms of diabetes care National Health service reports.
The bottom line is that there s evidence playing Wii Fit Plus daily can help those with type 2 diabetes though it s not exactly a proven treatment yet.
#Drug Cures Mice Of Down syndrome With A Single Dose Cure Down syndrome with a single injection?
A team of scientists from John Hopkins University and the National institutes of health have cured newborn mice of Down syndrome by injecting them with a drug that stimulates
People with Down syndrome usually have smaller brain volumes than control groups including significantly smaller cerebellums a portion of the brain involved in motor control.
The researchers led by Roger Reeves of the John Hopkins University School of medicine treated newborn mice that had been engineered genetically to have Down syndrome-like characteristics with a small molecule called SAG.
It's possible enhancing the biochemical events that lead to growth in the brain would cause issues elsewhere in the body like potentially raising the risk of cancer.
Down syndrome is very complex and nobody thinks there's going to be a silver bullet that normalizes cognition Reeves said in a statement.
What about the physical characteristics of Downs syndrome? Will the child still have mongoloid characteristics
Down syndrome creates a great many genetic expressions to the individual. some dont get all that are possible. most likely any physiological characteristics would be largely permanent after birth.
mosquitoes whiteflies and dragonflies which pick up dinner and pathogens from various food sources. We call them flying syringes she says.
Sampling the viruses they carry could enable her to detect a pathogen early. Usually you wait for an outbreak
An associate professor of food safety and plant biosecurity at Virgina Tech Schmale sends drones armed with petri dishes into the atmosphere to capture airborne crop pathogens.
The data he has gathered explains how pathogens ride on wind currents and provides a glimpse into an almost unknown ecosystem far above our heads.
He's planning to adapt his model to predict the movement of plant pathogens which could help farmers preemptively protect their crops by describing where to strategically deploy pesticides.
They dramatically sped up the study of genetics and disease. The techniques Zhang helped develop called TALE
Zhang plans to use the techniques to study the genetics of autism and schizophrenia. He has begun already to insert genes linked to each disorder one by one into animal models to observe their effects.
and reassembled as often happens in cancer even undamaged genes are expressed at different levels than in a normal chromosome.
Just last year, more than 200 people in Lahore died after contaminated cardiac medicines containing a toxic amount of an anti-malaria drug hit the city's supply.
-which might not actually manage to develop into a human even under the right conditions-than of individuals who suffer daily with crippling diseases that were thrust upon them by chance
Stem cell research is an incredibly valuable source of information concerning real diseases that real humans are really suffering from right at this very moment.
Stem cell-derived organs might in future provide accurate disease models for screening of pharmaceutical compounds reducing the requirement for animal testing
#Which Drugs Actually Kill Americans Infographic Death reporting in the U s. requires an underlying cause the event or disease that lead to the death.
or one on diabetes or obesity it would fit but not here. How can you put up this graph
Upon autopsytheir fatty liver disease resembled that of an alcoholic. However the culprit was excess sugar
but in reality those levels could never be reached. http://www. druglibrary. org/schaffer/library/mj overdose. htmmarijuana also doesn't cause cancer. http://www. washingtonpost. com/wp-dyn/content/article/2006/05/25
It does not show deaths from chronic health problems caused by drug use nor accidents (car crashes falls) nor suicides while intoxicated.
when people email about topics like cancer or depression ads for spiritual meditation services will appear.
They can also track protein buildup in numerous degenerative diseases such as Alzheimer s or Parkinson s. In fact nanoscopy can even be used to visualize the individual proteins in fertilized eggs.
In animal studies this enabled reseachers to recognize the subtle brain signals that seem to give rise to seizures#a capability#he hopes doctors can use to better understand epilepsy in humans.
These arrays have tremendous potential to improve the quality of life for people with many kinds of disabilities.
#Building Better Knees For The NBA The stress of repetitive jumping makes NBA players#particularly prone to painful even career-ending cartilage lesions.
#The Substitute that Deliversto fix a lesion doctors use osteochondral autograft transplant#surgery#(OATS)# to transfer cartilage from a non-load-bearing section of the patient s knee.#
The New Last Resortused to treat large injuries autologous chondrocyte implantation (ACI) involves harvesting cartilage from the patient
Paralyzed Rats Walk Again, Now Farther Than Ever Like a severed telephone line (from back in the days when phones had wires) a spinal cord injury can cut off communication between the brain
It's one of the leading causes of paralysis in the United states and the debilitating effects often can be permanent.
But over the past few years scientists have begun to overcome some kinds of paralysis using epidural electrical stimulation or EES for short.
one above the injury and one below. Then the top array reads the electrical commands from the brain and beams them to the lower array.
Essentially the EES is a bridge that bypasses the spinal cord injury. The technology has given already paralyzed rats
In the experiment the rats'spinal cords were severed completely causing total paralysis of the hindlimbs. Yet the researchers got the rodents walking again with the help of EES and some training sessions (during
and even tuberculosis#have developed numerous mechanisms to keep themselves alive at all cost#mostly against antibiotics.
and even brain cancer but the MIT researchers are the first to use them to combat antibiotic resistance.#
They also guided the CRISPR to attack bacterial genes that make the microorganism capable of causing disease in the first place.
But if CRISPR is designed to remove the bacteria s genes that make them deadly in the first place the system can effectively destroy the infection.
According to the Centers for Disease Control and Prevention at least 2 million people become infected with antibiotic-resistant bacteria each year in the United states resulting in at least 23000 deaths.
if a blow was powerful enough to potentially cause a head injury. At a time when the sport has been hammered with bad news this#might be a game changer.
It also doesn't make use of any bleeding-edge technology. Instead it puts together neurorobotics software
Upper right corner for 1 bottom right corner for 0.)This part of the process takes advantage of technology that several labs have developed to allow people with paralysis to control computer cursors or robot arms.
Kidding aside an app like this could help people with conditions such as autism that makes it hard for them to read emotions.
The boy named Minghao had developed a malignant tumor on his spinal cord and some of his bones needed to be removed.
and weak health infrastructure and where accurate data on the spread of the disease is difficult to come by.
director of the National Institute of Allergy and Infectious diseases, told USA Today. The U k. fund comes from a pool worth $10. 8 million (6. 5 million British pounds),
#MERS Virus May be Able To Spread Through The Air Research strongly suggests that camels carry Middle east Respiratory Syndrome (MERS),
a viral illness that has sickened nearly 700 and killed at least 209 people as of early June, according to the latest update from the World health organization.
When an electric current is applied to one of the DEAS it creates a biased stress between the two DEAS thus bending the actuator.
No casualties or even small injuries were reported although the area is being contained and treated with caution.
A fun, affordable mealtime assistant for people with upper limb disabilities Shaped like a baby elephant Hellospoon is intended a robot to help children
An Interview with Conor Russomanno Brain-computer interfacing (BCI) is a rapidly growing field that offers huge potential for many applications such as medical grade BCIS to help people with sensory-motor disabilities.
A robotic learning coach for kids with type 1 diabetes Less than three campaign days left!
Back Sproutel#sâ crowdfunding campaignâ to help get robotic healthcare coach Jerry the Bear into the hands of kids with type 1 diabetes.
Jerry the Bear is a robotic learning coach for children diagnosed with type 1 diabetes (T1d) that helps them master their medical procedures all through play!
and even become empowered to practice their own disease care. We were ecstatic to learn that over 5 months after this first shipment families are still playing with Jerry for over an hour each week.
The first bears distributed from our campaign will fulfill a queue of families that have submitted already hardship applications to the Type 1 Diabetes Network.
Android developer hacker hustler and resident diabetes expert if our bears ever become sentient you#ll know whom to blame.
Previouslyâ building rehabilitative toys for kids with cerebral palsy. Happiest in a machine shop with a well-made spreadsheet or fly fishing.
For someone who is paraplegic a major issue when using an exoskeleton is that the person is not able to feel their legs
along with giving those with disabilities a hope for the future. To keep up to date with NCCR Robotics please sign up to ourâ monthly infoletter
) geometry (with Droplets measuring angles and distances between them) or the spread of infectious diseases. Using the robots together with an overhead projector allows projecting an RGB coordinate system
It notably supports citizen empowerment through self management of health and disease health promotion and disease prevention.
Their advances have allowed individuals with extensive paralysis and locked-in syndrome to interact with the world around them by controlling a computer mouse with their mind.
Moving a mouse is something that most of us take for granted but an individual with locked-in syndrome that is fully awake and conscious has no other means of producing speech move limbs
or make facial movements. Through a device implanted in the skull the Braingate device interfaces with a computer allowing the individual to interact with their environment.
and supports assistive communication technologies for individuals who are unable to effectively communicate due to neurological injury and disease.
Says Bacher#if we develop a piece of technology for someone with a spinal cord injury who is moving their head to control a computer there s no reason that can#t help someone
The system was developed originally to improve the quality of life of individuals with severely impaired motor abilities such as those with motor neuron disease or cerebral palsy.
For people who have become paralyzed due to a spinal injury the normal flow of brain signals through the spine
This means that even an individual with complete body paralysis can still move their eyes over images on a screen.
However first jump up tests showed that the stress resulting from a sudden braking of the momentum wheel led to mechanical deformations of the momentum wheels and aluminium frame.
and breaking mechanism to reduce the mechanical stress caused by the jump up. In addition to balancing my colleagues are now investigating the use of controlled manoeuvres of jumping up balancing
which will promote efficient rehabilitation. e would like to see these robots used for rehabilitation training in hospitals nursing homes and private homes after an injury or for use as a preventive measure prior to injury. i
The mechanical stress of loading and unloading and the corrosive properties of seawater all take their toll on a vessel#structure.
#OAK, a Kinect-based active support system for the severely disabled OAK which stands for bservation and Access with Kinectis a software application for use by people with severe disabilities.
For example if a person has a cervical injury and can only move from the neck up you can put a switch next to their head.
and (4) Monitoring dementia patients. Once standards are in place it will give a boost to full-scale production of nursing-care robots from all over the world but particularly from Japan n
whether genetically transmitted diseases are present, evaluate future risks, and identify genes related to illness. y investigating SNPS,
we can determine that this drug will work for this person, or this drug will have severe side-effects on that person.
and treat paralysis. Until now implants placed beneath the dura mater of the spinal cord have caused significant tissue damage
Previous work by the team have enabled animals paralysed by spinal cord injury (SCI) to voluntarily walk again using both chemical and electrical stimulation.
E-dura is implanted over the lumbosacral segments below the site of injury and engages with the#dormant#lumbar locomotor circuits.
#A new weapon in the fight against cancer Cancer happens when cells in the body start growing uncontrollably.
But what if the tissue surrounding a tumour could be enlisted to stop the cancer spreading?
Many cancer researchers believe that targeting the spread of cancer to other organs, otherwise known as metastasis, holds the key to successfully treating the disease
because metastasis is the cause of death for 90%of those who die of cancer.
In the past, many treatments aimed at preventing metastasis have been targeted at tumour cells themselves, for example with chemotherapy,
but after a while the tumour cells can become resistant to the treatment and the cancer then spreads.
recruiting their help in creating a micro-environment with suitable conditions for the cancer to spread.
A large proportion of the cells found in the tumour micro-environment are associated cancer fibroblasts (CAFS.
and helps heal wounds. However in cancer, fibroblasts are coopted into re-sculpting and stiffening the surrounding matrix.
This helps the tumour to grow larger by encouraging cells to divide and allows cancer cells to escape into the bloodstream from where they can then spread to other parts of the body.
and help bring the cancer-associated fibroblast cells back on side against the cancer. Further experiments found that the CAFSCHANGE in behaviour was caused by a protein that is involved in sensing the amount of oxygen available to the cells.
The team then used a drug in the mice with cancer that fools this oxygen sensor into behaving
They found that the cancer was then less likely to spread in those mice that had been treated with the drug than in those that hadn.
However, it is an exciting development in the way we think about how cancer can be treated.
One of the great challenges in cancer treatment is that tumour cells are genetically unstable
As our understanding of the complex relationship between cancer and our bodies evolves, we will find new ways to target
and combat the disease. It is very likely that the chemotherapies of the future will exploit these interactions
#US ARMY Turns to Computer Software for Medic Training Technology already has pushed medical and emergency responder training well beyond the days of mock wounds and static mannequins.
Combat Medic, developed for the service by Applied Research Associates, places trainees in a 3-D collaborative world where they learn to treat the three injuries most associated with preventable battlefield deaths hemorrhage, blocked
Suppressing immunity in this way opens up the risk of new infections and certain cancers. Ott's ambitious technique therefore has an ambitious goal--to one day provide amputees with fully functional limbs that can be transplanted
"I wanted to make the best possible disease-detection instrument that we could almost distribute for free.
"However), in situations where people have spinal cord injury, so they are quadriplegic...you probably couldn't give them sensation back through the nerves,
"because they have lost the use of the nerves in their arm, said Dr. Paul S. Cederna, professor of plastic surgery and biomedical engineering at the University of Michigan.
The big benefit of Sanchez's approach is being able to use prostheses for people with spinal cord injuries,
The 28-year-old man in the current demonstration has been paralyzed for more than a decade because of a spinal cord injury.
"arguing that descendants of cloned animals showed no health problems while a complete ban might be difficult to sustain in law w
Cells moving from the original cancer site to infect other organs in a stealthy process called metastasis are detected usually too late to save a patient's life.
The early detection of circulating tumor cells, or CTCS, in the bloodstream can speed up diagnosis and lifesaving treatment.
The study, published in the journal Nature Communication, suggests that capturing CTCS would prevent their spread and help halt disease progression."
"Animals receiving an implant had reduced a significantly burden of disease in their lungs relative to animals that did not have an implant,
"The combined systems can enable the early detection of metastatic disease, "Shea said by email."
"Shea said he hoped clinical trials with human cancer sufferers could begin soon n
#Robotic Limb System Learns From Its Mistakes The science of brain-machine interface, or BMI, has made enormous leaps in the last few decades.
and said only that he had suffered a spinal cord injury.""By wiring a sense of touch from a mechanical hand directly into the brain,
#Smart Mirror Diagnoses Health problems Mirror, mirror on the wall, what my cholesterol level? The Wize Mirror, developed by 11 European research groups,
and to actually displaying information about your health from your cholesterol levels to indicators for diabetes.
which are substances that have been linked with diabetes and other diseases. The mirror can also assess nutrition and physical activity.
as well as the possibility of using gene-editing to engineer a disease-free human. The finding reported this week by Harvard university researchers in the journal Science Express uses a technology known as CRISPR/Cas-9,
I do have Huntingtons or Tay-sachs or some other miserable disease,?, said Arthur Caplan, professor of bioethics at New york University. omeone will say let try to engineer embryos to see
Rats without worm protection will have an overreactive immune response to the initial E coli infection, which increases levels of a specific type of signaling molecule in the brain called interleukin-1 ß (IL-1ß).(
if a second infection occurs, in this case, LPS. To test the effects on the brain, specifically memory,
and infection-free, suggesting that the worms had protected somehow the rats against memory loss after the infections.
Pups born to wormy moms showed no increase in IL-1ß after the E coli infection,
The theory suggests immune systems that evolve without enough exposure to infections (like the wormless rats) overreact
when exposed to even milder forms of infection (like E coli or the LPS injections). Following that theory,
or Prepo all people at ubstantial riskof infection. Currently, only 15 million HIV-infected people are receiving antiretrovirals.
The Joint United nations Programme on HIV/AIDS earlier called for a ast-trackapproach to end the world AIDS epidemic by 2030 that would increase the necessary annual investmentsow at $21. 7 billiony $12 billion.
Doing so will require more domestic spending by low-income countries that are hardest hit by the epidemic as well as larger contributions from wealthy nations.
a HIV cure researcher who directs the Peter Doherty Institute for Infection and Immunity in Melbourne,
was conducted by a team from the Vaccine Research center at the U s. National Institute of Allergy and Infectious diseases (NIAID) in Bethesda, Maryland.
Both groups designed artificial versions of antibodies, the Y-shaped molecules made by the immune system to target pathogens.
He further points out that two cancer bispecific antibodies on the market both have anti-CD3 arms. he key is to find the right balance between CD3 activation and toxicity,
and a member of MIT Koch Institute for Integrative Cancer Research, is the paper senior author.
#Researchers identify new target for anti-malaria drugs A new target for drug development in the fight against the deadly disease malaria has been discovered by researchers at MIT.
which causes toxoplasmosis, and Plasmodium, which causes malaria, access vital nutrients from their host cells.
Around one-third of the world deadly infectious diseases, including malaria and tuberculosis, are caused by pathogens that spend a large portion of their life inside specially built compartments within their host cells.
These compartments known as arasitophorous vacuoles, separate the host cytoplasm and the parasite by a membrane,
and thereby protect the parasites from the host cell defenses. They also provide an environment tailored to their needs, according to Dan Gold,
This makes it more difficult for the parasite to release proteins involved in the transformation of the host cell beyond the membrane in order to spread the disease
and for the pathogen to gain access to vital nutrients, Gold says. ltimately what defines a parasite is that they require certain key nutrients from their host,
Similar research into how the related Plasmodium pathogen performs this trick had identified a so-called rotein export complexthat transports encoded proteins from the parasite into its host red blood cell,
which transforms these red blood cells in a way that is vital to the spread of malaria. he clinical symptoms of malaria are dependent on this process
they could be used as a drug target against the diseases they cause, including malaria, he says. his very strongly suggests that you could find small-molecule drugs to target these pores,
which would be very damaging to these parasites, but likely wouldn have any interaction with any human molecules,
he says. o I think this is a really strong potential drug target for restricting the access of these parasites to a set of nutrients. n addition to malaria,
a professor of immunology and infectious diseases at Harvard School of Public health who was involved not in the research. trikingly,
#How chronic inflammation can lead to cancer Chronic inflammation caused by disease or exposure to dangerous chemicals has long been linked to cancer,
but exactly how this process takes place has remained unclear. Now, a precise mechanism by which chronic inflammation can lead to cancer has been uncovered by researchers at MIT a development that could lead to improved targets for preventing future tumors.
In a paper published this week in the Proceedings of the National Academy of Sciences,
the researchers unveil how one of a battery of chemical warfare agents used by the immune system to fight off infection can itself create DNA mutations that lead to cancer.
As many as one in five cancers are believed to be caused or promoted by inflammation These include mesothelioma,
a type of lung cancer caused by inflammation following chronic exposure to asbestos, and colon cancer in people with a history of inflammatory bowel disease, says Bogdan Fedeles,
a research associate in the Department of Biological engineering at MIT, and the paper lead author.
Innate immune response Inflammation is part of the body innate response to invading pathogens or potentially harmful irritants.
However, these molecules can also cause collateral damage to healthy tissue around the infection site:
he presence of a foreign pathogen activates the immune response, which tries to fight off the bacteria,
and James Fox all professors of biological engineering at MIT had identified the presence of a lesion,
or site of damage in the structure of DNA, called 5-chlorocytosine (5clc) in the inflamed tissues of mice infected with the pathogen Helicobacter hepaticus.
This lesion, a damaged form of the normal DNA base cytosine, is caused by the reactive molecule hypochlorous acid the main ingredient in household bleach
The lesion 5clc, was present in remarkably high levels within the tissue, says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
who led the current research. hey found the lesions were very persistent in DNA, meaning we don have a repair system to take them out,
Essigmann says. n our field lesions that are persistent, if they are also mutagenic, are the kind of lesions that would initiate cancer,
he adds. DNA sequencing of a developing gastrointestinal tumor revealed two types of mutation: cytosine (C) bases changing to thymine (T) bases,
and adenine (A) bases changing to guanine (G) bases. Since 5clc had not yet been studied as a potentially carcinogenic mutagen,
the researchers decided to investigate the lesion further, in a bid to uncover if it is indeed mutagenic.
the researchers first placed the 5clc lesion at a specific site within the genome of a bacterial virus. They then replicated the virus within the cell.
when triggered by infection, fires hypochlorous acid at the site, damaging cytosines in the DNA of the surrounding healthy tissue.
he explains. his scenario would best explain the work of James Fox and his MIT colleagues on gastrointestinal cancer.
the researchers replicated the genome containing the lesion with a variety of different types of polymerase,
or patterns of DNA mutations, associated with cancerous tumors. e believe that in the context of inflammation-induced damage of DNA,
says the paper provides a novel mechanistic link between chronic inflammation and cancer development. ith a combination of biochemical,
a type of mutation that is frequently observed in human cancers, Wang says. Studies of tissue samples of patients suffering from inflammatory bowel disease have found significant levels of 5clc,
Fedeles adds. By comparing these levels with his team findings on how mutagenic 5clc is,
the researchers predict that accumulation of the lesions would increase the mutation rate of a cell up to 30-fold,
who was honored with the prestigious Benjamin F. Trump award at the 2015 Aspen Cancer Conference for the research.
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