The team identified novel factors that might be used in reprogramming cells into so-called pluripotent stem cells for possible treatment of a range of diseases including infertility.
#More effective drugs for diabetes in the offing Scientists have found a new way to lower blood sugar levels by reducing glucose production in the liver,
paving the way for more effective drugs for type 2 diabetes. Some treatments for type 2 diabetes make the body more sensitive to insulin,
the hormone that lowers blood sugar. But new research at Washington University School of medicine in St louis suggests a different strategy:
They did so by shutting down a liver protein involved in making glucose, an approach that may work in patients with type 2 diabetes."
"We think this strategy could lead to more effective drugs for type 2 diabetes, "said principal investigator Brian N Finck, associate professor of medicine in the Division of Geriatrics and Nutritional Science."
"A drug that shuts down glucose production has the potential to help millions of people affected by the most common form of diabetes,
and the biopharmaceutical company Metabolic Solutions Development Co. The company is involved in clinical trials that are evaluating the drug compound MSDC-0602 as a treatment for diabetes.
In addition to diabetes, the researchers also think that interfering with pyruvate transport may help patients with nonalcoholic fatty liver disease, a condition common in people with obesity y
Such a molecular profile could be useful for distinguishing people at earlier risk of age-related diseases.
This could improve upon the use of chronological age and complement traditional indicators of disease, such as blood pressure.
The researchers demonstrated that patients diagnosed with Alzheimer's disease had altered an'healthy ageing'RNA signature in their blood,
and therefore a lower healthy age gene score, suggesting significant association with the disease. Timmons added that this is the first blood test of its kind that has shown that the same set of molecules are regulated in both the blood
and the brain regions associated with dementia and it can help contribute to a dementia diagnosis. He noted that this also provides strong evidence that dementia in humans could be called a type of'accelerated ageing
'or'failure to activate the healthy ageing program.''The authors say that their'healthy age gene score'could be integrated to help decide which middle-aged subjects could be offered entry into a preventative clinical trial many years before the clinical expression of Alzheimer's.
They wanted to edit the gene responsible for B-thalassemia, a fatal blood disorder. CRISPR (pronounced like`crisper')has swept through the scientific world in the last few years
Its CEO Katrine Bosley said they are working to translate the promise of CRISPRCAS9 genome editing technology into a new class of medicines to treat serious, genetically driven diseases."
and we are working to apply it to treat a broad range of diseases at the genetic level where patients don't have good therapeutic options."
Scientists have developed a breakthrough lab-on-chip device that can substantially reduce the cost of sophisticated lab tests for medical disorders and diseases such as HIV,
Lyme disease and syphilis. The new device uses miniaturised channels and valves to replace"benchtop"assays-tests that require large samples of blood
Until now, animal research on central nervous system disorders, such as spinal cord injury and Parkinson's disease, has been limited because researchers could not extract sufficient cerebrospinal fluid to perform conventional assays."
The discovery could also lead to more comprehensive research on autoimmune joint diseases such as rheumatoid arthritis through animal studies.
Proteins called broadly neutralising antibodies (bnabs) are a promising key to the prevention of infection by HIV, the virus that causes AIDS.
The bnabs have been found in blood samples from some HIV patients whose immune systems can naturally control the infection.
even as it takes on different conformations during infection-making it easier to detect and neutralise the viruses in an infected patient.
In 2013, invasive MRSA infections were estimated responsible for an 9, 937 deaths in the US, researchers said.
Although current infection rates are declining, the majority of these deaths, about 8, 150, were associated with inpatient stays in health care facilities, according to the Active Bacterial Core surveillance report by the Centres for Disease Control and Prevention in US.
The discovery shows that the potential new antibiotics are unlike contemporary antibiotics because they contain iridium,
which is important for delivery of antibiotics to where they are needed to fight infections in the body.
The machine's ability to speedy disease recognition could potentially save lives as well as predict patients'imminent demise, the report added."
Paralysed for more than a deca de due to a spinal cord injury, the man could even identify which me chanical finger was being gently to uched,
Young men with cancer could be helped by the process s
#From reel to real: Potter-style invisibility cloak a reality now WASHINGTON: Scientists have developed a Harry Potterstyle ultra-thin invisibility cloak that can conform to the shape of tiny objects
#Protein system can detect viral infection, kill cancer cells MIT engineers have developed a modular system of proteins that can detect a particular DNA sequence in a cell
The researchers can programme the system to produce proteins that alert immune cells to fight the infection, instead of GFP."
#Paraplegic man walks using only his brain power A brain-to-computer echnology that can translate thoughts into leg movements has enab ed a man paralysed from the waist down by a spinal cord injury to become the first such
The slow, halting first steps of the 28-year-old paraplegic were documented in a preliminary study published in The british-based Journal of Neuroengineering and Rehabilitation,
and spinal injury victims regain some mobility. Dr An Do, a study co-author, said clinical applications were many years away.
brain-controlled walking after a complete spinal cord injury,"said biomedical engineer Zoran Nenadic, who led the research.
#Paraplegic man walks using only his brain power A brain-to-computer technology that can translate thoughts into leg movements has enabled a man paralysed from the waist down by a spinal cord injury to become the first such patient to walk without the use of robotics,
The slow, halting first steps of the 28-year-old paraplegic were documented in a preliminary study published in The british-based Journal of Neuroengineering and Rehabilitation,
and spinal injury victims regain some mobility. Dr An Do, a study co-author, said clinical applications were many years away.
brain-controlled walking after a complete spinal cord injury,"said biomedical engineer Zoran Nenadic, who led the research.
accurate detection of Ebola infections is needed to control outbreaks. Laboratory tests using preparations of Ebola virus
#Two-step therapy for breast tumour shows promise Disabling a cancer-causing pathway and administering an immune-molecule-based'mop-up'therapy can eradicate a type of breast tumour in mice,
#Cure for cancer might accidentally have been found, and it could be malaria Scientists might have made accidentally a huge step forward in the search for a cure for cancer discovering unexpectedly that a malaria protein could be an effective weapon against the disease.
Danish researchers were hunting for a way of protecting pregnant women from malaria, which can cause huge problems
because it attacks the placenta. But they found at the same time that armed malaria proteins can attack cancer, too an approach
which could be a step towards curing the disease. that can then bury into cancer cells and release the toxin,
killing them off. The scientists have found that in both cases the malaria protein attaches itself to the same carbohydrate.
It is the similarities between those two things that the cure could exploit. The carbohydrate ensures that the placenta grows quickly.
and a tumor,"said Ali Salanti from University of Copenhagen.""The placenta is an organ,
In a manner of speaking, tumors do much the same, they grow aggressively in a relatively foreign environment."
"The process has already been tested in cells and on mice with cancer, with the findings described in a new article for the journal Cancer cell.
because the protein appears to only attach itself to a carbohydrate that is only found in the placenta and in cancer tumors in humans."
"In the tests on mice, the animals were implanted with three different types of human cancers.
It reduced non-Hodgkin's lymphoma tumours to about a quarter of their size, got rid of protstate cancer entirely in two of six mice
and kept alive five out of six mice that had metastatic bone cancer compared to a control group all of
which died.""We have separated the malaria protein, which attaches itself to the carbohydrate and then added a toxin,
"said Mads Daugaard, a cancer researcher at Canada's University of British columbia and one of the scientists that worked on the research."
"By conducting tests on mice, we have been able to show that the combination of protein
#Blood cancer develops from prior blood disorder Researchers have discovered how an incurable type of blood cancer develops from an often symptomless prior blood disorder.
and ways to identify those most at risk of developing the cancer. All patients diagnosed with myeloma,
a cancer of the blood-producing bone marrow, first develop a relatively benign condition called'monoclonal gammopathy of undetermined significance'or MGUS."
"Our findings show that very few changes are required for a MGUS patient to progress to myeloma as we now know virtually all patients with myeloma evolve from MGUS,
"A drug that interferes with these initial metabolic changes could make very effective treatment for myeloma,
and only progresses to cancer in approximately one in 100 cases. However, currently there is no way of accurately predicting which patients with MGUS are likely to go on to get myeloma.
It specifically affects antibody-producing white blood cells found in the bone marrow, called plasma cells. For the study, the researchers compared the cellular chemistry of bone marrow
and blood samples taken from patients with myeloma, patients with MGUS and healthy volunteers. Surprisingly, the researchers found that the metabolic activity of the bone marrow of patients with MGUS was significantly different to plasma from healthy volunteers,
but there were very few differences at all between the MGUS and myeloma samples. The research team found over 200 products of metabolism differed between the healthy volunteers
and patients with MGUS or myeloma, compared to just 26 differences between MGUS patients and myeloma patients.
The findings suggest that the biggest metabolic changes occur with the development of the symptomless condition MGUS and not with the later progression to myeloma.
The researchers believe that these small changes could drive the key shifts in the bone marrow required to support myeloma growth.
The study was published in Blood Cancer Journal l
#Premature birth may weaken brain connections Premature birth may result in weakened connections in brain networks linked to attention, communication and the processing of emotions, thereby increasing risk of neurological and psychiatric disorders,
and abnormalities in brain circuits in the infants born early, compared with those of infants born at full term,
These brain circuit abnormalities likely contribute to problems that materialize as the children get older,
which could improve vision in older people with presbyopia and cataracts. As people age, their lenses lose flexibility and elasticity.
This leads to a condition known as presbyopia, common in people over 45 years old, and can require optical aids, such as reading glasses.
The lens could also have application in tackling cataracts-the clouding of natural lenses -which affect many people in later life and
"Given the impact of atrophy on astronauts in space, I wondered if a suit like the one worn by Freeman could fool the body into thinking it was on the ground rather than in space,
What more, Aprecia have just been awarded FDA approval for the first of 3d printed drug of its kind, the epilepsy drug Spritam.
myoclonic seizures and primary generalized tonic-clonic seizures in adults and children with epilepsy, they write.
This is good news for the large number of patients suffering from epilepsy-related afflictions, of which there are an estimated three million in the US alone
Surely epilepsy drugs already exist? Well you would be absolutely right, but the company argues that many patients have reported finding it difficult swallowing the large pills necessary. n my experience,
and seniors, having an option for patients to take their medication as prescribed is important to managing this disease. nd that where 3d printing comes in.
they mysteriously say about the exact way the technology works. y combining 3dp technology with a highly-prescribed epilepsy treatment,
remove a tumor from a 60-year-old woman kidney and to help repair a 28-year-old woman atlantoaxial dislocation condition.
when we are working out treatment for a child with congenital heart disease we can create a 3d dissection model of the patient
According to experts from Materialise, a majority of the 3d printing applications for the pediatric unit will focus on complex diseases including congenital heart disease, premature skull formations and congenital bronchial softening.
where hip disease and other issues (necrosis, dysplasia, fractures, and bone diseases such as arthritis) necessitating hip replacement is becoming more and more common.
As dr. Zhang Ke recently pointed out, joint replacement surgery is very common in China about 400,000 took place in 2014,
#3d printed Tadpole Endoscope device can improve cancer diagnoses Very recently, we reported on 3d printed icrofishrobots that can be injected directly into our blood to perform complex medical tasks.
A team from the Institute of Precision Engineering at the Chinese University of Hong kong as developed 3d printed tadpole-like devices that can improve diagnosis of various cancers by entering the patient stomach
A traditional procedure for diagnosing cancers of the gastrointestinal (GI TRACT which rank as the second most prevalent among all types of cancers in the world,
is endoscopy, wherein a long, flexible tube with a light and camera attached to its end passes through a person digestive system.
and relatively noninvasive solution that could improve the very way we diagnose cancers. Developed to be swallowed just like a large pill (it is a bit bigger than a small coin),
when it comes to cancer diagnosis. Once the stomach has been checked thoroughly, the device wimsinto the lower GI TRACT aided by natural peristaltic actionhat is,
and could be useful for tissue engineering, providing invaluable aid to neurosurgeons and cancer researchers.
The gel, similar to common hand sanitizer, minus alcohol and perfume, is able to rapidly switch from a solid to liquid state in response to stress.
Unfortunately, a number of injuries, infections and conditions directly affect the backbone and spine, limiting movement or at times even the very functioning of our bodies.
K2m, a global medical device company focused on developing complex and minimally invasive spine solutions for patients suffering from the most complicated spinal pathologies
"The announcement was made today at the 2015 North american Spine Society (NASS) Annual meeting in Chicago and offers an unprecedented application for 3d printing in spinal implants and the treatment of complex spinal pathologies
and more fracture resilience than regular metals because of the lack of pattern in their composition, so to speak.
Their eyes have caused defects largely by refractive errors, cataract, or glaucoma. They don see the world as the rest of the seeing world does and, due to the high costs of healthcare or unavailability of medical facilities,
they probably never will. 80%of all visual impairment can be prevented or cured, but 90%of these people live in developing countries,
Earlier in May, he delivered a talk at TEDX Auckland on his journey in fighting for preventable blindness
If a Makerbot Replicator 3d printer can be used in pharmacological research labs for advances studies on how to administer cancer fighting drugs,
According to the American Cancer Society, more than 220,000 men in the US will be diagnosed with prostate cancer this year,
prostatectomy procedures remove the entire prostate gland. 80%of these procedures in the US are, the National Cancer Institute states,
and feels just like their patient kidney tumor. This technology has the potential to reinvent the way we teach
Mercedes explained. believe that this technique is the future for tissue replacements as it allows tailored solutions by capturing the anatomical information of the patient wound by computed tomography and magnetic resonance, for example,
#Cancer Patient Receives 3d Printed Sternum and Ribs in First of its Kind Surgery Only months after Australia scientific research arm launched its $6 million 3d printing facility,
helping to improve the life of one Spanish cancer patient. With a 3d printed titanium sternum and rib implant, designed
an international collaboration has aided a 54-year-old patient diagnosed with a chest wall sarcoma.
First, Anatomics produced a 3d reconstruction of the patient chest wall and tumor with high-resolution CT SCANS, with
and nothing could be more hype-worthy than the regeneration of nerves after an injury.
a affliction suffered by more than 200,000 people worldwide due to disease and injury. The Mayo Clinic suggests that
his represents an important proof of concept of the 3d printing of custom nerve guides for the regeneration of complex nerve injuries.
you may never have to hear your uncle complain about his sciatica ever again v
without corners, we have rounded edges that you can really stress. And we were able to print them in half-rings.
surgery itself can lead to complications such as nerve damage, damage to other teeth, infection, swelling,
bleeding, pain or affect a patient's ability to open their mouth fully. Tennant and colleagues, including graduate student Abed Anjrini,
However he was excited most about the technology's potential in treating diseases such as cancer by delivering drugs more efficiently."
Mazdiyasni says future plans include investigating the technology for other engine components including coated parts and fracture critical parts s
#Spot Glaucoma With Your Smartphone Researchers from the Indian Institute of Science, Bangalore, have developed a method to diagnose glaucoma from smartphone images.
Scientists at the Indian Institute of Science (IISC), Bangalore, have announced the development of a new and simple method to detect glaucoma early enough to prevent blindness.
Glaucoma is usually the result of increased pressure in the eye, resulting in damage to the optic nerve,
which carries information to the brain. Since the symptoms of glaucoma do not show up until very late stages,
early detection by a procedure called fundus imaging is advised. Fundus imaging involves taking photographs of the retina
professor of electrical engineering at the IISC and leader of the team that developed the new method. his pre-screening tool can detect glaucoma with 90 percent accuracy,
Net that currently available technologies for detection of glaucoma are expensive while the new method is not only cheap,
but will also help with mass-screening for glaucoma. About 12 percent of India 1. 2 billion people are estimated to be affected by glaucoma. amage to the optic nerve due to glaucoma is not reversible.
If we detect it early then it is possible to halt the progression of glaucoma by appropriate medications or surgery,
Pakrasi says. ision may be preserved at nearly normal levels if glaucoma is detected and treated early. c
#ab-In-A-Needledetects Liver Toxicity In 30 Minutes The researchers are currently working on a prototype that miniaturizes a test lab into the size of a needle.
#Telomeres Implicated In Premature Aging Scientists have established successfully a comprehensive model of rare accelerated aging disorder, Hutchinson-gilford progeria syndrome (HGPS), opening up the possibility of treatment for the rare disease.
HGPS is an extremely rare genetic disease which causes patients to start aging rapidly when they are around one year old.
Symptoms include stunted growth and joint abnormalities, and patients often die of heart failure by their teenage years.
One in four million children suffer from HGPS, which currently has no effective treatment. The syndrome is caused by a mutated protein called progerin
which induces DNA damage, triggers premature cellular aging and slows down cell proliferation, resulting in accelerated aging.
or debilitating lung conditions including cancer, tuberculosis, asthma and cystic fibrosis. But the Respitetm nebulizer also has the potential to be used to administer insulin to people with diabetes
or to painlessly vaccinate infants currently subjected to needles. Professor Leslie Yeo, Director of RMIT University Micronanophysics Research Laboratory, said the Respite technology had the potential to revolutionize how patients were treated with drugs
Respitetm allows allows the dose to be adjusted based on a patient's size, age, gender, physiological profile and disease severity.
shift work and, perhaps, seasonal affective disorder. The study also provides a mathematical model that accurately predicts the behavior of the clock under different circumstances.
Perhaps in the future it may be possible for doctors to apply flexible bandages to severely burnt skin to reprogram the cells to heal that injury with functional tissue instead of forming a scar.
#Microbubble Technology for Delivery of Nanoparticles to Tumours Biomedical researchers led by Dr. Gang Zheng at Princess Margaret Cancer Centre have converted successfully microbubble technology already used in diagnostic imaging into nanoparticles that stay
potentially overcoming one of the biggest translational challenges of cancer nanotechnology. In addition, we have demonstrated that imaging can be used to validate
organic nanoparticle delivery platforms capable of transporting cancer therapeutics directly to tumours. Source: http://www. uhn. ca a
Yet local ph changes can provide invaluable early signals of many pathologies. For example, the ph around a cancer cell is slightly lower than normal,
the presence of an unseen tumor or show whether an infection has developed around a surgical implant."
to better differentiate between different pathologies, "Zabow says.""We think that these sensors can potentially be adapted to measure a variety of different biomarkers,
which can be a complication of cataract surgery. The company envisions a wide application of this immunodepletion strategy in other fibrotic diseases and cancer,
and has completed recently in-licensing intellectual property and additional assets for targeting Myo/Nog cells for therapeutic purposes from LIMR Development Inc. LDI),
a disease that typically occurs in approximately 30%of adults and greater than 70%of children after cataract surgery.
Additional studies testing this formulation in rabbits undergoing cataract surgery are ongoing with Drs. Liliana Werner and Nick Mamalis, Co-Directors of the Intermountain Ocular Research center at the University of Utah.
"Dr. Mindy George-Weinstein, Professor of Biomedical sciences at the Cooper Medical school of Rowan University, stated,"Myo/Nog cells have also been found in a variety of tumors,
where we predict they contribute to tumor growth. This targeted 3dna immunodepletion strategy may be useful as an adjuvant therapy to reduce tumor expansion and recurrence."
"Dr. Robert Getts, Chief Science Officer of Genisphere, said, "Since the antibody has broad utility
and now is a professor at the University of Houston. ne of the bottlenecks in automated pathology is the extensive processing that must be applied to stained images to correct for staining artifacts and inconsistencies.
which can then be used for other tests. his approach promises to have immediate and long-term impact in changing pathology to a multiplexed molecular science in both research and clinical practice,
and the University of Illinois Cancer Center at the University of Illinois at Chicago were partners in this work e
#Researchers Determine Molecular Structure of Nanobody-P Domain Complex for Norovirus Infection with highly contagious noroviruses,
while not usually fatal, can lead to a slew of unpleasant symptoms such as excessive vomiting and diarrhea.
This makes the development of an effective vaccine to protect against infection, as well as antiviral therapy to combat already-existing infections,
particularly challenging",says Dr. Grant Hansman, a virologist who leads the CHS Research Group on Noroviruses at the German Cancer Research center (Deutsches Krebsforschungszentrum, DKFZ) and Heidelberg University.
Hansman's research team recently discovered that a"nanobody"called Nano-85 was able to bind to intact norovirus-like particles (VLPS) in culture.
This could be especially beneficial to immunosuppressed individuals such as cancer patients. Administering a vaccine to protect against infection would overwhelm the patient's immune system.
However, if he or she has the option of receiving an antiviral to eliminate the infection,
the norovirus becomes much less dangerous.""Source: http://www. dkfz. d d
#Canatu Announce Multitouch, Button-Free Automotive Panels with Carbon nanobud Films Canatu, a leading manufacturer of transparent conductive films, has in partnership with Schuster Group
#Lab on a Chip Acoustofluidic Sputum Liquefaction Device for Safe Asthma and Tuberculosis Diagnostics A device to mix liquids utilizing ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis
of sputum from patients with pulmonary diseases such as tuberculosis and asthma. The device, developed by engineers at Penn State in collaboration with researchers at the National Heart, Lung,
or around 19 million people, have asthma, and in undeveloped regions where TB is still a widespread
and treatment approaches for patients with pulmonary diseases, we have to analyze sample cells directly from the lungs rather than by drawing blood,
different drugs are used to treat different types of asthma patients. If you know what a person immunophenotype is
you can provide personalized medicine for their particular disease. There are several issues with the current standard method for sputum analysis. The first is that human specimens can be contagious,
Stewart J. Levine, a Senior Investigator and Chief of the Laboratory of Asthma and Lung Inflammation in the Division of Intramural Research at NHLBI, said his on-chip sputum liquefier is a significant advance regarding our goal
This will allow health care providers to individualize asthma treatments for each patient and advance the goal of bringing precision medicine into clinical practice.
This research was supported by the American Asthma Foundation Scholar Award the National Science Foundation, and the NHLBI Division of Intramural Research.
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