a common brain cancer whose ability to grow, migrate and hack into the brain blood supply appears to rely on a pattern of gene activity similar to that now identified in these neural stem cells. he cerebral cortex is so different in humans than in mice,
and the Damon Runyon Cancer Research Foundation e
#Gene Test Finds Which Breast cancer Patients Can Skip Chemo Many women with early-stage breast cancer can skip chemotherapy without hurting their odds of beating the disease-good news from a major study that shows
whose cancers are so likely to respond to hormone-blocking drugs that adding chemo would do little
In the study, women who skipped chemo based on the test had less than a 1 percent chance of cancer recurring far away
"said the study leader, Dr. Joseph Sparano of Montefiore Medical center in New york. An independent expert, Dr. Clifford Hudis of New york's Memorial Sloan Kettering Cancer Center, agreed."
The study was sponsored by the National Cancer Institute. Results were published online Monday by the New england Journal of Medicine
and discussed at the European Cancer Congress in Vienna. The study involved the most common type of breast cancer-early stage, without spread to lymph nodes;
and could seed a new cancer later. Doctors know that most of these women don't need chemo
About 94 percent were free of any invasive cancer, including new cancers at other sites or in the opposite breast."
"These patients who had low risk scores by Oncotype did extraordinarily well at five years,
#Pseudo-platelet Drug Delivery System Targets Cancer Researchers are using patients own platelet membranes to coat drugs and use as nanovehicles for anticancer treatments.
#Identifying Cancer's Food Sensors May Help Halt Tumor Growth Oxford university researchers have identified a protein used by tumors to help them detect food supplies.
A team from Oxford university's Department of Physiology, Anatomy and Genetics led by Dr. Deborah Goberdhan worked with cancer doctor and researcher, Professor Adrian Harris,
and acquire nutrients is critical for a cancer to grow. Dr. Goberdhan's and Prof Harris's groups collaborated to develop an antibody that could be used to highlight PAT4 in human tissue samples.
This was used then to study anonymous tumor samples taken from patients with colorectal cancer, a common form of the disease.
'The research, funded by Cancer Research UK, the Wellcome Trust and the Biotechnology and Biological sciences Research Council will be published in the science journal Oncogene on 5 october 2015.
It continues and may eventually provide a way of increasing survival from cancer r
#Scientists Grow Old Brain cells from Patientsskin Cells Researchers from the Salk Institute for Biological Studies have found a way to create aged brain cells from patientsskin samples for the first time.
#Radiotherapeutic Bandage Could Treat Skin cancer Research behind a new radiotherapeutic bandage that could potentially treat squamous cell carcinoma (SCC) cancer was presented Wednesday, at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Expo in Orlando.
This procedure could eventually also be extended to men who have lost their penises from penile cancer or as a last-resort treatment for severe erectile dysfunction due to medication side effects.
whose cancer had spread to the central nervous system (CNS)( CNS ORR: 57.1 percent and 68.8 percent, respectively.
and the NP28761 study will be presented by Dr. Leena Gandhi, assistant professor of medicine, Dana-Farber Cancer Institute, Boston (Abstract#8019, Monday, June 1, 8: 00-11:30 A m. CDT).
About Lung cancer According to the American Cancer Society, it is estimated that more than 221,000 Americans will be diagnosed with lung cancer in 2015,
A team at Barts Cancer Institute, Queen Mary University of London, has shown that the three-protein'signature'can both identify the most common form of pancreatic cancer
-and distinguish between this cancer and the inflammatory condition chronic pancreatitis, which can be hard to tell apart.
03 august in the journal Clinical Cancer Research, was funded by the UK charity, the Pancreatic cancer Research Fund.
while patients suffering from chronic pancreatitis had significantly lower levels than cancer patients. When combined, the three proteins formed a robust panel that can detect patients with stages I-II pancreatic cancer with over 90 per cent accuracy.
when the cancer has already spread. This means they are not eligible for surgery to remove the tumour-currently the only potentially curative treatment.
The five-year survival rate for pancreatic cancer in the UK is the lowest of any common cancer
if the 3-biomarker signature is present during the latency period-the time between the genetic changes that will cause the cancer to develop and the clinical presentation."
"For a cancer with no early stage symptoms, it's a huge challenge to diagnose pancreatic cancer sooner,
"says co-author and Director of Barts Cancer Institute, Professor Nick Lemoine.""With pancreatic cancer, patients are diagnosed usually
when the cancer is already at a terminal stage, but if diagnosed at stage 2,
Early diagnosis is an important part of our overall efforts against this aggressive cancer, alongside developing new treatments to tackle the disease once diagnosis is made.
#Real-time Data For Cancer Therapy, MIT Study Biochemical sensor implanted at initial biopsy could allow doctors to better monitor
and adjust cancer treatments. In the battle against cancer, which kills nearly 8 million people worldwide each year,
doctors have in their arsenal many powerful weapons, including various forms of chemotherapy and radiation.
Now, researchers at MIT Koch Institute for Integrative Cancer Research are closing that information gap by developing a tiny biochemical sensor that can be implanted in cancerous tissue during the initial biopsy.
Making cancer treatments more targeted and precise would boost their efficacy while reducing patientsexposure to serious side effects. e wanted to make a device that would give us a chemical signal about what happening in the tumor,
While the primary application of these sensors would be cancer care, Cima is also eager to collaborate with researchers in other fields, such as environmental science. or example,
and demonstrate for opioid pain relievers can be adapted to produce many plant-derived compounds to fight cancers, infectious diseases and chronic conditions such as high blood pressure and arthritis.
bring researchers closer to creating an implantable intestine as replacement therapy for a range of devastating disorders-including infections, cancer and trauma-that result in loss or death of gut tissue.
Strangely shaped cells often indicate cancer. While this old, simple technique may seem a quaint throwback in the age of high-technology health care tools like genetic sequencing
and Genistein, the compound found in soybean which has been suggested to play a role in prevention of steroid-hormone related cancers, particularly breast cancer.
'mini tumors'in a culture dish,"explains the study's corresponding author Senthil Muthuswamy, Phd, Director of the Cell biology Program in the Cancer Research Institute at Beth Israel Deaconess Medical center
therefore, can serve as an innovative platform for both cancer research and for cancer treatment."
These models are used to help understand various biological processes such as tissue development and cancer growth, and Muthuswamy's laboratory has spent the past 15 years growing normal and cancer-derived cells from human breast tissue as 3d organoids.
This new paper provides an innovative new direction for this technology.""We have developed now a new methodology to grow human pancreatic tumor cells from surgical tissues
and biology of the cancer tissue in the patient, "says Muthuswamy, who conducted this research while at the University of Toronto.
"said Pier Paolo Pandolfi, MD, Phd, Director of the BIDMC Cancer Center.""Patients diagnosed with locally advanced
#Cancer Patient Receives 3d Printed Titanium Ribs & Sternum 3d printing continues to profoundly affect the modern world.
#Scientists brew cannabis chemical THC for better drugs for cancer sufferers An active ingredient typically found in cannabis has been engineered genetically in the lab for the first time.
They believe the breakthrough will lead to more effective and easier-to-manufacture cancer and HIV drugs
It's often used to treat nausea associated with HIV or cancer therapies but this new process could offer a less expensive,
It's often used to treat nausea associated with HIV or cancer therapies, but this new process could offer a less expensive,
'Interestingly, some of these markers have also been shown to be good targets for therapy in some cancers.'
or end stage cancer. Researchers are now considering how to manipulate immune cells with the PD1 marker in their HIV research.
and turnover,"said senior author Jamey Marth, Ph d.,professor in SBP's NCI-designated Cancer Center."
"It has been known that circulating glycosidase enzyme levels are altered in diseases such as sepsis, diabetes, cancer and various inflammatory conditions.
and Genistein, the compound found in soybean which has been suggested to play a role in prevention of steroid-hormone related cancers, particularly breast cancer.
#New finding offers clues for blocking cancer gene A new study suggests a potential new way to block one of the most common cancer-causing genes, without causing severe side effects.
The Notch gene plays a role in many types of cancer. It's the most common cancer-causing gene in T-cell acute lymphoblastic leukemia.
About 60 percent of children and adults with T-cell leukemia harbor a Notch mutation. But drugs designed to block Notch have caused serious side effects such as severe diarrhea or skin cancers.
Now a team from the University of Michigan Comprehensive Cancer Center offers a potential new target to block Notch without the toxic effects.
triggering the gene to turn on its cancer function. But Zmiz1 does not impact normal healthy Notch functions."
"Notch controls the genes that cause cancer, but it's also important for normal health.
The challenge is to knock out the cancer function of Notch but preserve its normal function,"says Mark Chiang, M d.,Ph d.,assistant professor of internal medicine at the University of Michigan Medical school."
And Zmiz1 seems to be selective in turning on the cancer functions of Notch, "Chiang adds.
We think this would block the Notch cancer pathway without causing toxic side effects, like we see with current Notch inhibitors,
"We need to develop therapies against Notch to help kids with relapsed cancer and to cure kids with fewer toxicities or long-term effects,
the brushes also could someday deliver cancer therapeutics s
#Researchers want to turn acid-loving microbes into safe drug-carriers Usually the microbe S. islandicus is found in hot and acidic volcanic springs,
Together with Professor Jonas A Nilsson at Sahlgrenska Cancer Center at the University of Gothenburg
#Study charts'genomic biography'of form of leukemia A new study by scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard offers a glimpse of the wealth of information
including two that had never before been linked to human cancer. They began to trace how some of these abnormalities affect the course of the disease and its susceptibility to treatment.
"Our work has enabled us to discover novel cancer genes, begin to chart the evolutionary path of CLL,
BRAF-mutant melanoma A team of Massachusetts General Hospital (MGH) investigators has discovered a new combination of drugs that may be effective against one of the deadliest cancers, malignant melanoma.
whether very-large-scale screening across a diverse collection of cancer cell lines and a large number of drugs could yield new combinations for patients with cancer,
"says Adam Friedman, MD, Phd, of the CBRC and the MGH Cancer Center, who led the study."
"By conducting such a screen, we found one specific combination of agents that are already being used clinically that potentially could be used for a specific group of patients-those with BRAF-mutant cancers."
'In recent years, Héctor Peinado, Head of the Microenvironment and Metastasis Group at the Spanish National Cancer Research Centre (CNIO), David Lyden from Weill Cornell Medical College,
and Jaqueline Bromberg from the Memorial Sloan Kettering Cancer Center, have developed a theory that supports Paget's'seed
and pancreas cancer to the liver--metastasis is reduced in these organs. LAYING THE GROUNDWORK The researchers have discovered also the molecular signals that intercede in the reaction of the recipient tissue
inflammation is associated a process with cancer. These results represent the identification of potential new pharmacological targets,
as well as plasma from cancer patients. The latter served for the preliminary study of the predictive power of the integrins identified, that is,
and pancreas cancer seems to predict the organ where the metastasis will occur, "says Peinado."
and is the leading cause of cancer-related deaths worldwide.""Sometimes there are hundreds of mutations in the genes of a patient's tumors,
"We found a new way by which to identify cancer suppressor genes and understand how they could be targeted for therapies."
who is also an American Cancer Society Professor of Molecular biology.""This molecule Epha2 is having a huge effect on restraining cancer growth
when KRAS is mutated.""Mutated KRAS is a common culprit in approximately 10 to 20 percent of all cancers, particularly colon cancer and human lung cancer."
"Since activating Epha2 led to the suppression of both cell signaling and cell proliferation, we believe that the enzyme might serve as a potential drug target in KRAS-dependent lung adenocarcinoma,
A 10-year national project called the Cancer Genome Atlas mapped the genomes of hundreds of patients for over 20 different cancers
From the Cancer Genome Atlas data, the Salk team found that genetic alterations of Epha2 were detected in 54 out of 230 patients with adenocarcinoma.
The team also found, surprisingly, that the loss of Epha2 activated a pathway commonly associated with cancer (dubbed Hedgehog) that promotes tumor growth."
and smuggle cancer signals their neighbors A new discovery published in the Nov. 2015 issue of The FASEB Journal shows that cancer cells use previously unknown channels to communicate with one another and with adjacent non-cancerous cells.
Not only does this cast an important light on how cancer metastasizes and recruits cellular material from healthy cells,
suggesting that this protein is a key regulator of cell-cell communication in cancer. Live cell imaging confirmed that the transfer is contact-dependent.
#New research opens door to understanding human tonsil cancer Researchers at Simon Fraser University and the BC Cancer Agency have developed a groundbreaking method to identify
and separate stem cells that reside in the tonsils. Their research, which sheds new light on the fight against oral cancer, is published today in the journal Stem Cell Reports.
While stem cells in many other body tissues have been studied well, little is known about these stem cells,
Ninety per cent of human tonsil cancers show evidence of HPV (human papillomavirus) infection. But little is known about its role in causing these cancers.
Researchers suspect it is a key player, as HPV is the major risk factor for cervical cancer.
Kang, who is working with BPK professor Miriam Rosin, director of the BC Oral Cancer Prevention Program,
and made them incorporate a cancer-causing gene normally transmitted by HPV, the cells grew abnormally in a special tissue culture system,
and created what one might imagine what the beginning stages of human tonsil cancer would look like."
as it is the first stage of human cancer development that researchers need to learn how to detect
Cancer of oropharynx, or the tonsils in particular, is an important health concern with rising incidence worldwide, especially in men.
The researchers, including Dr. Raj Kannan of the BC Cancer Agency's Terry Fox Laboratory,
only a handful may be true"drivers"of cancer. In research that appeared today in Nature Genetics,
This discovery might open new doors to understanding how this cancer grows and spreads, and it may lead in the future to new directions in treating this disease.
Thus studying these genes is crucial in cancer biology.""The identification of targetable alterations in melanoma is need an urgent.
"As the RAS pathway is highly dysregulated in cancer, the discovery of an alternative mechanism for its activation is likely to stimulate an avalanche of further research in this field,
"Most targeted cancer therapies nowadays work by inhibiting the products of oncogenes that are overactive in melanoma cells.
#DNA in blood can track cancer development and response in real time Scientists have shown for the first time that tumour DNA shed into the bloodstream can be used to track cancers in real time as they evolve
and respond to treatment, according to a new Cancer Research UK study published in the journal Nature Communications today (Wednesday).
Over three years, researchers at the University of Cambridge took surgical tumour samples (biopsies) and blood samples from a patient with breast cancer that had already spread to other parts of her body.
and timing of genetic changes appearing as the cancer developed and responded to treatment. The results provide the first proof-of-principle that analysing tumour DNA in the blood can accurately monitor cancer within the body.
Study author Professor Carlos Caldas, senior group leader at the Cancer Research UK Cambridge Institute, said:"
"This definitively shows that we can use blood-based DNA tests to track the progress of cancer in real time.
The findings could change the way we monitor patients, and may be especially important for people with cancers that are difficult to reach,
as taking a biopsy can sometimes be quite an invasive procedure.""The patient in the study had had breast cancer that already spread to a number of other organs.
and Nitzan Rozenfeld laboratories at the Cancer Research UK Cambridge Institute-were even able to distinguish between the different secondary cancers
We now need to see if this works in more patients and other cancer types,
"Dr Kat Arney, science information manager at Cancer Research UK, said:""Spotting tumour DNA in the bloodstream is a really promising area of research,
and monitoring cancers. But this work gives us a window into the future, where we'll use less invasive techniques to track the disease in real time
stealth bombs that slip past the brain's defenses to attack an incurable form of cancer.
Efstathios Karathanasis, a biomedical engineer at Case School of engineering, has developed chainlike nanoparticles that can carry drugs across the blood-brain barrier that keeps standard medicines from reaching their target--a highly aggressive brain cancer called
Their goal is to develop a treatment that eradicates the cancer with one safe dose."
The median survival rate among adults is just under 15 months, according to the American Brain Cancer Association.
In testing with mouse models of the cancer, models injected with an inducible nitric acid synthase inhibitor had fewer and smaller tumors compared to control models.
In addition to the grant money, the researchers will have access to the National Cancer Institute's Alliance for Nanotechnology in Cancer,
Strangely shaped cells often indicate cancer. While this old, simple technique may seem a quaint throwback in the age of high-technology health care tools like genetic sequencing
"It has been known that circulating glycosidase enzyme levels are altered in diseases such as sepsis, diabetes, cancer and various inflammatory conditions.
and skin cancers Scientists from the University of Granada (UGR) have patented an effective drug for treating cancer stem cells (CSCS) in breast, colon, and skin cancers.
They have managed also to successfully describe the mechanisms by which the drug acts on the cancer stem cells (CSCS.
Differentiation, Regeneration and Cancer",directedby Professor Juan Antonio Marchal Corrales. The Córdoba-based company Canvax Biotech has participated also in the development of the patent.
the scientists had managed already to create an effective drug (called Bozepinib) for treating cancer stem cells,
a huge advantagewhen compared to other cancer treatments such as chemotherapy. Althoughcscs are only found in small quantities in tumors,
Lungs and pancreas Having proved the preclinical effectiveness of the new drug in treating cancer stem cells in breast, colon,
and skin cancers, the scientists will proceed now to study the drug's effect on lung and pancreas cancers, two of the most aggressive types.
and certain forms of cancer may also prove to be responsive to Vasotide, "said Sidman."
#New genetic discovery advances understanding of prostate cancer A new and important genetic discovery, which sheds light on how prostate cancers develop
and spread, has been made by an international research team led by scientists at The University of Nottingham.
Prostate cancer is one of the most common cancers affecting men. In the UK about one in eight men will develop it at some point in their lives, with older men and those with a family history of prostate cancer most at risk.
It is not yet possible to accurately distinguish between'indolent'prostate cancers, which need little, if any treatment,
and'aggressive'cancers, which require intensive interventions. Now in new research published in Oncotarget, a multi-disciplinary team at Nottingham, Weill Cornell Medical school,
Lund University in Sweden and Copenhagen University in Denmark, have identified a significant gene called mir137 that is switched off in prostate cancer cells.
"With many men continuing to die from metastatic prostate cancer, there is an urgent need to develop new ways to enable the early identification of aggressive cancers
when such tumours remain localised within the prostate gland when surgery is most effective. We also need to make sure that men with indolent disease do not receive unnecessary treatment
"The researchers studied the role of androgens in prostate cancer. Androgens are important signaling molecules,
However defective and amplified androgen signaling can trigger prostate cancer and its spread. For this reason, many available prostate cancer treatments are aimed at blocking androgen signaling.
However, resistance to such therapies is a major clinical challenge. The gene identified by the team,
In prostate cancer where mir137 is switched off, the effect of androgen signaling is increased. Therefore the loss of mir137 leads to enhanced androgen signaling which contributes to prostate cancer initiation and progression.
The study has identified also many new potential targets for the next generation of drugs to treat prostate cancer.
New research is now underway in the Mongan's laboratory at Nottingham to test the effect of various pharmacological treatments in preclinical prostate cancer studies
#Study finds how Alzheimer's-associated protein tangles spread through the brain Massachusetts General Hospital (MGH) investigators have discovered a mechanism behind the spread of neurofibrillary tangles-one of the two hallmarks of Alzheimer's disease-through the brains
Future applications of such a DNA walker might include a cancer detector that could roam the human body searching for cancerous cells
constantly computing whether a cancer is present.""More immediate practical applications may include deploying the DNA walker in the body
Although it may be a long march from diagnosing cancer to curing it, "All breakthroughs begin with baby steps.
So just as nude mice can be really good models for cancer research, 'nude'versions of crop plants could also speed up agricultural research,
#A possible broad spectrum cancer cure is in the offing, but human trials could be up to 4 years away For almost
cancer has been nipping at our heelsnd brains, stomachs, kidneys, and so on. The fossil record indicates humanity embittered relationship with the disease extends even to prehistoric times.
Over the centuries, cancer has proven a most intractable foe. One reason for this is that cancer is a big family, with numerous subtypes and categories,
a veritable medusa head which immensely complicates finding a universal cure. A remedy for one cancer is no guarantee that it will work against another type of cancer.
Worse the treatments that work against multiple types of cancer like chemotherapy and radiation are often so harsh and hazardous that doctors hesitate to prescribe them.
Badly needed is a broad spectrum cancer cure that doesn ruin the human body in the process.
Thanks to a research group studying malaria, such a cure now looks to be in the offing.
what appears to be broad spectrum cancer cure in the form of a modified malaria strain.
the Malaria virus, may contain the mechanism for curing an even worse nemesis cancer. Ali Salanti, a researcher behind the possible cancer cureor decades, scientists have been searching for similarities between the growth of a placenta
and a tumor, says Ali Salanti, who headed up one of the teams responsible for the discovery. he placenta is an organ,
Ali Salanti noticed that a carbohydrate the malaria parasite attaches itself to in the placenta of pregnant women is identical to a carbohydrate found in many cancers.
Aside from the obvious tremendous benefit that would come from a broad spectrum cancer cure, these developments highlight another nemesis to human health:
With 7. 6 million people dying of cancer a year, in the four years it will likely take to bring this cancer treatment to market,
this discovery of potential broad spectrum cancer cure would seem to make it r
#Big data driving market disruption, leaving many organizations fearing irrelevance: Study A global report by Capgemini, provider of consulting, technology and outsourcing services, in partnership with EMC Corporation, reveals that amid the market disruption being driven by Big data,
Because the lesions can progress to cancer, they are removed today usually by surgery, freezing, or laser treatment.
They pose less of a cancer risk and usually regress on their own. CLEARS OUT THE VIRUS
or more years for precancerous cells to become cancer, so there is a window of opportunity to intervene with nonsurgical approaches,
She is also studying other types of vaccines to prevent high-grade cervical lesions from developing into cancer.
Although intralesional IL-2 has recently been included in the US National Comprehensive Cancer Network guidelines for management of melanoma metastases of the skin
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