| Allergy (104) |  |
preventing allergies and assisting the immune system in a number of other ways. The evidence that the balance of different microbes we have inside us is important to our health has been growing rapidly in recent years.
A National institutes of health grant to Hayes and Ziegler through the National Institute of Allergy and Infectious diseases supported this work
#Vaccine triggers alarm to fight dust mite allergy A new vaccine uses a booster normally found in cancer vaccines to combat dust-mite allergies by naturally switching the body immune response.
Preying on skin cells on the body, the mites trigger allergies and breathing difficulties among 45 percent of those who suffer from asthma, according to some studies.
and holds no guarantee of success. Alleviate mite-induced asthma ur research explores a novel approach to treating mite allergy in
which specially-encapsulated miniscule particles are administered with sequences of BACTERIAL DNA that direct the immune system to suppress allergic immune responses,
public health professor and a contributing author of the paper. his work suggests a way forward to alleviate mite-induced asthma in allergy sufferers.
but never had been tested as a vaccine for dust-mite allergies. Put broadly, Cpg sets off a fire alarm within the body, springing immune cells into action.
says immunologist Richard Koup, deputy director of the Vaccine Research center at the National Institute of Allergy and Infectious diseases (NIAID) in Bethesda, Maryland,
autism obesity acne and allergies. The co-directors are presenting their research collaboration this week at an MGH-hosted conference on microbes metabolism and mucosal circuits.
In principle this should have caused an acute allergic inflammatory reaction. However the opposite was true. The interaction between CNTS and C1q (a starter-protein for complement) was anti-inflammatory.
director of the National Institute of Allergy and Infectious diseases, told USA Today. The U k. fund comes from a pool worth $10. 8 million (6. 5 million British pounds),
was conducted by a team from the Vaccine Research center at the U s. National Institute of Allergy and Infectious diseases (NIAID) in Bethesda, Maryland.
may aid efforts to build point-of-care devices for quick medical diagnosis of various diseases ranging from cancer, allergies, autoimmune diseases, sexually transmitted diseases (STDS),
A team of scientists at the Vaccine Research center (VRC) of the National Institute of Allergy and Infectious diseases, part of NIH, created VRC07-acd3 under the leadership of VRC Director John R. Mascola, M d.;
The study was funded by the Stanford Department of Surgery and by the National Library of Medicine and the National Institute of Allergy and Infectious diseases.
and Blood Institute, National Institute of Allergy and Infectious diseases Extramural Activities and the National Institute on Deafness and other Communication Disorders s
such as for instance rheumatism and allergy. Now, researchers from Umeå University and University of Gothenburg have identified a molecular switch-MYSM1-that can suppress such an overreaction
#At home Molecular Diagnostics could become Reality with New Test Design Does being able to test for allergies, STD,
may aid efforts to build point-of-care devices for quick medical diagnosis of various diseases ranging from cancer, allergies, autoimmune diseases, sexually transmitted diseases (STDS),
"may aid efforts to build point-of-care devices for quick medical diagnosis of various diseases ranging from cancer, allergies, autoimmune diseases, sexually transmitted diseases (STDS),
and reduce side effects of allergy shots Whether triggered by cats, bees, pollen or mites, allergies are on the rise.
And the bad news doesn stop there. The only current therapy that treats their causes is allergen-specific immunotherapy or allergy shots
which can cause severe side effects. Now, researchers report in Biomacromolecules("Biodegradable ph-Sensitive Poly (ethylene glycol) Nanocarriers for Allergen Encapsulation and Controlled Release")the development of a potentially better allergy shot that uses nanocarriers to address these unwanted issues.
For many people, allergies are a seasonal annoyance. But for others exposure to a particular allergen can cause adverse reactions such as itching, breathing problems or even death.
Allergy shots can reduce sensitivity by slowly ramping up exposure to the offending substance. But because these shots expose the body to the very thing people are allergic to,
the treatment itself can sometimes trigger reactions. In order to develop a safer, more direct, cause-based therapy,
researchers have developed nanoparticles that envelop an allergen and deliver it to specific cells. But these carriers degrade too slowly,
"The UC Berkeley engineers teamed up with Dr. Thomas Nutman from the National Institute of Allergy and Infectious diseases,
and the U s. National Institute of Allergy and Infectious diseases report their discoveries and implications for future studies of epidemic diseases in an upcoming Journal of Clinical Investigation (early online).
cigarette smoke and car fumes and airways twitchiness in allergic asthma. ur paper shows how these triggers release chemicals that activate Casr in airway tissue
The UC Berkeley engineers teamed up with Dr. Thomas Nutman from the National Institute of Allergy and Infectious diseases (NIAID),
, autoimmune disorders or allergies. Now, scientists at the Salk Institute have discovered that T cell triggering relies on a dynamic protein network at the cell surface,
and unhygienic environment during infancy reduces the risk of allergy later in life. ygiene hypothesisis used to explain why in more developed countries with better hygiene habits the incidence of allergies
Their findings in the Journal of the American Chemical Society, may aid efforts to build point-of-care devices for quick medical diagnosis of various diseases ranging from cancer, allergies, autoimmune diseases, sexually transmitted diseases (STDS),
Their findings may aid efforts to build point-of-care devices for quick medical diagnosis of various diseases ranging from cancer, allergies, autoimmune diseases, sexually transmitted diseases (STDS),
Helena Boshoff at the National Institute of Allergies and Infectious diseases performed complementary studies showing that these inhibitors do in fact efficiently block mycobacterium growth l
#Key step in allergic reactions revealed By studying the mode of action of the interleukin-33 protein an alarmin for white blood cells a team at the Institut de Pharmacologie et de Biologie Structurale (IPBS--CNRS
/Université Toulouse III--Paul Sabatier) has been able to evidence truncated forms of the protein that act as potent activators of the cells responsible for triggering allergic reactions.
This breakthrough in the understanding of the mechanisms underlying allergy could have important applications in the treatment of asthma and other allergic diseases such as eczema and allergic rhinitis.
and is truncated then by enzymes secreted by mastocytes white blood cells that are key factors in allergy.
By triggering the chain reactions responsible for the allergic symptoms of asthma eczema or allergic rhinitis these cells have an essential role in allergy.
For the research team preventing production of the truncated forms of interleukin-33 in order to reduce the allergic reactions triggered by ILC2 represents a promising strategy for the treatment of asthma and other allergic diseases.
Story Source: The above story is provided based on materials by CNRS (Délégation Paris Michel-Ange. Note:
#Unusual skin cancer linked to chronic allergy from metal orthopedic implant In rare cases patients with allergies to metals develop persistent skin rashes after metal devices are implanted near the skin.
The patient turned out to be allergic to nickel in the implant which led surgeons at the other hospital to remove it.
To investigate whether inflammation from the implant contributed to the tumor the researchers studied mouse models of contact allergy.
A contact allergy is a different kind of reaction from allergies to pollen pet dander or food said senior author Wayne M. Yokoyama MD a Howard Hughes Medical Institute investigator at the School of medicine.
A contact allergy usually develops when an allergen touches the skin or is close to it.
Skin rash in response to nickel and poison ivy are two common examples of contact allergies. The researchers showed that contact allergy brings inflammatory cells and molecules to the site of the allergic reaction.
If the contact allergen remains a long time--as was the case with the patient's implant--different inflammatory cells
and molecules involved in chronic contact allergy in mice they identified several that already had been linked to tumor development.
If you're allergic to something the first thing to do is to avoid it but the patient couldn't said Yokoyama the Sam and Audrey Loew Levin Professor of Medicine.
It's as if a patient allergic to poison ivy kept putting poison ivy on the skin. To prevent such adverse events the researchers suggested that the potential for allergic reactions to metal implants be assessed in patients who have had the implants
and in patients preparing to receive them. Allergen-free versions of some implants are said available Demehri.
Similar to metal implants some dental restoration materials and tattoo inks contain substances associated with allergic reactions and cancers on the skin or in the mouth.
or just patience It's that time of the year where a perfect storm of fall allergies
if sinus problems are allergic, viral or bacterial. However, many patients will end up with a diagnosis of bacterial sinusitis
#Skin exposure may contribute to early risk for food allergies Many children may become allergic to peanuts before they first eat them
Early in the process of developing an allergy skin exposure to food allergens contributes to sensitization which means the skin is reactive to an antigen such as peanuts especially by repeated exposure.
The question of how peanut allergies start is an important one given the extremity of some reactions the prevalence (1 to 2 percent of the population)
and because such allergies tend to be lifelong. Past studies have shown that children may first become allergic
when exposed to peanut proteins through breast milk or in house dust but this current study adds skin exposure to the list of culprits that make a child allergic by the first time they taste a peanut.
The results also make elements of the human immune system in the skin targets for future treatments or preventive efforts.
The peanut protein responsible for most allergic reactions in humans is seen as foreign or dangerous by the immune system of the skin said Cecilia Berin Phd Associate professor of Pediatrics at the Icahn School of medicine at Mount sinai.
Blocking those immune pathways activated in the skin prevented the development of peanut allergy in the mice
In a collaboration among the Jaffe Food Allergy Institute The Mindich Child Health and Development Institute Immunology Institute and Tisch Cancer Institute at The Mount sinai Hospital researchers exposed mice
and observed that repeated topical exposure to peanut allergens led to sensitization and a severe whole-body allergic reaction upon a second exposure.
This research helps us to understand why peanut out of the many foods in our diet is such a common cause of food allergy said Berin..
and prevent the food allergy altogether. Story Source: The above story is provided based on materials by The Mount sinai Hospital/Mount sinai School of medicine.
Technologies Work Hand in hand The Nature study, led by researchers at the National Institute of Allergy and Infectious diseases,
not only autoimmune diseases but other acute or chronic conditions such as allergy chronic obstructive pulmonary disease sepsis and immunodeficiency said Stefan G. Tullius MD Phd BWH Chief of Transplant Surgery
it will automatically send potential allergies and blood type info to first responders to help them properly handle your conditions.
"said Stephen Fowler, clinical lecturer in the University of Manchester's Centre for Respiratory Medicine and Allergy.
Tuberculosis experts gathered in a workshop at the National Institute of Allergy and Infectious diseases at the National institutes of health in Bethesda, Maryland,
Terapio can recognize possible allergies and potentially dangerous medication interactions. And naturally, when not displaying data,
and the Public health Agency of Canada in helping conduct the studies have been NIH and its National Institute of Allergy and Infectious diseases,
Allergic response Another device, the Veta, made by Aterica, is essentially a smart case for an Epipen,
a name brand injection device that delivers the medication epinephrine to treat the life-threatening allergic response called anaphylaxis.
This work was supported by the National Institute of Allergy and Infectious diseases (grant numbers AI072677 and AI44129),
tissue damage or inflammatory diseases such as arthritis or allergies, whereas too few could denote a viral infection or bone marrow deficiency.
or the allergy-inducing ragweed (Ambrosia artemisiifolia) will end up on the"Union List","as the cost of eliminating them would be too high."
#New cellular pathway triggering allergic asthma response identified Researchers at the University of California, San diego School of medicine,
with collaborators in Korea and Scotland, have identified a novel signaling pathway critical to the immune response of cells associated with the initiation of allergic asthma.
could point the way to new therapies that suppress the inflammatory allergic response, offering potential relief to millions of Americans with the chronic lung condition and potentially other allergic diseases.
the scientists demonstrated that T helper 2 (Th2) type inflammation in allergic asthma involves dendritic cells (DC), a type of white blood cell,
"The role of camp formation and action in dendritic cells in the induction of allergic response was added really surprising
parasites and toxins that operate outside of cells) and also plays a major role in allergic reactions and related diseases.
Allergic asthma is triggered by inhaled allergens, such as pet dander, pollen, mold and dust mites. It is characterized by inflammation
The common form of allergic asthma is associated with an exaggerated Th2 immune response. Allergic asthma affects people of all ages, most often appearing in childhood.
More than 25 million Americans suffer from the condition.""This research will open a new field of exploration of DC-related molecules as mediators that influence Th2 induction
or ones that mimic or block them might be used as novel therapeutics of allergic and asthmatic diseases."
"Raz noted that the genetic mouse model developed for the research shares multiple similarities with human allergic asthma,
"We are quite optimistic the mice will reveal additional, novel insights into human allergy, "he said d
and Dr Yasmine Belkaid from the National Institute of Allergy and Infectious diseases (NIAID) in the USA will be published in the journal Immunity.
I didn't know anyone with a peanut allergy. At school peanut butter and jam sandwiches were standard fare for lunches.
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