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futurity_medicine 00569.txt

#Dog genes may offer clues to cleft palate in humans Researchers have identified the genetic mutation responsible for a form of cleft palate in a breed of dog, the Nova scotia Duck Tolling Retriever. They hope the discovery, which provides the first dog model for the craniofacial defect, will lead to a better understanding of cleft palate in humans. Although cleft palate is one of the most common birth defects in children, affecting approximately one in 1, 500 live human births in the United states, it is understood not completely. The findings appear online this week in the journal PLOS Genetics. his discovery provides novel insight into the genetic cause of a form of cleft palate through the use of a less conventional animal model says study leader Professor Danika Bannasch, a veterinary geneticist at the UC Davis School of veterinary medicine. t also demonstrates that dogs have multiple genetic causes of cleft palate that we anticipate will aid in the identification of additional candidate genes relevant to human cleft palate. Bannasch explains that common breeding practices have made the dog a unique animal model to help understand the genetic basis of naturally occurring birth defects. By conducting a genome-wide study of these particular retrievers with a naturally occurring cleft palate, researchers identified a mutation responsible for the development of cleft palate in the breed. Dogs with this mutation also have shortened a lower jaw similar to humans who have Pierre Robin Sequence. The disorder, a subset of cleft palate, affects one in 8, 500 live human births and is characterized by a cleft palate, shortened lower jaw, and displacement of the tongue base. Cleft palate condition occurs when there is a failure in the formation of the secondary palate, which makes up all of the soft palate and the majority of the hard palate. A disruption in the sequential steps of palate development causes a cleft palate and leads to the spectrum of cases that are observed. Children born with cleft palate may develop hearing loss and difficulties with speech and eating. They also may be increased at risk for neurological deficits. The Center for Companion Animal health at the School of veterinary medicine and the National institutes of health supported the research

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