Synopsis: Pharma: Drugs: Drug:

Meanwhile a fluidic microchannel in the implant delivers neurotransmitting drugs to reanimate the nerve cells beneath the injured tissue.

paedophiles and drug dealers in the online underworld The deep web is a hive of illegal activity,

when the FBI made a series of raids on Silk road-an online marketplace described as the'ebay for illegal drugs'.

and patients have to take powerful immunosuppressant drugs -which weaken the immune system to prevent the rejection of a transplant-for life.

then it could be enhanced or supressed with the use of drugs. Dr Poon said: rogrammed cell death occurs throughout life in essentially all tissues in the human body as part of the normal process of development and death,

'Importantly we've also discovered drugs that affect this process so, once we know more,

But despite the drug's legal status in many parts of the world, the debate rages as to

And weaker evidence still that the drug eased nausea and vomiting in chemotherapy patients, sleep disorders,

And there was very-low quality evidence the drug eased anxiety. In addition, Dr Whiting and her team found weak evidence to support the claim that medicinal cannabis has no effect on psychosis,

Meanwhile, the drug was linked with several adverse effects. Notably, cannabinoids were found to cause dizziness, dry mouth, nausea, fatigue, euphoria, vomiting, disorientation, drowsiness, confusion, a loss of balance and hallucination.

#Scientists crack morphine gene in poppies amid homebrew drugs fears Scientists have identified a key gene used by poppies to make morphine.

The discovery paves the way for better methods of producing the medically important drug, potentially without the need for cultivating poppy fields.

and codeine from a common sugar, boosting the prospect of'home-brew'drug supply. But whether making morphine in bubbling vats of yeast will be commercially viable-either for drug companies

'he told Reuters. That could lead to agricultural production of drugs such as noscapine, a cough-suppressant that may also fight cancer,

opiates have been the go-to drugs for pain relief and they remain the most potent treatments for severe pain,

The molecular structure of these drugs is so complex that chemists have never been able to produce them from off-the-shelf components.

disease or exposure to certain drugs, including some antibiotics. But it will not help the one to three babies per 1

The new hearts will allow new drugs to be tested, and give researchers a new insight into how the heart develops.

and a drug-screening tool to make pregnancies safer.''We believe it is the first example illustrating the process of a developing human heart chamber in vitro,

'This technology could help us quickly screen for drugs likely to generate cardiac birth defects, and guide decisions about

which drugs are dangerous during pregnancy.''Published in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate

To test the potential of the system as a drug-screening tool, the researchers exposed the differentiating cells to thalidomide,

a drug known to cause severe birth defects. They found that at normal therapeutic doses, the drug led to abnormal development of microchambers, including decreased size,

problems with muscle contraction and lower beat rates compared with heart tissue that had not been exposed to thalidomide.'

'Each year, as many as 280,000 pregnant women are exposed to drugs with evidence of potential fetal risk.

and the potential for generating cardiac defects is of utmost concern in determining drug safety during pregnancy.'

and other UC Berkeley researchers publicly debuted a system of beating human heart cells on a chip that could be used to screen for drug toxicity.

Schoellhammer explains. he outer layer is a bit of a barrier so the needles are a nice way to introduce a drug into the tissue

the drug gets into your system faster than it would if administered via injection. Although an image of the pill that was used in testing might remind people of a cactus or a porcupine,

Once the drugs are delivered, the capsule can pass through the body safely. In the future, though, Schoellhammer hopes he can create the needles out of crystallized sugar.

or agic bulletto describe new drugs he was working on to cure syphilis and cancer. In theory, such drugs would leave healthy tissue intact

while targeting only the diseased. Psychologists later appropriated this term to describe the phenomenally widespread panic that ensued

DNA microcapsules have been studied for their potential to deliver drugs directly to where theye needed most.

They would have no reason to think differently from the Food and Drug Administration (FDA),

#Device delivers drugs to brain by remote control A new wireless device the width of a human hair can be implanted in the brain

and activated by remote control to deliver drugs. The technology, demonstrated for the first time in mice, may one day be used to treat pain, depression, epilepsy,

researchers made the tiny wireless devices capable of delivering drugs directly into the brain, with the remote push of a button.

it should be possible to manufacture therapeutic drugs that could be activated with light, says co-principal investigator Michael R. Bruchas, associate professor of anesthesiology and neurobiology at Washington University in St louis. ith one of these tiny devices implanted,

we could theoretically deliver a drug to a specific brain region and activate that drug with light as needed.

This approach potentially could deliver therapies that are targeted much more but have fewer side effects. Previous attempts to deliver drugs or other agents

such as enzymes or other compounds, to experimental animals have required the animals to be tethered to pumps

But the new devices were built with four chambers to carry drugs directly into the brain.

By activating brain cells with drugs and with light, the scientists are getting an unprecedented look at the inner workings of the brain.

If we want to influence an animal behavior with light or with a particular drug, we can simply point the remote at the animal

OTHER PARTS OF THE BODY, TOO As part of the study, the researchers showed that by delivering a drug to one side of an animal brain

But the researchers were able to interfere with that light-activated pursuit by remotely controlling the release of a drug that blocks the action of dopamine on its receptors.

the devices contain only four chambers for drugs, but in the future, the researchers hope to incorporate a design much like a printer ink cartridge

so that drugs can continue to be delivered to specific cells in the brain, or elsewhere in the body, for as long as required without the need to replace the entire device.

says Dandekar. ithout drugs, the virus can come back at the same threat level for patients.

The UC Davis team may have succeeded with PEP005, the active ingredient in the FDA-approved anticancer drug PICATO

The findings raise the possibility that drugs recently tested as treatments for fragile X may be ineffective, at least in part,

and cartilage grafts without the need for anti-rejection drugs, and the donor tissue becomes part of the joint.

at the very place where the drugs could be the most effective. This could be a strong model for fighting Parkinson's

#Could cell#backpacks#deliver inflammation drugs? Scientists have created ellular backpacksthat could carry therapeutic agents to the site of inflammation

ASICALLY THE MAIN BENEFIT IS THAT YOU CAN DELIVER THE DRUG IN A MORE EFFECTIVE DOSE However,

we could deliver the drug there, says Mitragotri, who specializes in targeted drug delivery. By taking advantage of natural body processes, researchers at UC Santa barbara and MIT have developed a method of targeting inflamed tissues

creating a way to treat both the inflammation and its underlying cause. t a cell-mediated approach to targeted drug delivery,

says grad student researcher Aaron Anselmo, lead author of a study in the current issue of the Journal of Controlled Release.

Further studies will include research into how much drug can be loaded into the cellular backpacks. Ideally, Anselmo says,

the cellular backpacks loaded with drugs would be injected into the bloodstream, whereupon they would attach to these traveling monocytes

and release their drugs.""It is a good idea to get your levels checked on a yearly basis

say the researchers. asically the main benefit is that you can deliver the drug in a more effective dose,

but it could also allow for higher doses of drug to the site, which could decrease treatment time h

The drug PDUFA target date for a decision is January 24. That date was delayed three months in October,

NPSSINGLE marketed drug is Gattex (teduglutide rdna origin), an injection drug indicated for long-term treatment of adults with short bowel syndrome (SBS) who need parenteral support.

would complement Shire existing stable of drugs for gastrointestinal diseases.""The acquisition of NPS Pharma is a significant step in advancing Shire's strategy to become a leading biotechnology company, Shire CEO Flemming Ornskov, M d,

"This makes drug screening much easier, faster and less expensive than using a mouse model, for instance,

Drugs that successfully block its action have been developed, but these drugs have to be administered for long periods of time to successfully trigger cell death and shrink tumors,

leading to considerable toxicities. This outcome is partially because cells in any one tumor have chromosomes with different telomere lengths

#Whole-Exome Sequencing Technology Identifies Drug Resistance Gene in Testicular cancer A study, funded by the Movember Foundation and conducted by scientists at The Institute of Cancer Research (ICR) in London,

in addition to uncovering a gene that may aid tumors in promoting resistance to existing drug therapies.

about 3%of patients develop resistance to platinum-based drugs, which consequently is associated with a diminished long-term survival rate.

as Johnson & johnson leadership in this area now extends from sharing its drug data to sharing its device

Eleven drug developers have committed to sharing clinical trial data through clinicalstudydatarequest. com and allow an independent review panel to decide data requests:

but not the open-access sought by Europe chief drug regulator and Glaxosmithkline. The European Medicines Agency in October issued a more expansive data sharing policy last October,

including live cells and drugs, according to the researchers. Thousands of times thinner than the average human hair, nanofibers are used by medical researchers to create advanced wound dressings and for tissue regeneration

drug testing, stem cell therapies, and the delivery of drugs directly to the site of infection."

"The process we have developed makes it possible for almost anyone to manufacture high-quality nanofibers without the need for expensive equipment,

and officials to negotiate drug prices with developers. Now years of talk is finally translating into action on bringing down the price of cancer drugs.

The payer won say which drugs or companies are the subject of discussions, first reported last month by The Wall street journal. Brian Henry, Express Scriptsvp,

Cancer was the third most expensive category of specialty drugs last year measured per-member-per year, according to Express Scripts;

and is among a handful of key drivers of rising costs here are drugs in cancer that may give five months of life in one indication and 12 days of life in another.

Henry said June 3. hen you get to the point where you have orphan drug pricing for non-orphan drugs,

Express Scripts sees similar cost-reduction opportunity for inflammatory and MS drugs, he added. Drug makers have resisted traditionally value-based pricing,

arguing they need to recoup R&d costs. The about-face reflects the convulsive changes wrought by U s. healthcare reform

and Europe embrace of government-led value-based drug pricing. In the U k.,the National Institute for Health and Care Excellence (NICE) makes formulary determinations through a ost-effectivenessthreshold assessing estimated costs of treatments or services in relation to their expected health benefits.

setting reimbursements for new drugs at the same level as the best existing comparator unless the new drugs show superiority to that comparator;

not just important new drugs. Theye also a new idea. I also think it true for Gleevec.

which are the sole buyers of drugs for state-run healthcare systems, numerous U s. payers exist.

Ph d.,research associate professor with the Tufts Center for the Study of Drug Development, told GEN. Having numerous payers,

the U s is less likely to see drug developers offer the extent of free trials or money-back guarantees,

or rebates for new drugs, as many have done in Europe to gain market access. Numerous payers is one reason why prices set by U s. payers will likely be more palatable to drug developers than

as payer cut prices for less-effective treatmentsven after developers invest in IT systems, drug utilization programs,

the company immediately added Abbvie Viekira Pak to its National Preferred Formulary as the exclusive option for patients with genotype 1 hepatitis Cust three days after the FDA approved the drug.

Henry said the lower price is consistent with discounts given for the drug in Europe for Sovaldi,

Express Scriptsindependent Pharmacy & Therapeutics Committee concluded that Viekira Pak was at least clinically equivalent to two Gilead sciences drugs, Harvoni (ledipasvir and sofosbuvir) and Sovaldi (sofosbuvir.

and drug developerss well as pooling and sharing of resources. Institutions, developers, and patient groups should be encouraged to form consortia capable of assembling subpopulations large enough to speed up development,

Cancer treatments marketed by eight companies accounted for six of the Top 25 Best-selling Drugs of 2014 as listed by GEN,

000 uninsured or underinsured patients in the U s. annually for the past six-and-a-half yearsore than $1 billion in free medicine. ecause the cost of drugs is one of the few transparent healthcare costs,

drugs get much public attention, yet are only a small percentage of spending and demonstrate remarkable rewards,

such rules may require treatment with a cheaper drug whose patent protection will expire soon,

The scientists believe their research paves the way to an entirely new approach for finding a drug that can cure

which can be blocked by existing drugs. Dr. Parker's team is already testing drugs that have been approved previously by the FDA for treatment of such disorders as rheumatoid arthritis

to see if they work with ALS. Obstacles still remain, however, before finding a remedy for curing

the drug-treated mice showed a six-day-faster reconstitution of hematopoiesis after bone marrow transplantation. tudying mouse models,

such as RNA and protein expression, will help resolve regulatory relationships that govern higher order phenotypes such as drug resistance,

"There is a need to more fully understand the long-term molecular changes in the brain involved in drug craving and relapse."

"There are changes in the brain caused by drug use that occur and persist, but are unmasked only after withdrawal from a drugn this case, cocaine,"notes Dr. Dietz."

and gene therapies to prevent drug relapses, "explains Dr. Dietz.""If we can control this pathway,

which provides the map to design potent new drugs to fight MERS, "said Dr. Mesecar,

#New Drug Prevents Cancer cells from Staging Last Stand Unlike many last stands in human history,

one that would include a new drug, a small molecule called SBI-0206965 that inhibits autophagy.

The new drug targets ULK1, an enzyme that initiates autophagy. The drug, which was developed by scientists at Salk Institute

and Sanford Burnham Prebys Medical Discovery Institute (SBP), was described June 25 in Molecular Cell, in an article entitled, mall Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1

"This allowed us to find a drug that targeted ULK1 not just in a test tube but also in tumor cells.

Our work provides the basis for a novel drug that will treat resistant cancer by cutting off a main tumor cell survival process. i

Moreover, the rate of resistance to current drug therapies is growing exponentially and scientists are always on the hunt for novel targets that have the potential to not only treat symptoms of infected patients,

"As drug resistance is a major problem for malaria control and eradication, it is critical that that we continue to develop new antimalarials that act against previously unexploited targets in the parasite to keep priming the drug pipeline."

"The findings from this study were published recently in Cell Host Microbe through an article entitled"Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans."

"In addition to a possible drug target, calcineurin underlies a very basic aspect of parasite biology. l

and in human tumor cells in the lab, showed that a specific drug can stop cancer cells without causing damage to healthy cells or leading to other severe side effects.

which started as an anti-cholesterol drug candidate, turns down fat synthesis so that cells can't produce their own fat.

The drug also has a good safety profile; it is effective without causing weight loss, liver toxicity,

The challenge for researchers in this scenario will be to find a way to allow the drug to cross this barrier, the body's natural protection for the brain,

drugs that modify LSD1 levels could provide a new approach to treating glioblastoma, according to the researchers.

"For instance, glioblastomas can escape the killing effects of a drug targeting MYC by simply shutting it off epigenetically

and turning it on after the drug is no longer present. Ultimately, strategies addressing this dynamic interplay will be needed for effective glioblastoma therapy."

and whether drugs could be developed to stop it from happening

#Sperm RNA Test May Improve Evaluation of Male Infertility Many couples who struggle with infertility also suffer uncertainty.

Since the first biopharmaceutical drug Humulin was launched in 1982 to the beginning of this decade (between 1982 and 2009 27 year period),

It will be maintained as the source of all cells used to produce the company drug through preclinical and clinical testing and then into commercial sale.

2012, the U s. Food and Drug Administration approved the use of Flucelvax, which is the first U s.-licensed (trivalent inactivated) influenza vaccine manufactured using cell culture technology.

The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function, according to the researchers.

The hope is that this could lessen the side effects of pain relief drugs.""You don want to feel sleepy or unaware,

and required technology to actually test different drugs to find something that targets the peripheral nervous system and not the central nervous system in a patient specific, or personalized manner."

This step was all-important as it prevents the drug from replicating with normal healthy cells

Around 16 percent of those given T-VEC demonstrated durable responses of more than six months, compared to just over two percent of those given the control drug.

The researchers found the drug to be most effective when used in the less advanced stages of the cancer, suggesting that T-VEC could prove a valuable early treatment option for skin cancers that are unable to be removed by a surgeon.

The drug has been submitted to both the US Federal Drug and Food administration and the European Medicines Agency for consideration, with the scientists hopeful of winning approval later this year.

the treatment doesn't carry the risk of side effects that are associated often with drug treatments."

It also houses four separate chambers for carrying drugs directly to the brain and cellular-scale inorganic light-emitting diode(-ILED) arrays, allowing it to shine light on targeted cells.

If we want to influence an animal behavior with light or with a particular drug, we can simply point the remote at the animal and press a button."

the researchers were able to negate this action by remotely releasing a drug that blocks the function of the dopamine neurotransmitter.

so that drugs can be drip-fed to targeted cells as needed over a long time.""Wee successfully produced

the implant received market approval from the Food and Drug Administration (FDA) in the US, for the treatment of Retinitis Pigmentosa (RP) a degenerative condition that affects the peripheries of patient vision.

the researchers gave the men a drug called buspirone during the final four weeks of the 18-week study.

This drug mimics the neurotransmitter serotonin and it is known to induce walking motions in mice with spinal cord injuries.

But by the end of the study, after they had received the buspirone drug, they could all move their legs with no stimulation at all.

Drugs already exist that can deactivate those cells. They are known as calcilytics and are used to treat people with osteoporosis. Researchers found that,

when the drug is inhaled, it deactivates the cells and stops all symptoms. Go ahead and Let Dogs Lick You,

Scientists are hopeful that patients can take the drug to prevent asthma attacks before they start ending the need to constantly carry an inhaler to end symptoms once an attack has started.

and received $200 million from the Gates Foundation, is making RTS, S available as a nonprofit drug.

A vial of the drug Glycopyrrolate with a strength of 1mg/ML became the five-millionth RFID-tagged dose at UVMC tracked by Kit Check, a Washington, D c,

what the drug is, the quantity, the lot number and the expiration date. Then they print out the RIFD tag from that information and label the drugs with it."

"There's an independent double-check where a second person goes in and puts in the information to help prevent an error

what they refer to"critical inventory"used by hospitals high-cost medications in refrigerators and high-risk drugs in anesthesia kits and trays.

if RFID chips will ever displace barcodes on drug packages any more than on cereal boxes in grocery stores.

Other focus points include staying ahead of drug-resistant bacteria, finding cures to Alzheimer and other diseases, developing new clean energy technologies,

#Delivering drugs straight into the brain A team of Canadian scientists has found a way to inject the drugs directly into the brain,

such as disease fighting drugs from entering the nervous system. It only allows a selected few types of molecules to cross including water, some gases and lipid soluble molecules.

and get the drugs to where they are needed most to the human brain. Currently, researchers say they have found a way based on the so-called ingle domain antibodiessda.

The discovery follows years of scientific Work at the moment drugs are placed usually into the blood

This makes it much easier to home in on potential drug targets for therapy. Scientists also no longer have to solely rely on mouse models of human disorders.

Using the invention on carboplatin a common cancer treatment drug, used against ovarian and lung cancers has boosted the potency by almost five times.

"The tool can be used to take away the wastage in a drug, meaning that you need less of it to do the same work.

and could mean that the drugs treat tumours much more effectively. As well as helping with treatment, the tool could cut down the wastage created during the process of making drugs.

That could make the pharmaceutical much more sustainable and reduce their impact on the environment.

as well as how certain drugs affect babies before they are born. The team present their findings in a paper,

#Researchers Develop 3d printing Method to Produce Shell Capsules That Can Be loaded with Therapeutic Drugs Researchers at the University of Minnesota have introduced a novel 3d printing based method to produce highly monodisperse core/shell capsules that can

be loaded with biomolecules such as therapeutic drugs. They expect that this platform of 3d printed programmable release capsules will be useful in applications such as dynamic tissue engineering, 3d printed drug delivery systems, synthetic/artificial tissues, programmable matter,

and bionic nanosystems. Another important application area could be combinatorial screening of biomolecular gradients drugs, toxins, pollutants,

etc. against cell types. ur method provides us with robust control over particle properties, passive release kinetics,

and Drug Administration approval next year to expand its use to men. n the U s,

As a Phase III clinical trial, this technology is in the last phase of testing needed to obtain U s. Food and Drug Administration (FDA) approval for use in clinical settings.

#Shaping Implantable Medical devices to Avoid Immune system Tiny medical implants that can ferry drugs, cells, or other therapies safely to sites of disease are already seeing the light of day.

So far the device has been able to identify drugs and certain metabolites in animal tissue, hopefully soon moving on to trials with human samples.

Food and Drug Administration

#Optical Probe to Help Remove Only Cancerous Tissues in Brain Surgeries Neurosurgeons removing a tumor have to be obsessive about resecting just enough

#Electromagnetic field Activated Drug Loadded Nanowires Drug releasing implants can be of great benefit for conditions requiring long term treatment in a targeted area of the body.

Researchers at Purdue University have come up with a new way of releasing drugs into the body in a controlled manner using tiny injectable nanowire implants.

Applying an electromagnetic field over the wires caused them to release the drug. Turning off the EM field immediately stopped the drug release process.

The team tested the technology on mice with compression injuries, demonstrating that the drug reduced inflammation in the areas where the EM field was applied.

This worked over a period of weeks, pointing to this approach being applicable in long-term clinical applications.

< Back - Next >

Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011