The researchers note that other compounds could also be added to release drug molecules, make a robot glow
Scientists at the Univ. of Nebraska Medical center designed a new delivery system for these drugs that,
when coupled with a drug developed at the Univ. of Rochester School of medicine and Dentistry, rid immune cells of HIV and kept the virus in check for long periods.
Nebraska researcher Howard E. Gendelman designed the investigational drug delivery system so-called"nanoformulated"protease inhibitor.
The nanoformulation process takes a drug and makes it into a crystal, like an ice cube does to water.
Next, the crystal drug is placed into a fat and protein coat, similar to what is done in making a coated ice-cream bar.
The coating protects the drug from being degraded by the liver and removed by the kidney.
a new drug discovered in the laboratory of UR scientist Harris A.("Handy")Gelbard M d.,Ph d,
URMC-099 boosted the concentration of the nanoformulated drug in immune cells and slowed the rate at
"The chemical marriage between URMC-099 and antiretroviral drug nanoformulations could increase drug longevity, improve patient compliance,
whether the drugs could be administered safely together. Much to Gelbard and Gendelman's surprise, URMC-099 increased the effectiveness of the nanoformulated drug."
"Our ultimate hope is that we're able to create a therapy that could be given much less frequently than the daily therapy that is required today,
"If a drug could be given once every six months or longer that would greatly increase compliance,
particularly for patients who take anticoagulant drugs to thin their blood. t interesting that you can take something so deadly
an anticoagulant drug. rom a clinical perspective, that far and away the most important issue here, Hartgerink said. here a lot of different things that can trigger blood coagulation,
and change how different people respond to drugs. But only if the CRISPR technique is specific enough.
and how they vary between cell types, during development or in response to drug treatment."
"Current methods for controlling gene switches, including drugs used in clinical trials, change the activity of many switches across the genome simultaneously,
but slow progress is being made toward developing a drug treatment, "said Barbara Sahakian from the department of psychiatry at Cambridge university."
demonstrates that the memory game can help where drugs have failed so far. And) because the game is interesting,
and Drug Administration has approved, for the first time a drug that uses 3d printing technology, paving the way for potential customization of drugs to suit patients'needs.
The drug, made by privately held Aprecia Pharmaceuticals Co, was approved for oral use as a prescription adjunctive therapy in the treatment of epilepsy,
the company said on Monday. Spritam uses Aprecia's"Zipdose"technology, a delivery system that creates premeasured doses
which disintegrate in the mouth with a sip of liquid. 3d printing could help companies make products"to the specifications of an individual patient rather than (take a) one-size-fits-all kind of approach,"
with a drug targeting its toxins rather than its life. C. difficile is responsible for more than 250,000 hospitalizations
the drug used has already been tested in clinical trials to treat other, unrelated conditions. So the researchers believe it could be moved rapidly into human trials for the treatment of C. difficile, as well.
possibly its chief cause--the drug didn't kill the bacteria, "Bogyo said. Instead, it disabled a toxin C. difficile produces,
Realizing they might have a potentially effective drug on their hands, Bogyo and his colleagues brought in Sonnenburg,
multi-drug-resistant C. difficile strain and then began oral dosing with ebselen. They observed a nearly complete block of inflammation and damage to colon tissue as the result of ebselen treatment.
They realized that the sugar molecule--oncofetal chondroitin sulfate--could be a target for anticancer drugs,
and attached an anticancer drug to it, it would bind with the oncofetal protein in the cancer,
delivering the drug to the tumor.""Scientists have spent decades trying to find biochemical similarities between placenta tissue and cancer,
"They administer drugs which are also very fast-acting, but because it's free in the blood stream everywhere it causes side effects like bleeding
"The drug-loaded nanocapsule is coated with an antibody that specifically targets activated platelets, the cells that form blood clots,
releasing the clot-busting drug. We are effectively hijacking the blood clotting system to initiate the removal of the blockage in the blood vessel."
and it can spot recent drug use and whether or not the person has recently been in contact with guns and explosives.
or pilots could be tested for recent drug use. Further down the line, Arrogen is hoping to be able to use its finely tuned procedures to create full prints out of partial ones,
drugs that target the so-called IL-1/IL1RAP pathway already exist for the treatment of various inflammatory conditions,
In addition to Tu's malaria drug, Artemisinin, China has pioneered also development of solar and wind technology, and is working on trains that will reach 500 km h.
The next step is to apply the findings to research that is already investigating how new drugs could inhibit PRC2 enzyme activity According to Liu,
researchers are looking at the potential of such drugs as a treatment for several types of lymphoma."
and we believe our work will shed light on these and other studies in drug development by offering insights into how PRC2 works at the atomic level,
the researchers tested for the first time to pre-treat undifferentiated mouse embryonic stem cells with mitomycin C a drug already prescribed to treat cancer.
"This simple strategy of shortly exposing pluripotent stem cells to an anticancer drug turned the transplant safer,
and how it relates to disease or response to drug therapies.""Gersbach added, "Not only can you start to answer those questions,
and so maintaining the long-term effectiveness of the drugs. The collaborative international research, led by Professor Robert Beardmore from the University of Exeter
The research indicates that drug treatments with two antibiotics can be designed to kill bacteria at dosages that would ordinarily cause rapid development of drug resistance and sustained bacterial growth,
sequential treatments could deal with the bacteria, even when much higher doses of single drugs or mixtures of two drugs failed to do so."
bacterial population densities and drug resistance,"said lead author, Professor Beardmore.""As we demonstrate, it is possible to reduce bacterial load to zero at dosages that are said usually to be sub lethal and,
therefore, are assumed to select for increased drug resistance.""The researchers also discovered that, although sequential treatments didn't suppress the rise of all drug resistance mutations in the bacteria,
one drug would'sensitize'the bacteria to the second drug, and therefore reduce the risk of resistance occurring.
Study co-author Dr Ayari Fuentes-Hernandez said:""Research has concentrated for decades on synergistic drug cocktails.
We believe'sequential synergies'might be just as potent if we look for them, this research will
and render them susceptible to concentrations of antibiotics that would normally induce drug resistance and continued existence.
when using drug doses below their maximal potency. She said:""One outcome of this highly surprising result will be to set in motion a series of studies to determine ways of using antibiotics not only in combination,
who are now seeking potential drug compounds that could do just that t
#Study on new treatment for prostate cancer Published in The british Journal of Cancer (BJC), the study is the first time low temperature plasmas (LTPS) have been applied on cells grown directly from patient tissue samples.
"The new information learned from these types of studies could assist in identifying pathogen targets for drug development,
can also be tested for drug discovery using our strategy.""The research team evaluated about 6,
000 compounds from both the KU Chemical Methodologies and Library Development Center and the Food and Drug Administration in a process known as"High Throughput Screening,"hunting for compounds that obstruct Hur's interface with healthy
and could help scientists design more effective drugs to counteract cancer's hallmark trait, uncontrolled cellular growth."
Learning the specific genetic cause of symptoms is a key step in finding new therapeutic drugs that could treat the patient's disease.
The development of a drug based on this discovery is a possibility, although not a certainty,
and the road to such a drug is long and far from simple
#Researchers test smartphones for earthquake warning The study, led by scientists at the U s. Geological Survey
and could provide a potential new drug target for prostate cancer, "Franceschi said.""It could also be a potential biomarker to discriminate between fast and slow growing tumors."
or for transporting lethal drugs into the cancer cells. Since the protein is not found in all of the cells of our body,
This feature also helps them become resistant to antiviral drugs. But scientists have developed therapeutic antiviral agents for HIV
But together their research teams were able to fruitfully undertake one of the first 2d infrared spectroscopic studies of the therapeutic mechanism of an antiviral drug."
including biodegradable plastics, pharmaceutical drugs and even liquid fuels. Scientists with the U s. Department of energy (DOE)' s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have created a hybrid system of semiconducting nanowires and bacteria
The yields of target chemical molecules produced from the acetate were also encouraging--as high as 26-percent for butanol, a fuel comparable to gasoline, 25-percent for amorphadiene, a precursor to the antimaleria drug artemisinin,
#Electronic micropump to deliver treatments deep within the brain Drugs constitute the most widely used approach for treating brain disorders.
However, many promising drugs failed during clinical testing for several reasons: Epilepsy is a typical example of a condition for
which many drugs could not be commercialised because of their harmful effects, when they might have been effective for treating patients resistant to conventional treatments.
whether these are ions or drugs. When an electrical current is applied to it, the flow of electrons generated projects the molecules of interest toward the target area.
in order to activate the pump to inject the drug at just the right moment. It may therefore be possible to control brain activity where
In addition to epilepsy, this state-of-the-art technology, combined with existing drugs, offers new opportunities for many brain diseases that remain difficult to treat at this time e
They also added two other drugs that temporarily inhibited key biochemical pathways associated with the pluripotent state of the stem cells.
and far longer progression-free survival than giving one of those drugs alone, new research shows.
and far longer progression-free survival than giving one of those drugs alone. Further the combination was effective in the portion of melanoma patients--the majority--who currently have few effective treatment options.
Both drugs have been approved by the US Food and Drug Administration. The Phase 2, double-blind trial enrolled 142 patients with advanced melanoma who had received not prior therapy.
#Drugs stimulate body's own stem cells to replace the brain cells lost in multiple sclerosis Led by researchers at Case Western Reserve,
a multi-institutional team used a new discovery approach to identify drugs that could activate mouse
The two most potent drugs--one that currently treats athlete's foot, and the other, eczema--were capable of stimulating the regeneration of damaged brain cells
"Our approach was to find drugs that could catalyze the body's own stem cells to replace the cells lost in multiple sclerosis."
and less invasive approach by using drugs to activate native stem cells already in the adult nervous system
federally approved drugs enhances the likelihood that the compounds can be made safe for human use.
they could begin to test different existing drug formulations to determine which, if any, induced the OPCS to form new myelinating cells.
the investigators quantified the effects of 727 previously known drugs, all of which have a history of use in patients, on OPCS in the laboratory.
both drugs prompted native OPCS to regenerate new myelin.""It was a striking reversal of disease severity in the mice,
"The drugs that we identified are able to enhance the regenerative capacity of stem cells in the adult nervous system.
"While the drugs proved to have extraordinary effects on mice, their impact on human patients will not be known fully until actual clinical trials.
in addition to the tests with animal cells, they also tested the drugs on human stem cells
if these drugs could also stimulate human OPCS to generate new myelinating cells.""Tesar, who recently received the 2015 International Society for Stem Cell Research Outstanding Young Investigator Award,
said investigators next will work to deepen their understanding of the mechanism by which these drugs act.
researchers will modify the drugs to increase their effectiveness in people. The team is optimized enthusiastic that versions of these two drugs can be advanced to clinical testing for multiple sclerosis in the future,
but Tesar emphasized the danger of trying to use current versions for systemic human administration."
"but off-label use of the current forms of these drugs is more likely to increase other health concerns than alleviate multiple sclerosis symptoms.
We are working tirelessly to ready a safe and effective drug for clinical use.""While multiple sclerosis is the initial focus for translating this research into the clinic,
Any drugs developed that enhance myelination in multiple sclerosis also hold promise for benefiting these other disorders."
"The approach from Case Western Reserve University combines cutting-edge stem cell and drug screening technologies to develop new chemical therapeutics for myelin disorders,
#Researchers discover new drugs to combat the root cause of multiple sclerosis At the pathological level,
These two drugs, miconazole and clobetasol, were found to treat the source of the problem by reversing this process,
and associate professor in the Department of Genetics & Genome Sciences at the Case Western Reserve School of medicine, found seven drugs that enhance generation of mature oligodendrocytes
Miconazole was found to function directly as a remyelinating drug with no effect on the immune system,
and less invasive approach by using drugs to activate native stem cells already in the adult nervous system
""Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo, "was published in Nature on April 20 0
The surfaces could also be used to test drugs in the lab, Wong says, or perhaps as biomimetic surfaces for implantable tissue scaffolds or neural implants.
He adds that it could potentially be improved for applications in the monitoring of explosives or drugs.
or baggage for drugs or explosives it is useful for the terahertz radiation to be as'broadband'as possible,"
but also for drug use and development: Causal or target genes may be identified better for treatment, and previously unexpected drug interactions and disruptions may be anticipated."
"Biomedical researchers can use these networks and the pathways that they uncover to understand drug action and side effects in the context of specific disease-relevant tissues,
and to repurpose drugs,"Troyanskaya says.""These networks can also be useful for understanding how various therapies work and to help with developing new therapies."
"The researchers have created also an online resource so that other scientists may use Netwas and access the tissue-specific networks.
The modeling of these arrangements could inform the cluster's use as a transporter of pharmaceutical drugs
could allow biomedical engineers to identify appropriate binding sites for drugs used to treat cancer and other diseases.
Ozcan's group next plans to test their device in the field to detect the presence of malaria-related drug resistance e
If cells are exposed to a drug called etoposide, SIRT1 ubiquitination blocks cell death. However, if cells are exposed to oxidative stress,
potentially leading to more effective therapeutic drugs in the future.""SIRT1 is known to be expressed abnormally in a variety of cancers
what's the best way of getting her drug-packed exosomes to the brain? It looks like a simple nasal spray will do the trick,
say Elena Batrakova and her colleagues at the UNC Eshelman School of Pharmacy's Center for Nanotechnology in Drug Delivery.
Getting drugs into the brain is extremely difficult in general because it is protected and isolated from the rest of the body by the blood-brain barrier,
"Traditional drugs--from cold medicine to chemotherapy--are composed of small molecules of a few dozen atoms, typically.
Proteins such as catalase are tens of thousands of times larger than the small molecules that make up traditional drugs.
Since 2010, the FDA has approved vaccines and other immunotherapy drugs for melanoma, prostate cancer, and lung cancer.
The second method involved using drugs that block the activity of arginase. Although both approaches restored nitric oxide production and reversed hypertension in obese rats, the use of arginase-inhibiting drugs may be a better solution."
"Blocking arginase activity offers a more specific approach in treating hypertension, because you are directly targeting the underlying biochemical defect in obesity,
The antiparasitic drug ivermectin, or IVM, can be used to treat these diseases, but mass public health campaigns to administer the medication have been stalled because of potentially fatal side effects for patients co-infected with Loa loa,
#3d'organoids'grown from patient tumors could personalize drug screening Three-dimensional cultures (or'organoids')derived from the tumors of cancer patients closely replicate key properties of the original tumors,
These'organoid'cultures are amenable to large-scale drug screens for the detection of genetic changes associated with drug sensitivity
As a result, it has been challenging to predict the drug sensitivity of individual patients based on their unique spectrum of genetic mutations.
To link drug sensitivity to genetic changes, the researchers next screened the responses of the organoids to 83 experimental and approved cancer drugs.
the organoids displayed a range of sensitivities to the drugs. In validation of the approach, the researchers identified previously reported associations between specific mutations and resistance to particular drugs.
The organoids also revealed a novel gene-drug association, indicating that the subset of cancer patients with RNF43 mutations would strongly benefit from a drug that inhibits a protein called porcupine."
"At some point in the future, this approach may be suitable for modeling individual patient response to cancer therapies to inform clinical treatment,
"Garnett says. Moving forward, the researchers plan to expand the panel of existing colon organoids as well as develop an organoid biobank for other tumor types."
3-D printed'tissue'to help combat disease A bench-top brain that accurately reflects actual brain tissue would be significant for researching not only the effect of drugs,
Pharmaceutical companies spend millions of dollars testing therapeutic drugs on animals only to discover in human trials that the drug has an altogether different level of effectiveness.
We're not sure why, but the human brain differs distinctly from that of an animal.
A bench-top brain that accurately reflects actual brain tissue would be significant for researching not only the effect of drugs,
in addition to providing an experimental test bed for new drugs and electroceuticals.""We are still a long way from printing a brain
but also for more common problems involving maladaptive daily decisions about drug or alcohol use, gambling or credit card binges.
#Scientists determine how antibiotic gains cancer-killing sulfur atoms In a discovery with implications for future drug design,
that include many drugs such as erythromycin (antibacterial) and lovastatin (cholesterol lowering).""Sulfur is critical not only to human life,
one of the co-first authors of the study and a member of the Shen lab."Since polyketide synthases are a large family of enzymes that have been proven amenable for polyketide structural diversity and drug discovery,
"Whereas traditional pharmaceutical drugs have a transient effect, gene editing could possibly provide a permanent cure for a lot of different diseases,
It's a major step forward in creating a quantum computer to solve problems such as designing new drugs
The technique should speed the development of drug and diagnostic compounds that would not have been possible otherwise--including powerful hormone-based therapies."
The most commonly used tranquilizing drug, benzodiazepine, activates GABA receptors in our brains. There are two kinds of GABA receptors.
a drug that stimulates extra-synaptic GABA receptors.""It's like we got them a little inebriated,
However, when scientists put the mice back on the drug and returned them to the box,
"This establishes when the mice were returned to the same brain state created by the drug,
when the extra-synaptic GABA receptors were activated with the drug, they changed the way the stressful event was encoded.
In the drug-induced state, the brain used completely different molecular pathways and neuronal circuits to store the memory."
The drug rerouted the processing of stress-related memories within the brain circuits so that they couldn't be accessed consciously d
exciting advance that may open up possibilities for targeting new drugs to control neurotransmitter release. Many mental disorders, including depression, schizophrenia and anxiety,
better drugs for autoimmune conditions and new ways to expedite recovery from sepsis. The research
and Drug Administration, is the first and only recapturable and repositionable device commercially available in the United states. It sets a new standard for transcatheter aortic valve replacement (TAVR) in the United states. J. Michael Tuchek,
After the device was approved by the U s. Food and Drug Administration, Loyola became the first Illinois center to offer it outside of a clinical trial.
The materials that pharmaceutical companies use to test drugs'effects on cells don't allow for three-dimensional vascularization, a network of capillaries that carry drugs and other materials throughout the body.
but also aid in drug screening.""The microenvironment actually has a significant effect on how the cells respond to a drug,
"Grolman said.""These companies might have the next big drug, but they might not know it.""
""The long-term vision would be: A patient goes in and finds out they've been diagnosed with some sort of solid tumor,
and building a model of their tissue to use as a personalized drug screening platform.
and do not respond to the drugs or deep brain stimulation used for Parkinson's symptoms.
This multi-device approach, much like multi-drug therapy, may ultimately benefit patients with impaired mobility in a wide variety of rehabilitation settings."
as a result of misdiagnoses can results in new, drug-resistant strains of the disease in addition to increasing costs for malaria medications, Coté notes.
"Given that these drugs are the most common anesthetics used in the operating room, "there is a serious need to understand how they work
"A therapy based on these inhaled drugs may help deal with new viral and bacterial strains that are resistant to conventional vaccines
"We hope our study opens the door to the development of new drugs and therapies that could change the infectious disease landscape."
"Simultaneously employing different drugs to target different cancer subclasses could prevent remission, scientists have proposed. One powerful single-cell analytic technique for exploring CNV is whole genome sequencing.
and used drugs to block their ability to transport potassium. Blocking potassium efflux created cells that were resistant to E. histolytica."
"There is a clear need for new drugs targeting E. histolytica, "Petri says.""Right now there is a single antibiotic that works against this parasite.
#Pancreatic cancer subtypes discovered in largest gene expression analysis of the disease to date Dense surrounding tissue can block drugs from reaching pancreatic cancer tumors,
Each of these products is a potential new drug. One of them has already been identified as an antibiotic.
"This 15 percent drug-development success rate is much higher than the 0. 1 percent average estimated for natural products as a whole."
The researchers describe the new findings as a proof of concept that genome mining can be used on a scale that will speed the process of drug discovery,
which are among the most promising new drug leads.""These biologically produced small molecules have been the source of,
#New drug-like compounds may improve odds of men battling prostate cancer, researchers find Researchers at Southern Methodist University,
Dallas, have discovered three new drug-like compounds that could ultimately offer better odds of survival to prostate cancer patients.
The drug-like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers,
So far there's no approved drug on the market that reverses cancer chemotherapy resistance caused by P-glycoprotein
One potential drug, Tariquidar, is currently in clinical trials, but in the past, other potential drugs have failed at that stage."
"The problem when a person has cancer is that the treatment itself is composed of cellular toxins--the chemotherapeutics that prevent the cells from dividing.
who is director of SMU's Center for Drug Discovery, Design, and Delivery.""Sometimes, however, the cancer returns,"she said."
"As a result, P-gp causes resistance of the diseased cells to a majority of drugs currently available for the treatment of cancer,
as well as drugs used for treatment of infectious diseases like HIV/AIDS. Using computer-generated model speeds up the drug discovery process The new drug-like compounds discovered by Vogel
and her co-authors offer hope that using a computer-generated P-gp model, explained here http://bit. ly/1lvmr7a,
chemical and biological functions of the protein in the human body, will speed up the drug discovery process
so that's a pretty good predictor that they may be good candidates for drug development. But we need to do much more work."
so it can eventually be delivered to patients as a therapeutic drug. In the case reported here,
The timeline from drug discovery to development to clinical trials and approval can take a decade or more.
Researchers virtually screened 15 million drug-like compounds via SMU supercomputer The SMU researchers discovered the three hit compounds after virtually screening more than 15 million small drug-like compounds made publically available
including interactions with drug-like compounds while taking on different shapes. The ultra-high throughput computational searches by Maneframe led the researchers to 300 compounds that looked like they may inhibit P-gp.
Also, each was tested on a companion cell line already multi-drug resistant, as if the patient already had undergone chemotherapy using Paclitaxel.
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