A New Direction for Drug Research The startling discovery of TMPRSS2 role in triggering cancer pain may lead to the creation of targeted cancer pain therapies that effectively shut down the expression of this gene
#Nanoparticles used to breach mucus barrier in lungs Proof-of-concept study conducted in mice a key step toward better treatments for lung diseases Nanotechnology could one day provide an inhaled vehicle to deliver targeted therapeutic genes
that therapeutic genes may one day be delivered directly to the lungs to the levels sufficient to treat cystic fibrosis (CF), chronic obstructive pulmonary disease,
Unfortunately, Suk notes, this essential protective mechanism also prevents many inhaled therapeutics, including gene-based medicine,
but it also makes the airway mucus harder to overcome by inhaled therapeutic nanoparticles. Most of the existing drugs for CF help clear infections but do not solve the disease underlying problems.
This could eventually become an effective therapy for the lungs of patients, regardless of the mutation type.
, production of therapeutic proteins for several months, Suk says, adding that the nanoparticles did not appear to show any adverse effects,
and that treatment of human disorders with nanowrapped therapies is years away a
#Small tilt in magnets makes them viable memory chips UC Berkeley researchers have discovered a new way to switch the polarization of nanomagnets,
#Real-time data for cancer therapy In the battle against cancer, which kills nearly 8 million people worldwide each year,
however, is good reconnaissance a reliable way to obtain real-time data about how well a particular therapy is working for any given patient.
and adjust dosages or switch therapies accordingly. Making cancer treatments more targeted and precise would boost their efficacy
and adjust or switch therapies. Photo courtesy of the researchers. Measurements without MRI The sensors developed by Cima team provide real-time,
In fact, some therapies will trigger an immune system reaction, and the inflammation will make the tumor appear to be growing,
even while the therapy is effective. Oxygen levels, meanwhile, can help doctors gauge the proper dose of a therapy such as radiation,
since tumors thrive in low-oxygen (hypoxic) conditions. t turns out that the more hypoxic the tumor is,
leading to potentially better therapies and easier tumor identification. The findings have been licensed to Genomeon, a company co-founded by Garner to develop new ways to assess cancer risk,
#Engineering a permanent solution to genetic diseases In his mind, Basil Hubbard can already picture a new world of therapeutic treatments for millions of patients just over the horizon.
replacing the damaged genetic code with healthy DNA. here is a trend in the scientific community to develop therapeutics in a more rational fashion,
when their therapeutic job is done. As a result ipscs carry a high risk of giving rise to tumors.
and early detection is critical in tailoring appropriate and effective therapeutic interventions. While multiple imaging techniques, including MRI,
Can therapeutics be used to disrupt that communication? What sets the team model apart from mouse avatars
the optoclamp could facilitate research into new therapies for epilepsy, Parkinson disease, chronic pain and even depression. ur work establishes a versatile test bed for creating the responsive neurotherapeutic tools of the future,
said Steve Potter, an associate professor in the Wallace H. Coulter Department of Biomedical engineering at Georgia Tech and Emory University. eural modulation therapies of the future,
said Newman. his is potentially a very big deal in terms of developing therapies for aberrant forms of synaptic plasticity.
such as the bionic eye or retinal stem cell therapy. c
#DNA-Guided 3-D Printing of Human Tissue Is unveiled A UCSF-led team has developed a technique to build tiny models of human tissues, called organoids,
They could be used for therapeutic drug screening and to help teach researchers how to grow whole human organs.
as rapid and early detection will significantly improve therapeutic outcomes. The current results establish a foundation for biophysical separations as a direct diagnostic tool,
and could have implications that go far beyond basic neuroscience from informing education policy to developing new therapies for neurological disorders such as epilepsy.
when we age, has enormous implications that go beyond fundamental neuroscience, from informing education policies to developing new therapies for neurological disorders such as epilepsy
#Filling a void in stem cell therapy Stem cell therapies are limited often by low survival of transplanted stem cells
Stem cell therapies bear tremendous hopes for the repair of many tissues and bone or even the replacement of entire organs.
and function correctly at the site of injury to be useful for clinical regenerative therapies.
To improve the therapeutic ability of transplanted stem cells, Mooney team has drawn inspiration from naturally occurring stem cell iches.
That means that patients have to ingest more of a drug to get the therapeutic dose increasing the cost, risk of side effects,
the development of new synthetic materials for the delivery of therapeutic proteins and genetic material. In 2015, he received a Faculty Early Career development (CAREER) award from the National Science Foundation (NSF),
funding research into a new way to deliver protein-based cancer-fighting drugs and other therapeutics directly into cells.
they have found both a possible reliable biomarker for diagnosing certain forms of autism and a potential therapeutic target.
More Precise Cancer Therapies UCSFUC San francisco researchers have engineered a molecular n switchthat allows tight control over the actions of T cells,
immune system cells that have shown great potential as therapies for cancer. The innovation lays the groundwork for sharply reducing severe,
scientists pursuing cell therapy, one branch of the burgeoning field of cancer immunotherapy, have been refining cell-surface sensors known as chimeric antigen receptors, or CARS.
Dangers of CAR T cell Therapy CAR-equipped T cells have proven to be remarkably successful in the treatment of various forms of chemotherapy-resistant leukemia
But CAR T cell therapy can cause side effects so serious that they may require monitoring in an Intensive care unit several patients have died after receiving CAR T cells
These combined control capabilities could be employed to manage the various side effects of CAR T therapy.
and the ability to document these alterations aid in the development of novel therapies. ethylation is really key in development,
or water and therapeutic drug monitoring at home, a feature which could drastically improve the efficient of various class of drugs and treatments v
and for the production of advanced therapeutics to combat the disease. Human cells express Interferon Induced Transmembranes (IFITM) proteins that possess antiviral characteristics.
we are getting closer to finding better therapeutic approaches in the fight against HIV. The study, FITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein,
The newly described Cpf1 system differs in several important ways from the previously described Cas9, with significant implications for research and therapeutics,
These groups plan to offer licenses that best support rapid and safe development for appropriate and important therapeutic uses. e are committed to making the CRISPR-Cpf1 technology widely accessible,
Zhang says. ur goal is to develop tools that can accelerate research and eventually lead to new therapeutic applications.
or water and therapeutic drug monitoring at home, a feature which could drastically improve the efficient of various class of drugs and treatments v
and in efforts toward an effective therapy. But the implications are even broader because the approaches that the investigators used could aid therapy development for a vast array of other mitochondrial diseases,
said Maryann Redford, D d. S m. P. H.,a program director in Collaborative Clinical Research at NIH National Eye Institute,
and testing potential therapies for such diseases. Until now here was no efficient way to get DNA into mitochondria,
The transplanted photoreceptors migrated naturally within the retina of their host. one transplant represents a therapeutic solution for retinal pathologies caused by the degeneration of photoreceptor cells,
But in order to undertake a complete therapy, we need neuronal tissue that links all RPE cells to the cones.
offering the possibility of directly testing potential avenues for therapy on the patient own tissues e
This ideal therapy has remained in the realm of science fiction until now. The team stresses that there are significant hurdles before this could offer new treatments a key issue is being able to alter the heart to be light-sensitised
and design of therapies to treat them. But finding a specific biomarker in a massive amount of genetic code is hard.
This ideal therapy has remained in the realm of science fiction until now. he team stresses that there are significant hurdles before this could offer new treatments a key issue is being able to alter the heart to be light-sensitised
and serving as models to develop therapeutic agents to treat these diseases, explained Joseph Bonventre, senior author of the study.
and therapies that might work in humans. The researchers found that genetically matched kidney organoids without disease-linked mutations showed no signs of either disease.
RISPR can be used to correct gene mutations explained Freedman. ur findings suggest that gene correction using CRISPR may be a promising therapeutic strategy.
and serving as models to develop therapeutic agents to treat these diseases, Bonventre said. Kidney disease costs the United states 40 billion dollars per year and affects 700 million people worldwide.
better ways of testing out drugs and therapies that might work in humans. g
#Snake venom helps hydrogels stop the bleeding Rice university lab employs clotting powers of viper-derived drug,
It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.
therefore increasingly focusing on new therapeutic options that have few side effects, states Prof. Becker. If the zinc ions or the transcription factor MTF1 were inhibited specifically in the brain,
#Scientists create a new simple method to create stem cells Many new innovative therapies that scientists come up with rely on stem cells,
especially when immune therapy and regenerative medicine are considered. However, these promising research fields are limited by the difficulty of creating stem cells.
Of course, there had to be experiments with human stem cells to test potential of the method for future therapeutic application.
which could then be used for regenerative medicine or immune therapy. It is hard to overestimate researches like that.
which in turn will most likely spawn many new researches and new therapies for harsh conditions in immune therapy and regenerative medicine.
and there are currently no targeted therapies available. ersonalised medicine is about targeting treatment to an individual particular genetic profile,
which means that any drug therapy will likely have few side effects. Second the location of the receptors on the outer surface of cancer cells means they can be accessed easily by drugs.
and other members of this specific class of receptors have been targeted successfully for cancer therapies. The cancer drugs Herceptin, Gleevec and Iressa all target receptors of this class.
#Nanotechnology could spur new heart treatment for arrthymia A new nanoparticle developed by University of Michigan researchers could be the key to a targeted therapy for cardiac arrhythmia,
The major challenge of adapting the therapy to heart cells was developing a nanoparticle small enough to penetrate the tiny pores inside heart capillaries,
and a research lab specialist in internal medicine. his cell-selective therapy may represent an innovative concept to overcome some of the current limitations of cardiac ablation,
which is already in clinical trials as a cancer therapeutic; and a more precise next-generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis pharmaceuticals,
so may find applications in drug toxicity tests, the search for new drugs and cell therapy.
The goal of some antiviral therapies, therefore, is to buy more and give the immune system a leg up on the virus. A new study led by Bruce Freedman
The work paves the way toward designing a potential broad-spectrum drug that could serve as a therapy for a number of serious viral infections. ur work is aimed at handicapping the virus
said Freedman. e could also imagine this type of drug would be part of a cocktail therapy,
Freedman and Harty have launched a company called Intervir Therapeutics Inc.,with support from the Penn Center for Innovation UPSTART program,
In addition, if used as part of a combination therapy, ORAI inhibitors could be administered at lower doses m
There also may be implications for future delivery of nanoscale therapeutics. Although it may be a long march from diagnosing cancer to curing it,
but it also suggests that these physical channels might be exploitable to deliver drug therapies. hope that the tools we have developed,
or use them to deliver lifesaving therapies. o
#New treatment targets cancers with particular genetic signature Oxford university researchers have found the Achilles heel of certain cancer cells mutations in a gene called SETD2.
and provide a step towards personalized cancer therapy i
#Google Project Loon Set to Enmesh the Globe with Internet Balloons by 2016 Project Loon is yet another highly ambitious project of the tech-giant Google,
The GM pigs are being produced in Blacksburg, Virginia, by Revivicor, a division of the biotechnology company United Therapeutics.
says Romesberg. he home run is the ability to produce therapeutic proteins with unnatural amino acids in them. ynthorx achievement falls a bit short of that.
but the study tells us the enzyme has the right properties to eventually become a successful therapeutic.
and its degradation of nicotine produced no toxic metabolitesll good signs for a potential therapeutic. opefully we can improve its serum stability with our future studies
Spritam (levetiracetam) is an oral adjunctive therapy to treat a range of seizures in adults and children with epilepsy.
According to Aprecia, potential therapies made via Zipdose are assembled in layers without using compression forces or traditional moulding techniques.
The paper, tretch-Triggered Drug Delivery from Wearable Elastomers Containing Therapeutic Depots, is published online in the journal ACS Nano.
n conjunction with medication and current psychological therapies, Wizard could help people with schizophrenia minimise the impact of their illness on everyday life. eople with schizophrenia often find studying
#Personalized cellular therapy achieves complete remission in 90 percent of acute lymphoblastic leukemia patients studied Ninety percent of children
or failed to respond to standard therapies went into remission after receiving an investigational personalized cellular therapy CTL019 developed at the Perelman School of medicine at the University of Pennsylvania.
The durable responses we have observed with CTL019 therapy are unprecedented. Shannon Maude MD Phd an assistant professor of Pediatrics and a pediatric oncologist at CHOP and Noelle Frey MD MSCE an assistant professor of Medicine and an oncologist at Penn's Abramson's Cancer Center
Nineteen patients in the study remain in remission 15 with this therapy alone including a 9 year old who was the first ALL patient to receive the therapy more than two years ago.
Five patients went off-study for alternate therapy three of whom proceeded to allogeneic stem cell transplants while in remission.
Our results support that CTL019 can produce long-lasting remissions for certain heavily pre-treated ALL patients without further therapy Frey said.
In July 2014 the U s. Food and Drug Administration granted CTL019 its Breakthrough Therapy designation for the treatment of relapsed and refractory adult and pediatric ALL a step
and review of new medicines that treat serious or life-threatening conditions if a therapy has demonstrated substantial advantages over available treatments.
CTL019 is personalized the first cellular therapy to receive the designation. The first multicenter CTL019 trial has opened recently in the U s
and cells offer new solutions for cancer diagnosis and therapy. Understanding the interdependency of physiochemical properties of nanomedicines in correlation to their biological responses
which impact the overall therapeutic efficacy against cancers stated Li Tang first author of this PNAS article.
Mcdonnell and colleagues searched libraries of thousands of approved therapies to identify those that rely on copper to achieve their results.
or similar compounds and copper especially beneficial for men who have been on hormone therapies that have failed to slow tumor growth.
Unfortunately hormone therapies do not cure prostate cancer and most patients experience relapse of their disease to a hormone-refractory
Mcdonnell said clinical trials of the combination therapy are planned in upcoming months. Andrew Armstrong M d. associate professor of medicine was involved with a recent study at Duke testing disulfiram in men with advanced prostate cancer.
No efficient causal therapy exists for HCC patients of which approximately 800000 die every year. T cells involved in the development of fatty liver disease NASH
and therapeutic strategies to combat these diseases. The initial studies are already under way in the preclinical model.*
Researchers used the new therapy to inhibit a pathway in the cancer cells known as mtor signaling--putting the brakes on this pathway combined with the current standard therapy caused more of the cancer cells to die.
and therapies that can be tested in the clinic provides the greatest hope for brain cancer patients
and Dr. Greg Cairncross--director of SACRI and leader of the Terry Fox Research Institute (TFRI'Therapeutic Targeting of Glioblastoma research program at the university--are now working with cancer researchers Dr. Warren Mason (Princess
Most current therapeutic approaches are limited in their ability to reduce injury-induced brain swelling and no treatments are available to resolve excess fluid at a later stage.
Their results could help to develop therapeutics to treat stress-related disease and have been published in the journal Genome Research.
A detailed understanding of the stress reaction on a molecular level could help to develop therapeutics to treat stress-related disease.
understanding of diseases and possibly to new therapies according to UC San francisco scientists. The key to the advance is a new invention called the Suntag a series of molecular hooks for hanging multiple copies of biologically active molecules onto a single protein scaffold used to target genes or other molecules.
Lab studies suggest that DTP3 could have therapeutic benefit for patients with multiple myeloma and potentially several other types of cancer but we will need to confirm this in our clinical trials the first
but such compounds have not been developed successfully as therapies because they also block the many important processes controlled by NF-kb in healthy cells causing serious toxic side effects.
-B pathway with our DTP3 peptide therapeutic selectively kills myeloma cells could offer a completely new approach to treating patients with certain cancers such as multiple myeloma Professor Franzoso said.
A spinout company Kesios Therapeutics was formed to commercialise DTP3 and other drug candidates based on Professor Franzoso's research with support from Imperial Innovations a technology commercialisation company focused on developing the most promising UK academic research.
To help develop this ground-breaking research further Imperial Innovations created the spin out Kesios Therapeutics explained Dayle Hogg from the Healthcare Ventures team at Imperial Innovations i
In the longer term this may give us new therapeutic targets to try to slow
so drugs targeting STAT3 could be used in cancer therapy. However STAT3 is also important in the development of the immune system.
Anti-STAT3 therapy may thus be highly promising. The so-called Signal Transducers and Activators of Transcription or STATS are key components of many different signalling pathways.
Considerable efforts are going into developing inhibitors of STAT3 for use in cancer therapy but it is unclear
senior author of the new study with TSRI Assistant professor of Chemistry Luke Leman. his research clears a big step toward clinical implementation of new therapies.
With the option of an orally effective peptide, Ghadiri believes researchers are closer to developing an accessible new therapy for atherosclerosis.
The researchers believe that finding new targets in the gastrointestinal tract could lead to new therapies for many more diseases. hat one of the fun things in scienceow we get to follow up on these different avenues,
The institute was picking the therapeutic areas that would be their focus. They were considering various exotic diseases
and opened the door for drug discovery and transplantation therapy in diabetes, "Fuchs said. And Jose Oberholtzer, M d.,Associate professor of Surgery, Endocrinology and Diabetes,
human beta cells through controlled differentiation of stem cells will accelerate the development of new therapeutics.
In particular, this advance opens to doors to an essentially limitless supply of tissue for diabetic patients awaiting cell therapy."
and may provide a resource for discovery of beta cell therapies that promote survival or regeneration of beta cells and development of screening biomarkers to monitor beta cell health and survival to guide therapeutic
A study published by Cell Press October 9th in the American Journal of Human genetics shows that neurodevelopmental disorders caused by distinct genetic mutations produce similar molecular effects in cells suggesting that a one-size-fits-all therapeutic approach could be effective
"This gives us a therapeutic avenue to target autophagy in tumors, "said Josh Andersen, a BYU chemistry professor."
which conservative therapy or surveillance would be appropriate treatment, the clinical challenge is not only how to identify those with prostate cancer,
We are working now to improve the technology to achieve the imaging precision we need to make broadly effective therapies,
Thus it is highly important to identify more sensitive and specific markers to improve early diagnosis as well as therapeutic strategies.
#Worlds first novel method for label-free identification of stem cells will lead to more consistent, efficacious stem cell therapies,
Dry powder inhaler formulation Despite advances in vaccination and antimicrobial therapy, community-acquired pneumonia remains a leading cause of morbidity and mortality, even in highly developed countries.
Current experimental drugs generally target only one of Ebola's five species."The current growing epidemic demonstrates the need for effective broad-range Ebola virus therapies,
or new Ebola species. Development of a broadly acting therapy is an important long-term goal that would allow cost-effective stockpiling of a universal Ebola treatment."
and more efficient targeted therapy to improve the clinical outcome. Story Source: The above story is provided based on materials by University of Kansas. Note:
and may be key to developing new drugs and therapies. Specifically principal investigator Albert R. La Spada MD Phd professor of cellular and molecular medicine chief of the Division of Genetics in the Department of Pediatrics and associate director of the Institute for Genomic
and overall homeostasis or a healthy equilibrium. he therapeutic potential of let-7 remains to be explored.
It is possible that modulation of let-7 could be pursued for therapeutic application using very carefully targeted delivery systems
Dr Murphy said institute scientists would now embark on a collaborative project with Catalyst Therapeutics to develop a potent new drug based on the small molecule identified in the study.
and may serve for the development of novel therapeutics. The study is published online October 7 2014 in Nature Communications.
Thus we hope that its potential as a powerful therapeutic agent for the treatment of autoimmune diseases will facilitate its use in future clinical trials.
and disease and finding personalized therapies Maggert said. However this topic is incomplete unless biologists can look at the entire genome.
The optimal drug therapies we have today often aren't enough to manage this disease for some patients
so we are always looking for new types of therapies. Abraham and other cardiovascular researchers at seven U s. centers examined an extra-aortic counterpulsation system called C-Pulse made by Sunshine Heart Inc. It's a cuff that wraps around the aorta
Drug and device therapies that are currently available for heart failure improve that same quality of life score by only five or 10 points.
and antibiotic therapy could reduce that risk in future studies. There were no hospitalizations among the participants for stroke thrombosis sepsis or bleeding
In a new study that should make it easier to develop such stem-cell-based therapies a team of researchers from MIT
and calling stem cells are producing a beneficial therapeutic outcome but many of the cells that you're putting in are not Van Vliet says.
You can now find the needles in the haystack and use them for human therapy.
or even to manipulate it to our own therapeutic needs.""Hijacking the hijacker"A tempting premise is to use this same machinery to introduce drugs or genes into the nervous system,"Dr. Perlson added.
and only one therapy has been approved by the Food and Drug Administration. While most of these vaccines are created with dendritic cells,
but they are being appreciated increasingly for their practical advantages in therapies, says Bishop, who was involved not in this research. his new technical approach permits loading B cells effectively with virtually any antigen
in this new study, demonstrates promise as a versatile platform for creating more effective cell-based vaccines. ur dream is to spawn out a whole class of therapies
and less expensive method for developing cell-based therapies for patients. own the road, you could potentially get enough cells from just a normal syringe-based blood draw,
and one day develop customized cell therapies for individual patients. The Yale team used a new form of transciptome analysis that allowed them to more fully explore impact of all types of RNA on cell reprogramming.
a discovery that could have therapeutic potential for diabetes, obesity, and other metabolic diseases. Harvard Stem Cell Institute (HSCI) scientists have found a way to both make more energy-burning human brown fat cells
a discovery that could have therapeutic potential for diabetes, obesity, and other metabolic diseases. Unlike energy-storing white,
Knowing which genes control UCP1 should help scientists develop therapies. e could take fat samples from patients undergoing liposuction
Tseng believes cell therapy would be uch safer and much less invasive. ontrolling the genes might allow scientists to make mediocre brown fat cells work better.
we may discover novel therapeutics for the treatment of obesity and metabolic disease, said Chad Cowan, an HSCI principal faculty member who, among other things,
also studies the therapeutic potential of brown fat cells. In 2014, Cowan identified two drugs with the potential to convert stem cells that make white fat into those that would make brown. his latest study gives us new tools and targets to use in the battle against obesity
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