#Printing silicon on paper, with lasers Recently, a group of researchers at Delft University of Technology,
The findings could have therapeutic implications specific to this rare form of the disease, say the authors.
could have therapeutic implications specific to this rare form of the disease, say the authors.
It is normally very sensitive to estrogen-targeting therapies because of high expression of the estrogen receptor protein,
"Figuring out specific differences that are not visible under the microscope allows us to intervene with more appropriate and potentially lifesaving therapy.
we have an opportunity to identify anticancer therapies that would specifically target that abnormality and that would otherwise not be given to those patients who could benefit.
the opportunity exists to provide tailored therapies for patients,"notes Lorna Rodriguez, MD, Phd, director of the precision medicine initiative at the Cancer Institute and professor of obstetrics, gynecology and reproductive sciences
such findings can also aid in developing the next generation of therapies through clinical trials. It is our aim at Rutgers Cancer Institute of New jersey to build upon this work,"notes senior author of the work, Shridar Ganesan, MD, Phd, associate director for translational science at the Cancer Institute
Our results lead us to imagine unprecedented therapeutic strategies aimed at mobilising the resident pulpal stem cells
"Current therapies focus on stopping immune system attacks, slowing the progression of the disease. Our research is focused on trying to repair the brain itself,
researchers discovered the therapeutic compounds for enhancing myelination from oligodendrocyte progenitor cells through screening a library of bioactive small molecules.
Finding this cellular target for pharmacological intervention, Miller and co-author Paul Tesar, Ph d.,the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics
The Tekmira sirna-based therapeutic is now being evaluated in Ebola-infected patients in Sierra leone e
"These networks can also be useful for understanding how various therapies work and to help with developing new therapies."
Other key collaborators on this study were Emanuela Ricciotti, Garret A. Fitzgerald and Tilo Grosser of the pharmacology department and the Institute for Translational Medicine and Therapeutics at the Perelman School of medicine, University of Pennsylvania;
#Uncovering new functions of a gene implicated in cancer growth opens new therapeutic possibilities Two decades ago,
Targeting Id1 might provide a three-pronged therapeutic approach, which would first reduce the metastatic potential of the tumor itself,
potentially leading to more effective therapeutic drugs in the future.""SIRT1 is known to be expressed abnormally in a variety of cancers
and might be a good target for therapy. Ubiquitin-proteasome inhibitors have already been used successfully in cancer therapy and clinical trials.
Therefore, this research might provide molecular bases and insights for developing additional therapeutic strategies in the future,"explained Ed Seto, Ph d.,senior member of the Cancer Biology and Evolution Program at Moffitt t
#Percentage of Texans without health insurance drops dramatically The report found that from September 2013 to March 2015, the percentage of uninsured adult Texans ages 18-64 dropped from 25 to 17 percent."
2015 in Molecular Cell, offer guidance for improving stem cell therapies. The new work also reveals more about certain cancers that arise
and optimizing the efficiency of stem cell therapies.""When they looked closer at the genes that both pathways activated,
so that preventive therapies can be given. But exercise stress testing is inappropriate for diagnosis in hemodialysis patients who have multiple complications including muscle weakness, osteoporosis and peripheral arterial disease."
which could be an effective therapeutic target for preventing sudden cardiac death.""He concluded:""Further diagnostic tests should be considered in high risk patients with abnormal BMIPP scintigraphy.
and help physicians select a prophylactic therapeutic strategy against sudden cardiac death in hemodialysis patients."
so that preventive therapies can be given. But exercise stress testing is inappropriate for diagnosis in hemodialysis patients who have multiple complications including muscle weakness, osteoporosis and peripheral arterial disease."
which could be an effective therapeutic target for preventing sudden cardiac death.""He concluded:""Further diagnostic tests should be considered in high risk patients with abnormal BMIPP scintigraphy.
and help physicians select a prophylactic therapeutic strategy against sudden cardiac death in hemodialysis patients
and lay the foundation for the next era of cancer therapy, "said corresponding author Jinghui Zhang, Ph d.,a member of the St jude Department of Computational biology."
This is the first time a large therapeutic protein like catalase has been delivered to the brain using exosomes. Getting drugs into the brain is extremely difficult in general
There are currently dozens of active clinical trials evaluating vaccines for cancer therapy. Approximately 235,000 new diagnoses of breast cancer were made last year,
In this case, HER2 is both a naturally occurring hormone receptor and an antigen target for therapy.
World health organization guidelines recommend antiretroviral therapy for individuals with a CD4+T cell count of less than 500 cells/ml.
"At some point in the future, this approach may be suitable for modeling individual patient response to cancer therapies to inform clinical treatment,
Pharmaceutical companies spend millions of dollars testing therapeutic drugs on animals only to discover in human trials that the drug has an altogether different level of effectiveness.
Various sight recovery therapies are being developed by companies around the world, offering new hope for people who are blind.
what vision would be like after two different types of sight recovery therapies. Lead author Ione Fine,
to be a therapeutic target in human patient groups
#Missing piece surfaces in the puzzle of autism A study carried out by the Laboratoire Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS/Aix-Marseille Université),
in the longer term, lead to the development of therapeutic tools and new diagnostic methods d
This deeper understanding of how cells become differentiated is extremely important when considering therapeutic potentials.
This new discovery could open the way to incorporating sulfur into other natural products, potentially advancing new therapies for indications beyond cancer."
"With many other natural products, sulfur could add other therapeutic properties. This is the beauty of fundamental research--it lays the foundation to create novel technologies that enable innovative translational research with implications far beyond the original discovery."
#Engineering a permanent solution to genetic diseases In his mind, Basil Hubbard can already picture a new world of therapeutic treatments for millions of patients just over the horizon.
"There is a trend in the scientific community to develop therapeutics in a more rational fashion,
"We can use this information to develop novel therapeutics, advanced diagnostic techniques and new ways to prevent,
and develop novel strategies for therapeutic interventions. In addition to scientists from the ZMBH, DKFZ and HITS, researchers from the Leibniz Institute for Molecular Pharmacology in Berlin, the Northwestern University in Illinois (USA) and The swiss Federal Institute of technology in Zurich (Switzerland) also participated in the work k
#Better way to engineer therapeutic proteins into antibodies Some proteins exist so fleetingly in the bloodstream that they can't be given effectively as therapies.
and diagnostic compounds that would not have been possible otherwise--including powerful hormone-based therapies.""Unlike prior approaches to this design problem,
First identified by Friedman in 1994 as a satiety hormone that switches off hunger, leptin initially failed as an obesity therapy,
Leptin on its own and in an unmodified state isn't ideal as a therapy because it doesn't last long in the bloodstream."
and function properly, the researchers used a selection system that they had developed previously for finding therapeutic antibodies in large antibody libraries.
"It's difficult for therapists to help these patients, Radulovic said, because the patients themselves can't remember their traumatic experiences that are the root cause of their symptoms.
and food insecure people with HIV are less able to take anti-HIV therapies, make clinic visits,
Participants were HIV positive individuals between 18 and 49 years old on anti-HIV therapy
The finding was confirmed in samples from patients receiving high-dose interleukin 2 therapy to treat metastatic melanoma."
Can therapeutics be used to disrupt that communication? What sets the team's model apart from mouse avatars
such as the preparation of foods, dietary supplements, therapeutics and chemical materials. A major goal in biotechnology is to modify enzyme activity
facilitate the development of therapeutics that prevent the proliferation of harmful viruses. The scientific paper entitled"Mutational interference mapping experiment (MIME) for studying RNA structure
, by introducing therapeutic (e g. COMPLEMENTARY RNA, the virus could be rendered harmless. Currently, many RNA-based therapies are under investigation worldwide.
The MIME method can make a significant contribution to this research by helping to identify the appropriate RNA segments.
which mutations are tolerated by the virus and which not, a factor that is useful for the design of therapeutic RNA,
"This is a great example of a therapeutic approach that combines two very different modalities--neuromodulation
This multi-device approach, much like multi-drug therapy, may ultimately benefit patients with impaired mobility in a wide variety of rehabilitation settings."
"A therapy based on these inhaled drugs may help deal with new viral and bacterial strains that are resistant to conventional vaccines
and therapies that could change the infectious disease landscape.""The investigators say they are currently testing an oral small molecule immune modulator in phase 2 clinical trials that acts like volatile anesthetics to help reduce secondary infections after someone becomes sick with the flu u
which has documented many well therapeutic benefits.""We like to think our Gingko'trees'will provide benefits as well,
what she calls"mini guts"to test therapeutics that may be useful in human patients. And technological advances make this study's general technique more efficient,
and guide the development of new therapies.""The study reveals the most rigorously validated classification system for pancreatic ductal adenocarcinoma to date.
"Basal-like tumors also trended toward a better response to adjuvant therapy.""If we know that your tumor is aggressive,
then it may be important to treat your whole body first with neoadjuvant therapy, which is given therapy prior to surgery,
as opposed to just trying to remove the tumor with surgery at the outset, "said Yeh, who,
which respond to therapies differently than other tumor subtypes, so we are interested very in seeing
"For pancreatic cancer in particular, it's a race against the clock, every therapy counts, so you want your first therapy to work,
"she said.""With this cancer, you don't have a lot of time to try different therapies. If a patient is given a therapy that is unsuccessful, that is time in
which the patient's disease has progressed. So the goal is to start patients on the right therapy from the get-go
#New molecule found to prevent preterm birth Premature births are linked intimately with inflammation of the uterine tissue, a biological response
which induces contractions and preterm labor. In their search for a mean to prevent this phenomenon
which they tested therapeutic agents known to target that messenger --although they were used traditionally never such an application.
scientists have developed another therapeutic agent, which proved much more effective, in addition to being safer than the existing molecules designed for the same target."
so it can eventually be delivered to patients as a therapeutic drug. In the case reported here,
so it can eventually be delivered to patients as a therapeutic drug. In the case reported here,
#Filling a void in stem cell therapy Stem cell therapies are limited often by low survival of transplanted stem cells
Stem cell therapies bear tremendous hopes for the repair of many tissues and bone or even the replacement of entire organs.
and function correctly at the site of injury to be useful for clinical regenerative therapies.
To improve the therapeutic ability of transplanted stem cells, Mooney's team has drawn inspiration from naturally occurring stem cell"niches."
so that we can identify the best therapeutic targets for neurodegenerative disorders
#Whole genome-sequencing uncovers new genetic cause for osteoporosis Using extensive genetic data compiled by the UK10K project,
and no curative therapies available. The UK10K project has measured genetic variations in 10,000 individuals in great detail,
Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients.
''explains Dr. Wing who is also the director of the Experimental Therapeutics and Metabolism Program at the RI-MUHC."
possibly paving the way for new therapies that can either hone the pathway's cancer-killing role or reduce its role in inflammation.
and virus biology that could translate into valuable therapeutic and diagnostic applications Dr Jonathan Loh,
With the new insights, we can better identify the good stem cells and use them more efficiently and safely in clinical therapies.
in order to bring advancement in therapeutics and improve lives. With the growing importance of stem cell therapy, this study is a fitting example of how upstream research can potentially benefit
and shape its applications
#Targeting DNA: Protein-based sensor could detect viral infection or kill cancer cells MIT biological engineers have developed a modular system of proteins that can detect a particular DNA sequence in a cell
#Virus re-engineered to deliver therapies to cells Stanford researchers have ripped the guts out of a virus
and therapies directly where they are needed. The study reported today in the Proceedings of the National Academy of Sciences breathes new life into the field of targeted delivery,
"We make it smart by adding molecular tags that act like addresses to send the therapeutic payload where we want it to go."
they could break down into additional therapeutic agents. We can now design two things into one."
Insights could lead to targeted therapies The research team performed a proof of principle experiment to demonstrate how valuable information about metastatic gene expression could be for drug development.
but more information about the microbiome is needed to effectively design such therapies.""The paper's lead author is Hiroki Ando, an MIT research scientist.
The newly described Cpf1 system differs in several important ways from the previously described Cas9, with significant implications for research and therapeutics,
These groups plan to offer licenses that best support rapid and safe development for appropriate and important therapeutic uses."
"Our goal is to develop tools that can accelerate research and eventually lead to new therapeutic applications.
since the results may change the standard of care in patients with advanced kidney cancer who have received prior standard therapy that targets the vascular endothelial growth factor receptor (VEGFR)."
"Although treatment with VEGFR-targeted drugs has been very effective in the first line of therapy for patients with advanced kidney cancer,
Regaining tumour control after prior targeted therapy may reduce symptoms related to kidney cancer and eventually help patients live longer."
"An early evaluation of overall survival from the ongoing METEOR trial has shown a strong trend indicating that survival may be improved in patients receiving cabozantinib compared to standard therapy.
Their disease had to have progressed within six months of receiving prior treatment with VEGFR tyrosine kinase inhibitor (TKI) therapy.
or resistance to standard therapies is critical for improving long-term outcome for our patients with advanced kidney cancer.
Combinations with other emerging therapies, such as agents boosting the immune system, are of interest and an early stage clinical trial combining cabozantinib with immune checkpoint inhibitors has been initiated in urological cancers,
In the USA, the Food and Drug Administration (FDA) has designated it as a breakthrough therapy,
"Cone transplant represents a therapeutic solution for retinal pathologies caused by the degeneration of photoreceptor cells,
But in order to undertake a complete therapy, we need neuronal tissue that links all RPE cells to the cones.
offering the possibility of directly testing potential avenues for therapy on the patient's own tissues s
and with the group Bacterial Infections and Antimicrobial Therapies led by Dr Eduard Torrents, of the Institute for Bioengineering of Catalonia (IBEC) I
"Therapeutic Applications of Ultrasound")have developed just a noninvasive brain imaging method using MRI that provides the same information as physical palpation.
With a poor prognosis and limited options for targeted therapies, fighting SS needs new treatment approaches.
These results highlight the genetic vulnerabilities that we can use in designing precision medicine therapies."
From this, they will also be able to identify distinct subsets of the disease to stratify patients for precision therapy based on their unique mutations and the inhibitors available for those mutations s
our research could help us design novel therapeutic agents for the treatment of AML, "Dr Mace said."
thereby prolonging its therapeutic effect.""The chemical marriage between URMC-099 and antiretroviral drug nanoformulations could increase drug longevity,
"The two therapies were tested together in laboratory experiments using human immune cells and in mice that were engineered to have a human immune system.
as any patient prescribed URMC-099 would also be taking antiretroviral therapy. The goal was to determine
"Our ultimate hope is that we're able to create a therapy that could be given much less frequently than the daily therapy that is required today,
This ideal therapy has remained in the realm of science fiction until now.''The team stresses that there are significant hurdles before this could offer new treatments--a key issue is being able to alter the heart to be light-sensitised
will pave the way for the development of restorative therapies for thousands of patients. Dr Davinia Fernández-Espejo
""However, before we take the crucial step of developing targeted therapies to help these patients,
Dr Fernández-Espejo added,"The ultimate aim is to use this information in targeted therapies that can drastically improve the quality of life of patients.
"Though it may be a number of years before an effective therapy is developed, the team believe that a significant milestone has been reached with the discovery e
and design of therapies to treat them. But finding a specific biomarker in a massive amount of genetic code is hard.
a therapeutic protein in testing for treating Parkinson's disease, to the brains of mice. They showed through behavioral
because the therapy has been shown to delay and even reverse disease progression of Parkinson's disease in preclinical models.
where there remains a specific unmet need for blood-brain penetrating therapeutic delivery strategies.""We see this expanding beyond Parkinson's disease,
as there are multiple diseases of the brain that do not have good therapeutic options, "Dr. Bleier said."
"it will be several years before a potential glioblastoma therapy can be tested in humans. SKOG102 must first undergo detailed pharmacodynamic,
Such sensors could also be used to monitor the effectiveness of stem cell therapies Jasanoff says."
"As stem cell therapies are developed, it's going to be necessary to have noninvasive tools that enable you to measure them,
From the researchers'point of view, this goes some way into explaining why some people are resistant to some forms of cancer therapy.
Arrayso, does the absence of the VRAC protein promote therapy resistances?""The data suggest that LRRC8A
Heparin is used widely as an anticoagulant in cardiovascular surgery as well as in postoperative and long-term therapy.
it may be worth developing therapies based on it even if it is not fully understoods long as it can be proved to be safe and effective t
While medical therapy is usually the first line of treatment, a new minimally invasive implant can dramatically reduce symptoms for men. his is a safe procedure for men with BPH to improve urination
the researchers were able to durably wipe out cancer cells in mice implanted with cells from the drug-resistant tumor. ven in cancers that are responding to targeted therapy by conventional criteria,
n this work we have begun to crack open the question of why residual disease persists after targeted therapy.
suggesting that combining a compound like PBS-1086 with erlotinib at the outset of therapy may help to prevent acquired drug resistance in EGFR-mutant NSCLC.
Combined drug regimens designed to overcome drug resistance at the outset of therapy are now the norm in treating certain forms of melanoma,
and that a substantial number of patients, this could be a very powerful companion therapy to minimize
new therapies may be ahead Duke researchers have developed a new method to precisely control when genes are turned on and active.
and how it relates to disease or response to drug therapies. Gersbach added, ot only can you start to answer those questions,
Known as deep brain stimulation, it is a therapeutic procedure that is already used in some parts of the world to treat various neurological conditions such as tremors or Dystonia,
#In first human study, new antibody therapy shows promise in suppressing HIV infection In the first results to emerge from HIV patient trials of a new generation of so-called broadly neutralizing antibodies,
Rockefeller University researchers have found the experimental therapy can dramatically reduce the amount of virus present in a patient blood.
researchers are able to harness them as therapeutic agents against HIV infections that have had less time to prepare.
an antibody therapy for HIV might require treatment just once every few months, compared to daily regimens of antiretroviral drugs that are now the front-line treatment for HIV. n contrast to conventional antiretroviral therapy,
antibody-mediated therapy can also engage the patient immune cells, which can help to better neutralize the virus,
says co-first author Florian Klein, also assistant professor of clinical investigation in the Nussenzweig laboratory.
#New Way to Fight Cancer Targeted cancer therapies work by blocking a single oncogenic pathway to halt tumor growth.
they are often able to evade these therapies and regrow. Moreover, tumors contain a small portion of cancer stem cells that are believed to be responsible for tumor initiation, metastasis and drug resistance.
a treatment for APL that is considered to be the first example of modern targeted cancer therapy,
HMS professor of medicine and director of translational therapeutics in the Cancer Research Institute at Beth Israel Deaconess. in1 is a common key regulator in many types of cancer
In this new work, co-senior author Xiao Zhen Zhou, HMS assistant professor of medicine and an investigator in the Division of Translational Therapeutics at Beth Israel Deaconess, decided to take a different
and are part of the body first-line of defensehe so-called nnateimmune systemt first work in concert with the therapy
and first author Lee B. Rivera, Phd, a UCSF postdoctoral scholar in the Bergers laboratory, also identified a potential way to stop myeloid cells from sabotaging the therapy
During anti-angiogenic therapy, said Bergers, the Neill H. and Linda S. Brownstein Endowed Chair in Brain tumor Research and a member of the UCSF Helen Diller Family Comprehensive Cancer Center,
But we have learned that we can also manipulate this process to make therapy more effective.
The researchers found that during the initial phase of therapy, VEGF inhibition stimulates myeloid cells within the tumor to release the signaling protein CXCL14,
During this phase, myeloid cells complement the therapy to prevent the creation of new blood vessels,
therapy becomes ineffective, and you have said relapse, she. In breast cancer, Bergers noted, anti-VEGF therapy is not very effective to begin with. his tells us why,
she said. n a laboratory model of breast cancer, about 45 percent of myeloid cells are activated already,
so the cancer just ignores the therapy. The researchers found that targeting specific innate immune cells within the tumor did not reverse the negative effects of PI3K activation.
This so-called myeloid-cell oscillation maintained the tumor resistance to the therapy. Instead, said Bergers,
Ultimately, the researchers demonstrated that combining a PI3K inhibitor with anti-VEGF therapy prevented relapse
Bergers noted that the discovery potentially gives physicians a way to determine how effective anti-VEGF therapy might be in individual patients
as well as to monitor the course of therapy. n some new patients, we could test to determine how many myeloid cells in the tumor were activated already,
which could tell us to what extent the tumor would still be responsive to anti-VEGF therapy,
In patients undergoing therapy, e could take advantage of the fact that myeloid cells occur not only in the tumor,
Right now, one of the major issues in anti-VEGF therapy is that there are no biomarkers for response and relapse. t
Future work may investigate how modifying the Wnt signal can be used to manipulate synaptic plasticity, with possible therapeutic applications for neurodegenerative or mental diseases n
have developed a biocompatible micropump that makes it possible to deliver therapeutic substances directly to the relevant areas of the brain.
we can be more precise in defining the therapy moving forward. Eye on immune therapies and prevention In his lab, professor of immunology Dr. Kevan Herold has used the technology to explore key questions about type 1 diabetes, an autoimmune condition.
Cytof is helping his team get more data about a limited repertoire of cells specific to type 1 diabetes
are involved there pathways that we can target for therapies? Those are the types of questions wee interested in.
The goal is not only to develop immune therapy to treat type 1 diabetes but potentially to use the data for prevention. here are antigen-reactive T cells that are found in individuals at risk for type 1 diabetes,
and the immune therapies that emerge. e tend to think of our analyses of cells as unidimensional or bi-dimensional.
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