#Engineering Therapeutic Proteins into Antibodies Scientists at the Scripps Research Institute (TSRI) have devised an improved method for building proteins into larger proteins such as antibodies.
otherwise, including powerful hormone-based therapies.""Unlike prior approaches to this design problem, ours is based a selection method,
First identified by Dr. Friedman in 1994 as a satiety hormone that switches off hunger, leptin initially failed as an obesity therapy,
Leptin on its own and in an unmodified state isn't ideal as a therapy because it doesn't last long in the bloodstream."
and function properly, the researchers used a selection system that they had developed previously for finding therapeutic antibodies in large antibody libraries.
such as the preparation of foods, dietary supplements, therapeutics, and chemical materials. The ability to precisely tune enzymatic reactions with small biomolecules holds enormous potential for industrial manufacturing, analytical science,
and drug therapeutics. Now, researchers at the University of Chicago have developed what they believe is a novel approach to control the activity of enzymes through the use of synthetic,
offering the possibility of directly testing potential avenues for therapy on the patient's own tissues. ur work, the Development article concluded, rovides a unique platform to produce human cones for developmental, biochemical,
and therapeutic studies
#Malaria Protein as a Cancer drug Delivery Tool The devastating global effects of malaria have been documented widely,
"This could open the door to as yet unknown new therapies and preventions.""Knothe Tate has used already the system to demonstrate a link in osteoarthritic guinea pigs between disease status and molecular transport through blood, muscle, and bone.
they then went on to develop a therapeutic patch made from collagen that incorporated this compound.
Not everyone with ovarian cancer would benefit from this particular combination of therapies. The good news is these two types of cells are present in about 50%of ovarian cancer patients who would be candidates for this dual treatment.
"When we make the leap into therapies for humans, I think we have shot a better with noninvasive sonogenetics approaches than with optogenetics."
using gene therapy and a therapeutic virus, it may be possible to make target human neurons temporarily susceptible to the ultrasound signal in a clinical setting for certain neurological treatments."
and other diseases could benefit. his breakthrough opens the way for therapeutic avenues that have been awaited eagerly by clinicians for many years,
which will use a combined therapy of romidepsin with a HIV vaccine to kill the infected cells. ombination studies are of highest interest now.
This produced a therapeutic response in mouse models of sepsis, in human lung cells and an ex vivo human lung model.
but the novel therapeutics like this present additional manufacturing challenges and might encounter an extended regulatory approval process,
where they can then release the therapeutics they need, straight into the nervous system. Doctors have been trying to get through the barrier
there is no proven drug therapy for treating losses in episodic memory, which has led scientists to find ways of training the brain through computer-based games. e need a way of treating the cognitive symptoms of schizophrenia, such as problems with episodic memory,
used in conjunction with medication and current psychological therapies, this could help people with schizophrenia minimise the impact of their illness on everyday life. i
Rodelis Therapeutics acquired the rights to TB drug cycloserine in August, and subsequently raised the price from $500 for 30 capsules to $10,
If the drug in question is the backbone of a specific therapy, laboratories need increased access to confirm efficacy
It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.
and serving as models to develop therapeutic agents to treat these diseases, says Joseph Bonventre,
and therapies that might work in humans. Genetically matched kidney organoids without disease-linked mutations showed no signs of either disease,
explained Freedman. ur findings suggest that gene correction using CRISPR may be a promising therapeutic strategy.
Pollock became the first subject in a UCLA experiment that set out to meld electrical stimulation therapy with a robotic exoskeleton that effectively walks for paralyzed patients.
it can help us to design therapeutics, and learn how effective our exercise or physical therapy programs are. o
Others are developing stem-cell therapies, such as those from Stempeutics, Novadip or Bonus Biogroup. In this method
Therapy using implanted organic bioelectronicsource: Linköping University i
#First 3d printed Drug Approved by FDA Youl rarely see medication news on the pages of Medgadget,
The specific FDA approval is for SPRITAM (levetiracetam) that used as a therapy for epileptics to help control partial onset seizures, myoclonic seizures,
#Implantable Electrical Stimulation Therapy for Treating Scoliosis Some scientists believe that in many people scoliosis develops because of the unequal pressure that muscles on the sides of the spinal column tend to exert.
though there are no clinical trials that have confirmed this therapy or how to use it properly.
#White blood cell Mediated Therapy for Neurons in Patients with Parkinson Disease Scientists at the University of North carolina at Chapel hill have begun researching the delivery of neurotropic factors to the brain as a potential therapeutic for Parkinson disease.
However, one potential therapy is the development of smarter immune cells that deliver neurotropic factors to neurons damaged by the disease.
Delivering the protective proteins through immune cells is a breakthrough in GDFP therapy. This new macrophage mediated protein delivery system could potentially provide a therapy for patients who are afflicted by this debilitating disease e
#New Self-Positioning Transcatheter Mitral valve Developed by National University of Singapore Transcatheter heart valve replacements have become life savers for many frail patients who are unsuitable for open heart surgery.
Such sensors could also be used to monitor the effectiveness of stem cell therapies, Jasanoff says. s stem cell therapies are developed,
it going to be necessary to have noninvasive tools that enable you to measure them, he says.
#Gold-diamond nanodevice for hyperlocalised cancer therapy: Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells,
which can potentially be applied to thermal cancer therapy. Pei-Chang Tsai from the Institute of Atomic and Molecular Sciences, at the Academia Sinica, Taipei,
therefore act as switchable nanoheaters for therapies based on delivering intense and precise heat to cancerous cells,
#Advance in photodynamic therapy offers new approach to ovarian cancer The findings were published just in the journal Nanomedicine:
and the University of Nebraska takes existing approaches to photodynamic therapy and makes them significantly more effective by adding compounds that make cancer cells vulnerable to reactive oxygen species,
"Photodynamic therapy is a different approach that can be used as an adjunct to surgery right during the operation,
and genetic therapy, composed of"small, interfering RNA,"are attached to what researchers call"dendrimer-based nanoplatforms,
Compared to existing photodynamic therapies, this approach allows the near-infrared light to penetrate much deeper into abdominal tissues,
Using photodynamic therapy alone, some tumors in laboratory animals began to regrow after two weeks. But with the addition of the combinatorial genetic therapy to weaken the cancer cell defenses,
there was no evidence of cancer recurrence. During the procedures, mice receiving the gene therapy also continued to grow
We believe a key to the success of this therapy is that it takes away those defensive mechanisms."
is associated with invasion, metastasis, resistance to cancer therapies, and overall cancer cell survival. That excess of DJ1 is silenced by the genetic therapy composed of sirna.
The findings of this research, Taratula said, could also build upon some other recent advances in photodynamic therapy, in
which a different compound called naphthalocyanine could be administered prior to surgery, causing the cancer cells to"glow
"Our study established a prospective therapeutic approach against ovarian cancer, "the researchers wrote in their conclusion."
"The tumors exposed to a single dose of a combinatorial therapy were eradicated completely from the mice
"While this proof of principle study demonstrates specific delivery of therapeutic agents to treat cardiovascular disease and bacterial infections,
it also has broad implications for targeted therapy for other diseases such as cancer and neurological disorders,"said Chien.
"Our platelet-mimicking nanoparticles can increase the therapeutic efficacy of antibiotics because they can focus treatment on the bacteria locally without spreading drugs to healthy tissues
or water and therapeutic drug monitoring at home, a feature which could drastically improve the efficient of various class of drugs and treatments a
and help design new drug therapies against pathogens by targeting enzymes that interact with DNA."
or find protein properties that would be ideal targets for drug therapies.""For example, viral genes code for their own proteins that process their DNA,
meaning the atom-by-atom modifications that researchers need to optimize these molecules into therapeutic compounds
and Sergei Gryaznov of Aurasense Therapeutics is the first to show spherical nucleic acids (SNAS) can be used as potent drugs to effectively train the immune system to fight disease,
The study also shows that a spherical structure is the ideal architecture for delivering nucleic acids into cells for therapeutic purposes.
or if you want to modulate the immune system using nucleic acids, for vaccines or systemic suppression therapies,
#Novel nanoparticle therapy promotes wound healing (w/video)( Nanowerk News) An experimental therapy developed by researchers at Albert Einstein College of Medicine of Yeshiva University cut in half the time it takes to heal
Details of the therapy, which was tested successfully in mice, were published online in the Journal of Investigative Dermatology("Fidgetin-like 2:
"e envision that our nanoparticle therapy could be used to speed the healing of all sorts of wounds,
Dr. Sharp and project co-leader Joshua Nosanchuk, M d.,professor of medicine at Einstein and attending physician, infectious diseases at Montefiore Medical center, developed a wound-healing therapy that uses
Dr. Sharp plans to start testing the therapy on pigs, whose skin closely resembles that of humans, within months a
#Nanoparticles provide novel way to apply drugs to dental plaque Therapeutic agents intended to reduce dental plaque
and describes how the research team used nanotechnology to watch tumor stem cells respond to therapy. ee never been able to directly observe the actions of potential cancer treatments this way before,
Sheng said. heye aggressive and resistant to therapeutics. With our imaging techniques, we may be able to gain new insights into how the cells dynamically respond to treatments.
while developing new imaging tools at the single-cell level to visualize the course of therapies needed to eradicate these cells,
we should be able to improve our chances of developing effective treatments by being able to directly observe the effects of the possible therapeutics. e
while counteracting these effects, with a protein-bound version of the drug called Abraxane currently the leading therapy.
it could be a game-changer for cancer therapy.""In future work, Chilkoti and coworkers will begin applying the packaging system to other cancer drugs with the goal of developing a"one size fits all"technology to improve the effectiveness of many other cancer drugs s
#Engineering a permanent solution to genetic diseases (Nanowerk News) In his mind, Basil Hubbard can already picture a new world of therapeutic treatments for millions of patients just over the horizon.
There is a trend in the scientific community to develop therapeutics in a more rational fashion,
Taking this incremental approachdding to the structure one step at a time, this group is making great strides on the path to creating therapeutic quantities of platelets on demand. t
they could break down into additional therapeutic agents. We can now design two things into one."
This would represent a quantum leap in antiviral therapy, says Fussenegger, who was involved not in the study.
or water and therapeutic drug monitoring at home, a feature which could drastically improve the efficient of various class of drugs and treatments a
The only current therapy that treats their causes is allergen-specific immunotherapy or allergy shots
In order to develop a safer, more direct, cause-based therapy, researchers have developed nanoparticles that envelop an allergen
and help design new drug therapies against pathogens by targeting enzymes that interact with DNA"There are other single-molecule tools around,
or find protein properties that would be ideal targets for drug therapies.""For example, viral genes code for their own proteins that process their DNA,
and potentially use this knowledge to subsequently modulate its activity, especially for therapeutic or biotechnological purposes.
thereby prolonging its therapeutic effect.""The chemical marriage between URMC-099 and antiretroviral drug nanoformulations could increase drug longevity,
"The two therapies were tested together in laboratory experiments using human immune cells and in mice that were engineered to have a human immune system.
as any patient prescribed URMC-099 would also be taking antiretroviral therapy. The goal was to determine
Much to Gelbard and Gendelman surprise, URMC-099 increased the effectiveness of the nanoformulated drug. ur ultimate hope is that wee able to create a therapy that could be given much less frequently than the daily therapy that is required today,
There also may be implications for future delivery of nanoscale therapeutics. Although it may be a long march from diagnosing cancer to curing it,
Pharmaceutical companies spend millions of dollars testing therapeutic drugs on animals only to discover in human trials that the drug has an altogether different level of effectiveness.
to be a therapeutic target in human patient groups. m
#Brain Friendly Interface Could Change the Way People with Spinal cord Injuries Lead Their Lives Recent research published in the journal Microsystems
& Technology (TVST), open up new areas of research in the pursuit of neuroprotective therapies. Glaucoma is a neurodegenerative disease where patients lose seemingly random patches of vision in each eye.
Glaucomatous eyes at all stages of the disease appear to provide a highly accessible paired-organ study model for developing therapeutics to optimize conservation of function in neurodegenerative disorders. efined Frequency Doubling Perimetry Analysis Reaffirms Central nervous system Control of Chronic
his is a great example of a therapeutic approach that combines two very different modalities neuromodulation
much like multi-drug therapy, may ultimately benefit patients with impaired mobility in a wide variety of rehabilitation settings.
DARPA portfolio of neurotechnology programs includes the Restoring Active Memory (RAM) and Systems-Based Neurotechnology for Emerging Therapies (SUBNETS) programs,
No effective therapy for Alzheimer exists. And scientists have yet to completely identify the cause,
#Researchers Identify Protein That Opens the Door to Cell Death Findings could aid development of novel therapeutics for conditions ranging from heart failure and stroke to cancer and neurodegeneration.
Dr. Madesh also explained that the new findings could aid the development of novel therapeutics for conditions ranging from heart failure and stroke to cancer and neurodegeneration all of
possibly paving the way for new therapies that can either hone the pathway cancer-killing role or reduce its role in inflammation
they have found both a possible reliable biomarker for diagnosing certain forms of autism and a potential therapeutic target.
Scientists would like to be able to study their formation both for therapeutic reasons and so that they can test the effect of new drugs on inhibiting their growth.
San francisco. his opens up the possibility for new types of therapies that target blood coagulation factors, upstream of autoimmune processes.
The researchers are now attempting to block fibrinogen using biological and small-molecule approaches as potential new therapies to suppress autoimmunity directed against the brain,
a therapeutic protein in testing for treating Parkinson disease, to the brains of mice. They showed through behavioral
because the therapy has been shown to delay and even reverse disease progression of Parkinson disease in preclinical models.
where there remains a specific unmet need for blood-brain penetrating therapeutic delivery strategies. e see this expanding beyond Parkinson disease,
as there are multiple diseases of the brain that do not have good therapeutic options, Dr. Bleier said. t is a platform that opens doors for new discovery
#iphone leak reveals new parts The video at Unbox Therapy shows what is claimed to be leaked parts of the Apple iphone 6s,
although it said it was xtremely rarethe Unbox Therapy video out today shows the backplate for the iphone 6s,
They probably wouldn trap enough cells to work as an anticancer therapy says Shea, but the implant could boost people chances of survival by identifying early on that cancer cells are on the move allowing the patient to begin chemotherapy right away.
Simple stem cell therapies are finally making their way towards the clinic, and a treatment for wounds caused by Crohn disease could be the first off-the-shelf therapy to get European union approval.
Hard-to-treat wounds near the anus afflict around 50,000 people in Europe every year. In a phase III trial, a treatment developed by Tigenix in Belgium improved the chances of healing such wounds by 50 per cent and apparently with no adverse side effects.
The therapy uses stem cells derived from donated liposuction tissue which have extremely low levels of the proteins that trigger immune reactions,
the neurons responsible for a headache no longer surged with activity. hese receptors could genuinely represent a new therapeutic target for migraine,
In need of relief New therapies are needed desperately. Triptans don work for half the people who try them,
#World first trial of stem cell therapy in the womb Their bones are so brittle that they fracture while in the womb.
Now a clinical trial of stem cell therapy in the womb aims to help babies born with brittle bone disease start life with stronger skeletons. o our knowledge,
or can predict the response to a therapy. The Fraunhofer FIT will make the first public demonstration of the system alongside its ZETA imaging software that is used in drug research at the forthcoming BIOTECHNICA expo in Hanover, Germany, between October 6 8, 2015.
and as we learn more about how to stimulate the brain ever more precisely to achieve the most therapeutic effects,
thereby prolonging its therapeutic effect.""The chemical marriage between URMC-099 and antiretroviral drug nanoformulations could increase drug longevity,
"The two therapies were tested together in laboratory experiments using human immune cells and in mice that were engineered to have a human immune system.
as any patient prescribed URMC-099 would also be taking antiretroviral therapy. The goal was to determine
"Our ultimate hope is that we're able to create a therapy that could be given much less frequently than the daily therapy that is required today,
It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.
was approved for oral use as a prescription adjunctive therapy in the treatment of epilepsy, the company said on Monday.
The findings also open the possibility of new therapies aimed at measuring and preventing dangerous imbalances in cells.
ultimately, use a precision medicine-based approach to develop a therapeutic approach. Our study demonstrates that genetic screening alone is not enough."
#Normalization Of Testosterone Level After Testosterone Replacement Therapy Patients with low testosterone levels who have gone then on to have testosterone replacement therapy (TRT) could be at lower risk of cardiovascular events such as heart attack or stroke,
but offers hope in finding new therapies.""""Understanding the mechanisms used by cancer cells to adapt to their environment creates new possibilities to treat this deadly disease,
Chinese scientist Youyou Tu was awarded jointly the Nobel prize in Physiology or Medicine for her discovery of a new malaria therapy.
any of these factors could be therapeutic targets to extend healthspan. What we have to do now is figure out which ones are amenable to targeting.
which suggests that it could work as a targeted cancer therapy. And for some reason, the NK cells also didn't seem to attack all cancer types-only their former brethren.
But they're pretty keen to get the therapy into clinical trials soon.""We're in discussions with pharmaceutical companies to take this straight into humans after the appropriate preclinical toxicity studies,
#Possible progress against Parkinson's and good news for stem cell therapies Parkinson's, which affect as many 10 million people in the world,
and how it relates to disease or response to drug therapies.""Gersbach added, "Not only can you start to answer those questions,
and a viable, more cost-effective alternative to current radiotherapy and photodynamic therapy (PDT) treatments.
when using LTP treatment is different from other therapies. The active agents in the LTP break up DNA
This is different to some current therapies which cause apoptosis, where cells are prompted to die through natural mechanisms that can result in treatment resistance.
In the case of early stage organ confined tumours, patients may be treated with a focal therapy, for example cryotherapy, photodynamic therapy,
we have presented the first experimental evidence promoting the potential of LTP as a future focal cancer therapy treatment for patients with early stage prostate cancer.
and developed as a whole new class of cancer therapy, especially for cancer stem cells, "he said."
not a well-defined pocket seen in other druggable proteins targeted by many current cancer therapies."
and drug discovery--aiming to translate discovery in the lab into clinical therapy, to help cancer patients and their families,
"We hope to find a better therapy--and eventually a cure--for cancer
#Study revises theory of how PTEN, a critical tumor suppressor, shuts off growth signals Today,
Learning the specific genetic cause of symptoms is a key step in finding new therapeutic drugs that could treat the patient's disease.
which can be essential to choosing the most appropriate therapy, supports the need for molecular profiling strategies that are more accessible to providers, clinical investigators and patients;
The replacement of these cells through bone marrow transplantation is the only widely established therapy involving stem cells in human patients.
But scientists have developed therapeutic antiviral agents for HIV Hepatitis C, and influenza using a strategy called lethal mutagenesis.
"KP1212 is about 20 percent of the way toward being an ideal therapeutic mutagen. The hints given us by the spectroscopy guide us toward even better mutagenic molecules,
But together their research teams were able to fruitfully undertake one of the first 2d infrared spectroscopic studies of the therapeutic mechanism of an antiviral drug."
have developed a biocompatible micropump that makes it possible to deliver therapeutic substances directly to the relevant areas of the brain.
"Currently, there are no disease modifying therapies and much attention has been focused upon prevention and early diagnosis,"said Ole A. Andreassen, MD, Phd,
and cancer, opening the door to new therapies. Experiments in mice and human cells have shown that the protein promotes the proliferation of cytotoxic T cells,
we hope we can provide a robust treatment for patients. ext we will test the therapy in mice,
and see if it can be combined with other therapies. If all goes well, we hope to be ready to carry out human trials in about three years.
This discovery has immediate consequences for the delivery of innovative therapeutic approaches to cancer. Its ramifications,
"Preclinical studies suggested that this combination therapy would have better outcomes than those elicited by their individual
and Immunotherapeutics Service at MSK, found that the same concurrent combination of therapies generated notably positive responses in previously treated patients."
"It was apparent following that trial that the combination should be tested as a first line therapy for metastatic melanoma,
The Phase 2, double-blind trial enrolled 142 patients with advanced melanoma who had received not prior therapy.
while melanoma patients with the mutant BRAF gene can be treated with a targeted therapy, the majority
Patients with BRAF mutations had similar outcomes for each of the therapies. The combination therapy also induced effects that continued well after the last administration of the therapy.
Of those patients who died, 25 in the combination group (27%)and 17 in the monotherapy group (37%)died from progressive disease.
Notably, three of the deaths in the combination group were determined to have been combined related to the therapy."
"In general, and as might be expected, side effects were more prevalent in patients who received the combination therapy,
But we also look forward to following up with the patients who benefitted from the combination therapy to assess the durability of the responses we have observed
"said Paul Tesar, Phd, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics,
Current multiple sclerosis therapies aim to slow further myelin destruction by the immune system, but the Case Western Reserve team used a new approach to create new myelin within the nervous system.
Their work offers great promise of developing therapies that reverse disabilities caused by multiple sclerosis or similar neurological disorders."
Neither had been considered previously as a therapeutic for multiple sclerosis, but testing revealed each had an ability to stimulate OPCS to form new myelinating cells.
"The approach from Case Western Reserve University combines cutting-edge stem cell and drug screening technologies to develop new chemical therapeutics for myelin disorders,
It is the first time that a gene therapy based on genetically modified stem cells is tested in a multicenter, international clinical trial that shows a reproducible and robust therapeutic effect in different centers and different countries.
to produce these advanced therapy products, to work with international teams and to manage the regulatory aspects of the trials in France and abroad.
"The results obtained in this multicenter clinical trial constitute an important therapeutic advance (overhang) because they concern a complex pathology
which existing therapies are either unsatisfactory or unavailable
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