Synopsis: Health: Medical procedure: Therapeutics:

and additional assets for targeting Myo/Nog cells for therapeutic purposes from LIMR Development Inc. LDI),

This targeted 3dna immunodepletion strategy may be useful as an adjuvant therapy to reduce tumor expansion and recurrence."

thus having the capacity of becoming a standard method of quality control of stem or pluripotent cells before their use in cell therapy or research in biomedicine.

as well as antiviral therapy to combat already-existing infections, particularly challenging",says Dr. Grant Hansman, a virologist who leads the CHS Research Group on Noroviruses at the German Cancer Research center (Deutsches Krebsforschungszentrum, DKFZ) and Heidelberg University.

this could be a very promising lead in developing norovirus antiviral therapy. This could be especially beneficial to immunosuppressed individuals such as cancer patients.

while counteracting these effects, with a protein-bound version of the drug called Abraxane currently the leading therapy.

it could be a game-changer for cancer therapy.""In future work, Chilkoti and coworkers will begin applying the packaging system to other cancer drugs with the goal of developing a"one size fits all"technology to improve the effectiveness of many other cancer drugs s

Revolutionary cell-based therapies, which exploit modified human cells to treat diseases such as cancer, have advanced greatly over recent years.

However, targeted application of cell-based therapy in specific tissues, such as those lying deep in the body where injection is not possible,

showed an 800 per cent increase in the effects of the therapy. Dr Munitta Muthana, from the University of Sheffield, said:"

"Our results suggest that it is possible to use a standard MRI SCANNER to naturally deliver cell-based therapies to both primary and secondary tumours

"This not only increases the therapeutic efficacy but also decreases the risk of unwanted side effects.""The beauty of using the MRI SCANNER to administer the therapy is that you can also use it for its original purpose providing a real-time image-guide to ensure the treatment has gone where it is needed

#Universitat Jaume I Patents Graphene-Based Catalysts for Energy conversion and Storage Researchers at the Universitat Jaume I have developed materials based on graphene that can catalyse reactions for the conversion and storage of energy.

Natural melanin nanoparticles will be used as biomarkers to diagnose and as targets for therapy. Because not all melanoma cells highly express melanin

laser and nanotechnological methods to increase diagnostic and therapeutic efficiency. The researchers also discovered that many standard medical procedures especially vigorous manipulation of the tumor,

and then eradicate the CTCS by well-timed therapy including nanobubble-based treatment. A similar approach can be used to monitor the effectiveness of the different types of treatment for cancer by counting the CTCS before, during and after therapy.

The best individualized therapy will lead to a faster and more significant decrease of CTC count,

and hence, decrease deadly metastasis development. Zharov team has demonstrated already that laser-induced nanobubbles significantly decrease the level of CTCS,

or if they should be used in conjunction with conventional cancer therapy, Zharov said. The clinical team will first test a large group of healthy volunteers to make sure the treatment does no harm. urprisingly,

and melanoma could be the first cancer with metastatic spread that could be treatable by well-timed therapy,

There are only therapies to address quality of life, such as dopamine replacement, "Batrakova said.""However, studies have shown that delivering neurotrophic factor to the brain not only promotes the survival of neurons

Successfully delivering the treatment to the brain is the key to the success of GDNF therapy,

these platelet copycats greatly increased the therapeutic effects of drugs that were administered to diseased rats and mice.

"While this proof of principle study demonstrates specific delivery of therapeutic agents to treat cardiovascular disease and bacterial infections,

it also has broad implications for targeted therapy for other diseases such as cancer and neurological disorders,"said Chien.

"Our platelet-mimicking nanoparticles can increase the therapeutic efficacy of antibiotics because they can focus treatment on the bacteria locally without spreading drugs to healthy tissues

or water and therapeutic drug monitoring at home, a feature which could drastically improve the efficient of various class of drugs and treatments a

and further, how these structures can find uses in therapeutics and bionanotechnological applications. In the review article, the researchers outline the superior properties of DNA NANOSTRUCTURES,

The new method has a wide range of potential therapeutic applications. Selective intermolecular recognition is at the heart of all biological processes.

Targeted modification of such proteins therefore plays a significant role in medical diagnostics and therapies.

One obvious and highly promising application is in the production of so-called antibody-drug conjugates (ADCS) for use in tumor therapy.

It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.

This would represent a quantum leap in antiviral therapy, says Fussenegger, who was involved not in the study.

Scientists would like to be able to study their formation both for therapeutic reasons and so that they can test the effect of new drugs on inhibiting their growth.

"But when we make the leap into therapies for humans, I think we have shot a better with noninvasive sonogenetics."

"With these new blood tests, many patients will now be proceed able to right to therapy for their condition."

are expected to accelerate the development of targeted therapies for inflammatory gastrointestinal diseases. Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, are disorders of unknown etiology that are characterized often by abdominal pain, diarrhea, bloody stool, fever,

and the medical community is awaiting new definitive therapies. Although recent studies have demonstrated that intestinal epithelial cells play a critical role in regulating bowel inflammation,

Our future research interests are centered on the development of new therapeutics for inflammatory bowel disease that take advantage of our understanding of SAP-1 and CEACAM20 functions

and killing of latently HIV-infected helper T cells when the cells were taken from patients on antiretroviral therapy

when given to monkeys infected with a simian form of HIV and receiving antiretroviral therapy.

whether this could lead to a meaningful therapy, 'said Betsy Bogard, director of global research development for the International FOP Association i

and butter of our industry today with a suitcase-sized device that will make GMP therapeutics at the point of care within a few hours. know it sounds completely nuts. ield tests

and butter of our industry today with a suitcase-sized device that will make GMP therapeutics at the point of care within a few hours. know it sounds completely nuts.

because human B-cell acute lymphoblastic leukemia cases show increased levels of DYRK1A, said Crispino. he results suggest that DYRK1A may be a novel target for therapy in this form of leukemia.

Cancer drugs or other therapeutics can then be added to better monitor how cells respond in a patient.

AIM Biotech recently discovered that its devices revealed discrepancies in some clinically tested therapeutics. In a study published in Integrative biology,

Because of its role in the cell, glucokinase has received considerable attention by pharmaceutical companies as a potential therapeutic target.

"A therapy based on these inhaled drugs may help deal with new viral and bacterial strains that are resistant to conventional vaccines

and therapies that could change the infectious disease landscape.""The investigators say they are currently testing an oral small molecule immune modulator in phase 2 clinical trials that acts like volatile anesthetics to help reduce secondary infections after someone becomes sick with the flu.

-and scientists now hope that the results will help finding for example new therapies against infertility.

and points the way to future anticancer approaches, including combination therapies of coiled-coil STAT3 inhibitors in tandem with other agents,

As a synthetic biologist, Jewett uses cell-free systems to create new therapies, chemicals and novel materials to impact public health

the ultimate targets for this kind of therapy, are much more resistant to genetic repair than to genetic disruption, Bauer added. herefore,

and bacterianfortunately prevents targeted therapies from reaching the lungs. Other attempts to penetrate the barrier with nanoparticles were unsuccessful

#Down syndrome Research Untangles Therapeutic Possibilities for Alzheimer More than five million Americans are living with Alzheimer disease (AD.

and underscores the need for additional studies, said Rafii. his study will set the stage for the first clinical trial of anti-beta amyloid therapy in the preclinical treatment of Alzheimer disease in adults with Down syndrome.

they could break down into additional therapeutic agents. We can now design two things into one.

This would represent a quantum leap in antiviral therapy, said Fussenegger, who was involved not in the study.

and others that indicate a likely response to hormone therapy treatment. Past studies have looked at how women classified as low,

Women in the middle group were assigned randomly to get hormone therapy alone or to add chemo. Results on these groups are not yet ready-the study is continuing.

The new therapy has been licensed to the Kurt+Peter Foundation, which supports Limb Girdle Muscular dystrophy 2c research

and development of this potential therapy. here are always new ways to treat a disease,

Northwestern University and The Kurt+Peter Foundation will support the development of therapies for Limb Girdle Muscular dystrophy Type 2c.

and develop the therapy. Mcnally and Frewing are looking to clear the hurdles necessary to begin clinical trials.

and resources to the table and work together to develop new therapeutics for small groups of patients,

and paves the way toward new and improved therapies for the disease. The study reveals a new mechanism for the development of fibrosis in skin tissues

and could help us develop therapeutic strategies that are more effective than existing ones. ibrosis is a condition in which tough,

until now. linical trials to test the effectiveness of potential therapies for many known fibrotic diseases have so far been disappointing.

and stiffening from occurring. anipulating the fibulin-5 levels could be a therapeutic strategy to treat skin fibrosis,

which only become radioactive immediately prior to therapy, on mice with SCC for one hour. After 15 days of monitoring tumor size, three out of 10 mice that wore the radioactive bandage had their tumors completely eliminated.

It is expected that the technology will similarly create new opportunities in other therapeutic areas as well as the industrialization of the technology will help refine

which has been granted Breakthrough Therapy Designation--2015 ASCO Annual Meeting SOUTH SAN FRANCISCO, Calif.--BUSINESS WIRE)--Genentech,

Alectinib was granted Breakthrough Therapy Designation by the U s. Food and Drug Administration (FDA) in June 2013 for people with ALK-positive NSCLC

Breakthrough Therapy Designation is designed to expedite the development and review of medicines intended to treat serious diseases

director of the National Institute of Biomedical Imaging and Bioengineering. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;

#Real-time Data For Cancer Therapy, MIT Study Biochemical sensor implanted at initial biopsy could allow doctors to better monitor

however, is good reconnaissance a reliable way to obtain real-time data about how well a particular therapy is working for any given patient.

and adjust dosages or switch therapies accordingly. Making cancer treatments more targeted and precise would boost their efficacy

In fact, some therapies will trigger an immune system reaction, and the inflammation will make the tumor appear to be growing,

even while the therapy is effective. Oxygen levels, meanwhile, can help doctors gauge the proper dose of a therapy such as radiation,

since tumors thrive in low-oxygen (hypoxic) conditions. t turns out that the more hypoxic the tumor is,

which future natural therapies can be developed. More than 1. 2 million people in the United states have HIV.

While there are antiretroviral therapies available, they can only prolong life, albeit dramatically, but they cannot cure the disease.

but the issue is that it hard to push these therapies against severe blood flow,

Gut Lining In Dogs-Findings can lead to gut replacement therapy in people with intestinal deficiencies.

bring researchers closer to creating an implantable intestine as replacement therapy for a range of devastating disorders-including infections, cancer and trauma-that result in loss or death of gut tissue.

Hackam says, a finding that highlights the therapeutic potential of certain probiotics for NEC. Next,

This ideal therapy has remained in the realm of science fiction until now.''The team stresses that there are significant hurdles before this could offer new treatments-a key issue is being able to alter the heart to be light-sensitised

Griffith University Study Griffith University researchers have opened a new avenue to advance a therapy to repair the paralysed spinal cord.

"In light of the overwhelming impact of spinal cord injury, new therapeutic interventions for drug discovery and cell therapy are needed urgently."

thus demonstrating this therapy can work, "says Mr Vadivelu.""What is needed now is to make the transplantation therapy more effective and suitable for patients with a range of different spinal cord injuries."

"The new method enables transplanted cells to survive and better integrate into the injury site.

"Burnes probably didn't think they could be used to help develop a therapy for spinal cord repair,

Clonally derived organoids could be used to ID patient-specific sensitivities to novel therapeutics. The development of a new method to grow three-dimensional organoid cultures of pancreatic tumors directly from patients'surgical tissue offers a promising opportunity for testing targeted therapies

and drug responses and personalizing treatments in a rapid, cost-effective manner. The findings are reported currently in the Advance Online issue of the journal Nature Medicine."

The research team also demonstrated that these clonally derived organoids could be used to identify patient-specific sensitivities to novel therapeutic agents."

and validation of new drugs and targets and modeling resistance to therapy,"says Muthuswamy.""By using a cohort of patient samples from

and for drug screening to identify precision therapy strategies

#New lab-on-chip device promises faster TB diagnosis Singapore: US researchers have developed a new low-cost lab-on-a-chip device to aid analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.

Ga.-based company that develops therapies for eye diseases. Game meant to be said engaging Ferland the game involves controlling moles on the tablet screen.

and Drug Administration in the United states to market this therapy. The company says it will look to receive approval from Health Canada once Dig Rush has been approved by the FDA g

used in conjunction with medication and current psychological therapies, this could help people with schizophrenia minimise the impact of their illness on everyday life.'

This is done using Bright light Therapy which artificially triggers the light sensors in a person's eyes to make their brain believe the sun is coming up.

The therapy can be used to rouse people gently so that they feel more refreshed and less tired

and with light therapy it can manage the production of sleep hormone in the brain.'

and develop therapeutics other than rodents.''To build the replica brain, the team transformed adult skin cells into induced pluripotent stem (ips) cells by altering their genes.'

they also hope to use the model to study stroke therapies. Military applications include research on Gulf war syndrome, traumatic brain injury,

It's often used to treat nausea associated with HIV or cancer therapies but this new process could offer a less expensive,

It's often used to treat nausea associated with HIV or cancer therapies, but this new process could offer a less expensive,

which seem to predict who can stop therapy and stay well.''Interestingly, some of these markers have also been shown to be good targets for therapy in some cancers.'

'We hope now to find out more about these markers -and others-to discover if new strategies for treating

'Working with researchers at the University of New south wales, the team at Oxford analysed data from a patient trial where anti-retroviral therapy was interrupted at 48 weeks.

Anti-retroviral therapy has improved dramatically life-expectancy for people with HIV. Recent studies have advised patients should start the treatment

and the therapy is delayed until a patient's viral load reaches a certain level. But the drug treatment is not a cure.

after stopping the therapy. Dr Frater and his team analysed the data from a study of patients with primary HIV infection involved in the SPARTAC trial.

The researchers found that in patients where high levels of these three biomarkers attached to'exhausted'T-cells prior to patients beginning anti-retroviral therapy,

'Focusing on the exhaustion markers was an important step as it has given us vital clues as to why some people are able to better control the virus after therapy has been interrupted.'

'We want to be able to predict how the virus will behave before we take patients of anti-retroviral therapy to test drug therapies aimed at eradicating HIV,

This ideal therapy has remained in the realm of science fiction until now.''The team stresses that there are significant hurdles before this could offer new treatments-a key issue is being able to alter the heart to be light-sensitised

could someday lead to new therapies for autoimmune diseases.""These results suggest that inhibition of the enzyme cgas may be an effective therapy for autoimmune diseases such as Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE),

which are linked to the same inflammatory pathway, "said senior author Dr. Zhijian"James"Chen, Professor of Molecular biology and a Howard Hughes Medical Institute (HHMI) investigator at UT Southwestern.

To date, no targeted therapies exist for these kids.""We need to develop therapies against Notch to help kids with relapsed cancer

and to cure kids with fewer toxicities or long-term effects, "Chiang says.""Our current treatments may often be curative,

the brushes also could someday deliver cancer therapeutics s

#Researchers want to turn acid-loving microbes into safe drug-carriers Usually the microbe S. islandicus is found in hot and acidic volcanic springs,

The survey also increases the potential opportunity to receive appropriate symptomatic therapies in a timely fashion,

The hope is to find new therapeutics against infections and other inflammatory diseases e

#Study charts'genomic biography'of form of leukemia A new study by scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard offers a glimpse of the wealth of information

which these mutations are acquired to allow the malignancy to thrive and overcome therapy.""Wu and her team collected tumor and normal tissue samples from 538 patients with CLL, 278 of

and demonstrate specific mutations affect patients'response to therapy. These discoveries will form the basis for precision medicine of CLL and other tumor types

and Center for Molecular Therapeutics have been published in the open-access journal PLOS ONE.""We wanted to see

Most of those treated with targeted-therapy drugs will relapse within a year, often because their tumors have become resistant,

This study utilized 36 well-characterized melanoma cell lines assembled by the MGH Center for Molecular Therapeutics to test all possible combinations of more than 100 oncology drugs,

had synergistic effects against cell lines that were resistant to treatment with vemurafenib alone but not those sensitive to single-agent therapy.

"This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma,

and understand how they could be targeted for therapies.""Two gene mutations in particular are known to spur the growth of human tumors:

when designing new therapeutics,"adds Yifeng Xia, a Salk staff researcher involved in the work k

but it also suggests that these physical channels might be exploitable to deliver drug therapies."

or use them to deliver lifesaving therapies

#New research opens door to understanding human tonsil cancer Researchers at Simon Fraser University and the BC Cancer Agency have developed a groundbreaking method to identify

as well as in the cells'response to targeted therapy, "says Samuels.""Most targeted cancer therapies nowadays work by inhibiting the products of oncogenes that are overactive in melanoma cells.

However, loss or mutations in tumor suppressor genes like RASA2 also contribute to melanoma development;

Promising candidate for new forms of therapy The helper proteins are true multi-talents. They can bind large numbers of badly folded proteins

"directed by Professor Joaquín Campos Rosa, and"Advanced Therapies: Differentiation, Regeneration and Cancer",directedby Professor Juan Antonio Marchal Corrales.

3-D cell growth opens new pathway for spinal cord repair Griffith University researchers have opened a new avenue to advance a therapy to repair the paralysed spinal cord.

"In light of the overwhelming impact of spinal cord injury, new therapeutic interventions for drug discovery and cell therapy are needed urgently."

thus demonstrating this therapy can work, "says Mr Vadivelu.""What is needed now is to make the transplantation therapy more effective and suitable for patients with a range of different spinal cord injuries."

"The new method enables transplanted cells to survive and better integrate into the injury site.

"Burnes probably didn't think they could be used to help develop a therapy for spinal cord repair,

#New drug candidate is promising therapeutic option for angiogenic retinal diseases A research team led by scientists at Beth Israel Deaconess Medical center (BIDMC)

a discovery that offers a promising alternative to current therapies for these retinal diseases, which require monthly injections of large molecules directly into the eyeball."

"Although a few other anti-VEGF drugs have been approved for therapy of AMD, they must be delivered directly into the eye through monthly intravitreal injections."

safe for treatment-resistant autoimmune blood conditions The immunosuppressant sirolimus is an effective and safe steroid-sparing therapy for children and young adults with highly treatment-resistant autoimmune blood conditions,

Few effective and well-tolerated therapies exist to manage these chronic autoimmune issues. While standard immunosuppressive therapy with corticosteroids may help some patients,

others are resistant, intolerant, or cannot successfully maintain healthy blood cell counts when they discontinue medication.

Based on these findings, the authors propose use of sirolimus as early therapy for patients with these chronic treatment-resistant autoimmune blood conditions

sirolimus should be considered an early therapy option for patients with autoimmune blood disorders requiring ongoing therapy

However, resistance to such therapies is a major clinical challenge. The gene identified by the team,

Their study published online ahead of print in PNAS Early Edition suggests a new therapeutic strategy for patients with Duchene muscular dystrophy

There also may be implications for future delivery of nanoscale therapeutics. Although it may be a long march from diagnosing cancer to curing it,

a known therapeutic protein for treating Parkinson's disease, to the brains of mice. They showed through behavioral

because the therapy has been shown to delay and even reverse disease progression of Parkinson's disease. Nasal mucosal grafting is a technique regularly used in the ENT field to reconstruct the barrier around the brain after surgery to the skull base.

where there remains a specific unmet need for blood-brain penetrating therapeutic delivery strategies.""We see this expanding beyond Parkinson's disease,

as there are multiple diseases of the brain that do not have good therapeutic options, "Dr. Bleier said."

Feinberg leads the Regenerative Biomaterials and Therapeutics Group, and the group's study was published in the October 23 issue of the journal Science Advances.

compared with just 8%for regularly stem cell therapies. The team did not invent a treatment for this heart disease,

This comes soon after a separate team from Harvard university announced their porous hydrogel could also achieve huge increases in the effectiveness of stem cell therapies.

and a company called VAR2 Pharmaceuticals has been spun out of this research to bring the therapy to market.

And the sheer demand for medication therapy is only going to rise, as chronic health conditions worsen:

according to the US Centers for Disease Control and Infection. very standard therapeutic option for women with these lesions destroys part of the cervix,

and serving as models to develop therapeutic agents to treat these diseases, says senior author Joseph Bonventre, chief of the renal division at Brigham and Women Hospital.

and therapies that might work in humans. Genetically matched kidney organoids without disease-linked mutations showed no signs of either disease,

explained Freedman. ur findings suggest that gene correction using CRISPR may be a promising therapeutic strategy.

#Drug combo shows promise for skin cancer n transitnew melanoma research finds a combination therapy is highly effective at treating patients with skin metastases.

The treatment, interleukin (IL)- 2 combined with imiquimod and topical retinoid therapy, is a promising option for patients with so-called n-transit metastases.

t unclear if the recently developed targeted melanoma therapies that have revolutionized management of patients with internal melanoma metastases are useful in patients with metastatic disease limited of the skin,

Davis. ur results demonstrate that intralesional therapy with a protein that causes immune cells to divide,

or stage IV melanoma who had history of treatment with IL-2 therapy combined with imiquimod and a topical retinoid.

TWO YEARS LATER The data indicate that all patients achieved complete clinical response to the treated lesions within one to three months of starting the intralesional IL-2-based therapy.

and suggest that the therapeutic regimen may have a survival benefit, conclude Maverakis and the research team.

and there were no experiments conducted to determine the effects of the therapeutic regimen on the systemic immune response.

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