or other therapies safely to sites of disease are already seeing the light of day.
The team was developing implantable capsules that can hold pancreatic islet cells as a potential therapy for Type 1 diabetes.
particularly for new therapies to combat motor neuron disease. Here we show direct optogenetic stimulation of skeletal muscle from transgenic mice expressing the light-sensitive channel Channelrhodopsin-2 (Chr2.
It smaller than any other comparable device and unlike other primary cell systems, it comes with a wireless remote that can be used by the patient to adjust therapy options.
and maintain comfortable therapy for my patients. Unlike any other primary cell system, the Precision Novi intuitive Illumina 3d neural targeting software incorporates three-dimensional lead location,
Minimally Invasive Therapies Group at Medtronic. orking very closely with Dr. Trivedi, we were able to develop the Gastrisail system as a unique solution that promotes consistency of the sleeve,
and delivering therapy consistently at all times. The current device is still quite bulky and is incomparable in size to natural neurons,
while the ipod touch is for the patient to control the level of therapy throughout the day.
preventing most therapeutic compounds from crossing its barricades. To get around this challenge and to be able to treat a variety of neurological conditions,
The devices were placed close to the spinal cord near the lower back of the patients who underwent weekly sessions for about four months to see how they respond to the therapy.
along with an international team, have come up with an ingenious way of creating therapeutic heat in a light, flexible design.
The project is funded through the Flexible Resorbable Organic and Nanomaterial Therapeutic Systems (FRONTS) program of the National Science Foundation.##
and minimizing the harms of therapy, "Roy said. In this study, researchers analyzed prostate tissue biopsies from two cohorts of prostate cancer patients.
2015innovative light therapy reaches deep tumors March 9th, 2015a new tool for detecting and destroying norovirus March 9th,
who are now exploring business opportunities for marketing the classification and determination of the degree of pluripotency of stem cells before their use in cell therapy or research in biomedicine.
thus having the capacity of becoming a standard method of quality control of stem or pluripotent cells before their use in cell therapy or research in biomedicine e
March 10th, 2015photonics/Optics/Lasers Innovative light therapy reaches deep tumors March 9th, 2015quantum sensor's advantages survive entanglement breakdown:
this could be a very promising lead in developing norovirus antiviral therapy. This could be especially beneficial to immunosuppressed individuals such as cancer patients.
or precisely tailoring therapeutics to an individual's cancer cell biology. Toner and his collaborator Dr. Daniel Haber, M d.,Ph d.,also at MGH, recently used Cluster-Chip to capture
"Given the increasing number of cancer therapies that engage the immune system, the ability to monitor tumor-immune cell interactions via the blood could be of great value."
becomes resistant to current therapies or recurs.""A primary tumor is not what kills patients.
Understanding which cells are likely to metastasize can help us direct more targeted therapies to patients,
drug testing, stem cell therapies and the delivery of drugs directly to the site of infection.
Nanofibers can also be loaded with proteins, nanotubes, fluorescent materials and therapeutic agents.""We can use almost any kind of polymer with this platform,
Molecular machines, novel sensors, bionic materials, quantum computers, advanced therapies and much more can emerge from this endeavour.
"The team tested the therapeutic potential of the nanoparticles by loading them with an anti-melanoma drug
so you can do multidrug therapy with the same particles.""""By using defined surface chemistry,
The paper,"Tunable luminescent carbon nanospheres with well-defined nanoscale chemistry for synchronized imaging and therapy,"is available online:
and non-invasively, opening the door to many other known therapies, such as the cases that dexamethasone cannot be applied safely systemically in large concentrations.
2015nanomedicine Nanoparticle'wrapper'delivers chemical that stops fatty buildup in rodent arteries Experimental therapy restores normal fat metabolism in animals with atherosclerosis June 23rd, 2015picosun ALD
2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Nanoparticle'wrapper'delivers chemical that stops fatty buildup in rodent arteries Experimental therapy restores normal fat metabolism
and the Environment June 24th, 2015nanoparticle'wrapper'delivers chemical that stops fatty buildup in rodent arteries Experimental therapy restores normal fat metabolism in animals with atherosclerosis June 23rd,
Gianneschi says they will broaden their approach to create delivery systems for other diagnostic and therapeutic molecules."
"We want to open up this therapeutic window."#"##Additional authors include Matthew Thompson in Gianneschi's chemistry research group and Christopher Barback, David Hall and Robert Mattrey in UC San diego's Moores Cancer Center.
that we could use them as the basis of a therapy for cancer patients. We've taken a big step toward solving that problem,
and streamline immune cellular therapies, Schneck, Karlo Perica, a recent M d./Ph d. graduate who worked in Schneck's lab,
not all patients are eligible for this therapy, because not all have tumor-infiltrating lymphocytes.
Schneck says it could also potentially work for therapies against chronic infectious diseases, such as HIV. He says that
Duke university researchers add a drug delivery mechanism to a nanoparticle therapy already proven to target,
Duke university researchers add a drug delivery mechanism to a nanoparticle therapy already proven to target,
becomes resistant to current therapies or recurs.""A primary tumor is not what kills patients.
Understanding which cells are likely to metastasize can help us direct more targeted therapies to patients,
and only one therapy has been approved by the Food and Drug Administration. While most of these vaccines are created with dendritic cells,
but they are being appreciated increasingly for their practical advantages in therapies, says Bishop, who was involved not in this research.
Our dream is to spawn out a whole class of therapies which involve taking out your own cells, telling them what to do,
and less expensive method for developing cell-based therapies for patients. Down the road, you could potentially get enough cells from just a normal syringe-based blood draw,
Since the advent of biotechnology, researchers have modified bacteria to produce therapeutic drugs or antibiotics. In this novel study
they also expose recipients to the risks of lifelong immunosuppressive therapy. While the progenitor cells needed to regenerate all of the tissues that make up a limb could be provided by the potential recipient
The engineered organ has implications for everything from rapid production of immune therapies to new frontiers in cancer or infectious disease research.
and clear out D-PDMP was a major hurdle in efforts to test its therapeutic potential in larger animals and humans.
#University spinout signs deal to commercialize microchips that release therapeutics inside the body (Nanowerk News) An implantable,
each capped with a metal membrane, that store tiny doses of therapeutics or chemicals. An electric current delivered by the device removes the membrane,
A lot of the therapies are trying to chemically trick the endocrine systems, Cima says. We are doing that with this artificial organ we created.
a single dose of therapeutics is released into the body. Wild ideas Inspiration for the microchips came in the late 1990s,
"says principal investigator Xiaoming (Shawn) He, Phd, associate professor of Biomedical engineering and a member of the OSUCCC-James Translational Therapeutics Program."
and the underpinning processes are potential targets for therapeutic interventions that prevent cancer onset and spread.
Ultimately, this could help the rational design of more specific therapies to inhibit the division of cancer cells,
when those therapies are proved to be safe and effective. Billions of stem cells are needed as trials move into second phase Using a high throughput materials discovery approach the research team has found this man-made material,
Against such a background, recently neutron capture therapy (1) has been drawing attention. By irradiating the affected area with a pinpoint light beam, ultrasonic waves,
This therapy has a lower burden on patients. However, the technological development to deliver the neutron sensitizer molecules to cancer cells has been a great challenge.
or magnevist) broadly used as an MRI contrast agent to the affected area("Hybrid Calcium phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron capture Tumor Therapy").
Moreover, when the Team applied the nanomachine to cancer neutron capture therapy, they confirmed a remarkable curative effect.
This nanomachine therapy enables an imaging-guided thermal neutron irradiation treatment; thus it can be expected to lead to a reliable cancer treatment with no missed cancer cells.
which the desired rate of molecule delivery could be tuned dynamically over time to achieve the optimal therapeutic outcome.
patients adherence to long-term therapies for chronic illnesses is only 50 percent in developed countries, with lower rates of adherence in developing nations.
they envision an emerging field of orally delivered devices that can maximize adherence and therapeutic efficacy y
or producing designer therapeutics and perhaps one day even non-biological polymers. No one has developed ever something of this nature. e felt like there was a small very small chance Ribo-T could work,
The USC Neurorestoration Center primary mission is to leverage partnerships to create unique opportunities to translate scientific discoveries into effective therapies. e are at a point in human research where we are making huge strides in overcoming a lot of neurologic disease,
The rehabilitation team of occupational therapists who specialize in helping patients adapt to loss of function in their upper limbs
which could be a potential therapeutic target for the treatment of Alzheimer disease. In a study that appeared in a recent edition of Nature Neuroscience,
and brings to light novel potential therapeutic targets for increasing amyloid-beta clearance in Alzheimer disease.
The team also will work on developing therapeutic strategies, including gene therapy, and screening for new drugs to overcome PICALM deficiency e
this knowledge can be helpful in the development of therapeutic interventions for neurological diseases underlined by altered dendritic spine density, such as autism spectrum disorder, Schizophrenia or Alzheimer's disease.
This makes the TIR-1 protein (or SARM1 in humans) an excellent therapeutic target for development of a medication.
In practice, carers and therapists take advantage of this phenomenon to stimulate their patients with music. It is often possible for music to reactivate memories, emotions and impressions.
a sound understanding of the complex relationships could lead to a real therapeutic benefit of music in patient care,
10.1016/j. bios. 2015.04. 058abstractan organic electronic biomimetic neuron enables auto-regulated neuromodulationcurrent therapies for neurological disorders are based on traditional medication and electric stimulation.
The results demonstrate the potential of the organic electronic biomimetic neuron in therapies involving long-range neuronal signalling by mimicking the function of projection neurons.
described in a study led by researchers in the Department of Pharmacology and Systems Therapeutics at the Icahn School of medicine at Mount sinai,
Assistant professor of Pharmacology and Systems Therapeutics at the Icahn School of medicine at Mount sinai. y identifying this new mechanism of epigenetic regulation,
and uses biotechnology to convert viruses into therapeutic agents, effectively allowing them to go on seek
said Dr Kevin Harrington, professor of biological cancer therapies at the Institute of Cancer Research London (ICR),
The test could also be used for tracking the progress of therapies and recovery, says Kalluri.
which is so deadly partly because of its limited treatment options, with few new and effective drugs and therapies available l
Robert Lanza, chief scientific officer at Ocata Therapeutics formerly Advanced Cell Technology-in Marlborough, Massachusetts,
and deploy the next generation of screening, diagnostic and therapeutic tools for eye care. One of these solutions will be eyemitra,
#Nivolumab helps fight Cancerous Lung Tumors A trial has suggested that a therapy for lung cancer has the ability to double the life expectancy in patients.
As per the trial results, patients on standard therapy lived for about 9. 4 months
and the almost 1. 3 million who have spinal cord injuries. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
many therapies can reverse its harmful effects and allow the afflicted to live normal lives.
That is a life-changing therapy for that patient. And crucially what it does is it changes that patient from a patient into a consumer;
and the underpinning processes are potential targets for therapeutic interventions that prevent cancer onset and spread. ut before we get there,
this could help the rational design of more specific therapies to inhibit the division of cancer cells,
The identified transcription factor and its regulators have great potential for the development of new precision therapeutic interventions in cancers that harbor the TERT mutations.
said, hile stem cell therapy is an exciting new development for the treatment for osteoarthritis,
It will help in the search to develop more targeted therapies for arthritis patients. o-Lead author Dr. James Fox said,
takes us a step closer to our aim of developing an injectable, safe, stem cell therapy for people with osteoarthritis. pcoming in Stem Cell Reports
That general approach is in clinical trials as a therapy for other cancers, viral infections and other illnesses.
or after the rodents are inoculated with the virus. This finding suggests that the antibody may act as both a preventative and a therapeutic agent.
--but in the not-too-distant future we think it could be developed for therapeutic use in humans,
"Current therapies for profound hearing loss like that caused by the recessive form of TMC1 are hearing aids,
"This is a great example of how the basic science can lead to clinical therapies, "says Holt."
and the underpinning processes are potential targets for therapeutic interventions that prevent cancer onset and spread. ut before we get there,
Ultimately, this could help the rational design of more specific therapies to inhibit the division of cancer cells,
"So in addition to the destructive power of the T-VEC cells themselves, the therapy summons the immune system right to where it's needed-the tumour."
#These tiny plastic chips can deliver therapeutic genes into cells A graduate student is developing a cost-effective new method of delivering desirable genes into human cells using a tiny plastic chip.
and reprogram them to have a therapeutic effect. his process could substantially bring down the cost of gene therapy,
it has far fewer side effects than traditional therapies, and early trials show that they may also be far more effective-with studies so far proving immunotherapy is successful against aggressive forms of melanoma and glioblastoma.
Manufacturing these therapies by viral vectors requires industrial-sized manufacturing plants and costs tens of millions of dollars but it only enables the treatment of thousands of patients per year.
Even better, theye also been able to show that the therapeutic cells their lab-on-a-chip creates are highly viable
yet have remained the backbone of therapy over the last decade, "said senior researcher Scott Lowe from the Weill Cornell Medical College in New york
whether Wnt inhibition or similar approaches would provide long-term therapeutic value in the clinic.""And while this specific treatment will most likely only work for colon cancer,
so you can do multidrug therapy with the same particles.""H/T: Techrada d
#This new insulin patch could soon replace injections for diabetics A new'smart patch'lined with painless microneedles full of insulin has been developed by researchers in the US in an effort to do away with the uncomfortable injections that have become a part of life for the millions
"The potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
so that the physician and the patient can select a therapy that is best for them.""The results have been published open-access in the Journal of Neurotrauma u
and may guide frequency of post-transplant surveillance and adjuvant therapy y
#Rate of investment in medical research has declined in U s. increased globally From 2004 to 2012,
and therapeutics and help assess recovery such as when a patient can safely return to work following a head injury.
suggests therapies, and allows some patients to join clinical trials. While more than 200 genes for retinal degenerations have been identified,
#Mechanism leading to drug resistance metastasis in melanoma patients discovered Moffitt Cancer Center researchers have discovered a mechanism that leads to resistance to targeted therapy in melanoma patients
Targeted biological therapy can reduce toxicity and improve outcomes for many cancer patients, when compared to the adverse effects of standard chemotherapeutic drugs.
However, patients often develop resistance to these targeted therapies, resulting in more aggressive cells that can spread to other sites or cause regrowth of primary tumors.
However over time many patients become resistant to B-Raf and B-Raf/MEK inhibitor therapy.
and MEK inhibitors are given to patients intermittently may reduce the aggressiveness of the diseasemeaning patients could stay on therapy for more time,
This suggests that drugs that target Epha2 may prevent the development of new disease in patients who receive B-Raf and B-Raf/MEK inhibitor therapy.
This opens up new therapeutic possibilities for patients suffering from neurological trauma or disorders, particularly individuals who have become paralyzed following spinal cord injury,
TESI may one day offer a therapeutic alternative to the current standard treatment which is intestinal transplantation
professor in the Department of chemistry and core member of the Center for Diagnostics and Therapeutics at Georgia State, organized a research team,
The findings also explain the longstanding paradox of why insulin therapy does not exacerbate but instead reduces fatty liver disease in patients with type 2 diabetes.
Newer genome editing tool shows promise in engineering human stem cells In a recent online report on the work in Molecular Therapy the Johns Hopkins team says the findings could streamline
when we can use ipscs for human therapy aren't that far away says Zhaohui Ye Ph d. an instructor of medicine at the Johns hopkins university School of medicine.
therapies for type 2 diabetes.""We wanted to understand what was initially happening to cause the body to become unresponsive
which we can approach drug therapy for this disorder
#Byproducts from bacteria awaken dormant T-cells HIV viruses Dental and medical researchers from Case Western Reserve University found another reason to treat periodontal disease as soon as possible.
HIV antiviral therapy prevents active HIV cells from replicating and doesn't affect the quiet viruses in sleeping T-cells.
#Blood test for prostate cancer investigated Mitchell believes the technique will be transformative in providing improved cancer diagnostics that can both predict treatment outcomes and monitor patient responses to therapy.
not only before a patient begins therapy but also following patient responses to therapy said Mitchell the paper's corresponding author and professor of Pathology Microbiology and Immunology.
The study collected serum from more than 200 patients with prostate cancer and more than 200 controls.
Since cell-free DNA has a relatively short half-life in the circulation sequencing of cell-free DNA soon after therapy may be used to detect minimal residual disease in solid tumors Mitchell said.
Mitchell further predicted that liquid biopsies will quantify immediate tumor responses to therapy y
#New technology focuses diffuse light inside living tissue In the Jan 5 issue of Nature Communications Wang the Gene K. Beare Professor of Biomedical engineering at Washington University in St louis reveals for the first time a new
This improvement in speed is an important step toward noninvasive optical imaging in deep tissue and photodynamic therapy.
or plan for the next one or rule out therapies that are unlikely to remain effective for long said Duke graduate student Pablo Gainza-Cirauqui who co-authored the paper.
and therapeutic approaches for epileptogenesis says Dr. Musto o
#Researchers use sound to slow down speed up and block light Researchers from the University of Illinois at Urbana-Champaign have demonstrated experimentally for the first time the phenomenon of Brillouin Scattering Induced Transparency (BSIT)
and the brain might hold the key to creating therapeutic solutions for blindness stroke and other seemingly unrelated conditions associated with the central nervous system notes Dr. Bazan.
However if there is no approved treatment for an ailment the FDA has a compassionate therapy exception that allows the patient to agree to try an experimental approach.
which is working to get the therapy into production for human use. Human patients would likely take a pill each morning to help control their diabetes March said d
and neuroscientists to use to address questions ranging from fundamental mechanisms in cell biology to the underlying causes of mental illness to the discovery of novel therapeutics.
The researchers suggested cells'internal expression of jagged may also increase the production and maintenance of therapy-resistant cancer stem cells.
The discovery could lead to targeted therapies and interventions for Alzheimer's disease, autism and other neurological conditions.
#New cancer-fighting strategy would harden cells to prevent metastasis Existing cancer therapies are geared toward massacring tumor cells
This is a novel approach to cancer therapy that we believe could fight the disease with less potential for side effects
and this means of course that they've got incredibly interesting therapeutic potential that we'll investigate further.
A small number of therapeutic antibodies already exist some of which have the same effect as the antibodies developed by the Aarhus University researchers.
The demand for therapeutic antibodies for cancer treatment is steadily increasing. In 2013 alone worldwide sales amounted to more than DKK 340 billion.
and possibly developing new forms of therapy says Associate professor Kristensen. The researchers isolated their antibodies from a library consisting of billions of different antibodies
if the abnormal aggregation of this type of glycoprotein is somehow related to them it is tempting to speculate that inhibition of ENGASE activity may serve as a therapeutic target for patients carrying mutations in the NGLY1 gene.
could point the way to new therapies that suppress the inflammatory allergic response, offering potential relief to millions of Americans with the chronic lung condition and potentially other allergic diseases.
or ones that mimic or block them might be used as novel therapeutics of allergic and asthmatic diseases."
whether inhibition of Ezh2 may be a valuable therapeutic strategy for skin diseases related to keratinocyte differentiation defects s
which might give an impact on tyrosine kinase-targeted leukemia therapy, was found to be expressed in a leukemia cell line.
and may help to develop new leukemia therapies. Recent transcriptomic studies have revealed the existence of numerous RNAS that are relatively long
Leukemia characterized by a mutated copy number of CCDC26 might be treated by KIT-targeted therapy"quoted Dr. Hirano o
Since the advent of biotechnology, researchers have modified bacteria to produce therapeutic drugs or antibiotics. In this novel study, they have actually become a diagnostic tool.
Cancer researchers have been interested in these proteins as markers for cancer and as potential targets for therapeutic cancer vaccines."
"Understanding how PASD1 is regulating the circadian clock could open the door to developing new therapies.
"Current therapies only treat the symptoms and slow the progression of the disease, "Professor Thomas said."
"We are committed to the quest to discover therapies that make healthy tissue regeneration a possibility in humans
School of medicine have discovered now a new therapeutic target for IPF. The main focus of their research was to identify causative mechanisms involved in the disease.
this might lead to a new therapeutic approach. Further experiments confirmed that knockdown of this protein in IPF fibroblasts diminished the collagen synthesis."Thus,
FKBP10 represents a potential new target molecule for the individualized therapy of IPF, "said Claudia Staab-Weijnitz."
"In the future, these results could also lead to new therapeutic options for the treatment of other fibrotic diseases."
Together with his team of researchers, he is studying the pathogenic mechanisms with the aim to develop causal therapies--and thus one day to actually cure IPF.
At the moment a lot of therapies are focused on the site of infection or injury itself but this data suggests that it's the signals that are being sent out from the gut that are impacting the whole immune system.
"While stem cell therapy is an exciting new development for the treatment for osteoarthritis, up to now it has been something of a lottery
It will help in the search to develop more targeted therapies for arthritis patients.""Co-Lead author Dr James Fox said"Working with colleagues across the Arthritis Research UK Tissue Engineering Centre will help to bring our discovery closer to patient treatment."
takes us a step closer to our aim of developing an injectable, safe, stem cell therapy for people with osteoarthritis
doctors gave her hormone replacement therapy to induce the onset of menstruation. Ten years later the patient received counselling after expressing a desire to become pregnant.
Belgium), stopped the hormone replacement therapy, thawed some, but not all of the frozen ovarian tissue and grafted four fragments on to the remaining left ovary,
when hormone replacement therapy is an efficient, standard, and noninvasive alternative for inducing puberty? Should the procedure only be proposed for patients with a high risk of ovarian failure or for those at low risk as well?
improve manufacturing and help develop therapies for disease. The need for this optics technology will grow with the construction of the next-generation of light sources
as well as for the identification of new targets for drug therapy.''The identification of more than one stem cell pool in the colon has proven challenging,'stresse Asfaha.'
'These findings are exciting as we have identified an important new target for cancer therapy. It is also proof that more than one stem cell can give rise to
telling us that our cancer therapy needs to target more than one stem cell pool.''Until now, the only stem cell population linked to colon cancer was radiation sensitive,
and we must find new forms of therapy to target the disease, 'says Asfaha a
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