Researchers develop a faster way to treat the heart after a heart attack Stem cell have been the main focus of healing therapy research
For healing after a heart attack, the ideal time to administer these therapies is when reopening the clogged blood vessel
A new study in the American Journal of Physiology--Heart and Circulatory Physiology reports a more practical approach called microsphere therapy that can be kept on hand
The therapy, however, did not improve heart function. It also did not decrease the size of the area damaged by the heart attack or the composition of the scar.
the study shows that microsphere therapy can potentially be an"off-the-shelf and immediate alternative to stem cell therapy"for treating heart attacks and potentially other diseases s
such as the creation of manufactured goods, biofuels and therapeutic drugs. Lead author of the study Professor Rudolf Allemann,
where therapeutics are incorporated and delivered to match a complex injury. The published research was restricted to one ink cartridge,
'In people who already have colorectal cancer, therapies that boost the expression of AIM2, such as interferons, might reduce tumor progression.
Seeding measurements can also aid in determining the optimal dosage of a new therapy. Additionally, gauging the seeding property of misfolded proteins may prove to be useful in the development of new treatments for other neurodegenerative diseases, such as Alzheimer's, ALS and Parkinson's.
and are actively pursuing the creation of novel therapies. Earlier this year, study contributor Leslie Thompson of UCI's Sue & Bill Gross Stem Cell Research center and UCI MIND received a $5 million grant from the California Institute for Regenerative medicine to continue her CIRM
In this project, Thompson and her colleagues plan to create a therapy employing human embryonic stem cells that can be evaluated in clinical trials s
and provide the basis for developing new and more effective therapies s
#Iron: A biological element? Arrayclark Johnson, a professor of geoscience at the University of Wisconsin-Madison,
This work improves the therapeutic efficiency of the drugs, while reducing the need for frequent injections,
and may provide clues to the development of therapies for infectious diseases, cancers and immune diseases.,"
but we have identified a possible personalized therapeutic strategy to help them, said Jenny Ting, William R. Kenan Jr.
Wilson said the researchers believe their findings mean that drugs used to inhibit Akt could be used as a personalized therapy for people who don have AIM2. ur research paves the way for future clinical trials that screen for AIM2 expression in colon cancer
and possibly other cancers to identify patients who may potentially benefit from personalized anti-Akt therapy,
along with an international team, have come up with an ingenious way of creating therapeutic heat in a light, flexible design.
and exhibited features indicating they were more stable--the ideal therapeutic goal for treating the disease in people.
Moreover, her studies are the first to indicate that therapies targeted at controlling the properties of smooth muscle cells within lesions may be highly effective in treating a disease that is the leading cause of death worldwide.
"Our research paves the way to explore therapeutic approaches for microcephaly involving the inhibition of the protein p53,
#Activated T cell therapy for advanced melanoma developed Published in the July/August issue of Journal of Immunotherapy,
"This study is unique in that the source of T cells for therapy is derived from the lymph node,
The new Phase I clinical trial is being supported by University Hospitals as well as a significant philanthropic effort including the Immunogene Therapy Fund, Paula and Ronald Raymond Fund and the Kathryn and Paula Miller Family Fund."
Our goal is to eventually combine these T cells with other immune therapies which will result in cures.
These types of clinical trials place the UH Seidman Cancer Center at the forefront of immune therapy of cancer."
"Additionally, the research team has been researching the possibility of using lymph nodes from patients with pancreatic cancer to develop T cell therapy.
from which fifteen times more ips cells were produced by adding netrin-1. From a therapeutic point of view,
--but in the not-too-distant future we think it could be developed for therapeutic use in humans,
"Current therapies for profound hearing loss like that caused by the recessive form of TMC1 are hearing aids,
"This is a great example of how the basic science can lead to clinical therapies, "says Holt."
which could potentially better inform future cancer therapies.""As a charity we fund only the highest standard of research,
Advances in the understanding of the molecular processes that cause these tumors has resulted in therapies aimed at delivering specific genes into tumors--genes that make proteins to kill
"In the future, the investigators envision that doctors would administer this therapy during the surgery commonly used to treat glioma in humans.
--which could broaden the use of the therapy for a wide range of solid tumors and systemic cancers s
and the underpinning processes are potential targets for therapeutic interventions that prevent cancer onset and spread."
Ultimately, this could help the rational design of more specific therapies to inhibit the division of cancer cells,
This new trial will be for patients advancing on standard of care therapies, and will be available at multiple centers connected through the Prostate Cancer Clinical Trials Consortium,
so that we can treat them with more aggressive therapy earlier, "says Dr. Knudsen.""Given the role of DNA-PKCS in DNA repair as well as control of tumor metastasis,
More specifically, in a subgroup of 41 patients who had received previously anti-EGFR therapy, it was revealed that they had acquired KRAS mutations during the course of their disease.
lead to a selection of therapy which may not be the most appropriate for these patients.
enabling us to better target therapy to the specificities of patient's tumor; this could have a considerable impact on clinical practice,
and deliver targeted therapies tailored to the particularities of each tumor for an increasing number of patients.
Since few to no causal therapies are in place for most lung diseases, it is important to understand how these healing processes,
and may also be relevant for developing new tumour therapies in the future, "explains Markus Hengstschläger g
Gianneschi says they will broaden their approach to create delivery systems for other diagnostic and therapeutic molecules."
"We want to open up this therapeutic window.""Additional authors include Matthew Thompson in Gianneschi's chemistry research group and Christopher Barback, David Hall and Robert Mattrey in UC San diego's Moores Cancer Center.
despite antiretroviral therapy,"describes Dr. Cohen, who also leads Cancure, a team of leading Canadian researchers working towards an HIV cure."
the protein must be provided with a special sugar structure for enhanced therapeutic effect and duration.
Longer-lasting and improved therapeutic effect and not least, faster and cheaper production.""We have seen previously examples of optimised sugar structures making pharmaceuticals up to a hundred times more effective.
which--by the way--is a very expensive form of therapy, "says Zhang Yang g
#Simulations lead to design of near-frictionless material While reviewing the simulation results of a promising new lubricant material,
Many therapies are designed therefore to suppress IL-6 or STAT3. But the situation is different in prostate cancer.
this can help to prevent unnecessary therapeutic interventions with severe side effects such as incontinence and impotence.
According to Kenner, this means that therapies that block the IL-6 pathway may enhance the growth of prostate cancer.
"Women who receive combination antiretroviral therapy (cart) during pregnancy do not pass HIV on to their baby.
"This work has tremendous therapeutic implications, "Benovic said.""The study is a critical first step and provides key insight into the structural interactions in these protein complexes."
"So far, therapies aimed at lowering the production of beta amyloid have shown only a modest ability to slow cognitive decline
possible therapeutic target for breast cancer A new way to detect --and perhaps treat--one of the deadliest types of breast cancer has been found.
"which means it is not responsive to the common medical therapeutics. BLBC is more likely to metastasize
Personalized cancer therapies could be developed by targeting breast cancer cells that express copious levels of IL13RA2,
and ultimately drug development and therapy y
#Paper Test Quickly Detects Ebola, Dengue, And Yellow fever Researchers in the US have developed a silver nanoparticle-based paper test to simultaneously detect dengue, yellow fever and Ebola.
genetic manipulation and surgery are therapeutic approaches worth pursuing. Dr. Josep Dalmau, a neurology professor at the University of Pennsylvania not involved with the new study, agrees that the new findings could help to explain the initiation, maintenance,
better brain implants may prove powerful therapeutic toolshether easing the symptoms of Parkinson or restoring a degree of freedom to those suffering paralysis. And more.)
That is why Toronto Sickkids Centre for Image-Guided Innovation & Therapeutic Intervention (CIGITI) turned to the Canadian space technology behind Canadarm,
These encouraging results from in vitro tests in humans and in vivo tests in mice were published in the Annals of Neurology. e believe we have identified the first therapy that will impact the quality of life of people with multiple sclerosis by significantly reducing the disability and the disease progression
By means of two new therapeutic strategies, using an HTRA3 inhibitor or a broad-spectrum antioxidant to capture free radicals,
This progress both paves the way for new therapeutic approaches, which could soon be tested in patients,
The development of therapeutic strategies targeting premature aging diseases could therefore open new research possibilities in terms of preventive therapies for the pathologies associated with normal aging a
#Blood to feeling: Mcmaster scientists turn blood into neural cells Adult sensory neurons made from human patients blood samplescientists at Mcmaster University have discovered how to make adult sensory neurons from human patients simply by having them roll up their sleeve and providing
or personalized medical therapy for patients suffering with neuropathic pain. ource: Mcmaster Universit i
#Controlling a robotic arm with a patient intentions Giving himself a drink for the first time in 10 years,
such as those of the Andersen Lab at Caltech, to human patients, ultimately turning transformative discoveries into effective therapies, says center director Charles Y. Liu, professor of neurological surgery, neurology,
inoperable malignant melanoma to receive either an injection of the viral therapy, called Talimogene Laherparepvec, or a control immunotherapy.
because their infection defences are compromised by genetic errors. UK trial leader Professor Kevin Harrington, Professor of Biological Cancer Therapies at The Institute of Cancer Research, London,
and there is hope that therapies like this could be even more effective when combined with targeted cancer drugs to achieve long term control
and we also compared multipotent stem cells derived from fallopian tubes and fallopian tube mucosa according to their biological characteristics and therapeutic potential for treatment of autologous reproductive tract injury.
could help scientists design therapies to manipulate the cell repair process and direct immune cells away from sites where they are doing damage,
and allow us to design therapies to direct immune cells away from sites where they are doing damage
For some, the therapy has lengthened their survival by years. hari Wells from Ashland, Kentucky is one of those patients.
Wong said. his new knowledge will make it easier to design new therapeutic strategies to control immune responses.
#Petri dish tumor test could personalize drug therapy for cancer patients In a highly successful, first-of-its-kind endeavor,
a drug commonly used in multiple myeloma therapy. And after only three days, the researchers could determine
The researchersresults could have interesting and wide-ranging implications for the future of cancer treatment and therapy,
The engineered organ has implications for everything from rapid production of immune therapies to new frontiers in cancer or infectious disease research.
-based effector Therapeutics. effector is developing new treatments for patients with cancer and other serious diseases,
Alvarez-Buylla also noted that the paper has possible implications for the success of human stem cell therapy in the brain
the likelihood of our being able to use stem cell therapy to repair brain injury is very low. ource:
which allows for a better therapeutic potential. The team of researchers tested the therapeutic potential of these carbon nanoparticles by loading them with an anti-melanoma drug
and mixing them in a topical solution that was applied to pig skin. However, scientists have to make sure they coated particles properly,
as well as to make it carry several different drugs at the same time to allow for a multidrug therapy with the same particles.
which will eventually lead to innovative drug therapies for cancer and other diseases i
#Access to electricity and artificial light shortened time of our sleep Science knows that nowadays people tend to sleep less than they used to before modern times.
Collins says. ou can use this to kill off very specific species of bacteria as part of an infection therapy,
in order to get a more effective therapy, he says. This is in contrast to repeated infection with bacteriophages,
the research suggests that it is likely to take them far longer to develop resistance to phagemids than to conventional bacteriophage therapy,
The researchers have created an improved form of phage therapy that may become the antibiotics of the future,
a private British biopharmaceutical company focused on the development of therapies for retinal dystrophies. e are leading the way in the development of an effective gene therapy treatment for choroideremia,
Researchers believe this new approach to eye therapy has promise for treating people early on before too many cells in the retina have been lost.
These results suggest that idiopathic pulmonary fibrosis may be treated by therapies based on the activation of the enzyme telomerase.
This finding opens up new avenues for the development of therapies to treat a disease for
and this is already helping us to test novel therapies that we hope will prove effective
future we think it could be developed for therapeutic use in humans says Jeffrey Holt, Phd, a scientist in the Department of Otolaryngology and F. M. Kirby Neurobiology Center at Boston Children and an associate professor of Otolaryngology at Harvard Medical school.
Holt hopes to partner with clinicians at Boston Children Department of Otolaryngology and elsewhere to start clinical trials of TMC1 gene therapy within 5 to 10 years. urrent therapies for profound hearing loss like that caused by the recessive
restoring hearing in the recessive deafness model and partial hearing in the dominant deafness model. his is a great example of how the basic science can lead to clinical therapies,
In addition, more advanced genetic computing circuits could be built upon this genetic toolkit in Bacteroides to enhance their performance as noninvasive diagnostics and therapeutics. or example,
or even in-situ synthesis of therapeutic molecules as and when they are needed. Source: MIT, written by Helen Knigh
Shen said. ur expectation is that a PTEN blood test in the near future will help clinicians decide on the right therapies for each cancer patient,
and more than 2 million new infections develop each year. lthough antiretroviral therapies have prolonged the lives of HIV-1 infected patients,
They found that at normal therapeutic doses the drug led to abnormal development of microchambers, including decreased size,
and persist in small populations of long-lasting reservoirs despite antiretroviral therapy, describes Dr. Cohen, who also leads Cancure,
Bone marrow-derived autologous human mesenchymal stem cells (MSCS) are one of the most promising cell sources for cell therapy to treat heart failure.
and enhanced the efficacy of cell therapy. We hypothesized that the transplantation of MSC sheets may be a feasible, safe,
The innovative approach may lead to more effective therapies with fewer side effects, particularly for diseases such as cancer, heart disease and neurodegenerative disorders.
GPCR drugs that selectively modulate one pathway are preferred often as they can have better therapeutic benefits with fewer undesirable side effects than non-selective drugs. rrestin
interaction and function of each of these groups of proteins is vital to developing effective therapies.
Cell surface receptors are excellent therapeutic targets due to their location on the surface of the cell,
GPCRS are major targets in the development of new therapies and account for about 40 percent of current drug targets.
patientsadherence to long-term therapies for chronic illnesses is only 50 percent in developed countries, with lower rates of adherence in developing nations.
as well as a path toward CRISPR/Cas9-based therapies for many serious health problems. Using their novel approach,
then returned to the body to exert therapeutic effects. But in practice, editing T cell genomes with CRISPR/Cas9 has proved surprisingly difficult,
There are a lot of potential therapeutic applications and we want to make sure wee driving this as hard as we can.
and eventually for therapeutic use. e tried for a long time to introduce Cas9 with plasmids or lentiviruses,
He hopes that Cas9-based therapies for T cell-related disorders, which include autoimmune diseases as well as immunodeficiencies such as ubble boy disease,
director of the National Institute of Biomedical Imaging and Bioengineering. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
but also by their response to therapies. An international team of scientists from Berlin, Düsseldorf, Hannover, Heidelberg, Kiel,
paving the way for new therapeutic approaches. Although intensive research over the least decade has led to significant improvement of the survival rates of children suffering from ALL
With the aim of identifying therapeutic entry points for this incurable form of ALL THE consortium team decoded both the genome and the transcriptome of the cancer cells,
By establishing a umanized mouse model they provided an invaluable tool for testing the therapeutic response of the leukemic cells to different drugs.
nevertheless, the results signal significant progress towards the eventual goal of developing a therapy for a wide range of individuals with spinal cord injury. hese encouraging results provide continued evidence that spinal cord injury may no longer mean a lifelong
. director of the National Institute of Biomedical Imaging and Bioengineering at NIH. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
so that the physician and the patient can select a therapy that is best for them. ource:
or producing designer therapeutics and perhaps one day even non-biological polymers. No one has developed ever something of this nature. e felt like there was a small very small chance Ribo-T could work
and could be a more effective way to provide therapeutic stimulation. Understanding how the brain worksr doesn,
Further down the road, the concept could lead to a better way to deliver therapeutic stimulation to address neurodegenerative diseases,
One current therapeutic use of implanted electronics is called deep brain stimulation, which is approved FDA and used to treat Parkinson disease.
The therapy involves inserting electrodes into certain regions of the brain and producing electrical pulses meant to regulate abnormal ones.
an observation that could have important implications with the increased attention to immune-system-based cancer therapies. e are only at the beginning of our quest to understand the role and biology of CTC clusters,
it combines the effect of several other therapies but works faster. V, ozone and electrotherapy are already available,
but can still be repurposed to make a specific therapeutic protein, "we would be very happy,
and devise therapies to alleviate them s
#CERN Scientists Welcome Two New Particles To The Atomic Family CERN Large hadron collider in Europe, the giant atom-smashing machine, has discovered two new subatomic particles.
#After Celgene Deal, Juno Revs Armored CAR For Ovarian Cancer Trial Juno Therapeutics has built remarkable momentumncluding last week much-dissected $1 billion deal with Celgenepon
and lymphoma patients with a first generation of experimental T cell therapies developed by its academic partners.
'says Renier Brentjens, the director of cellular therapeutics at Memorial Sloan Kettering Cancer Center in New york and a Juno scientific founder.
T cell therapies have treated relatively rare blood-borne cancers. If that the extent of the treatment reach,
Overall, however, Brentjens cautions that no one can yet predict which patients might respond favorably to T cell therapy.
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