Ageing

Ageing (207)
Anti-ageing (22)
Apoptosis (26)
Autophagy (23)
Caregiving (22)
Geriatrics (84)

Synopsis: Ageing:

But another safety concern is our quickly aging population, which#can't navigate the city as efficiently on foot.

In Thailand, the Chaing Mai province is investing in retirement communities, including making improvements to its urban space that will help make its cities more welcoming to pedestrians.

NBS), a leader in the development and manufacturing of cell therapy products and regenerative medicine, and Invetech Pty Ltd("Invetech"),a global leader in instrument development, custom automation and contract manufacturing, today announced an agreement for the development of a new closed processing system (the"System")for cell

proliferation, apoptosis, and migration. The discovery that they are receptors for tumor-producing phorbol esters, plant-derived compounds that bind to and activate PKC,

The researchers conducted these experiments to try to understand the longevity difference between the two groups.

because in many other longevity models like caloric restriction or treatment with rapamycin, the animals live longer

led the molecular analysis of several pathways known to be involved in regulating longevity to find out how they might be different.

Zhao and Hoffman's studies also argue against a role for Myc in an oft-cited paradigm of greater longevity:

The different benefits of Myc reduction compared to other laboratory longevity extenders shows that just as there are many ways the body can break down with aging,

Past studies have shown that 40 percent of men with aggressive prostate cancers are treated with hormone therapy alone exposing a large gap in curative cancer care among baby boomers aging into their 70s.#

director of the Scripps Institute Center for Regenerative medicine, tried to use the Hanna lab's recipe for making naive cells.

security, and longevity. Customers across a number of industries including restaurants, retail, energy, and military have expressed their interest

HWT boasts more than 180 customers ranging from the healthcare and elderly care domains to hotels penal institutes swimming pools spas and cooling towers.

#Stressed girls show signs of premature aging Stanford university rightoriginal Studyposted by Dan Stober-Stanford on October 30 2014

Healthy but high-risk 12-year-old girls had significantly shorter telomeres a sign of premature aging.

It's the equivalent in adults of six years of biological aging Gotlib says but it's not at all clear that that makes them 18

The work reported in the journal elife suggests the protein might be a target for treating people who have suffered hearing loss due to noise or aging.

whether it s due to noise or normal aging##says Gabriel Corfas who led the team

or apoptosis which reduces the likelihood that they will go on to form tumors.####As luck would have it that was the first gene

Knowledge about both the maternal age effect and the bottleneck size is useful in family planning. e have some predictive power now

and the severe problems associated with reconstructive surgery says team leader Francesca Mariani assistant professor of cell and neurobiology and principal investigator in the Eli and Edythe Broad Center for Regenerative medicine and Stem Cell Research at University

The lab received support for this study and future work from the NIH the Merck Investigator Studies Program and the USC Regenerative medicine Initiative Award.

a California Institute of Regenerative medicine (CIRM) training fellowship; CIRM BRIDGES fellowships through California State university Fullerton and Pasadena City College;

The children and their primary caregivers participated in up to six annual and four semiannual assessments.

As part of the evaluation, caregivers were interviewed about their children expressions of sadness, irritability, guilt, sleep, appetite,

In addition, researchers used two-way mirrors to evaluate child-caregiver interactions because the team earlier research had shown that a lack of parental nurturing is an important risk factor for recurrence of depression.

or if their caregivers requested treatment, they were referred to mental health providers. Currently, there are no proven treatments for depression that arises in the preschool years.

The National institute of mental health, the National Institute on Aging, and the National Institute of Child Health and Human Development funded the study C

with mortality rates holding firm in older people. e can congratulate ourselves that we are doing well,

The study appears in the Journals of Gerontology. hat wee finding here is it important to be vigilant to find depression among people older than 50 because of a host of reasons,

The National Institute on Aging and the Eunice Kennedy Shriver National Institute of Child Health and Human Development-funded University of Colorado Population Center supported the research project d

and induce apoptosis. The cancer cell growth slowed by day 17 and all cells were dead by day 21.

and hints at an easier way to achieve longevity. Researchers have found that taking food away from C. elegans triggers a state of arrested development:

so that we can get the antiaging benefits without the pain of diet restriction. Over the last 80 years researchers have put a menagerie of model organisms on a diet

Outside the laboratory and in the real world organisms like C. elegans can experience bouts of feast or famine that no doubt affect their development and longevity.

not only for aging but also for cancer says Sherwood. One of the biggest mysteries in cancer is how cancer cells metastasize early

Both cataracts and glaucoma affect a similar aging population so it seems a natural pairing to place a pressure monitoring device in a new lens during cataract surgery.

has major implications for healthier aging, in which immune system decline contributes to increased susceptibility to disease as we age.

professor of gerontology at the University of Southern California. STARVING KILLS DAMAGED CELLS hen you starve, the system tries to save energy,

an effect previously discovered by the Longo team to extend longevity in simple organisms and

Now, if you start with a system heavily damaged by chemotherapy or aging, fasting cycles can generate, literally,

The National Institute of Aging of the National institutes of health supported the study. The V Foundation and the National Cancer Institute of the National institutes of health funded the clinical trails I

and decrease longevity. t appears that if you reduce inflammation, this may reduce the growth of fat tissues

and therefore have a positive impact on longevity, says Allon Caanan, associate researcher in genetics at Yale university and co-lead author of the study.

or as scaffolding in regenerative medicine Two papers in the Journal of the American Chemical Society the first published in May and the second this month show precisely how mimetic peptides developed at Rice may be aligned to form helices with sticky ends that allow them to aggregate into fibers

or older people are prone to lose their sight. The Braille studies will be presented in Seattle this September at the 18th International Symposium on Wearable computers (ISWC.

and they will continue to refine the technique to improve the silicon electrode s performance and longevity.

when it is present in high levels it results in longer leaf longevity. It was serendipity we weren't actually looking for this gene

a key step in the plant's pathway for controlling senescence that had been eluding scientists. At the start of that pathway is salicylic acid precursor of the active ingredient in aspirin

Plant senescence is estimated to involve 10 percent of genes in the genome. Plants use an expedited hypersensitive process to thwart pathogens by sacrificing infected cells to protect the surrounding healthy tissues.

In the current study the increase in leaf longevity was significant but was tallied in days.

Gan expects further research to enable the delay of senescence for weeks. In the current transport and storage-based food system senescence after harvest whittles away at fruit and vegetable quality.

Gan envisions applications that will produce leafy greens that stay fresh floral bouquets that last longer and crops that keep their nutrients with an extended shelf life and less postharvest loss.

Much of the progress plant breeders have made in improving plant yields is actually due to delaying leaf senescence Gan says.

and seeds so senescence limits the yield of many crops. His lab group is already working with other genes in the salicylic acid pathway including a master regulator gene with promising results.

and a growing number of geneticists is now exploring the role of misbehaving mitochondria in basic aging.)

socially and economically. t least one family member has to give up workto provide caregiving, said Kwak Young-soon, social welfare director for Mapo District, one of Seoul 25 geographic districts.

Because South korea encourages people to work well past retirement age, families may also lose dementia sufferersincomes.

Most families no longer have generations living together to help with caregiving, and some facilities have long waiting lists,

But South korea low birth rate will make family caregiving tougher. feel as if a tsunami coming, said Lee Sung-hee, the South korean Alzheimer Association president, who trains nursing home staff members,

The Aging-Friendly hall, financed by the Ministry of Knowledge Economy, encourages businesses to enter ilver industries,

she told 200 senior citizens interested in nursing home jobs or family caregiving advice. If patients say, good at making soy soup,

In South korea, sonsfamilies traditionally shoulder caregiving responsibilities. During one massage session, 16-year-old Oh Yu-mi rubbed a patient toes,

The dementia caregiving program had made him onder why I wasn able to do that with my own grandma,

The discovery has implications for understanding age-related diseases including cancers, neurodegenerative disorders and diabetes.##One way all mammalian cells produce energy is via aerobic respiration, in

if this aspect of aging could be reversed by increasing the amount of SIRT1 in the cells.

and therefore it gives a new pathway to target that can reverse some aspects of aging,

of which significantly contributes to aging, and also that this problem can be ameliorated by boosting NAD+production with key intermediates,

The TVA has not yet set a schedule for the retirement of the coal fired power plants but under the plan approved yesterday,

#Google hopes to cure death with its new health startup Calico Google is planning to launch a new company with the absurdly ambitious objective of extending our lives. alicois the name of the company

That, in a nutshell, is the goal of Calico. Sounds like a joke, but it not. On Google+,Google CEO Larry page wrote, K so youe probably thinking wow!

So, how is Calico going to go about extending our lives, and perhaps, ultimately curing death? Page doesn lay out any specific plan.

Time reports, hile the company is holding its cards about Calico close to the vest, expect it to use its core data-handling skills to shed new light on familiar age-related maladies.

It fine Calico doesn have an exact plan. It tackling a huge challenge. If there were some straight line

MOUNTAIN VIEW, CA September 18, 2013 Google today announced Calico, a new company that will focus on health and well-being, in particular the challenge of aging and associated diseases.

I excited to announce Calico, a new company that will focus on health and well-being, in particular the challenge of aging and associated diseases.

Art and I are excited about tackling aging and illness. These issues affect us allrom the decreased mobility

and I will be starting a new company focused on health, aging and well-being, called Calico.

me about a venture that would take the long term view on aging and illness, I was intrigued deeply.

and memory associated with neurodegenerative diseases and aging. The new research was published June 9 in the Proceedings of the National Academy of Sciences.

but also just associated with aging, said Yanhong Shi, Ph d.,lead author of the study and a neurosciences professor at City of Hope.

hp stock could be a nice retirement plan. Since snubbing Microsoft seems to be the sport of tech royalty this year,

#Longevity gene may enhance brain power For the first time ever, scientists have shown that people who have a variant of a gene called KLOTHO also have improved cognitive abilities,

For all its durability and timeless lustre, gold my pale to the longevity of a cryptocurrency system.

Other recent work in stem cell therapy has looked similarly for ways the cells could improve functioning of existing organs, rather than building replacements through regenerative medicine.

(and charge) at different rates and that throws off the efficiency and longevity. If every part of the pack can be monitored with the kind of Big data equipment that now hugely in vogue one bad apple won spoil the whole bunch

but said It's exciting to think about the new possibilities these findings offer us not only in regenerative medicine but cancer as well.

Chris Mason a University college London professor of regenerative medicine who was affiliated not with the two studies told the BBC that this is a game changer

The molecule, TIC10, activates the gene for a protein called TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand),

which apoptosis#or cell death#is induced in cancer cells immediately next to healthy ones. Healthy cells are stimulated also to increase the amount of TRAIL receptors on their cell surface.

Researchers at the University of Pennsylvania s Tissue Microfabrication Laboratory, the Wake Forest Institute for Regenerative medicine and elsewhere are developing methods for bioengineering functional vessels that could someday be used to ferry blood around 3-D-printed organs.

inflammation (a reaction to injury or infection) and autophagy (a cellular process involved in the removal of damaged cellular components.

especially since the inflammatory and autophagy pathways have been implicated previously in the disease, said Lucie Bruijn, Phd,

Both proteins are required for the normal function of inflammatory and autophagy pathways, and now we have shown that mutations in either gene are associated with ALS,

Thanks to our collaborators from the Consortium, the International Parkinson Disease Genetics Consortium, the Genetic and Environmental Risk in Alzheimer Disease, the Cohorts for Heart and Aging research in Genomic Epidemiology, decode Genetics and the Demgene cohort,

Sudha Seshadri, MD, professor of neurology at the Boston University School of medicine, the principal investigator of the Neurology Working group within the Cohorts for Heart and Aging research in Genomic Epidemiology consortium and a study co-author added:

Alzheimer s disease is an irreversible brain disease that tends to strike older people. It is progressive#impairing memory destroying motor skills and eventually causing death.

of the MGH Department of Surgery and the Center for Regenerative medicine and senior author of the research paper,

The video analysis data was combined then with clinical input by caregivers to determine pain level scores for each patient.

and more tractable in terms of thinking of human patients. he study is a solid confirmation of previous papers that showed B2m's important role in aging

This means smartphone batteries lose longevity and base stations waste energy and lose money. But Eta Devices has developed a chip (for smartphones)

They also found higher rates of apoptosis or programmed cell death in tumor cells near the capsules.

and building something that s compromised on performance a little bit but increases longevity. A new version of the fish that should be able to swim continuously for around 30 minutes will use pumped water instead of carbon dioxide to inflate the channels

The simple readout could even be transmitted to a remote caregiver by a picture on a mobile phone.

or apoptosis. Tumors that lack p53 can avoid this fate. Usually p53 is the main driver of cell death

If enough of these blockages form the cell undergoes a type of programmed cell suicide called apoptosis

Because mitochondria are involved in apoptosis the researchers wanted to see whether they could induce cell death by targeting MITOCHONDRIAL DNA particularly in cells that are already resistant to regular cisplatin.

The researchers also showed that the cells were dying through apoptosis and not some less-controlled form of cell death.

There are other ways for a cell to die besides apoptosis. You want a therapeutic agent to induce programmed cell death

and other agents but these eventually dissolve, limiting their longevity and effectiveness. Now, Semprus Biosciences, a startup co-founded by two MIT alumni Christopher Loose Phd 7

and other caregivers to begin or continue the necessary treatment. Emergency situations can be brought under control faster injuries can heal more quickly

Because of graphene's nonmagnetic and anti-corrosive properties these probes can also be a very promising technology to increase the longevity of neural implants.

#Researchers develop green tea-based'missiles'to kill cancer cells more effectively Green tea has long been known for its antioxidant, anticancer, antiaging and antimicrobial properties.

"At his Laboratory for Tissue Engineering and Regenerative medicine, Dr. Dvir explored the integration of gold nanoparticles into cardiac tissue to optimize electrical signaling between cells."

Anyhow there are other ways to immortality then what you described. I'd rather just use nanotech to keep the body

and aging population low productivity of the services sector and other challenges plaguing Japan and for developing the robot industry into a growth sector to explore global markets.

#The Times article went on to say that Savioke wasâ interested in a range of service industry applications like assisted living facilities and hotels.

and search and rescue robots and eldercare robots. We are way past the MULTI-BILLION dollars in investments by now.

#regenerative medicine;##agri-science;##advanced materials and nanotechnology;##energy and its storage. Robotics infographicthe IPO report also looks at the rate of robotics patents compared to other innovation patents on a country basis

and a mobile robot to assist older people in their homes and to connect them to family friends

and other devices could help older people live safer more independent lives. The sensors are designed to detect activities like cooking sleeping

They also allow the persons caregivers to monitor their wellbeing remotely and to check for falls.

The Active Assisted living Joint Programme(@AAL JP) is driven an initiative by the EU member states for applied research on ICT products

and services for ageing Well over a hundred projects have been funded since 2008 and it should be continued under H2020:

The European Innovation Partnership on Active and Healthy ageing(@EIP AHA) is a multi-stakeholder partnership to implement innovative ICT-driven technologies for active

and healthy ageing at European scale and to remove barriers that prevent their deployment. One of its six Action Groups focuses on independent living while others deal with related topics like the prevention and early detection of falls and age-friendly communities and environments.

The concept could also be designed to aid with assisted living applications for example. The BCI system was presented at the 6th International IEEE/EMBS Neural engineering Conference in San diego California by team member Dr. Owen Falzon

and rescue 3d bioprinting eldercare robots and a variety of other up-and-coming robotic endeavours. If you liked this article you may also be interested in:

RAS and the ageing population A gap that exists within the current social intelligence is the extent to

which publics might support RAS becoming part of the daily lives for an ageing population (for example measuring the support for homes

From heating bills to Hollywood Researchers say the technology could have major implications for everything from gaming and filmmaking to emergency response and eldercare.

including regenerative medicine strategies involving therapeutic cells, multifunctional drug delivery, surgical implants, and tissue engineered medical products.

who headed the Department of Technology Transfer at PPPL until his recent retirement. Explore further:

Defects in this process can lead to cancer, genetic problems and premature aging. In a research paper published in the Journal of Cell biology, Alessandro Vindigni, Ph d.,professor in the Edward A. Doisy Department of Biochemistry and Molecular biology at Saint louis University

or loss of genetic information that in turn can cause premature aging, cancer, and genetic abnormalities. Depending on the degree of genome instability

this accelerated aging of the retina affects nearly one in four. People with ARMD gradually lose their perception of colors

"said principal investigator Brian N Finck, associate professor of medicine in the Division of Geriatrics and Nutritional Science."

The study aimed to define a set of genes associated with'healthy ageing'in 65 year olds.

The researchers demonstrated that patients diagnosed with Alzheimer's disease had altered an'healthy ageing'RNA signature in their blood,

and it can help contribute to a dementia diagnosis. He noted that this also provides strong evidence that dementia in humans could be called a type of'accelerated ageing

'or'failure to activate the healthy ageing program.''The authors say that their'healthy age gene score'could be integrated to help decide which middle-aged subjects could be offered entry into a preventative clinical trial many years before the clinical expression of Alzheimer's.

which could improve vision in older people with presbyopia and cataracts. As people age, their lenses lose flexibility and elasticity.

patients and caregivers often have difficulty following a treatment regimen. Whether they are dealing with a swallowing disorder

This is good news for the aging Chinese society where hip disease and other issues (necrosis, dysplasia, fractures,

but all the signs are there that bioprinting is one of the ways if not the best way to go forward in many if not all regenerative medicine applications m

#Telomeres Implicated In Premature Aging Scientists have established successfully a comprehensive model of rare accelerated aging disorder, Hutchinson-gilford progeria syndrome (HGPS), opening up the possibility of treatment for the rare disease.

which causes patients to start aging rapidly when they are around one year old. Symptoms include stunted growth and joint abnormalities,

triggers premature cellular aging and slows down cell proliferation, resulting in accelerated aging. It was thought previously that progerin did so through causing the nucleus to be deformed,

thereby weakening the ability of cells to divide and proliferate. But there is more to HGPS than meets the eye.

The damaged telomeres in turn trigger premature cellular aging. While a few studies had reported that telomerase appeared to rescue progerin-induced DNA damage,

thus counteract the effects of progerin on cellular aging, and greatly increase their chances of survival past their teenage years.

and aging, given that telomere damage can cause accelerated aging. Such findings pave the way towards the future possibility of slowing down the aging process,

At the same time, while telomere damage already occurs in normal aging, increased damage has been associated with lifestyle choices such as smoking and obesity.

thus contribute to managing the overall issue of aging as well e

#Next Generation Nebulizer Could Replace Jabs Researchers have developed a nebulizer that could one day deliver lifesaving cancer drugs

a postdoctoral scholar in Healy lab and a California Institute for Regenerative medicine fellow. e designed this system

a postdoctoral scholar in Healy lab and a California Institute for Regenerative medicine fellow. e designed this system

and aims to expand its activities in the field of regenerative medicine and developing medical devices s

Institute, the Donald W. Reynolds Institute on Aging and the Translational Research Institute. It is the only adult Level 1 trauma center in the state.

plugs and kettles inside the flat, dubbed the Personalised Assisted living facility. The sensors will gather data to create a picture of a person's individual habits and needs.

Older people, have been recruited to help the lab scientists assess their work. How do older people respond to an automated machine asking them

if they want to play a game? What happens when Molly, the robot carer, talks to someone who has dementia?

The study aimed to define a set of genes associated with'healthy ageing'in 65 year olds.

and used the information to develop a signature of 150 RNA genes that indicated'healthy ageing'.

In particular, they demonstrated that patients diagnosed with Alzheimer's disease had altered an'healthy ageing'RNA signature in their blood,

and it can help contribute to a dementia diagnosis. This also provides strong evidence that dementia in humans could be called a type of'accelerated ageing

'or'failure to activate the healthy ageing program'."'"Given that early intervention is important in Alzheimer's

This finding is consistent with the theory that aging is associated with stiffening of the arteries.

-Longevity: In testing, cultured tissues live for at least a month. Hoffman-Kim, who is affiliated with the Brown Institute for Brain science

from older people are converted directly into induced neurons. his lets us keep age-related signatures in the cells

so that we can more easily study the effects of aging on the brain, said study author Rusty Gage, a professor in the Salk Institute Laboratory of Genetics.

Researchers believe this technique will be very helpful to scientists studying age-related diseases such as Parkinson and Alzheimer.

This made it difficult to study the aging of the human brain because researchers couldn create aged brain cells. s researchers starting using these cells more,

described ahead of print in the journal Regenerative medicine, bring researchers closer to creating an implantable intestine as replacement therapy for a range of devastating disorders-including infections, cancer and trauma-that result in loss or death of gut tissue.

"says study author Stephen Badylak, D. V. M.,Ph d.,M d.,professor of surgery and deputy director of the Mcgowan Institute for Regenerative medicine at the University of Pittsburgh."

normally undergo molecular aging and turnover,"said senior author Jamey Marth, Ph d.,professor in SBP's NCI-designated Cancer Center."

and alteration of secreted protein aging and turnover is able to change the composition of the circulatory system

Marth and colleagues identified more than 600 proteins in the bloodstream that exhibit molecular signs of undergoing this aging and turnover process.

"In these studies we further saw that the different life spans of distinct proteins are accounted for by the different rates of aging due to N-glycan remodeling,

"Altering this aging and turnover mechanism is the fastest way to change the abundance of a secreted protein,

or deceleration of secreted protein aging and turnover.""The discovery of this mechanism provides a unique window into disease origins and progression,"Marth added."

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