In mouse models, delivering sirna into cancer cells inhibited the expression of Twist, which in turn reduced epithelial-mesenchymal transition
noninvasive reath testthey believe will have the potential to screen for a variety of diseases, including diabetes, infections and cancers.
#Bacterial Computing The riendlybacteria inside our digestive systems are being given an upgrade, which may one day allow them to be programmed to detect and ultimately treat diseases such as colon cancer and immune disorders.
These basic computing elements will allow the bacteria to sense, memorize, and respond to signals in the gut,
such strains are only found at low levels within the human gut, according to Timothy Lu, an associate professor of biological engineering and of electrical engineering and computer science,
In addition, more advanced genetic computing circuits could be built upon this genetic toolkit in Bacteroides to enhance their performance as noninvasive diagnostics and therapeutics. or example,
and other UC Berkeley researchers publicly debuted a system of beating human heart cells on a chip that could be used to screen for drug toxicity.
Dr. Hauser and his team used a mouse model of Pseudomonas aeruginosa (PA) pneumonia to examine how the bacterium uses its secretion system to inject a toxin, called Exos, into cells.
#Software Turns Smartphones into Tools for Medical Research Jody Kearns doesn't like to spend time obsessing about her Parkinson's disease.
Yet since she enrolled in a clinical study that uses her iphone to gather information about her condition,
She taps the phone's screen in a certain pattern, records a spoken phrase and walks a short distance while the phone's motion sensors measure her gait."
'"Smartphone apps are the latest tools to emerge from the intersection of health care and Silicon valley,
and doctors together online, applying massive computing power to analyze DNA and even developing ingestible"smart"pills for detecting cancer.
More than 75,000 people have enrolled in health studies that use specialized iphone apps, built with software Apple Inc. developed to help turn the popular smartphone into a research tool.
Once enrolled, iphone owners use the apps to submit data on a daily basis, by answering a few survey questions
or using the iphone's built-in sensors to measure their symptoms. Scientists overseeing the studies say the apps could transform medical research by helping them collect information more frequently and from more people, across larger and more diverse regions,
than they're able to reach with traditional health studies. A smartphone"is a great platform for research,
"said Dr. Michael Mcconnell, a Stanford university cardiologist, who's using an app to study heart disease."
researchers also say a smartphone's microphone, motion sensors and touchscreen can take precise readings that,
in some cases, may be more reliable than a doctor's observations. These can be correlated with other health or fitness data and even environmental conditions, such as smog levels, based on the phone's GPS locater.
Others have had similar ideas. Google Inc. says it's developing a health-tracking wristband specifically designed for medical studies.
Researchers also have tried limited studies that gather data from apps on Android phones. But if smartphones hold great promise for medical research
experts say there are issues to consider when turning vast numbers of people into walking test subjects.
The most important is safeguarding privacy and the data that's collected, according to ethics experts.
Study organizers also acknowledge that iphone owners tend to be more affluent and not necessarily an accurate mirror of the world's population.
Apple had created previously software called Healthkit for apps that track iphone owners'health statistics and exercise habits.
Senior vice president Jeff Williams said the company wants to help scientists by creating additional software for more specialized apps
using the iphone's capabilities and vast user base-estimated at 70 million or more in North america alone."
"This is advancing research and helping to democratize medicine, "Williams said in an interview. Apple launched its Researchkit program in March with five apps to investigate Parkinson's, asthma, heart disease, diabetes and breast cancer.
For scientists, a smartphone app is a relatively inexpensive way to reach thousands of people living in different settings and geographic areas.
"Smartphones also offer the ability to collect precise readings, Dorsey added. One test in the Parkinson's study measures the speed at
which participants tap their fingers in a particular sequence on the iphone's touchscreen. Dorsey said that's more objective than a process still used in clinics,
who said she already used her iphone"constantly"for things like banking and email.""I figured that participating would help my family and friends,
But by reaching more people and gathering more data, advocates say smartphone apps can help doctors answer more subtle questions about a disease."
a genomics professor who's using an iphone app to study asthma at New york's Icahn School of medicine at Mount sinai."
transmitting their instructions in real time via internet from their home country. By virtue of its video camera, screen and wheels, the robot, located in an EPFL laboratory, was able to film itself as it moved
while displaying the face of the remote pilot via Skype. The person at the controls,
as if moving in place of the robot, was able to interact with whoever the robot crossed paths with. ach of the 9 subjects with disabilities managed to remotely control the robot with ease after less than 10 days of training,
and the computer, allowing the pilot to rest while navigating. No difference between healthy and disabled subjects In the end
Mature technology available The positive results of this research bring to a close the European project called TOBI (Tools for Brain-Computer Interaction
The varied approaches were effective in"recruiting"protective monocytes to"lesion sites"in the brain,
extracted from the bone marrow of healthy mouse donors and grafted into the bloodstream, can migrate into the brains of sick mice,
Koronyo added that the study gives unprecedented details about monocyte numbers migrating into brain lesion sites
#Smartphone-Based Device That Reads Medical Diagnostic Tests Quickly And Accurately Created, University of California,
Los angeles (UCLA) Reveals UCLA Researchers Create Smartphone-Based Device That Reads Medical Diagnostic Tests Quickly And Accurately Enzyme-linked immunosorbant assay,
A team of researchers from the California Nanosystems Institute at UCLA has developed a new mobile phone-based device that can read ELISA plates in the field with the same level of accuracy as the large machines normally found in clinical laboratories.
and two other undergraduates also contributed to the research. t is quite important to have these kinds of mobile devices,
and attaches to a smartphone, illuminates the ELISA plate with an array of light-emitting diodes. The light projects through each well and is collected by 96 individual plastic optical fibers in the attachment.
The smartphone transmits the resulting images to UCLA servers through a custom-designed app. The images are analyzed then by a machine-learning algorithm that the researchers wrote for this purpose,
and the diagnostic results are sent back to the phone within about one minute for the entire 96-well plate.
The app also creates a visualization of the results for the user. This mobile platform was compared with the standard FDA-approved well-plate readers in a UCLA clinical microbiology laboratory.
The ELISA tests included those for mumps, measles, and herpes simplex viruses 1 and 2. With a total of 571 patient samples used in the comparison,
and are looking to adapt the basic design of this ELISA cellphone reader to create smartphone-based quantified readers for other important medical tests,
#Detecting potent tumors using a smartphone! Ms Maryam Sadeghi shows off an early version of Molescope (Picture courtesy:
an innovative hand-held tool that uses a smartphone to monitor skin for signs of cancer.
Molescope comprises a mini-microscope that attaches to a smartphone, an app (ios, Android, or web compatible) and a cloud-based analytical platform called Dermengine.
Once people take high-quality, high-resolution images of suspicious moles or skin abnormalities, they can archive images
a sensor comprising multiple tiny test sites. The chip, known as proteo, functions by attracting a faintly luminous substance found in cancer patients,
I have noticed a promising trend the rise of open source drug R&d consortia that include large biotech
and this has been flat for nearly 20 years (See this blog post)..Other challenges I see include low commercial investment in pediatric medicine and devices, development of effective therapeutics for neurodevelopmental disorders,
drawing on the expertise of our external advisory board made up of pharma, device, diagnostic and software experts,
Leaders from companies like IBM Vertex and Johnson & johnson will interact with thought leaders from leading children hospitals in the US
Bayer developed an entire website page dedicated to bee care. It holds general information on bees and
How Innovation is Transforming Agriculture Data analysis and computational technologies are giving farmers the ability to monitor their land better,
and allow them to access information quickly through their smartphones. Nanette Byrnes, writer for the MIT Technology Review, calls this the ew food economy. y combining this information with data generated by soil sensors and weather reports,
and is popular among Google Ventures, Silicon valley, and Monsanto investors. Such investments led to the creation of water sensors and drones
Larrabee uses his smartphone or tablet to log on to see that data, which is available almost instantaneously.
It is nearly common knowledge that by 2050 farmers will struggle to feed the massive growing population;
#Computers can now see images Artificial intelligence has graduated past the infancy stage of figuring out what's in an image.
Computers have previously been capable of little more than a simple game of I Spy: Name a specific object or person,
The research was conducted by a team comprised of experts from the Chinese Internet search company Baidu and a student at the University of California at Los angeles,
and coincides with similar research from Microsoft, Virginia Tech, and various other academic institutions that came out recently."
"Our goal is to enable the computer to connect language with experiences in the physical world,
"says Wei Xu, a distinguished scientist in Baidu's research group.""This is important for solving the problem of common sense reasoning."
"Bloomberg put the Baidu and UCLA system to its own test. I took a picture of a small citrus fruit in the palm of my hand,
and sent it to Baidu with the question, "What is in the centre of the hand?"
"The software answered:""An orange."("It's actually a satsuma, but we'll let it slide.)
but teaching computers to discern what's inside of images and associate them with language has proved immensely challenging.
when we may be able to ask a search engine like Google or Baidu to ferret through millions of images,
The development from Baidu and UCLA, while important, is far from perfect. The system can't handle multiple questions in a row
Creating computers that can look at images and answer specific questions about them"has the distinctive advantage of pushing the frontiers on'AI-complete'problems,
"Microsoft says.""Given the recent progress in the community, we believe the time is ripe to take on such an endeavour."
Baidu is interested in other aspects, too.""In the future, potential applications are education and mobile image search,
With the new research, computers have reached a milestone, not unlike that of many young kids figuring out the world.
#Soon, a Mastercard phone app to verify online payments via selfies Mastercard is experimenting with a smartphone app
Users will have to download the Mastercard phone app and at checkout they will be asked to hold up their phone to stare
and blink at it.""The new generation, which is into selfies...I think they'll find it cool.
Currently, users can set up something called"Securecode, "which requires a password when shopping online. However, passwords can be forgotten,
Mastercard said it has partnered with every smartphone maker to make this method of verification possible.
They can choose fingerprint or facial recognition. Users who choose facial recognition have to stare at the phone and blink once.
Mastercard's security researchers believe blinking is the best way to prevent a thief from just holding up a picture of a person
Mastercard said it does not actually get a picture of the user's finger or face.
The facial recognition scan will map out a user's face, convert it to 1s and 0s and transmit that over the Internet to Mastercard.
Bhalla said Mastercard is also experimenting with voice recognition, so people may be able to simply approve an online transaction by speaking to their phone.
Mastercard is also working with a Canadian firm Nymi, to develop technology that will approve transactions by recognising a person's unique heartbeat t
#Google wants you to buy things straight through Youtube videos (GOOG) Youtube is rolling out a new feature that will let advertisers easily lists goods that they are selling alongside or within their video ads.
and links to their websites on their videos. Now, Youtube is linking videos ads into the same dashboard it uses for Google Shopping,
so instead of manually connecting individual products and ads, advertisers can have added product links automatically. Essentially, Google its taking the technology and infrastructure it built for Shopping
and letting advertisers use it in on Youtube.;With Trueview ads, which the company launched five years ago,
Google only charges advertisers if a viewer doesn't skip their ad and watches for at least 30-seconds or to the end of the video (whichever is less.)
When it rolled out cards, it started charging either for a click or a full-view,
The key is that Youtube bets the greater emphasis on this shopping element will make its ads more effective.
and then the more that Youtube can charge per view. Trueview for shopping is optimized for both desktop and mobile."
"Advertisers had used annotations in the past to make their videos interactive, but these didn't work on all screens
and viewers didn't always know what to expect, "Youtube product Manager Avi Fein told Business Insider via email."
"So with cards and Trueview for shopping we created a very consistent experience that creates a much more engaging and interactive format for viewers."
"Along with the feature announcement, Google also stressed that people are using Youtube to help them make shopping decisions more than ever.
There are now more than 1 million channels on Youtube focused on product reviews, and views of those videos have grown 50%year-over-year.
For example, Wayfair said it saw a 3x revenue increase per ad impression served over its previous Youtube campaigns.
This rollout comes not long after the Wall street journal reported that Google plans to roll out a new"buy"button in its Google Shopping search results that will let users make a purchase without being shuttled to a brands website e
the bulk collection of American phone records by the National security agency will no longer be permitted legally, Spencer Ackerman of the Guardian reports.
since October 2001 that US phone calls weren't collected en masse from America's three largest telecommunications providers.
for another 90-day extension of the order needed to continue the collection of domestic phone records. e did not file an application for reauthorization,
Mcconnell, whose bill would continue all phone-records collection by the FBI and NSA, and the rest of the Senate will meet again on May 31.
At that point, discovery was done by literally printing out every possible relevant e-mail for attorneys to sift through.
That print shop got tapped to print the emails for the landmark 2001 Microsoft antitrust case. Wilson recalls printing out piles and piles of Bill gates'and Steve Ballmer's emails
boxing them up, putting them on trucks, and delivering them to the courthouse, where as many as 300 attorneys would be searching them for anything relevant to the case."
"The way you pay for ediscovery software from legacy vendors like HP Autonomy and Symantec involves a lot of nickel-and-diming, according to Wilson.
First, you pay for the ediscovery software itself. Then, you pay for having your data processed. Then, you pay to keep your files in the system until the case is resolved
which can take a while, since some lawsuits can take years. Even once those documents are in the ediscovery software,
it usually goes into"really s---y databases, "Wilson says. You can search by keyword,
you could only access the database from a Windows computer running an outdated version of Internet explorer,
Wikimedia Commonsbill Gates gives his deposition during the landmark United states v. Microsoft case. Logikcull got its start as Logik. com,
Even without outside investment, Logikcull was able to hire the experts it needed to develop a browser-based, computer-plus-smartphone software solution,
what it will be like to use the iphone as a remote control for your entire home (AAPL) The first home appliances that will work with Homekit, Apple's platform for connecting all of the devices in your home,
and door locks that you can control with your iphone, Apple has added a new support page with a few new details about
including what role the Apple TV will play in it. Here are a few interesting things we learned:
-You'll need an Apple TV if you want to control your home appliances when you're not at home.
Apple's support page says you'll need a third-generation or later Apple TV running software 7. 0 or after.
As long as you're signed into the same Apple ID account on your iphone and Apple TV,
There's an option to group together gadgets in some third party apps for certain Homekit accessories. It's important to remember that this option might not be available for all Homekit devices, though.
#This US military-funded security company can tell who you are just from the way you touch your phone Passwords could soon be going the way of the dodo as digital security gets more sophisticated.
move your mouse or touch your phone screen. Behaviosec tracks these movements and maps them against past interactions to see
or pressing a phone screen harder the company will let the bank know it thinks someone else is trying to get into your bank account.
"Behaviosec's tech plugs directly into banks apps and websites, so even if you've never downloaded it you may have used it.
and software licensing as people wouldn't be able to share passwords a
#All of Germany just signed up to this micropayment app that people think is the future of news on the web Blendle,
the Dutch startup that allows users to pay small micropayments for individual newspaper and magazine articles rather than having to sign up to digital subscriptions,
has signed just up all the major German national newspapers to its service. Not just some of them all of them.
Blendle users register and enter their credit-card details just once. The service creates a type of digital newsstand that serves a feed of stories about the topics users are interested in,
trending stories, and those that have been curated by their friends or celebrities and public figures.
When users click on a headline, the app or website takes a small payment, with revenue split roughly 30/70 between Blendle and the publisher.
And if readers don't like an article they can get an instant refund if they provide feedback on what wasn't to their liking.
and Alexander Klöpping says it has attracted more than 300,000 users to date. It says Blendle has generated more revenue for Dutch publishers where most of its users are based than Apple.
Back in March The New york times (which is also an investor in Blendle, alongside the German publisher Axel Springer), The Washington post,
"In May, Facebook partnered with nine major news publishers to launch Facebook Instant, a feature that allows the publishers to publish directly to Facebook's mobile app.
And in April Google created a#150 million fund for journalism in Europe, partnering with eight European publishers to invest in training
and research n
#Intel is spending $125 million to solve one of the biggest problems in Silicon valley (INTC) Intel is opening its wallet to solve one of the biggest problems in Silicon valley:
gender and racial imbalance in the workforce. On Tuesday, Intel's investment arm, Intel Capital, launched a new $125 million fund intended to boost women and minority representation in tech.
The fund, called Intel Diversity Fund, will invest in startups run by women and underrepresented minorities.
At launch, it's already committed to invest in and share its network and expertise with four startups, including Brit+Co, Carecloud, Mark One,
and ultimately to benefit Intel and the broader economy through its success,""Intel CEO Brian Krzanich said in a statement.
Today's announcement is part of a bigger plan by Intel, revealed in January called Diversity in Technology initiative.
The plan is to spend $300 million to help train more female engineers and computer scientists,
and to achieve full representation of women and underrepresented minorities in the US workforce by 2020.
'Israel unleashed one of the world's most sophisticated cyber weapons on the Iran talks The computers in three luxury hotels that hosted high-stakes negotiations on Iran's nuclear program were infected with an improved version of one
and borrowed so heavily from Duqu that it'could not have been created by anyone without access to the original Duqu source code,"according to the Journal and Kaspersky's report.
extract files, track any activity that occurs on the infected Windows PC or laptop,"Jeff Bardin,
"This includes the capturing of user ids, passwords, and sensitive files.""Bardian added:""Once the code is installed,
Trojan) on computers through which it sucks information from networks by actions Bardin described as functions of Duqu.
#It's no longer all about ads ere's how publishers, streaming sites, and apps are using subscriptions to boost revenues
While ads account for the bulk of revenue at most publishers, music streaming sites, and on apps, the subscription model is gaining traction.
Internet companies are exploiting the opportunity to boost ARPU (average revenue per user), helped along by recurring payments from a subscriber base.
the categories are video, music, news publishing, social networks/messaging, and dating apps. Access The Full Report And Data sets By Signing Up For A Trial Membership Here are some of the key takeaways:
The proportion of paying subscribers within the total user base varies considerably across digital media industries.
Here are some of the proportions of subscribers in apps'user bases: Spotify (25%),Whatsapp (21%),Pandora (5%),Match Group (5%),The New york times (3),
%and Linkedin (2%).The report is full of charts, data, and case studies that can easily be downloaded
#Dropbox found a brilliant way to add a lot of new users by killing email attachments On Wednesday,
allowing users to request and receive files from non-Dropbox users. The goal is to make sharing big files even easier,
and possibly replace email attachments. But the service is designed cleverly in a way that also introduce Dropbox to a ton of new users.
The way it works is pretty simple: users send out file requests by email, and the recipient can upload files up to 2gb in size to a designated Dropbox folder,
without having to log in. For example, teachers can collect homework assignments all in one go in a single folder,
from both existing and non-Dropbox users, forgoing the need to go through multiple email attachments or physical copies.
This could potentially replace email attachments, as it offers bigger file limits and a more convenient way to upload files.
But the bigger play here is to introduce Dropbox to a much larger set of people.
multiple people, some of whom may not be Dropbox users yet, will get to try Dropbox. Dropbox calls it a any-to-onesharing model,
where a single file request attracts a group users. That means the new file request feature could play an even bigger role for Dropbox once it becomes available for Dropbox for Business in the next few weeks.
It available for Dropbox Basic and Pro users from today. Dropbox is counting on Dropbox for Business,
and sharing is far more common among business users than consumers, Dropbox could tap into a huge untapped market whol get introduced to its service for the first time through a simple file request.
Dropbox is by far the most popular file sync and sharing service, with over 300 million users worldwide.
It has over 100,000 business users, including MIT, Under Armour, and Hyatt
#Scientists made a major breakthrough in 3d printed electronics that will keep you from ever drinking spoiled milk again Researchers have used 3d printing to develop a sensor that can be placed inside a carton of milk to detect
This represents a breakthrough in terms of three dimensional printing of electronic circuits. Polymers are poor conductors of electricity
"One day, people may simply download 3d printing files from the Internet with customized shapes and colors and print out useful devices at home."
The research has been published in the journal Microsystems & Nanoengineering, in an article headed"3d printed microelectronics for integrated circuitry and passive wireless sensors. e
and perforated to guide users in construction, but features no written instructions, making it universally understandable.
Recently, Prakash also developed a computer than runs on water droplets. The droplets are suspended in a magnetic field
effectively serving as a computer clock, an essential piece of any working computer. More than just helping combat disease
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