Using computer-generated model speeds up the drug discovery process The new drug-like compounds discovered by Vogel
and her co-authors offer hope that using a computer-generated P-gp model, explained here http://bit. ly/1lvmr7a,
Researchers virtually screened 15 million drug-like compounds via SMU supercomputer The SMU researchers discovered the three hit compounds after virtually screening more than 15 million small drug-like compounds made publically available
San francisco. Using SMU's Maneframe high performance computer, Wise ran the compounds through a computer-generated model of P-gp.
The virtual model, designed and built by Wise, is the first computational microscope of its kind to simulate the actual behavior of P-gp in the human body,
One purpose of this experiment was to show we could integrate bacterial catalysts with semiconductor technology.
especially the catalysts that convert water and carbon dioxide into sugars at room temperatures.""This is not about mimicking nature directly
One purpose of this experiment was to show we could integrate bacterial catalysts with semiconductor technology.
especially the catalysts that convert water and carbon dioxide into sugars at room temperatures.""This is not about mimicking nature directly
therefore very important and contribute to the outlook where only five out of ten patients will survive for at least five years."
By combining Scales with Abscale--a variation for immunolabeling--and Chemscale--a variation for fluorescent chemical compounds--they generated multicolor high-resolution 3d images of amyloid beta plaques in older mice from a genetic mouse
As well as offering new opportunities for industry, it will stimulate the search for even better basic catalysts
#Building the electron superhighway TV screens that roll up. Roofing tiles that double as solar panels. Sun powered cell phone chargers woven into the fabric of backpacks.
photorealistic computer simulations allowing university and high-school students as well as the general public to virtually access unique instruments."
The engaging software was developed together with university and high-school students and was tuned fine by periodic didactic input.
In addition to Kang and Lerner, authors of the study,"Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signaling,"were Bo-Ram Bang, Kyung Ho Han
The oviductosomes from a female mouse were labeled pre with a fluorescent dye and incubated together with the sperm.
and printer right at the hospital to create custom nerve guides right on site to restore nerve function."
The computational elements in Safepay consist of a mobile device and a server which distributes disposable credit card numbers.
The physical entity is the magnetic credit card chip controlled by a mobile application inside a customer's mobile device.
The paper outlines the overall architecture and server-side deployment model the design of Safepay, prototype implementation and security analysis. Here's how it works:
which communicates with the bank server. During transactions, the mobile application acquires disposable credit card numbers from the bank server,
generates a wave file, plays the file to generate electrical current, and then drives the magnetic card chip via an audio jack
and print concentrated viscoelastic inks that allow for the simultaneous control of composition and geometry during printing.
and re-scan it--repeating the process until the desired spatial resolution is achieved--before combining the data from each scan using a computer algorithm.
This is a crucial step in creating a new generation of foldable electronics--think a flat-screen television that can be rolled up for easy portability--and implantable medical devices.
The researchers used mouse embryonic fibroblast cells to determine biocompatibility; that, along with the fact that the stretchability of gold nanomesh on a slippery substrate resembles the bioenvironment of tissue
a two-drug combination discovered by UF Health researchers that inhibits tumors and kills cancer cells in mouse models.
Researchers then tested its effectiveness on human pancreatic cells that had been implanted in mouse models. Daily doses of the compound reduced tumor volume by about 50 percent after 25 days, they found.
In testing on two mouse cell lines, the drug combination reduced the viability of cancer cells by about 50 percent
This is an important step on the way towards optical computers. Phase change materials that change their optical properties depending on the arrangement of the atoms allow for the storage of several bits in a single cell.
With optical elements, computers can work more rapidly and more efficiently. Optical fibers have long since been used for the transmission of data with light.
But on a computer, data are processed still and stored electronically. Electronic exchange of data between processors and the memory limits the speed of modern computers.
To overcome this so-called Von neumann bottleneck, it is not sufficient to optically connect memory and processor,
as the optical signals have to be converted into electric signals again. Scientists, hence, look for methods to carry out calculations and data storage in a purely optical manner.
but also with latest processors,"Professor Harish Bhaskaran of Oxford university adds. The new memory can store data for decades even
Permanent all-optical on-chip memories might considerably increase future performance of computers and reduce their energy consumption.
Against the backdrop of healthy mouse tissue, rogue metastatic cells from the human tumor stick out like flares.
The researchers developed a new method using flow cytometry that let them capture individual human metastatic cancer cells traveling through the mouse's blood
Whereas 44 percent of control mice (11 of 25) developed secondary tumors within four weeks, researchers could only find metastatic cells in one drug-treated mouse (4 percent.
The respondent is shown an object (for example, a dog) on a computer screen, and the second participant,
With the click of a mouse, the inquirer sends a question and the respondent answers"yes"or"no"by focusing on one of two flashing LED LIGHTS attached to the monitor,
which flash at different frequencies. A"no"or"yes"answer both send a signal to the inquirer via the Internet
or by the brain signal transmission being interrupted by hardware problems.""While the flashing lights are signals that we're putting into the brain,
on brain-computer interfaces that enable people to activate devices with their minds. In 2011, Rao began collaborating with Stocco
Traditional perovskites are typically metal-oxide materials that display a wide range of fascinating electromagnetic properties,
were randomised to receive either 60 mg a day of cabozantinib in tablet form, or 10 mg a day of everolimus, also in tablet form.
Their disease had to have progressed within six months of receiving prior treatment with VEGFR tyrosine kinase inhibitor (TKI) therapy.
Because we use essentially the same device technology as existing computer chips, we believe it will be much easier to manufacture a full-scale processor chip than for any of the leading designs,
which rely on more exotic technologies.""This makes the building of a quantum computer much more feasible,
since it is based on the same manufacturing technology as today's computer industry, "he added. The advance represents the final physical component needed to realise the promise of super-powerful silicon quantum computers,
which harness the science of the very small--the strange behaviour of subatomic particles--to solve computing challenges that are beyond the reach of even today's fastest supercomputers.
In classical computers, data is rendered as binary bits, which are always in one of two states:
"The silicon chip in your smartphone or tablet already has around one billion transistors on it, with each transistor less than 100 billionths of a metre in size,"said Dr Menno Veldhorst,
"He said that a key next step for the project is to identify the right industry partners to work with to manufacture the full-scale quantum processor chip.
Such a full-scale quantum processor would have major applications in the finance, security and healthcare sectors, allowing the identification
Virginia--a liquid-cooled FPGA was operated using a custom processor architecture provided by Altera. With a water inlet temperature of approximately 20 degrees Celsius and an inlet flow rate of 147 milliliters per minute
However, the same technology could also be used to cool CPUS, GPUS and other devices such as power amplifiers,
'We were able to understand this effect by performing extensive numerical computer simulations of the electronic properties
Preclinical studies using mouse models of bladder cancer have demonstrated the efficacy of the mycobacterium M. brumae in the treatment of this disease.
#Groundbreaking computer program diagnoses cancer in two days In by far the majority of cancer cases, the doctor can quickly identify the source of the disease, for example cancer of the liver, lungs, etc.
and created a new diagnostic technology based on advanced self learning computer algorithms which--on the basis of a biopsy from a metastasis--can with 85 per cent certainty identify the source of the disease
The pattern of mutations is analysed in a computer program which has been trained to find possible primary tumour localizations.
and represent it on a computer screen. In this article, Inserm researchers, using MRI, have succeeded in detecting natural shear waves in the brain using computational techniques borrowed from seismologists and known as"noise correlation."
#New graphene based inks for high-speed manufacturing of printed electronics A low-cost, high-speed method for printing graphene inks using a conventional roll-to-roll printing process,
the first time that graphene has been used for printing on a large-scale commercial printing press at high speed.
"Being able to produce conductive inks that could effortlessly be used for printing at a commercial scale at a very high speed will open up all kinds of different applications for graphene and other similar materials.""
which is in line with commercial production rates for graphics printing, and far faster than earlier prototypes.
it could also initiate entirely new business opportunities for commercial graphics printers, who could diversify into the electronics sector."
and the Cambridge area in particular, has always been strong in the printing sector, but mostly for graphics printing and packaging,"said Hasan, a Royal Academy of Engineering Research Fellow and a University Lecturer in the Engineering Department."
"We hope to use this strong local expertise to expand our functional ink platform. In addition to cheaper printable electronics, this technology opens up potential application areas such as smart packaging and disposable sensors,
But there's a step needed before optical connections can be integrated into telecommunications systems and computers:
Then, using a computer-controlled light projector, the team was able to control the speed of the cardiac waves,
In the short term, the ability to provide fine control means that researchers are able to carry out experiments at a level of detail previously only available using computer models.
what one can do in a computer model, except here it was done in real heart cells, in real time.'
"Zhang, lead authors Lucia Wu and J. Sherry Wang and their colleagues have written software to help researchers design their own probes.
Interestingly, a subsequent challenge with a lethal strain of mouse malaria parasite in these vaccinated animals showed considerable protection against malaria.
When you plug a device like a computer into the wall, electronic circuitry in the computer's power supply converts the AC oscillations into direct current (DC) that the device can use.
The AC to DC conversion is done by an electronic component called a rectifier. Similarly, electromagnetic oscillations in the air can be turned into DC current by a device called a rectenna,
Park's team uses software to analyze how the nanoscale topology of a surface--its bumps
The researchers also used computer modeling to design a bowtie-shaped antenna that would effectively capture the enhanced thermal emission.
reflectors, and USB detectors, combined with the all-plastic housing and lenses will allow for future versions of the prototype to be mass-produced d
and Ear/Harvard Medical school and Boston University have shown successfully neuroprotection in a Parkinson's mouse model using new techniques to deliver drugs across the naturally impenetrable blood-brain barrier.
computers and even gym facilities,"said Egidijus Auksorius, postdoctoral researcher, The Langevin Institute. Despite the widespread use of commercial fingerprint sensors, problems with the devices persist,
An LVAD is composed of a computer controller, a power pack and a reserve power pack that remain outside the body
#New research paves the way to begin developing a computer you can control with your mind A team of researchers led by Angelika Lingnau, from the Department of psychology at Royal Holloway,
and could be the first step in the development of brain-computer interfaces. Dr. Lingnau and her team used functional magnetic resonance imaging (fmri)
In mouse models of human glioblastoma, one molecule they found shrank the average tumor size by half.
as well as the San diego Supercomputer Center and Department of Neurosciences at UC San diego.""But we addressed this challenge
Canada and high-performance workstations at the San diego Supercomputer Center to run the search. With this approach, the researchers identified a few molecules that would likely fit the OLIG2 interaction.
The most effective of these candidate drug molecules, called SKOG102, shrank human glioblastoma tumors grown in mouse models by an average of 50 percent."
The discovery of magnetoresistance paved the way for magnetic field sensors used in hard disk drives and other devices,
We found that a bilayer structure of graphene and boron nitride displays an extremely large response with magnetic fields.
and finding applications as thermal switches, hard drives and magnetic field sensors. Our technology can even be applied to flexible applications,"added Assoc Prof Yang.
a portable USB-powered film scanner to image the test strips; and a portable computer for real-time data analysis.
The entire system can be carried in a small briefcase, handbag or laptop case, and requires just one operator with minimal training to conduct the test within 15 minutes--with no need for additional equipment or instruments.
One of the remarkable features of the lab-in-a-briefcase is that it uses whole blood without the need for any sample preparation--a previously challenging task outside of a laboratory setting.
and where one can place a saliva sample showing the results through a software. The director of FEMSA Biotechnology Center mentions that he considered using the camera phone to detect the marker in saliva,
By implementing Imsane as an open source MATLAB toolbox the KITP researchers provide a practical, highly accessible tool for data reduction and analysis of layered tissues.
which exceeds the hard drive capacity of most computers and would take 100 hours to transfer with a good Internet connection,
"The program is especially useful for biologists who otherwise would have to acquire the skillset and hardware to handle large data
Scientists have experimented for decades with a class of catalysts known as zeolites that transform alcohols such as ethanol into higher-grade hydrocarbons.
Instead, an energy-producing"hydrocarbon pool"mechanism allows the zeolite catalysts to directly produce longer hydrocarbon chains from the original alcohols."
#Researchers develop 3-D printing method for creating patient-specific medical devices A team of researchers at Northeastern University has developed an innovative 3-D printing technology that uses magnetic fields to shape composite materials
"Others have used composite materials in 3-D printing, says Joshua Martin, the doctoral candidate who helped design
Erb and Martin's 3-D printing method aligns each minuscule fiber in the direction that conforms precisely to the geometry of the item being printed."
"The magnets are the defining ingredient in their 3-D printing technology. Erb initially described their role in the composite-making process in a 2012 paper in the journal Science.
They then apply ultralow magnetic fields to individual sections of the composite material--the ceramic fibers immersed in liquid plastic--to align the fibers according to the exacting specifications dictated by the product they are printing."
layer by layer, using a computer-controlled laser beam that hardens the plastic. Each six-by-six inch layer takes a mere minute to complete."
#3-D printed'building blocks'of Life scientists have developed a 3-D printing method capable of producing highly uniform'blocks'of embryonic stem cells.
"Our next step is to find out more about how we can vary the size of the embryoid body by changing the printing and structural parameters,
#3-D-Printed Device Helps Computers Solve Cocktail-party Problem Artificial-intelligence researchers have struggled long to make computers perform a task that is simple for humans:
In their proof-of-concept study, they sent light from the LED through an optical fiber to stimulate neurons in mouse brain slices.
CITIES have created various open source resources to help people launch further schemes in other neighborhoods. What other forms of waste can also be reused in educational, community-building ways y
The Heattech Mirror visually displays the wearer body temperature rising in the mirror. The smart mirror is connected to a thermal camera
390 gram (0. 9-pound) Robohon sports a 2-inch touchscreen, a quad-core CPU, and can connect to 3g, LTE,
A Sharp spokesperson tells Tech in Asia that the robot has an original operating system that not based on Android (the company consumer smartphones have traditionally been powered by Google OS.
The company uses both hardware and software solutions to achieve this. Its system, bearing the catchy name Jamsdefender, combines active noise cancellation, digital volume normalization,
On the software side a method the company calls digital decibel equalizer technology normalizes the volume at a safe level.
The target was quite modest, especially for a hardware campaign, but the team says it had to balance estimated costs with a realistic crowdfunding target that wouldn deter backers by appearing too lofty.
The scientists analyzed the process using computer simulations to determine the best method of injecting the material
It a step towards enabling computers to process information hundreds of times faster than today machines.
Computers currently shuttle information around using electricity traveling down nanoscale metal wires. Although inexpensive and easy to miniaturize,
At a maximum voltagelose to the voltages used in today computer chipshe gap narrows, slowing the plasmons.
or suppress infection in mouse and nonhuman primate models of HIV. But these animal models are very rough approximations of human infections,
and being hooked up to a battery about the size of a small laptop computer whenever they want to go out and about.
which computers are turned loose on huge data sets to look for patterns. To make machine-learning applications easier to build,
computer scientists have begun developing so-called probabilistic programming languages, which let researchers mix and match machine-learning techniques that have worked well in other contexts.
At the Computer Vision and Pattern Recognition conference in June MIT researchers will demonstrate that on some standard computer-vision tasks,
short programs less than 50 lines long written in a probabilistic programming language are competitive with conventional systems with thousands of lines of code. his is the first time that wee introducing probabilistic programming in the vision area,
By the standards of conventional computer programs those odelscan seem absurdly vague. One of the tasks that the researchers investigate,
and Pushmeet Kohli of Microsoft Research Cambridge. For their experiments, they created a probabilistic programming language they call Picture,
Even though their computers were painfully slow by today standards, the artificial intelligence pioneers saw that graphics programs would soon be able to synthesize realistic images by calculating the way in
Kulkarni and his colleagues considered four different problems in computer vision, each of which involves inferring the three-dimensional shape of an object from 2-D information.
Built into Picture are several different inference algorithms that have fared well on computer-vision tasks.
if the learning machinery is powerful enough to learn different strategies for different tasks. icture provides a general framework that aims to solve nearly all tasks in computer vision,
who was involved not in the work. t goes beyond image classification the most popular task in computer vision
and tries to answer one of the most fundamental questions in computer vision: What is the right representation of visual scenes?
an approach that is not commonly used for this kind of screen. nitially, the screening results appeared to not have positive hits,
#Computer-Designed Rocker Protein Worlds First To Biomimic Ion Transport For the first time, scientists recreated the biological function of substrate transportation across the cell membranes by computationally designing a transporter protein.
Simulations on the Stampede supercomputer of the Texas Advanced Computing Center (TACC) bridged the gap between the drawing board
The molecular dynamics simulations were about a microsecond of aggregate simulation time with classical force fields using the NAMD software program.
The computer allocation was made through XSEDE, the Extreme Science and Engineering Discovery Environment, a single virtual system funded by the National Science Foundation (NSF) that scientists use to interactively share computing resources,
000 cores of the Stampede supercomputer. Grabe was cautious about the potential application of this research,
uses high-throughput computer screening to calculate the properties not only of these three components but also their interactions with each other. f we can come up with an electrolyte that has a higher electrochemical window for multivalent batteries,
Using the supercomputers at Berkeley Lab National Energy Research Scientific Computing Center (NERSC), the researchers can screen hundreds of molecules per day.
and significantly increased survival in a mouse model of pancreatic neuroendocrine tumor. Bergers noted that the discovery potentially gives physicians a way to determine how effective anti-VEGF therapy might be in individual patients
says Chris Chang, an expert in catalysts for carbon-neutral energy conversions. n our system, nanowires harvest solar energy and deliver electrons to bacteria,
the researchers reproduced the hyperexcitability of epileptic neurons in mouse brains in vitro. They then injected GABA,
With a panel of 40 markers Montgomery and her colleagues have already been able to discern distinctions between NK cells derived from the two patient groups.
light photo-catalysts and ferroelectric materials in electronics. nalogous to the best metallic conductors such as copper or silver where the current is transported by electron, in d-Bismuth oxide
and others to feel the environments they inhabit through the likes of three-dimensional heads-ups displays. The prototype glove introduced at the George R. Brown School of engineering Design Showcase
so you can hook this up to a video game and when you reach out and grab a virtual object,
but they say programmers should find it fairly simple to implement the glove protocols into their games and other projects.
and might one day lead to microprocessors that are 100 times smaller than the ones in today computers.
The team used mouse models of asthma and human airway tissue from asthmatic and non-asthmatic people to reach their findings.
Many interesting and important structures in biological cells and computer chips have features smaller than that.
From several pictures under different illuminations, a single high-resolution image is constructed in the computer. So far, scientists have selected carefully the clearest glass optics for such imaging.
Multiple low resolution images of the object are combined then in the computer which leads to a clear image. he resolution improvement looks like the fog has clearedsays Hasan Yilmaz,
OS e
#Against the Stream Scientists have created microbe-sized beads that can utilize energy in the environment to self-propel upstream by purely physical means.
and the controller transmits it wirelessly to a smartphone or tablet, which then informs the diabetes patient that it is time to change foot position
or reconfigure the hardware to recover from a failure, on the fly. In March, the team tested the autonomous mission-planning system during a research cruise off the western coast of Australia.
but this is the first device that combines the imaging technology with hardware and software automation to create a complete diagnostic solution,
said Daniel Fletcher, an associate chair and professor of bioengineering, whose UC Berkeley lab pioneered the Cellscope. he video Cellscope provides accurate,
microcontrollers, gears, circuitry and a USB port. Control of the device is automated through an app the researchers developed for this purpose.
With a single touch of the screen by the healthcare worker, the phone communicates wirelessly via Bluetooth to controllers in the base to process
The worm count is displayed then on the screen. Fletcher said previous field tests revealed that automation helped reduce the rate of human error.
starting from the time the sample is inserted to the display of the results. Pricking a finger
paving the way for high-density storage to move from hard disks onto integrated circuits. This image taken from a computer simulation shows nanomagnets tilted at various angles,
with the white regions indicating greater angles of tilt. Researchers have found that even a small tilt of 2 degrees will facilitate magnetic switching.
in the Proceedings of the National Academy of Sciences, will lead to computers that turn on in an instant,
we want to be able to manufacture a computer chip that includes memory so that it is close to the computational action,
which is why magnets have not yet been integrated onto computer chips. Instead, there are separate systems for long-term magnetic memory.
These include a computer hard disk drive where data are stored and the various kinds of random-access memory,
or RAM, on the integrated circuits of the central processing unit, or CPU, where calculations and logic operations are performed.
A large portion of the energy used in computing is spent on transferring data from one type of memory to another.
However, the tool also runs on standard computer workstations commonly used by the electric industry.
and color of optical materials used in computer screens along with other consumer products. The work is centered on enhancing the arrangement of colloidsmall particles suspended within a fluid medium.
a graduate researcher at the Wyss Institute who is pursuing his Ph d. in Engineering sciences from Harvard university. f we compared this to controlling a computer,
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