Synopsis: 5. medicine & health: 1. diseases: Diseases:


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and therefore the risk of cardiovascular disease a new study has found. However most people in North america would have to more than double their consumption of these foods known as pulses to reach that target said the researchers at St michael's Hospital.

He said that would translate into a five to six per cent reduction in the risk of cardiovascular disease the leading cause of death in the United states. One serving of pulses is 130 grams

Some study participants reported stomach upset such as bloating gas diarrhea or constipation but these symptoms subsided over the course of the study.

Story Source: The above story is provided based on materials by St michael's Hospital. Note: Materials may be edited for content and length.


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or low-fat milk may delay the progression of osteoarthritis (OA) of the knee. Results published in the American College of Rheumatology (ACR) journal Arthritis Care

& Research show that women who ate cheese saw an increase in knee OA progression.

OA is a common degenerative joint disease that causes pain and swelling of joints in the hand hips or knee.

While medical evidence points to obesity joint injury and repetitive use from some sports as risk factors for incident knee OA risks associated with OA progression remain unclear.

For the present study 2148 participants (3064 knees) with knee OA were recruited for the Osteoarthritis Initiative.

In a related editorial also published in Arthritis Care & Research Shivani Sahni Ph d. and Robert Mclean D. Sc.

which can lead to functional disability. Story Source: The above story is provided based on materials by Wiley.


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and promotions appealing said lead author Samir Soneji Phd Norris Cotton Cancer Center researcher and assistant professor at the Geisel School of medicine at Dartmouth and the Dartmouth Institute for Health Policy and Clinical

Norris Cotton Cancer Center prevention experts recommend stricter security for websites and increased enforcement for direct-to-consumer marketing.

The above story is provided based on materials by Norris Cotton Cancer Centerdartmouth-Hitchcock Medical center. Note: Materials may be edited for content and length.


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Likewise when cows were fed protein contaminated with bovine prions many of them developed mad cow disease. On the other hand transmission of prions between species for example from cows sheep or deer to humans is--fortunately--inefficient and only a small proportion of exposed recipients become sick within their lifetimes.

A study published on April 3rd in PLOS Pathogens takes a close look at one exception to this rule:

but they share features with more common neurodegenerative diseases like Alzheimer's disease. Trying to understand the unusual susceptibility of bank voles to prions from other species Stanley Prusiner Joel Watts Kurt Giles

When these mice get older some of them spontaneously develop neurologic illness but in the younger ones the bank vole Prp is in its normal benign folded state.


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and for treating complex tumors and degenerative spine problems resulting in fewer complications and better outcomes for patients.

The surgeons said the technology has others applications for treating spinal disorders serving as a tool to remove tumors decompress the spinal column

A third study determined that the image-guided technique can be useful for other minimally invasive procedures including thoracic endoscopic spine surgery to remove tumors infections


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or were susceptible to wind snow pests and pathogens. It is truly a unique achievement to design trees for deconstruction

and used in other applications such as adhesives insolation carbon fibres and paint additives. Genetic modificationthe genetic modification strategy employed in this study could also be used on other plants like grasses to be used as a new kind of fuel to replace petroleum.


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Controlling nonnative plants with herbicides and fungal infections has been tried with mixed results. But the factors that ultimately determine the survival of the sagebrush ecosystem may be out of managers'control.


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When crossing parent plants for example breeders often like to track the genes underlying their trait of interest such as resistance to a pathogen.


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A new study by Florida State university Associate professor Arturo Figueroa published in the American Journal of Hypertension found that watermelon could significantly reduce blood pressure in overweight individuals both at rest and while under stress.

More people die of heart attacks in cold weather because the stress of the cold temperatures causes blood pressure to increase

Thus people with obesity and high blood pressure face a higher risk for stroke or heart attack when exposed to the cold either during the winter or in rooms with low temperatures.

and women who also suffered from high blood pressure. To simulate cold weather conditions one hand of the subject was dipped into 39 degree water

In the past he examined how it impacts postmenopausal women's arterial function and the blood pressure readings of adults with pre-hypertension.

In addition to being published in the American Journal of Hypertension the study was published also in the US National Library of Medicine National institutes of health


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Norris Cotton Cancer Center researchers take a look at what we know about e-cigarettes and health.

and continues to use those other products is unlikely to greatly lower their risk of heart attack cancer or chronic lung disease.

The above story is provided based on materials by Norris Cotton Cancer Centerdartmouth-Hitchcock Medical center. Note: Materials may be edited for content and length h


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what ingredients in chocolate might help prevent obesity as well as type-2 diabetes. They found that one particular type of antioxidant in cocoa prevented laboratory mice from gaining excess weight

and type-2 diabetes. But not all flavanols which are a type of antioxidant are created equal.

They also improved glucose tolerance which could potentially help prevent type-2 diabetes. Oligomeric PCS appear to possess the greatest antiobesity


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#Allergy tablet approval warrants caution for somea pill a day keeps spring allergies away. In a perfect world it would be that easy.

And for those suffering from an allergy to some grasses the Food and Drug Administration's (FDA) approval of the oral dissolvable tablets designed to help treat symptoms may be beneficial.

But for the majority of seasonal sufferers allergic to pollens from the more than 30 other pollinating species relief isn't that easy.

The approval of oral immunotherapy tablets is advancement in the right direction said allergist Michael Foggs MD president of the American College of Allergy Asthma and Immunology (ACAAI.

It's an additional treatment option for those who are allergic to some types of grasses but not those allergic to other varieties of grass trees and weeds.

According to ACAAI those with seasonal allergies can be affected by the pollen of 11 different types of weeds and trees and eight varieties of grass.

Fortunately there is a longstanding solution for those suffering from multiple allergies. Immunotherapy also known as allergy shots has been used for 100 years

and is a natural treatment. Each injection can be customized to an individual's allergic needs.

Allergy shots can modify and prevent allergy progression while also relieving symptoms. They are also fast acting and cost-efficient.

It would be ideal if tablets could be customized like allergy shots but that's not on the horizon yet said Dr. Foggs.

Since allergy treatment is not a one-size-fits-all approach treatment needs to be tailored to an individual's needs.

Although the approved tablets are beneficial only for those suffering from some forms of grass allergy the FDA's approval will help open the door for others getting approved such as tablets for ragweed and dust mite allergy.

The best way to conquer allergy symptoms is to avoid allergens according to the ACAAI. During the spring sneezing season sufferers should:

â#¢Limit time outdoors when pollen counts are highest (midday and afternoon hours) â#¢Keep windows in the car and home closed â#¢Wash hair after working

or exercising outdoorsallergy sufferers should talk with their board-certified allergist to learn which treatment is suited best for their needs.

The above story is provided based on materials by American College of Allergy Asthma and Immunology (ACAAI.


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In an era of climate change pollution and the global spread of pathogens these new grains must also be able to handle stress.

The scientists looked at the genes'response to five abiotic stresses--drought heavy metal contamination salt cold and nutrient deprivation--and five biotic stresses--bacteria fungus insect predation weed


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New therapies possibleresearchers at Mcmaster University have discovered a key molecule that could lead to new therapies for people with celiac disease an often painful and currently untreatable autoimmune disorder.

Celiac disease is a food sensitivity to dietary gluten contained in cereals. In people who are predisposed genetically gluten containing food will trigger an immune response that leads to destruction of the intestinal lining abdominal pain changes in bowel habits malnutrition

and many other symptoms that include anemia and neurological problems. People with this disease cannot eat food containing wheat rye or barley

which is present in the intestine of healthy individuals is decreased significantly in patients with celiac disease.

When people with celiac disease eat food containing gluten the digestive enzymes cannot digest it and left over peptides from digestion induce inflammation.

School of medicine. â#oethere is need a great for a therapy that will protect patients with celiac disease from these accidental contaminations. â#Verdu says the results raise the possibility of elafin administration

and increase patientsâ##quality of life and potentially accelerate the healing of celiac lesions. â#The research has implications beyond celiac disease.

Recently gluten intolerance has been reported in patients who do not have celiac disease (non-celiac gluten sensitivity.

Development of new therapies such as this one could help in the management of common gastrointestinal disorders such as irritable bowel syndrome that could be triggered also by wheat containing food.

Story Source: The above story is provided based on materials by Mcmaster University. Note: Materials may be edited for content and length


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Eating seven or more portions reduces the specific risks of death by cancer and heart disease by 25%and 31%respectively.

and vegetable consumption with all-cause cancer and heart disease deaths in a nationally-representative population the first to quantify health benefits per-portion


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years old according to a new study by Dartmouth-Hitchcock Norris Cotton Cancer Center. In research published on March 31 2014 in JAMA Pediatrics Dartmouth researchers found that one-half to one-third of children did not identify milk

http://youtu. be/Tl9uhuewztyburger King's depiction of apple slices as'Fresh Apple Fries'was misleading to children in the target age range said principal investigator James Sargent MD co-director Cancer

Control Research Program at Norris Cotton Cancer Center. The advertisement would be deceptive by industry standards yet their self-regulation bodies took no action to address the misleading depiction.

The above story is provided based on materials by Norris Cotton Cancer Centerdartmouth-Hitchcock Medical center. Note: Materials may be edited for content and length.


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#Urban gardeners may be unaware of how best to manage contaminants in soilconsuming foods grown in urban gardens may offer a variety of health benefits

and challenges related to the perceived risk of soil contamination among urban community gardeners and found a need for clear and concise information on how best to prevent

and manage soil contamination. The results are featured online in PLOS ONE. While the benefits are far-reaching gardening in urban settings can also create opportunities for exposure to contaminants such as heavy metals petroleum products and asbestos

which may be present in urban soils said Keeve Nachman Phd senior author of the study and director of the Food Production and Public health Program with CLF.

and expertise to determine accurately the prior use of their garden site and potential contaminants in the soil.

or gaps in knowledge about how best to minimize their risk of exposure to contaminants that may be in urban soil.

As a result many soil contaminants have been found at higher concentrations in urban centers. To characterize urban community gardeners'knowledge

and perceptions of soil contamination risks and reducing exposure researchers conducted surveys among urban community gardeners and semi-structured interviews with key informants in the gardening community in Baltimore Maryland.

or organizational affiliation makes them knowledgeable about Baltimore City community gardening and soil contamination. People may come into contact with these contaminants

if they work or play in contaminated soil or eat food that was grown in it.

In some cases exposure to soil contaminants can increase disease risks especially for young children said Brent Kim MHS lead author of the paper and a program officer with CLF.


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and vegetables are less likely to have a heart attack or stroke but the relationship between fruit and vegetable consumption during young adulthood and heart disease later in life was less clear.

To study this concept researchers evaluated the association between dietary intake of fruits and vegetables in young adults and the presence of coronary artery calcification (CAC) 20 years later.

which is evaluating how heart disease develops throughout adulthood. CARDIA began in the mid-1980s with a group of men

CAC scoring is currently the best predictor we have for future heart attacks Miedema said. Calcium build up in the walls of the coronary arteries is an early sign of heart disease

and the presence of CAC substantially raises an individual's risk for a future heart attack.

In their analysis researchers controlled for smoking exercise consumption of red meat sugar-sweetened beverages and other dietary and cardiovascular risk factors that correlate with atherosclerosis.

Participants with extreme high or low caloric intake/day or those missing CAC scores were excluded from the analysis. The current findings are in line with the 2011 U s. Department of agriculture Dietary Guidelines that advise Americans to fill half of their plates

Plant-based diets in general have also been linked to greater longevity less cancer lower cholesterol lower blood pressure

and cardiovascular disease in men and women in addition to determining the best ways to increase compliance with a diet high in fruits and vegetables in the U s. population.


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#Using tobacco to thwart infectious disease? An international research group led by Arizona State university professor Qiang Shawn Chen has developed a new generation of potentially safer and more cost-effective therapeutics against West Nile virus and other pathogens.

The therapeutics known as monoclonal antibodies (MABS) and their derivatives were shown to neutralize and protect mice against a lethal dose challenge of West Nile virus--even as late as 4 days after the initial infection.

The overarching goal of our research is to create an innovative yet sustainable and accessible low cost solution to combat the global threat of West Nile virus said Chen a researcher at Arizona State university's Biodesign Institute and professor in the Department

Secondly we've wanted to improve the delivery of the therapeutic into the brain to combat West Nile virus at the place where it does the greatest harm.

A couple of years ago his team demonstrated that their first candidate phu-E16 could neutralize West Nile infection

and increasing amounts of a MAB therapeutic were delivered as a single dose the same day of infection.

whether the therapeutic called Tetra phu-E16 could be effective after infection. In this case the therapeutic was administered 4 days after West Nile virus infection

In each case they protected up to 90 percent of the mice from lethal infection. This is the first instance of such an effect

and makes possible neutralizing West Nile virus even after infection by a tetravalent MAB. The tetravalent MABS design will offer the researchers greater flexibility toward selection of disease tissue and antigen targets.

and highly competitive research field having been shown to effectively target cancer autoimmune and inflammatory diseases. Now a $60 billion market for the biotechnology and pharmaceutical sectors growth of the market has been hampered by high development costs of producing these in animal cell systems

For the study MABS were produced rapidly in tobacco plants in as little as ten days giving promise to change the image of scourged product that causes lung cancer into a manufacturing system for societal benefits against infectious diseases.


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However excessive consumption of sugars (simple carbohydrates) can cause life-style-related diseases such as obesity and diabetes.


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whether'Honeycrisp'apples were controlled susceptible to-atmosphere injury to determine the relative influence of O2

In the second phase the scientists evaluated options for avoiding injury to'Honeycrisp'during controlled-atmosphere storage.

We found that the controlled-atmospheres used induced injuries typical of those associated with CO2

(i e. small brown lesions and associated lens-shaped cavities) and also larger dark brown lesions with often irregular margins the authors said.

The extent of the injury was higher for those fruit in an atmosphere with elevated CO2 for each level of O2.

which the researchers reproduced the controlled-atmosphere (CA) injury from the preliminary study with varied intensity.

Although the researchers observed high variability between orchards and years they found two treatments that effectively controlled the CA injury.

We found that the brown lesions in the cortex were suppressed completely by DPA application even

For instance although the 7-day prestorage conditioning treatments provided some protection against the development of CA injury shorter durations should be investigated to prevent quality loss resulting from excessive ripening


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#Peaches inhibit breast cancer metastasis in micelab tests at Texas A&m Agrilife Research have shown that treatments with peach extract inhibit breast cancer metastasis in mice.

Cancer cells were implanted under the skin of mice with an aggressive type of breast cancer cells the MDA-MB-435 and

and plum polyphenols selectively killed aggressive breast cancer cells and not the normal ones Cisneros-Zavallos said.

In the western hemisphere breast cancer is the most common malignant disease for women he said. In the U s. last year the American Cancer Society estimated about 232340 new cases of invasive breast cancer among women.

Most of the complications and high mortality associated with breast cancer are due to metastasis Cisneros-Zevallos pointed out.

The importance of our findings are very relevant because it shows in vivo the effect that natural compounds in this case the phenolic compounds in peach have against breast cancer

and metastasis. It gives opportunity to include in the diet an additional tool to prevent

and compounds in different types of cancer as well as in diabetes studies in vitro and in vivo to understand the molecular mechanisms involved.


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Dong and his team will build miniature greenhouses that precisely control light intensity humidity temperature carbon dioxide chemicals and even pathogens.

and Madan Bhattacharyya who's studying how fungal pathogens interact with soybean seeds at different moisture levels.


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and the fruits sustained significantly more injury than tomato fruits grown in gardens without traps.

and it appears that the addition of traps to gardens may increase injury to tomato fruits.

Vegetable gardens with traps may sustain more injury than those without traps. Story Source: The above story is provided based on materials by Entomological Society of America.


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Future of early-stage breast cancer drugsone of every eight women in the United states will develop breast cancer.

Though the incidence of breast cancer began decreasing in 2000 it is still the second-leading cause of cancer death in women.

Better screening techniques increased awareness and improved treatments have increased the 5-year survival rate to nearly 100 percent for women with early-stage cancer.

In 2013 an estimated 65000 women were diagnosed with carcinoma in situ a noninvasive breast cancer that affects the milk ducts and lobules of the breast according to the American Cancer Society.

He and doctoral student Kaushalkumar Dave are developing a new method to deliver cancer-fighting drugs directly to the milk ducts where more than 95 percent of breast cancer originates.

The research has been supported by the Translational Cancer Research center a state-funded center which provides seed money for high-risk high-reward research.

Side effects of tamoxifen for example include increased risk of uterine cancer cataracts stroke and cardiovascular disease. Patients diagnosed with precancerous cells

or lesions may take tamoxifen anywhere from three months to five years. These significant side effects may be mitigated through a more direct localized drug delivery method according to Perumal.

A variety of compounds show promise in fighting the many types of breast cancer. Perumal points to a natural compound developed by former colleague

and Distinguished Professor Emeritus Chandradhar Dwivedi to prevent skin cancer--as having the potential to prevent breast cancer.


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Kwang Cheol Jeong an assistant professor in animal sciences and UF's Emerging Pathogens Institute examined cattle uterine illnesses

and because those maladies are linked often to bacteria he said. The UF researchers did their experiments in labs

Jeong said it may someday be possible for chitosan microparticles to be used to help humans who have become ill from consuming E coli-contaminated food

Dangerous infections are diminishing the role of some antibiotics making them less able to treat infections as pathogens are developing resistance to the drugs he said adding that about 23000 people die in the U s. annually because of exposure to pathogens that don't respond to antibiotics.

Scientists can use the UF study's findings to begin to develop better drugs that target bad pathogens

That year 21 people in 16 states fell ill from the pathogen including one in Florida the agency reported.

when two or more people get the same illness from the same contaminated food or drink the CDC says.


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#Pathogens in cheese: Case study on Austrian curd cheeseif food products are produced not in a hygienic environment consumers can face the threat of dangerous pathogens.

This is exactly what happened in 2009 and 2010 when two different strains of Listeria monocytogenes were found in the traditional Austrian curd cheese known as Quargel. 34 people were infected

This pathogen can be present in raw milk and soft cheeses smoked fish raw meat and ready-to-eat products.

When an outbreak occurs though the disease has among the highest mortality rate of all food-borne illnesses explains lead author Kathrin Rychli from the Institute for Milk Hygiene Milk Technology and Food Science at the University of Veterinary medicine Vienna.

The first contamination event from June 2009 to January 2010 was attributed to one L. monocytogenes strain very effective at infecting epithelial cells of the intestine and liver cells.

The average age of those taken ill was 70. Highest level of operational hygiene essential Listeria expert and co-author Stephan Schmitz-Esser emphasizes the importance of cleanliness in production:

Listeriosis generally manifests in healthy people with diarrhea and stomach cramps whereas the elderly newborns and people with weakened immune systems are more susceptible.

Listeriosis can result in septicaemia and meningitis. In pregnant women it can lead to miscarriage or stillbirth.


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and neural tube defects such as spina bifida in unborn babies. The NHMRC recommends pregnant women or those planning a pregnancy take 500 micrograms a day.


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Emerging Infectious diseases 18: 1508-1511 2012. This is the first wild Anopheles population to display such complete multiple resistance


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The genome also revealed the location of genes that may be involved in fighting off pathogens which will help scientists understand more about disease resistance in pines.


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and fungi that decompose plant matter in healthy ecosystems are hindered by radioactive contamination. They showed a smaller effect for small invertebrates such as termites that also contribute to decomposition of plant biomass.

It's another facet of the impacts of low-dose-rate radioactive contaminants on the broader ecosystem Mousseau says.

and redistribute the radioactive contamination that is in the trees and the plant biomass Mousseau says.

That would end up moving radio-cesium and other contaminants via smoke into populated areas. This litter accumulation that we measured


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Two decades later the U s. Department of agriculture still ranks head blight as the worst plant disease to hit the U s. since the rust epidemics in the 1950s.

Multiple hosts and pathogens Head blight can be caused by multiple pathogens and these pathogens can attack multiple hosts including grasses

and corn Yen explains. This makes the disease tougher to combat. Researchers are working to develop resistant types of grain alter tillage practices

Gene expression Yen has undertaken a molecular study of the disease investigating how the fungal infection impacts wheat gene expression.

How they respond to regulations triggered by the fungal infection makes the difference he says. That's why normal gene cloning didn't work.

because suppressing its function in the first eight to 60 hours after the infection causes the disease development.

Disease development Essentially Yen hypothesizes that the fungus softens the host cell wall during infection and triggers a chain of host resistance responses.

Only then can the researcher figure out how to prevent the disease from becoming an epidemic.


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and can cause gas bloating diarrhea and constipation. These include some Clostridia and some E coli.


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As an economist Baylis said that she studies how policy can create headaches for farmers and on the consumer end of the supply chain.


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#Study fingers chickens, quail in spread of H7n9 influenza virusamong the copious species of poultry in China quail and chickens are the likely sources of infection of H7n9 influenza virus

Knowing the likely poultry species lets us target our interventions better to prevent human infections says corresponding author David Suarez of the United states Department of agriculture.

The H7n9 avian influenza virus was reported first in humans in March 2013 in China. Since then over 375 human cases have been confirmed

According to the World health organization most known human infections have resulted from direct or indirect contact with poultry.

This work supports the need for better surveillance in animal species for avian influenza says Suarez.

The Chinese correctly closed the live bird markets where they had human infections and that reduced the number of cases for a while.


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