#Toxic nanoparticles might be entering human food supplyover the last few years the use of nanomaterials for water treatment food packaging pesticides cosmetics
#Celery, artichokes contain flavonoids that kill human pancreatic cancer cellscelery artichokes and herbs especially Mexican oregano all contain apigenin
and luteolin flavonoids that kill human pancreatic cancer cells in the lab by inhibiting an important enzyme according to two new University of Illinois studies.
Apigenin alone induced cell death in two aggressive human pancreatic cancer cell lines. But we received the best results
Pancreatic cancer is a very aggressive cancer and there are few early symptoms meaning that the disease is often not found before it has spread.
It is the fourth leading cause of cancer-related deaths with a five-year survival rate of only 6 percent she said.
which led to a decrease in the production of anti-apoptotic genes in the pancreatic cancer cells.
According to Johnson the scientists'in vitro study in Molecular Nutrition and Food Research is the first to show that apigenin treatment can lead to an increase in interleukin 17s in pancreatic cells showing its potential relevance in anti-pancreatic cancer activity.
Pancreatic cancer patients would probably not be able to eat enough flavonoid-rich foods to raise blood plasma levels of the flavonoid to an effective level.
which would certainly help to reduce the risk of cancer she noted. Story Source: The above story is provided based on materials by University of Illinois College of Agricultural Consumer and Environmental sciences.
It's also a potential gateway to new smokers particularly among teens and in emerging/foreign markets according to behavioral scientists at The University of Texas MD Anderson Cancer Center.
and thereby reducing their lung cancer risk. However MD Anderson cancer prevention experts Paul Cinciripini Ph d. director of the Tobacco Treatment Program and Alexander Prokhorov M d. Ph d. head of the Tobacco Outreach Education
Program caution that more research is needed to understand the potential role of e-cigarettes in smoking cessation.
The above story is provided based on materials by University of Texas M d. Anderson Cancer Center. Note:
The research could aid in the development of new drugs that use a similar mechanism as melittin's to attack cancer and bacteria.
People are interested in using these peptides to fight cancer and other diseases in part because organisms cannot change the makeup of their membrane so it would be very difficult for them to develop resistance to such drugs.
#Nanodrug targeting breast cancer cells from the inside adds weapon: Immune system attacka unique nanoscale drug that can carry a variety of weapons
a protein that stimulates the immune system to attack HER2-positive breast cancer cells. The research team developing the drug--led by scientists at the Nanomedicine Research center part of the Maxine Dunitz Neurosurgical Institute in the Department of Neurosurgery at Cedars-Sinai Medical center--conducted the study in laboratory mice with implanted human
breast cancer cells. Mice receiving the drug lived significantly longer than untreated counterparts and those receiving only certain components of the drug according to a recent article in the Journal of Controlled Release.
Researchers from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai the Division of Surgical Oncology at UCLA and the Molecular biology Institute at UCLA also participated in the study.
HER2-positive cancers--making up 25 to 30 percent of breast and ovarian cancers--tend to be more aggressive
and less responsive to treatment than others because the overactive HER2 gene makes excessive amounts of a protein that promotes cancer growth.
but many tumors become resistant within the first year of treatment and the drug can injure normal organs it contacts.
and does not home specifically to tumor cells. By attaching the new fusion antibody to the nanoplatform we were able to deliver Herceptin directly to HER2-positive cancer cells at the same time transporting IL-2 to the tumor site to stimulate the immune system.
Attaching IL-2 to the platform helped stabilize the protein and allowed us to double the dosage that could be delivered to the tumor.
Ljubimova led the study with Manuel Penichet MD Phd associate professor of surgery microbiology immunology and molecular genetics at the University of California Los angeles David Geffen School of medicine.
or stop cancers by blocking them in multiple ways. Polycefin is intended to slow their growth by entering cells and altering defined targets.
The new version also stimulates the immune system to further weaken cancers. We believe this is the first time a drug has been designed for nano-immunology anticancer treatment Ljubimova said.
With inventive drug engineering the anti-tumor components activate inside tumor cells. More study is needed to confirm our findings improve the effectiveness of this approach
but it appears that the nanobioconjugate may represent a new generation of cancer therapeutics in
which we launch a multipronged attack that directly kills cancer cells blocks the growth of cancer-supporting blood vessels
#Illinois scientists put cancer-fighting power back into frozen broccolithere was bad news then good news from University of Illinois broccoli researchers this month.
In the first study they learned that frozen broccoli lacks the ability to form sulforaphane the cancer-fighting phytochemical in fresh broccoli.
As little as three to five servings of broccoli a week provides a cancer-protective benefit but that isn't true for bags of broccoli that you pluck out of your grocery's freezer she noted.
which is necessary to form sulforaphane the powerful cancer-preventive compound in broccoli she said.
and sell a product that has the cancer-fighting component that it lacked before he said.
and it will retain its cancer-fighting capabilities Dosz said. Jeffery hopes that food processors will be eager to adopt this process
Until they do said she that consumers can spice up their frozen cooked broccoli with another food that contains myrosinase to bring the cancer-fighting super-food up to nutritional speed.
Undergoing a novel care plan he became a teaching case for veterinary oncologists at the Cornell University Hospital for Animals paving the way to combat cancer in large animals.
and laid down in the snow Goldner drove Nemo nearly four hours to Cornell's hospital where the pig was diagnosed with presumptive B-cell lymphoma a blood cancer.
Though little is known about the prognosis for pigs with cancer Nemo has the notable distinction of establishing a precedent giving veterinarians valuable information for helping large animals.
One of her creations gold nanoshells is the subject of several clinical trials for cancer treatment.
The study published in Nature Publishing Group's Scientific Reports looked at the frequency of'micronuclei'--a telltale sign of chromosomal damage (that has been shown by others previously to be linked to cancer) by screening more than 400000 individual cells extracted from urine samples
which has caused devastating health impacts including cancers in many parts of the world. The authors say their work raises considerable concerns about health impacts of consuming high arsenic rice as a staple particularly by people with relatively poor nutritional status--perhaps as many as a few hundred million people.
Increased frequency of these micronuclei has been shown by other groups to be linked to the development of cancers.
#New risk factors for bowel cancerfizzy drinks cakes biscuits chips and desserts have all been identified as risk factors for bowel cancer according to new research.
Scientists reported links with some established risk factors of colorectal cancer#such as family history of cancer physical activity and smoking.
The study#which used data from the Scottish Colorectal Cancer Study#carried out in 2012 builds on previous research into the link between bowel cancer and diet.
The healthy dietary pattern was found to be associated with a decreased colorectal cancer risk while the western dietary pattern was found to be associated with an increased risk.
While the positive associations between a diet high in sugar and fat and colorectal cancer do not automatically imply'cause
and American Cancer Society--were indifferent or skeptical to initiatives of the state and local activists.
Some of the characters involved have worked previously to deny the reality of the hole in the ozone layer acid rain and the link between tobacco and lung cancer.
It's a spectacular finding that by implementing these simple tobacco control policies governments can save so many lives said lead author David Levy Phd professor of oncology at Georgetown Lombardi Comprehensive Cancer Center
and treat diseases such as Alzheimer's Lou Gehrig's and cancer. The study reported this month in the journal Cell verifies a process that scientists knew existed
and cancer also are linked to protein folding disorders. One of the main roles for the molecular chaperones is preventing those protein misfolding events that lead to aggregation
and treat diseases such as Alzheimer's Lou Gehrig's and cancer. The study reported this month in the journal Cell verifies a process that scientists knew existed
and cancer also are linked to protein folding disorders. One of the main roles for the molecular chaperones is preventing those protein misfolding events that lead to aggregation
and we found we could use light to coax them to make more cancer-fighting antioxidants at certain times of day.
and neurological effects as well as increasing the risk of childhood leukemia she continues. The results show that 54%of pregnant women used some kind of insecticide inside the home
Grucza's team evaluated data from an ongoing National Cancer Institute survey that monitors smoking behavior in all 50 states.
Funding for this research comes from the National Institute on Drug abuse and the National Cancer Institute of the National institutes of health (NIH.
It also was supported by grants from the American Cancer Society and the American Foundation for Suicide Prevention.
We've also started exchanging ideas and information with scientists facing related challenges such as herbicide resistance in weeds and resistance to drugs in bacteria HIV and cancer.
This work was supported by National Cancer Institute grant CA-087472. The funders had no role in study design data collection
The study was funded by grant 1r25ca117887-01a from the National Cancer Institute. Co-authors of the study are John Spangler M d. Mara Vitolins Dr. PH. Stephen Davis M. S. Edward Ip Ph d. Gail Marion Ph d. and Sonia Crandall
and colleagues studied tomatoes enriched in anthocyanin a natural pigment that confers high antioxidant capacity The purple GM tomatoes have already been found to prolong the lives of cancer-prone mice
and the subtropical fruit may revolutionize how medical therapies like anticancer drugs are delivered to specific tumor cells.
The therapeutic potential of grapefruit derived nanoparticles was validated further through a Phase 1 clinical trial for treatment of colon cancer patients.
and a cancer causing agent found specifically in tobacco smoke--known as NKK--as measured by their metabolites cotinine and NNAL.
and skin cancers and has been associated with other conditions as well including heart disease type 2 diabetes cognitive deficits and adverse pregnancy outcomes.
There are indeed examples of H3n2 that we need to be concerned about says Sasisekharan who is also a member of MIT's Koch Institute for Integrative Cancer Research.
On surveillance in the war against cancerpredicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach
when it comes to the most deadly types of breast cancer. We know that one function of our immune system is to detect
and destroy pre-malignant cells before they can become cancer said lead author Lance D. Miller Ph d. associate professor of cancer biology at Wake Forest Baptist.
and a tumor develops. This unresponsiveness can be temporary and the immune system can remain alerted to the fact that there's a problem.
Immune cells can stand post along the borders of the tumor and even infiltrate the tumor core where they may gain a better position for eventual attack.
We now have technologies that allow us to quantify aspects of this interaction and from that information we can make predictions about cancer outcomes Miller said.
The study published online ahead of print last month in the journal Genome Biology. This approach is known as gene expression profiling
and by studying the expression profiles of 2000 human breast tumors Miller and his team identified several immune gene signatures that reflect the abundance
and anti-tumor properties of different types of tumor-infiltrating immune cells. They found that in certain aggressive types of breast cancer such as basal-like
or triple negative disease these immune signatures were highly predictive of cancer recurrence years after initial treatment.
Strikingly the patients who seemed to benefit the most were those with highly proliferative and clinically aggressive disease Miller said.
while low immune gene expression predicted for a high likelihood of cancer recurrence. An important next step Miller said will be translating this into a diagnostic test that may help doctors make more informed treatment decisions.
Knowing a tumor's immunogenic disposition could help oncologists know whether to prescribe more or less aggressive treatment regimens
For doctors like Bayard Powell M d. chief of hematology and oncology at Wake Forest Baptist's Comprehensive Cancer Center new drugs designed to enhance anti-tumor immune responses are beginning to play a major
role in the treatment of certain forms of cancer. At Wake Forest Baptist we are now fighting cancer with state-of-the-art therapies including immunotherapeutics Powell said.
How a tumor's immunogenic disposition influences the effectiveness of immunotherapeutic drugs is an important question that could lead to valuable new strategies in personalized medicine.
Co-authors include: Jeff W. Chou Ph d. Mark C. Willingham M d. Jimmy Ruiz M d. James P. Vaughn Ph d. Purnima Dubey Ph d. and Timothy L
and soy foods may be more effective in preventing prostate cancer when they are eaten together than
In our study we used mice that were engineered genetically to develop an aggressive form of prostate cancer.
Eating tomato soy and the combination all significantly reduced prostate cancer incidence. But the combination gave us the best results.
Prostate cancer is the most frequently diagnosed cancer in men but the disease has nearly a 100 percent survival rate
In older men it is often a slow-growing cancer and these men often choose watchful waiting over radiation
In countries where soy is eaten regularly prostate cancer occurs at significantly lower levels Erdman noted.
and one to two servings of soy foods daily could protect against prostate cancer Zuniga said.
When you eat whole foods you expose yourself to the entire array of cancer-fighting bioactive components in these foods Erdman said.
although low in genistein was still very effective at reducing cancer incidence. Story Source: The above story is provided based on materials by University of Illinois College of Agricultural Consumer and Environmental sciences (ACES.
This information is relevant to our efforts to improve muscle fitness in many health conditions such as aging cancer and heart failure.
Some studies have shown that trained dogs can detect cancerous tumours such as lung cancer by smelling a person's breath.
and prostate cancers and low levels can cause skin lesions diarrhea and other symptoms. The risks of arsenic in rice were highlighted recently in the national press
Funding for the study was provided by a PUSH grant from the Wake Forest Baptist Comprehensive Cancer Center
However in 2004 researchers contrary to popular assumptions revealed that isoprene was involved likely in the production of particulate matter tiny particles that can get lodged in lungs lead to lung cancer and asthma and damage other tissues not to mention the environment.
and reduces the risk of many common diseases including cancer cardiovascular disease depression and diabetes. The study to be presented consisted of 30 healthy adults who were randomized to take capsules containing 2000 International Units (IU) of vitamin D2 2000 IU of vitamin D3
The findings are published in Cancer Epidemiology Biomarkers & Prevention a journal of the American Association for Cancer Research.
or respiratory conditions and to higher levels of benzene long associated with leukemia risk. People want to know
If you are smoking from a hookah daily you are likely to be increased at risk for cancer.
Occupational exposure to benzene has been shown to increase the risk of developing leukemia. Furthermore the researchers measured carbon monoxide in the breath over 24 hours and found levels 2. 5 higher after water pipe use in comparison to cigarette smoking.
and can cause lung cancer. Intake of nicotine the addictive component of tobacco was less with water pipe use.
and treat cancer. In diagnosing cancer nanoparticles with cancer-seeking properties might be injected into a patient before a medical scan.
If even an early form of cancer were present the particles would accumulate in the abnormal tissue
and make it visible for early diagnosis and the best chances for recovery. For treating the disease nanoparticles would preferentially collect in
and destroy only the abnormal cells sparing healthy tissue from the damage that triggers side effects with existing cancer chemotherapy.
and embryonic stem cells as well as cancer stem cells. As stem cell-based treatments continue to develop the authors say it will be increasingly important to understand the role of autophagy in preserving stem cells'health
what's currently known about the process in hematopoietic neural cancer cardiac and mesenchymal (bone and connective tissue) stem cells.
The team is also looking at the role of autophagy in breast cancer stem cells because of intriguing findings about the impact of FIP200 deletion on the activity of the p53 tumor suppressor gene
which is important in breast and other types of cancer. In addition they will study the importance of p53 and p62 another key protein component for autophagy to neural stem cell self-renewal and differentiation in relation to FIP200.
Among adolescents active smoking has been associated with increased asthma risk reduced lung function and growth early atherosclerotic lesions and increased cancer risk as well as premature mortality in adulthood.
and grab circulating tumor cells or CTCS that break away from cancers and enter the blood often leading to the spread of cancer to other parts of the body.
If more studies confirm the technology's effectiveness the Nanovelcro Chip device could enable doctors to access
and identify cancerous cells in the bloodstream which would provide the diagnostic information needed to create individually tailored treatments for patients with prostate cancer.
The researchers believe this technology may function as a liquid biopsy revolutionizing conventional biopsy practices
Today's biopsies require the removal of tissue samples through a needle inserted into a solid tumor a procedure that is invasive and sometimes painful.
Biopsies are extremely difficult in metastatic prostate cancer because the disease often spreads to bone where the availability of the tissue is low.
The biggest challenges in the treatment of cancer are that every person's tumor differs greatly
Researchers hope that by analyzing these CTCS doctors will be able to understand the tumor evolution in each individual.
and their invasiveness in a tissue culture dish doctors may be able to quickly adjust their treatment plans in response We are optimistic that the use of our Nanovelcro CTC technology will revolutionize prostate cancer treatment.
We know that cancers evolve over time and that every patient's cancer is a unique problem--the'one-size-fits-all'approach is not going to allow us to cure prostate cancer
or any other cancer said Edwin M. Posadas MD medical director of the Urologic Oncology Program at Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute and senior author
of the article in the March online issue of Advanced Materials. This evolution means that we need to be able to monitor these changes over time
The existence of CTCS and their role in cancer metastasis was suspected first more than 140 years ago
the Nanovelcro CTC chip laser capture microdissection and whole exome sequencing said Yi-Tsung Lu MD a postdoctoral scientist at the Cedars-Sinai Samuel Oschin Comprehensive Cancer
This advancement will in principle allow us to track the genomic evolution of prostate cancer after we initiate a therapy
and will allow us to better understand the mechanism of drug resistance that is common in prostate cancer patients.
We hope the comprehensive understanding of cancer biology at the individual level will ultimately lead to better therapy choice for patients suffering from advanced cancer.
and may help doctors personalize therapies to a patient's unique cancer. To date CTC capture technologies have been able to do little more than count the number of CTCS which is informative but not very useful from a treatment planning perspective.
His enthusiasm is echoed by Leland W. K. Chung Phd director of the Urologic Oncology Research Program at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute.
Researchers from the Chinese Academy of Science Jonsson Comprehensive Cancer Center at UCLA and VA Greater Los angeles Healthcare System Beijing Genomics Institute in China Cytolumina Technologies
Cedars-Sinai researchers were supported by a Young Investigator Award and a Challenge Award from the Prostate Cancer Foundation research grants (P01 CA098912 and R01 CA122602) from the National institutes of health a Department of defense Idea
UCLA researchers were supported by a Creativity Award from the Prostate Cancer Foundation and research grants (R21 CA151159 and R33 CA157396) from the National institutes of health/National Cancer Institute Innovative Molecular Analysis
#Cancer biologists find DNA-damaging toxins in common plant-based foodsin a laboratory study pairing food chemistry
and cancer biology scientists at the Johns Hopkins Kimmel Cancer Center tested the potentially harmful effect of foods and flavorings on the DNA of cells.
and green teas and coffee activated the highest levels of a well-known cancer-linked gene called p53.
Funding for the study was provided by the National institutes of health's National Cancer Institute (CA62924) and the Everett and Marjorie Kovler Professorship in Pancreas Cancer Research.
Although there are medications that can compensate for the loss of female sex hormone production the drugs are recommended often not for long-term use due to the increased risk of heart disease and breast cancer.
and radiation treatments for certain types of cancer and menopause. The effects of hormone loss can range from hot flashes and vaginal dryness to infertility and increased risk of osteoporosis and heart disease.
We know that some people are much more vulnerable to alcoholism than others just like some people have a vulnerability to cancer
#Higher soy intake prior to lung cancer diagnosis linked to longer survival in womensummary of a study being published online March 25 2013 in the Journal of Clinical Oncology reports that Chinese women who consumed more soy before being diagnosed with lung cancer
New results from a large observational follow-up study conducted in Shanghai China indicate that women with lung cancer who consumed more soy food prior to their cancer diagnosis lived longer than those who consumed less soy.
The study published March 25 in the Journal of Clinical Oncology provides the first scientific evidence that soy intake has a favorable effect on lung cancer survival.
To our knowledge this is the first study to suggest an association between high soy consumption before a lung cancer diagnosis
Lung cancer is the leading cause of cancer-related death among women worldwide with only one in seven patients surviving for five years after diagnosis. Emerging evidence suggests that female hormones particularly estrogens
may affect lung cancer outcomes. Soy contains isoflavones estrogen-like substances that are known also to affect molecular pathways involved in tumor development and growth.
A recent study by the same research team showed that high intake of soy food was associated with a 40 percent decrease in lung cancer risk.
This new study assessed the impact of soy intake on lung cancer survival among participants of the Shanghai Women's Health Study which tracked cancer incidence in 74941 Shanghai women.
Information on usual dietary intake of soy food (soy milk tofu fresh and dry soybeans soy sprouts and other soy products) was collected in-person at study enrollment
During the course of the study 444 women were diagnosed with lung cancer. The median time between the first dietary assessment and cancer diagnosis was 5 8 years.
In this analysis patients were divided into three groups according to soy food intake prior to lung cancer diagnosis. The highest and lowest intake levels were equivalent to approximately 4 oz or more and 2 oz or less tofu
per day respectively. Patients with the highest soy food intake had markedly better overall survival compared with those with the lowest intake 60 percent of patients in the highest intake group and 50 percent in the lowest intake group were alive
The findings may not necessarily apply beyond this study's population which has a very low prevalence of cigarette smoking a known risk factor for the development of lung cancer
and postmenopausal hormone replacement therapy use a factor that may negatively affect lung cancer prognosis. In addition the overall soy food intake is higher in Chinese women than in Western women.
whether consumption of soy food after diagnosis of lung cancer affects survival particularly among patients with early-stage disease who may benefit most from a nutritional intervention.
This research was supported by the U s. National Cancer Institute and conducted by investigators at Vanderbilt University in collaboration with those from the Shanghai Cancer Institute and NCI.
Story Source: The above story is provided based on materials by American Society of Clinical Oncology (ASCO.
I had a number of people--mainly women from my breast cancer weight loss study--say how inexpensive a Mediterranean-style diet was approached so
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