#Toxicity map of brain may help protect cognition for cancer patientsnew research from Wake Forest Baptist Medical center is giving radiation oncologists who treat brain tumors a better understanding of how to preserve the brain's functions while still killing cancer.
Radiation treatment of organs with cancer is designed to give enough of a dose to be toxic to the cancer tumor with minimal impact to the surrounding tissue
While avoiding normal tissue death is important it doesn't necessarily help prevent the cognitive and functional problems associated with cancer treatments.
In one of those trials 57 brain cancer survivors returned six months or more after their radiation treatment to determine
Advances in cancer treatment have increased survivorship rates and the length of time individuals are able to live following treatment Peiffer said
#Strong anticancer properties discovered in soybeansproteins found in soybeans could inhibit the growth of colon liver and lung cancers.
The study looked at the role soybeans could have in the prevention of cancer. Using a variety of soybean lines
The study showed that peptides derived from soybean meal significantly inhibited cell growth by 73%for colon cancer 70%for liver cancer
and 68%for lung cancer cells using human cell lines. This shows that the selected high oleic acid soybean lines could have a potential nutraceutical affect in helping to reduce the growth of several types of cancer cells.
decreased lysophosphatidic acid a tumor-promoter that accelerates plaque build up in the arteries in animal models;
and colon cancer diabetes asthma and other disorders. The immune system normally triggers an inflammatory response to an acute event such as injury or infection
's Jonsson Comprehensive Cancer Center and senior associate dean for research at the Geffen School of medicine.
#Chemical trickery explored to help contain potato pestthe pale cyst nematode Globodera pallida is one bad roundworm.
However the eggs are encased in cysts that can resist fumigation according to Navarre who works at the ARS Vegetable and Forage Crops Research Laboratory in Prosser Wash.
what is believed to be a first of its kind study a research member at The Cancer Institute of New jersey
The Cancer Institute of New jersey is a Center of Excellence of the University of Medicine and Dentistry of New jersey-Robert Wood Johnson Medical school.
which is supported by The Cancer Institute of New jersey the UMDNJ-School of Public health and the UMDNJ-Robert Wood Johnson Medical school and provides help on quitting tobacco use through treatment education research and advocacy.
but there is more to the story according to Michael Steinberg MD MPH FACP a member of The Cancer Institute of New jersey
In fact smokers who relight cigarettes may be at higher risk of lung cancer and chronic bronchitis. That is something of which policy makers need to be aware he notes.
The study is supported by pilot funding through The Cancer Institute of New jersey. Story Source: The above story is provided based on materials by Cancer Institute of New jersey.
Note: Materials may be edited for content and length h
#Catastrophic loss of Cambodias tropical flooded grasslandsaround half of Cambodia's tropical flooded grasslands have been lost in just 10 years according to new research from the University of East Anglia.
#For smokers, low levels of Vitamin d may lead to cancernew research appearing online today in Clinical Chemistry the journal of AACC shows that decreased levels of Vitamin d may predispose smokers to developing tobacco-related cancer.
It is the primary causal factor for at least 30%of all cancer deaths and can lead to multiple kinds of cancer including bladder cervical esophageal head and neck kidney liver lung pancreatic and stomach as well as myeloid leukemia.
According to the Centers for Disease Control and Prevention the healthcare expenditures and productivity losses due to smoking cost the economy approximately $193 billion per year.
Researchers then followed the study participants for up to 28 years through the Danish Cancer Registry.
Of the participants 1081 eventually developed a tobacco-related cancer. The authors determined that the median Vitamin d concentration among these participants was only 14.8 ng/ml
These results show for the first time that the risk of tobacco-related cancers as a group is associated with lower concentrations of Vitamin d.
If further research confirms this it would be consistent with previous studies demonstrating the anti-tumorigenic effects of Vitamin d derivatives as well as the correlation of Vitamin d deficiency with favorable cancer-forming conditions and increased susceptibility to tobacco smoke carcinogens.
Interestingly though low Vitamin d levels were connected not with risk of other cancer types. Our analyses show that the association between lower concentrations of plasma Vitamin d
and higher risk of cancer may be driven by tobacco-related cancer as a group which has not been shown before stated author Børge G. Nordestgaard MD DMSC in the paper.
This is important for future studies investigating the association between plasma Vitamin d and risk of cancer.
#High-fat dairy products linked to poorer breast cancer survivalpatients who consume high-fat dairy products following breast cancer diagnosis increase their chances of dying from the disease years later according to a study by Kaiser permanente researchers.
The study published in the Journal of the National Cancer Institute is the first to examine the relationship between high-fat and low-fat dairy consumption following a diagnosis of breast cancer and long-term breast cancer survival.
Previous studies have shown that higher lifetime exposure to estrogen is a causal pathway to breast cancer.
The researchers studied a cohort of women who were diagnosed with early-stage invasive breast cancer between 1997 and 2000 primarily from Kaiser permanente's Northern California region (83 percent) and the Utah Cancer Registry (12 percent.
Those consuming larger amounts of high-fat dairy (one serving or more per day) had higher breast cancer mortality as well as higher all-cause mortality
and higher non-breast cancer mortality wrote lead author Candyce H. Kroenke Scd MPH staff scientist with the Kaiser permanente Division of Research
and a 49 percent increased risk of dying from their breast cancer during the follow-up period said Kroenke.
The study found an association between high-fat dairy and breast cancer mortality but no association with low-fat dairy products and breast cancer outcomes.
Women entered into the cohort approximately two years after their breast cancer diagnosis. At the beginning of the study 1893 women completed a self-administered food-frequency questionnaire
Of the total sample 349 women had a recurrence of breast cancer and 372 died of any cause 189 (50.8 percent) of them from breast cancer.
This research was part of the Life After Cancer Epidemiology (LACE) study one of several efforts by investigators with the Kaiser permanente Division of Research to consider the role of lifestyle factors such as nutrition exercise
and social support on long-term breast cancer survival and recurrence. While hundreds of studies have examined the role of lifestyle factors in cancer risk
and prevention this study is one of a small but growing number that focus on the role of lifestyle factors after a breast cancer diagnosis For example the Pathways study of breast cancer survivorship based at the Division of Research is collecting
and analyzing data about women's genetic background tumor characteristics and lifestyle choices immediately after diagnosis. Findings from this study along with the LACE study are providing objective information to help guide women as they make decisions following a breast cancer diagnosis;
among these findings are that soy decreases the risk of breast cancer recurrence quality of life after diagnosis influences outcomes
and physical activity is beneficial. Susan E. Kutner MD chair of the Kaiser permanente Northern California Regional Breast Care Task force said that the new study bolsters the counseling that Kaiser permanente gives breast cancer survivors about the importance of a low-fat diet as well as exercise
and weight management in preventing recurrence of the disease. Women have been clamoring for this type of information Dr. Kutner said.
They're asking us'Tell me what I should eat?''With this information we can be more specific about recommending low-fat dairy products.
Authors of the study in addition to Dr. Kroenke and Caan were Marilyn L. Kwan Phd and Adrienne Castillo MS RD of the Kaiser permanente Division of Research;
The National Cancer Institute of the National institutes of health funded this study (grant R01ca129059. Story Source: The above story is provided based on materials by Kaiser permanente. Note:
However a 2001 National Cancer Institute (NCI) report found that smokers compensate for the lower smoke yield in light cigarettes
#Bitter melon juice prevents pancreatic cancer in mouse modelsa University of Colorado Cancer study published this week in the journal Carcinogenesis shows that bitter melon juice restricts the ability of pancreatic cancer cells to metabolize glucose
Three years ago researchers showed the effect of bitter melon extract on breast cancer cells only in a Petri dish.
and kill pancreatic cancer cells says Rajesh Agarwal Phd co-program leader of Cancer Prevention and Control at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical
Diabetes tends to presage pancreatic cancer and bitter melon has been shown to effect TYPE II-DIABETES diabetes and has been used for centuries against diabetes in the folk medicines of China and India.
and directly explored the link between bitter melon and pancreatic cancer. The result Agarwal says is Alteration in metabolic events in pancreatic cancer cells
and an activation of the AMP-activated protein kinase an enzyme that indicates low energy levels in the cells.
After studies in cell cultures the group showed that mouse models of pancreatic cancer that were fed bitter melon juice were 60 percent less likely to develop the disease than controls.
The Agarwal Lab is now applying for grants that will allow them to move the study of bitter melon into further chemoprevention trials in mouse models of pancreatic cancer.
and who were enrolled already in the Flight attendant Medical Research Institute (FAMRI)- International Early Lung cancer Action Program CT screening program from 2005-2012.
By using this imaging/approach people who have been exposed to tobacco smoke can be evaluated for lung cancer emphysema
Cancer Society and the Institute of Global Tobacco Control at Johns hopkins university. Meeting attendees were warned by speaker after speaker that
This research group has published previously work showing the benefits of GSSE in combating obesity heart dysfunction brain lipotoxicity and kidney cancer.
A University of Colorado Cancer Center review published in this month's issue of the journal Current Opinion in Gastroenterology shows that resistant starch also helps the body resist colorectal cancer through mechanisms including killing pre-cancerous cells
and reducing inflammation that can otherwise promote cancer. Resistant starch is found in peas beans
But consumed correctly it appears to kill pre-cancerous cells in the bowel says Janine Higgins Phd CU Cancer Center investigator and associate professor of Pediatrics at the University of Colorado School of medicine.
and sizes of lesions due to colorectal cancer and an increased number of cells that express the protein IL-10 which acts to regulate the body's inflammatory response Resistant starch may also have implications for the prevention
of breast cancer Higgins says. For example if you let rats get obese get them to lose the weight
This effect on obesity may help to reduce breast cancer risk as well as having implications for the treatment of colorectal cancer.
There are a lot of things that feed into the same model of resistant starch as a cancer-protective agent Higgins says.
which benefits exactly will pan out as mechanisms of cancer prevention one thing is clear: resistant starch should be on the menu.
and were successful in doing So long-term smokeless tobacco use is associated with cardiovascular disease and cancer.
The study was funded by the National Cancer Institute (R01 CA121165. Story Source: The above story is provided based on materials by Mayo Clinic.
#Researchers find potential new therapeutic target for treating non-small cell lung cancerresearchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer.
IKBKE overexpression has been associated with breast and prostate cancers. However it had not been linked to environmental carcinogen such as tobacco smoke until now.
Tobacco smoke is documented the strongest initiator and promoter of lung cancer. The traditional model holds that tobacco components promote carcinogenesis through a process that leads to DNA damage.
Recent studies have shown that tobacco smoke can also promote lung cancer through changes in the pathways that regulate cell proliferation and survival.
in order to find potential drug targets to treat non-small cell lung cancer. In this study IKBKE was found to be induced by two tobacco carcinogens:
Their findings suggest that IKBKE is a key molecule related to tobacco-induced lung cancer. Since IKBKE kinase is induced by tobacco small molecular inhibitors of IKBKE could have a therapeutic drug potential for lung cancer explained lead author Jin Q. Cheng Ph d. M d. senior member
of the Molecular Oncology Department at Moffitt. Current treatments for non-small cell lung cancer include surgery radiotherapy and chemotherapy.
However patients eventually develop resistance to treatment. There is a great need to better understand the molecular mechanism of resistance
According to the researchers STAT3 is activated frequently in various types of human cancers and when activated STAT3 increases IKBKE overexpression and protein levels.
In non-small cell lung cancer nicotine-induced IKBKE depends on STAT3. The authors noted that the activation stage of STAT3 represents an attractive therapeutic potential
and IKBKE levels increase in response to nicotine and nicotine-derived nitrosamine ketone this evidence can be used potentially to develop a non-small cell lung cancer intervention strategy that targets IKBKE concluded Cheng.
The work was supported by National Cancer Institute Grants CA137041 and P50 CA119997 and James & Esther King Biomedical Research Program 1kg02 1kd04 and 1kn08.
The above story is provided based on materials by H. Lee Moffitt Cancer Center & Research Institute.
The research was supported by TRDRP Grant 18st-0201 and National Cancer Institute Grant CA-61021.
Long-term exposure can lead to the development of different types of cancer as well as serious cardiovascular neurological and other health problems.
and alternatives to traditional combustible tobacco says Robin Mermelstein director of the UIC institute and principal investigator of the National Cancer Institute-funded study.
The project is supported by the National Cancer Institute one of the National institutes of health under award number P01ca098262.
the National institutes of health (NIH)# ARP Diet and Health Study the Cancer Prevention Study II-Nutrition Cohort the Multiethnic Cohort the Health professionals Follow-up Study and the Nurses Health Study
and doughnuts is associated with an increased risk of prostate cancer and the effect appears to be slightly stronger with regard to more aggressive forms of the disease according to a study by investigators at Fred Hutchinson Cancer Research center.
Corresponding author Janet L. Stanford Ph d. and colleagues Marni Stott-Miller Ph d. a postdoctoral research fellow and Marian Neuhouser Ph d. all of the Hutchinson Center
While previous studies have suggested that eating foods made with high-heat cooking methods such as grilled meats may increase the risk of prostate cancer this is the first study to examine the addition of deep frying to the equation.
Eating more than once a week may raise risk Specifically Stanford co-director of the Hutchinson Center's Program in Prostate Cancer Research
and/or doughnuts at least once a week were increased at an risk of prostate cancer as compared to men who said they ate such foods less than once a month.
or more of these foods at least weekly had increased an risk of prostate cancer that ranged from 30 to 37 percent.
Weekly consumption of these foods was associated also with a slightly greater risk of more aggressive prostate cancer.
The researchers controlled for factors such as age race family history of prostate cancer body-mass index
when calculating the association between eating deep-fried foods and prostate cancer risk. The link between prostate cancer and select deep-fried foods appeared to be limited to the highest level of consumption--defined in our study as more than once a week--which suggests that regular consumption of deep-fried foods confers particular risk for developing prostate
cancer Stanford said. Deep frying may trigger formation of carcinogens in food Possible mechanisms behind the increased cancer risk Stanford hypothesizes include the fact that
when oil is heated to temperatures suitable for deep frying potentially carcinogenic compounds can form in the fried food.
They include acrylamide (found in carbohydrate-rich foods such as French fries) heterocyclic amines and polycyclic aromatic hydrocarbons (chemicals formed
For the study Stanford and colleagues analyzed data from two prior population-based case-control studies involving a total of 1549 men diagnosed with prostate cancer and 1492 age-matched
and risk of prostate cancer Stanford said. However deep-fried foods have previously been linked to cancers of the breast lung pancreas head and neck and esophagus.
Because deep-fried foods are eaten primarily outside the home it is possible that the link between these foods
and prostate cancer risk may be a sign of high consumption of fast foods in general the authors wrote citing the dramatic increase in fast-food restaurants and fast-food consumption in the U s. in the past several decades.
The project was supported by the National Cancer Institute and Fred Hutchinson Cancer Research center. Story Source:
The above story is provided based on materials by Fred Hutchinson Cancer Research center. Note: Materials may be edited for content and length.
and might even prevent cancer. But for the first time scientists have exposed extracts from numerous berries high in those pigments to human saliva to see just what kinds of health-promoting substances are likely to survive
Scientists say that these early findings will contribute to the further development of confectionaries gums and other delivery devices for the prevention and possibly the treatment of conditions such as periodontal disease and oral cancers.
Black raspberries in particular have been shown in numerous previous studies to have chemopreventive effects on tumors in the mouth esophagus and colon mostly in animal studies.
The extent of the pigment degradation in saliva was primarily a function of the chemical structure of a given anthocyanin said Failla also an investigator in Ohio State's Comprehensive Cancer Center and Food Innovation Center.
Killian and fellow scientists from Rice and the University of Texas MD Anderson Cancer Center co-founded Nano3d Biosciences in 2009 after creating a technology that uses magnetism to levitate
and vegetable intake and risk of overall breast cancer but vegetable consumption is associated with a lower risk of estrogen receptor-negative (ER-)breast cancer according to a study published January 24 in the Journal of the National Cancer
The intake of fruits and vegetables has been hypothesized to lower breast cancer risk however the existing evidence is inconclusive.
There are many subtypes of breast cancer including ER -and ER positive (ER+)tumors and each may have distinct etiologies.
Since ER-tumors which have lower survival rates and are less dependent on estrogen levels than ER+tumors account for only 15-20%of breast cancers large pooled analyses are needed to determine the suspected link to lower ER-breast cancer risk and the consumption of fruits and vegetables.
In order to determine if there is a link between the lowered risk of ER-breast cancers and the intake of fruits and vegetables Seungyoun Jung Sc.
D. formerly from the Department of Nutrition Harvard School of Public health and currently at the Channing Division of Network Medicine Brigham and Women's Hospital and colleagues analyzed data from 20 cohort studies of women
who were followed for a maximum of 11-20 years. They investigated the association of high compared to low intake of fruit
and vegetables and risk of developing breast cancer in each study and then combined the study-specific estimates to generate summary estimates for all studies combined.
and vegetable intake was linked statistically significantly to a lower risk of ER-breast cancer but not with risk of overall breast cancer or risk of ER+breast tumors.
These findings support the value of examining etiologic factors in relation to breast cancer characterized by hormone receptor status in large pooled analyses
because modest associations with less common breast cancer subtypes may have been missed in smaller studies the authors write.
In an accompanying editorial Cynthia A. Thomson Ph d. and Patricia A. Thompson Ph d. both of the University of Arizona Cancer Center write that the findings of the study support the emphasis on greater intake for vegetables
(and to a lesser extent fruit) to lower the risk of ER-breast cancer. However they also write that interpretation of these findings may also be challenged by the known effects of other potential confounders including the aggregation of health behaviors.
The above story is provided based on materials by Journal of the National Cancer Institute. Note: Materials may be edited for content and length h
along with 83 percent of the colon cancer cells while normal lung cells were unharmed virtually. Taxol was lethal to the cancer cells too
Wusirika thinks the rice callus culture may be attacking cancer with the same sort of plant chemicals that make vegetables so healthy to eat.
We think that's what is killing the cancer. Next Wusirika would like to try the rice callus solution on prostate lung and breast cancer cells the most common types of cancer in the US.
We think it will work with all of them but we need to find out he said.
He also wants to determine which of the compounds released by the rice callus have cancer-killing properties
and how they work against tumor cells. Or he notes it's possible that the suite of biochemicals found in the callus solution work as a team to fight cancer.
Story Source: The above story is provided based on materials by Michigan Technological University. The original article was written by Marcia Goodrich.
In one scenario an athlete was given heroic qualities such as working with ill children a commitment to the cause of cancer prevention dedicating his performance to his mother
when treating tumors, research findsnew research from Wake Forest Baptist Medical center shows that patients suffering from aggressive brain tumors can be treated effectively with smaller radiation fields to spare the rest of the brain and preserve cognition.
and does not seem to lead to an increase in the likelihood of the tumor recurring.
whether using these tighter margins would affect the tumors coming back outside of the radiation field
Smaller radiation margins around the tumor do not seem to lead to an increase in the tumor returning just outside of the radiation field Chan said.
and respiratory diseases including coronary heart disease and lung cancer. However until now it has been uncertain whether ETS increases the risk of dementia mainly due to lack of research.
--and best known for claims that it can help prevent certain cancers--may ease classic behavioral symptoms in those with autism spectrum disorders (ASDS).
He says that studies show that the cells of those with ASD often have high levels of oxidative stress the buildup of harmful unintended byproducts from the cell's use of oxygen that can cause inflammation damage DNA and lead to cancer and other
Oral HPV-16 is believed to be responsible for the increase in incidence of oropharyngeal squamous cell cancers in the United states. An association between self-reported number of cigarettes currently smoked per day
#U s. releases 13th Report on Carcinogensfour substances have been added in the U s. Department of health and human services 13th Report on Carcinogens a science-based document that identifies chemical biological and physical agents that are considered cancer hazards for people living
Identifying substances in our environment that can make people vulnerable to cancer will help in prevention efforts said Linda Birnbaum Ph d. director of the National Institute of Environmental Health Sciences (NIEHS) and the National
and it empowers the public with information people can use to reduce exposure to cancer causing substances.
A listing in the report indicates a cancer hazard but does not by itself mean that a substance will cause cancer.
Many factors including the amount and duration of exposure and an individual's susceptibility to a substance can affect
whether a person will develop cancer. One substance added as a known human carcinogensince 1983 ortho-toluidine has been listed in the Report on Carcinogens as reasonably anticipated to be a human carcinogen.
However new cancer studies led NTP to reevaluate and reclassify ortho-toluidine and it is added now to the category of known to be a human carcinogen based on studies in humans showing it causes urinary bladder cancer.
Ortho-toluidine is a synthetic chemical produced in other countries and imported into the United states by several companies in high volumes.
No human studies were identified that evaluated the relationship between human cancer and exposure specifically to 1-bromopropane.
However inhalation exposure to 1-bromopropane in rodents caused tumors in several organs including the skin lungs and large intestine.
Inhalation exposure to cumene caused lung tumors in male and female mice and liver tumors in female mice.
No human studies were identified that looked at the relationship between human cancer and exposure specifically to cumene.
It also caused tumors in the liver and other organs in mice. Story Source: The above story is provided based on materials by National Institute of Environmental Health Sciences (NIEHS.
but dietary quality could be improveda new American Cancer Society study suggests that participants in the Supplemental Nutrition Assistance program (SNAP) previously known as the food stamp program had lower dietary quality scores compared with income eligible nonparticipants.
For their study published in Mayo Clinic Proceedings researchers led by Binh T. Nguyen Phd of the American Cancer Society explored the diet quality of SNAP participants using data from a nationally representative sample of over 4000 adult
The above story is provided based on materials by American Cancer Society. Note: Materials may be edited for content and length.
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