Synopsis: 5. medicine & health: 1. diseases: Diseases: Endocrine diseases:


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Hyperuricemia has been associated with metabolic syndrome hypertension type 2 diabetes mellitus chronic kidney disease gout and cardiovascular morbidity and mortality.

either type 2 diabetes mellitus or were at risk of coronary heart disease. The findings below demonstrate the positive health effects of a Mediet in older adults:


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and obesity to diabetes asthma and depression he said. There is mounting evidence that exposure to a variety of environmental sources of microbes can affect long-term health findings known as the'hygiene hypothesis'said Song a graduate student in CU-Boulder's ecology and evolutionary biology department and first


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It has been proven to decrease the risk of obesity and diabetes. This discovery holds promise on many fronts beyond food systems.


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and body weight that underpin type 2 diabetes. Their presentation on chlorogenic acids#widely available as a dietary supplement#was part of the 245th National Meeting

Joe Vinson Ph d. who led the research pointed out that type 2 diabetes the most common form of diabetes is an increasing global health problem.

and foster weight loss at the same time would be a major advance in the treatment of type 2 diabetes Vinson said.

There is significant epidemiological and other evidence that coffee consumption reduces the risk of type 2 diabetes.

I am trying to make the coffee and diabetes story as clear as possible for the public.

The evidence points to chlorogenic acids as the active ingredients in coffee that both prevent diabetes

and improve glucose control in normal pre-diabetic and diabetic people. Chlorogenic acids are a family of substances that occur naturally in apples cherries plums dried plums and other fruits and vegetables.


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And consumption of too much food and less nutritious foods underpins epidemics in obesity and type 2 diabetes.


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and to verify that ABCB1 is in fact the gene that controls dwarfism. After Devos and Parvathaneni located the dwarfing gene they tested pearl millet dwarfs from around the world.


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The research focus of Bauer's fruit fly lab is nutrition and its relationship to longevity health and diabetes.

Because of the low costs associated with fly research and the fly's short life cycle researchers use fruit flies to study human diseases from diabetes to heart function to Alzheimer's disease.


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and colon cancer diabetes asthma and other disorders. The immune system normally triggers an inflammatory response to an acute event such as injury or infection


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#Community approach effective in fight against diabetesnew research from Wake Forest Baptist Medical center shows that a diabetes prevention program led by community health workers is effective at reducing blood glucose

and potentially reducing diabetes over the long term. This is the largest program to successfully replicate the results achieved by the Diabetes Prevention Project (DPP) a research study led by the National institutes of health

and supported by Centers for Disease Control and Prevention which demonstrated several years ago that lifestyle weight-loss interventions can reduce the incidence of diabetes by 58 percent.

The study is published in the March 18 issue of the American Journal of Preventive medicine. We wanted to take this intervention out to people in the community rather than having them have to come to us in a clinical setting said the study's lead author Jeff Katula Ph d. assistant professor of health and exercise sciences at Wake Forest University and joint

Given the high prevalence of obesity and metabolic syndrome and risk for diabetes our study shows we can provide an effective program in a community setting.

Latest estimates indicate that almost 26 million people in the U s. have diabetes and another 79 million adults have prediabetes a condition in

but not yet high enough to be diagnosed as diabetes. Despite improved treatment the overall public health burden continues to increase

This project was supported by award R18dk069901 from the National Institute of Diabetes and Digestive and Kidney diseases.


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and type 2 diabetes she said. Although scientists believe that dairy products guard against obesity and the health problems that accompany extra weight they aren't sure how it happens.

The analysis controlled for sex age family history of cardiovascular disease and type 2 diabetes and physical activity.


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in case of autoimmune disorders such as diabetes or lupus it might be possible to attenuate the immune response by blocking the formation of a memory pool.

which is what much of the immune response is reacting to in diabetes he said. But if you can tweak the immune cells in the right way then


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Diabetes tends to presage pancreatic cancer and bitter melon has been shown to effect TYPE II-DIABETES diabetes and has been used for centuries against diabetes in the folk medicines of China and India.

Following this line of thinking Agarwal and colleagues wondered what would happen if they closed out the middle man of diabetes

and directly explored the link between bitter melon and pancreatic cancer. The result Agarwal says is Alteration in metabolic events in pancreatic cancer cells

and an activation of the AMP-activated protein kinase an enzyme that indicates low energy levels in the cells.


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We actually found the risk of secondhand smoke exposure to be an equivalent or stronger risk factor for CAC than other well-established ones such as high cholesterol hypertension and diabetes.

and more likely to have diabetes high cholesterol and high blood pressure. Although his team did not use the standard Agatston score to assess CAC Dr. Hecht said this study further validates the utility of low-dose non-gated CT scans to measure the amount of plaque in the coronary arteries in nonsmokers exposed to secondhand tobacco smoke.


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#Exposure to pesticides in food, air and water increases risk of type 2 diabetes, study findsa study led by the University of Granada reveals that there is a direct relationship between the presence of Persistent Organic Pollutants

in the body and the development of type 2 diabetes regardless of the patient's age gender or body mass index.

A study conducted at the University of Granada has revealed that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants CPOS) in food air and water and prevalence of type 2 diabetes in adults regardless

and they might be one of the reasons why obese people are more likely to develop diabetes since the more fat the higher the COP concentrations in the body.

In a paper recently published in the journal Environmental Research researchers demonstrate that people with higher concentrations of DDE-the main metabolite in the pesticide DDT-are four times more likely to develop type 2 diabetes than other people.

In addition the risk of type 2 diabetes is associated also with exposure to Î-HCH (beta-Hexachlorocyclohexane)

According to professor Arrebola the mechanism of action by which COPS increases the risk of diabetes is still unknown.

The prevalence of diabetes in the world has increased significantly in the last decades. It is estimated that by 2030 4. 4%of the world population have this metabolic disorder.

The factors causing such increase in the prevalence of diabetes are not still clearly understood.


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and reduce diabetes in cattle. Research showed that omega-3 levels dramatically increased in the cattle as more flaxseed was introduced into their diet.


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which the body converts to a close cousin of Vitamin a may lower the risk for the most common form of diabetes

The scientists used a big data approach to hunt down interactions between gene variants previously associated with increased risk for type-2 diabetes

and blood levels of substances previously implicated in type-2 diabetes risk. In people carrying a double dose of one such predisposing gene variant the researchers pinpointed a highly statistically significant inverse association of beta carotene blood levels with type-2 diabetes risk along with a suspiciously high positive association of gamma

tocopherol with risk for the disease. Type-2 diabetes affects about 15 percent of the world's population

and the numbers are increasing said Atul Butte MD Phd associate professor of systems medicine in pediatrics.

Moreover the fact that both beta carotene and gamma tocopherol interact with the same gene variant to influence diabetes risk

This in turn triggers the release of insulin whose adequate secretion by the pancreas and efficient uptake in muscle liver and fat tissue counters the dangerous buildup of glucose in the blood and in the long run the onset of type-2 diabetes.

The genomes of some 50 to 60 percent of the U s. population carry two copies of that very gene variant which previous studies have shown to confer a slightly increased risk of contracting type-2 diabetes.

This variant was one of 18 each found by other researchers to have a mild association with type-2 diabetes risk that the Butte team incorporated into its analysis. These gene/disease connections had been identified via so-called genome-wide association studies

While plenty of genetic risk factors for type-2 diabetes have been found said Butte none of them taken alone

and not even all of them taken together comes close to accounting for the prevalence of type-2 diabetes.

or without high blood-glucose levels--a defining marker of type-2 diabetes--in pursuit of differences between the two groups'exposures to myriad environmental substances.

This enabled the researchers to perform a novel study pairing each of the 18 type-2-diabetes-implicated gene variants with each of the five suspect environmental substances to see how for individuals carrying a particular gene variant

None of the genetic factors studied in isolation had shown a particularly impressive impact on type-2 diabetes risk.

This vitamin was already known as being'good'with respect to type-2 diabetes so it was no surprise that we saw it too said Butte

or accelerating the onset of type-2 diabetes. It also may throw light on precisely how these substances affect the production or performance of the protein for which the implicated gene codes.


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Using outpatient electronic medical records the researchers identified whether the participants developed cardiovascular disease diabetes mellitus hypertension (high blood pressure) and metabolic syndrome during the five-year period.

They found no relationship between dietary pattern and prevalence of cardiovascular disease diabetes metabolic syndrome or mortality in the participants;


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and type 2 diabetes. Based on this evidence the U s. Department of agriculture's (USDA) 2010 Dietary Guidelines recommend that Americans consume at least three servings of whole grain products daily


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and diabetes than those who are shaped pear and carry weight more in the buttocks hips and thighs.

and increasing the risk for diabetes at least fivefold. Risk factors include having a large waistline low levels of high-density lipoproteins (HDL) or good cholesterol high blood pressure as well as high fasting blood sugar (insulin resistance) and high triglyceride levels.

and gluteal fat was thought to protect against diabetes heart disease and metabolic syndrome said Ishwarlal Jialal lead author of the study

and low levels of omentin-1--proteins that correlate with other factors known to increase the risk for heart disease and diabetes.

and colleagues recruited 45 patients with early metabolic syndrome--defined as having at least three risk factors for metabolic syndrome including central obesity hypertension mild increases in glucose levels not yet in the diabetic range(<126 mg/dl

) hyperlipidemia without cardiovascular disease or diabetes. A control group of 30 subjects had less than two risk factors for metabolic syndrome with normal glucose and triglyceride levels.

Future large epidemiological studies should focus on evaluating the role of chemerin as a biomarker for the development of diabetes

The study was supported by a grant from the American Diabetes Association. Story Source: The above story is provided based on materials by University of California-Davis Health System.


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As obesity rates have soared so too have related health problems such as heart disease and diabetes. Consequently Ard and his colleagues fear that the next generation may have a lower life expectancy than the current generation.


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The first pancreas transplant at University Hospital used to cure diabetes. The first kidney transplant in Utah using an organ from a donor with hepatitis C. The first en bloc kidney where two pediatric kidneys were transplanted into one adult.


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The discovery could help prevent some of the disorders associated with obesity such as low-grade chronic inflammation that can lead to diabetes.


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#Cow behavior changes in response to deterioration in healthwhen a cow develops mastitis her behaviour changes

A dairy cow becomes restless four hours after it contracts bacterial mastitis. Simultaneously the other symptoms of a steadily progressing inflammation such as increased body temperature

At a conventional milking stall mastitis is detected often as late as during a milking session

Mastitis is extremely harmful for both the farmer and the cow. When an inflammation has gained a footing the cow is seriously ill.


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and can reduce risk of metabolic diseases such as obesity and type 2 diabetes. Curious about these impacts researchers from CHU de Quã bec Research center and Laval University studied the dairy-eating habits of healthy French-canadians


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#Consumption of high-fat dairy products associated with lower risk of developing diabetesnew research presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD) in Vienna Austria shows that people with the highest

or more portions per day) have a 23%lower risk of developing type 2 diabetes than those with the lowest consumption (1 or less per day).

The research is by Dr Ulrika Ericson Lund University Diabetes Center Malmã Sweden and colleagues.

and insulin sensitivity and may therefore have a crucial role in the development of type 2 diabetes (T2d).

Modelling was used to estimate hazard ratios (HR) of diabetes incidence in quintiles of energy adjusted dietary intakes.

%)was associated with a 15%reduction in risk of developing type 2 diabetes. High-fat fermented milk*consumption also reduced the risk of developing diabetes by 20

%when comparing the highest consumers (180ml/day the top 10%of consumers) with the non-consumers (60%of participants).

In contrast to these findings there was no association found between intakes of low-fat dairy products and risk of developing type 2 diabetes.

but the increased risk was higher for lower fat meats (increased risk of type 2 diabetes for high fat meats 9%for low fat 24%)both referring to the risk

Meat intake was associated with increased risk of developing diabetes regardless of fat content. She adds:

Our findings suggest that in contrast to animal fats in general fats specific to dairy products may have a role in prevention of type 2 diabetes.


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In conditions such as type 2 diabetes where healthy dietary habits are essential for effective disease control Interventions focused on enhancing DLPFC activity through aerobic exercise


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Patients with diabetes should be cautious with honey because it does have a high sugar load.


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and diabetes could be developed following research into a protein that helps keep cells in our bodies healthy.

which are currently being trialled to decrease risk of developing diabetes and heart disease. Published by Antioxidants


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With climbing rates of obesity diabetes and other diet-related illnesses helping to drive health care expenses to an all-time high we are at a crossroads said first author Dariush Mozaffarian M d. Dr. P

It's clear that poor nutrition has a major role in some of the leading American health problems including diabetes and heart disease.


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An unhealthy diet is linked closely to cardiovascular disease diabetes and some cancers. Eating a healthy diet is an important part of the strategy to prevent adverse health outcomes.


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and observational studies of diabetes and nutrition Joslin Diabetes Center and Harvard School of Public health investigators have identified specific foods

and dietary patterns that are beneficial in preventing and controlling diabetes. The findings were published June 7 2014 in Lancet.

because we believe that most of the current dietary guidelines for patients with diabetes do not reflect recent evidence.

and control diabetes in a very effective way says Osama Hamdy M d. Ph d. Medical Director of Joslin's Obesity Clinical Program and Assistant professor of Medicine at Harvard Medical school.

With the global epidemic of type 2 diabetes it's critical to invest in effective diabetes prevention

An unhealthy diet has long been considered a major contributor to the development of diabetes but only in the past two decades has this role been confirmed by prospective observational studies and clinical trials.

and dietary patterns can help prevent type 2 diabetes even without weight loss. People who eat a Mediterranean diet with foods such as olive oil whole grains

and leafy vegetables and fruits have a lower risk of developing diabetes even when they don't lose weight Dr. Hamdy says.

Foods such as oat cereal yogurt and dairy products green leafy vegetables grapes apples blueberries and walnuts were associated with reduced diabetes risk.

Drinking coffee and even decaffeinated coffee were associated also with lower type 2 diabetes risk. Participants who followed a Mediterranean eating plan--without restricting calories--showed a greater improvement in glycemic control

In addition overweight patients with newly diagnosed type 2 diabetes who followed the Mediterranean diet had need less for antihyperglycemic medications compared with participants on a low-fat diet.

and high-protein diets improved glycemic control and cardiovascular disease risk factors in patients with diabetes compared with control diets.

This offers patients a range of options for diabetes management. Foods associated with a higher risk of diabetes include red and processed meat sugar-sweetened beverages alcohol in excess quantities and refined grains such as white flour.

Recent studies of fat intake and diabetes incidence support the notion that eating the right kind of fats is beneficial to health.

This goes against years of advocacy of a low-fat/high-carbohydrate diet. When people started eating less fat they compensated by eating more refined carbohydrates

and type 2 diabetes Dr. Hamdy says. Current evidence shows that some fats such as those from red and processed meats are associated with higher cardiovascular risk

The Joslin nutritional guidelines for diabetes recommend a diet with relatively high amounts of healthy fats and protein but moderately low amounts of carbohydrates.

and significantly reduced their diabetes medications by more than 50 percent. The program's nutritional guidelines have been adopted by many institutes and organizations across the globe.

Now that we have clear evidence we are striving to educate the American public about what foods to eat to prevent diabetes

Since almost all knowledge of dietary prevention and management of diabetes comes from research in developed countries more studies are needed in less developed regions to help patients with diabetes worldwide improve their health.

The above story is provided based on materials by Joslin Diabetes Center. Note: Materials may be edited for content and length.


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Their short stature is caused not by a single genetic mutation as occurs in many forms of dwarfism


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and other health problems such as diabetes and strokes a new research paper says. The paper found a modest decrease in blood fats known as triglycerides


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Mas cotek is used for example to treat pneumonia diabetes hypertension diarrhoea and gout. We found that dried Ficus deltoidea leaves extracted with water at 50 degree celsius for 20 hours yielded an aqueous extract with the highest content of flavonoids and total phenolics.


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She and her coworkers will study the potential of dandelions to inhibit bacteria related to bovine mastitis an infection in the mammary glands of dairy cows.


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and vegetables in your diet reduces the risk of heart disease stroke diabetes and even some forms of cancer The World health organization WHO recommends a daily intake of at least 400 grams of fruit and vegetables.


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Oats are now the third largest food staple in China growing in popularity as that country deals with rising rates of cancer diabetes heart disease and intestinal issues.


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and regular coffee drinkers and more likely to have a history of diabetes. They also had a higher dietary intake of fruit and vegetables.


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and new research from St michael's Hospital suggests it should also be one of the oils of choice for people with Type 2 diabetes.

Dr. David Jenkins head of the hospital's Clinical Nutrition and Risk Factor Modification Centre compared people with Type 2 diabetes who ate either a low glycemic index diet that included bread made with canola oil

His study published today (Saturday June 14) in the journal Diabetes Care found that those on the canola bread diet experienced both a reduction in blood glucose levels and a significant reduction in LDL or bad cholesterol.

and to find out which foods were best for people with diabetes. High GI foods--such as white bread most breakfast cereals potatoes

Other studies have linked low GI diets with a reduction in both diabetes and cardiovascular events and have shown monounsaturated fats such as canola

Dr. Jenkins said the combination of a low GI diet supplemented with canola oil had not been tested before on people with Type 2 diabetes.*


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#Improving diet quality reduces risk for type 2 diabetesimproving the overall quality of one's diet helps to prevent type 2 diabetes independent of other lifestyle changes according to a study presented at the American Diabetes Association

and vegetables and less sweetened beverages and saturated fats for example--reduced their risk for type 2 diabetes by about 20 percent compared to those who made no changes to their diets.

or increased physical activity or if it could independently reduce a person's risk for developing type 2 diabetes.

We found that diet was associated indeed with diabetes independent of weight loss and increased physical activity said lead researcher Sylvia Ley Phd a postdoctoral fellow at the Harvard School of Public health.

If you improve other lifestyle factors you reduce your risk for type 2 diabetes even more

and reduce their risk for diabetes. The study also showed that it didn't matter how good

The above story is provided based on materials by American Diabetes Association. Note: Materials may be edited for content and length g


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#Infant nutrition, development of type 1 diabetes: Is it possible to prevent the illness by splitting the proteins of cows milk?

Splitting the cow's milk proteins in a formula doesn't prevent the start-up of the disease process of type 1 diabetes in predisposed children shows a large international study.

Previous studies have indicated that early exposure to complex foreign proteins such as cow's milk proteins increases the risk of type 1 diabetes in predisposed individuals.

Therefore In 2002 we embarked on a large-scale study on more than 2100 infants with a family member affected by type 1 diabetes

whether delaying the exposure to complex foreign proteins will decrease the risk of diabetes tells Professor Mikael Knip from the University of Helsinki the leader of the TRIGR Study.

The first study endpoint was positivity for at least two diabetes-associated autoantibodies by the age of six years.

However the disease process resulting in clinical diabetes has clearly two phases the first being the appearance of autoantibodies and the other the progression from autoantibody positivity to clinical disease.


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There is a growing body of research demonstrating associations between obesity diabetes and cancer risk said lead author Jennifer A. Emond an instructor in the Department of Community and Family Medicine at the Geisel School of medicine at Dartmouth College.


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It can also give rise to hypothyroidism since selenium is required a chemical in the production of thyroid hormone.


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in addition to its role in calcium metabolism this critical nutrient reduces both the risk of current infections and the late-life development of such autoimmune diseases as multiple sclerosis and type 1 diabetes.


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The Dietary Guidelines for Americans recommend increased vegetable consumption to reduce the risk of heart disease certain cancers obesity type 2 diabetes high blood pressure osteoporosis and kidney stones.


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#Factors leading to diabetes may contribute to milk supply problems for new mothersnew studies provide fresh evidence that the same factors that lead to diabetes contribute to low milk supply in some new mothers.

The study found that women diagnosed with low milk supply were 2. 5 times more likely to have experienced gestational diabetes compared to women seen at the clinic solely

also affects lactation sufficiency--even among women who did not experience diabetes in pregnancy. She found that elevated body mass index elevated fasting insulin insulin resistance

and especially elevated fasting plasma glucose in the pre-diabetic range were all predictors of insufficient milk supply in women attempting to exclusively breastfeed.

However one consequence of the obesity epidemic is that nearly one out of every four reproductive-aged women is pre-diabetic.

Dr. Nommsen-Rivers and Dr. Riddle are planning to conduct a clinical trial of metformin a drug used to control blood sugar in type 2 diabetes.

whether metformin by improving insulin action in the mammary gland will boost milk production in pre-diabetic mothers diagnosed with low milk supply.


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mitigating genetic risk for diabetesas the number of people with type 2 diabetes continues to rise

A new study finds that African american children with a genetic predisposition to diabetes may be able to reduce their risk by getting the USDA-recommended dose of calcium.

Even though life expectancy for people with diabetes has gone up the disease has a significant impact on quality of life

so finding ways to prevent people from developing diabetes is said critical Laura Tosi M d. director of the bone health program at Children's National Medical center and one of the study's lead investigators.

We were excited to find that higher calcium intake appears to mitigate the impact of some of the risk genes for type 2 diabetes

An estimated 25 million people in the United states have diabetes or about 1 in 12 people.

and other health indicators in 142 African american children age 5-9. None of the study participants were diabetic

Among children who tested positive for gene variants known to be associated with type 2 diabetes those who consumed higher amounts of calcium had a significantly lower body mass index and percent body fat than those with lower

Body mass index and percent body fat are strong indicators of a child's risk for developing diabetes later in life.

Co-investigator Joseph Devaney Ph d. said the study could help lead to a more personalized approach to diabetes prevention.

or her specific risk factors for developing type 2 diabetes and then develop a targeted preventative approach to mitigate those risk factors with specific lifestyle interventions such as increasing calcium intake

or related dietary factors may cause epigenetic changes that affect how the diabetes-linked genes are expressed.

and environmental factors in children is especially helpful for a disease as complex as diabetes said Devaney.

By the time an adult is diagnosed with diabetes there are usually numerous risk factors that need to be addressed.


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