Synopsis: 5. medicine & health: 1. diseases: Diseases: Pathology:


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Hyperinflammatory responsein the new study which appears this week in the journal PLOS Pathogens Saeij


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Testosterone levels are highly reactive to environmental factors including pathogens parasites and food scarcity. If you get sick at all you see a decrease in testosterone said Trumble.

The Tsimane experience higher exposure to parasites and pathogens and less food security thus they face a tradeoff between investing energy to maintain good immune function


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and seed size and production defense against pests and pathogens and response to abiotic stresses such as drought and ozone Pandey said.


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Gastrointestinal illnesses caused by pathogens such as E coli and salmonella pathogens have been sporadic with scientists struggling to pinpoint exact causes

and their random nature argues for a perfect storm scenario the study said. It is now clear that salmonella

and other human pathogens can contaminate produce at any stage of the production cycle from farm to fork the UF/IFAS study said.

and crop and pathogen genotypes affect salmonella's ability to multiply in the fruit. They grew three types of tomatoes--Bonny Best Florida-47 and Solar Fire during three production seasons over two years in Live oak and Citra.

Bonny Best is an heirloom variety often used as a control variety in plant pathogen experiments he said.


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Developing effective control strategies for vampire bat-transmitted rabies virus in Latin america requires an understanding of the mechanisms that have allowed the highly virulent pathogen to persist


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Oilseed rape is prone to phoma stem canker also known as blackleg disease caused by two Leptosphaeria species. The more damaging pathogen Leptosphaeria maculans (L. maculans) has been spreading globally in oilseed rape crops over the last thirty years causing widespread losses

This put China the world's biggest producer of rapeseed at risk of this highly infectious crop pathogen.

The researchers modelled the potential spread of the destructive L. maculans pathogen across the oilseed rape crops in China--with predicted rates of spread of up to seventy kilometers per year

There is a pressing need to decrease the amounts of crop debris a potent source of pathogen inoculum in seed imports.

Short term strategies for the Chinese government include training farmers to recognise the symptoms of the disease to import oilseed rape through Chinese ports in regions where little oilseed rape is grown to test for the pathogen on imported seed


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Alpha-synuclein is the primary protein found in Lewy bodies--protein clumps that are the pathological hallmark of Parkinson's disease.


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Rhizophagus irregularis is the next in this linage to be released by the DOE JGI it follows the ectomycorrhizal fungal symbiont Laccaria the poplar rust pathogen Melampsora and dozens of bacterial genomes.


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and future work will focus on unpicking how the EPS molecules in the coat contribute to colonization and pathogen exclusion.


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Preliminary findings of the research were published in the Public library of Science One Journal by Ratna Ray Ph d. associate professor of pathology at Saint louis University.


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and researchers stress the importance of risk management at pathways of introduction especially where modern trade practices provide potential new routes of entry for pests and pathogens.

The term pest and disease was used to describe all pathogens and small-to medium-size insect herbivores that--by causing tree damage and death--disrupt the ecosystem services provided by trees.


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Later as larger lesions form in ash tissues the vc system might define the'territory'defended by each pathogen individual.

The fact that most isolates of Chalara fraxinea are incompatible with each other could mean that it might be difficult to deploy damaging fungal viruses against the pathogen as a disease control method


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whether probiotics could substitute for antibiotics by reducing pathogen populations in the intestines says first author Carmen Bednorz of Freie Universitat Berlin Germany.

because without them the rationale goes in such close quarters a surfeit of pathogens would slow growth.


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and her colleagues write that numerous genera of whitefly-transmitted plant viruses (such as Begomovirus Carlavirus Crinivirus Ipomovirus Torradovirus) are part of an emerging and economically significant group of pathogens affecting important food


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Because many fungal pathogens develop resistance to prolonged treatment with antifungal drugs it is desirable to find alternatives for their control in medical agricultural and those applications in which the fungi cause damage.


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or prevent pathologies associated with the metabolic syndrome including cardiovascular disease and diabetes. The metabolic syndrome (Mets) is a group of risk factors characterized by obesity hypertension inflammation dyslipidemia glucose intolerance

and endothelial function regular long-term wild blueberry diets may also help improve pathologies associated with the Mets. Story Source:


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Innate immune responses occur in subjects exposed to a foreign substance such as a pathogen or a toxic material like venom for the first time.

when a pathogen or toxin intrudes. In a previous study the researchers found that mast cells produce enzymes that can detoxify components of snake venom

By contrast during an adaptive immune response the immune system generates antibodies that recognize the invading pathogen or toxin;

or in the event of a snakebite said Stephen Galli MD professor and chair of pathology and the co-senior author of the study.


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The products tested in the study were two genetically different strains of bifidobacteria normal inhabitants of the gastroentestinal tract that inhibit the growth of harmful pathogens and bacteria:


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#Barley crops affected by disease found on common wild grassa major fungal pathogen which affects barley crops is also present on a common wild grass according to a new study by leading agricultural researchers including the University

and is caused by a fungal pathogen. This disease affects the leaves ears and stems of the barley--decreasing grain quality and reducing crop yields by up to forty per cent.

However our research shows that the fungal pathogen that causes barley leaf blotch can be found on wild ryegrasses which are common both as weeds within cereal crop fields and in the surrounding field margins.

In the study both DNA and plant testing showed that the leaf blotch pathogen that affects barley can be found on the wild grasses

And if this pathogen species can be spread from wild grasses onto barley crops and back again further investigation is needed to identify how widespread this species is and also the role that wild grasses play as sources of disease for other crops such as wheat.


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Bats which are important reservoir hosts for many pathogens particularly viruses have been hosts to malaria parasites for more than a century said coauthor Susan Perkins an associate curator in the Museum's Division of Invertebrate Zoology.

but the high diversity of parasites as well as the high proportion of individuals that are infected with the parasites suggest that this may be yet another example of the unusually high tolerance of these flying mammals for pathogens said co-author Juliane Schaer a researcher at the Max Planck Institute


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Moreover the developing fruit also has to contend with the attentions of pathogens and pests.

These compounds help to protect the developing fruit against predators pathogens and abiotic stresses. When the seeds are ripe the Anr gene is turned off.


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#Aggressive fungal pathogen causes mold in fruits, vegetablesa research team led by a molecular plant pathologist at the University of California Riverside has discovered the mechanism by

which an aggressive fungal pathogen infects almost all fruits and vegetables. The team discovered a novel virulence mechanism--the mechanism by

This pathogen can infect more than 200 plant species causing serious gray mold disease on almost all fruits

Many bacterial fungal and oomycete pathogens deliver protein effectors--molecules the pathogens secrete--into the cells of hosts to manipulate

The new study represents the first example of a fungal pathogen delivering RNA effectors specifically small RNA effector molecules into host cells to suppress host immunity

To date almost all the pathogen effectors studied or discovered have been said proteins lead author Hailing Jin a professor of plant pathology and microbiology.

We expect our work will help in the development of new means to control aggressive pathogens.

The process is similar to how protein effectors weaken host immunity in the case of most pathogens.

What we have discovered is a naturally-occurring cross-kingdom RNAI phenomenon between a fungal pathogen

if the novel mechanism they discovered also exists in other aggressive pathogens. Story Source: The above story is provided based on materials by University of California-Riverside.


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#Health of honey bees adversely impacted by seleniumtraditionally honey bee research has focused on environmental stressors such as pesticides pathogens and diseases.


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The class of compounds studied includes those used by some plant pathogens to coordinate their attacks.


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and a pathogen said Yan Liang a co-author of the study and postdoctoral fellow at MU.


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In addition to its role as a pathogen the bacteria have beneficial effects preventing certain chronic inflammatory and metabolic diseases including Type 2 diabetes and obesity.

Laboratory and the Center for Modeling Immunity to Enteric Pathogens. The results from our new pig model closely mimic

Researchers within the Center for Modeling Immunity to Enteric Pathogens are using results from the pig model and other experimental data to develop a computational model of H. pylori infection.

The Center for Modeling Immunity to Enteric Pathogens is funded by the National Institute of Allergy and Infectious diseases part of the National institutes of health under Contract No.


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--and inevitably the pathogens they harbor. This study is an excellent example the interface between veterinary and human medicine


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Sometimes the bacteria were similar to human pathogens. Again it wasn't clear what was going on Brock said.

Were they pathogens that were making the amoebas sick? But the amoebas carrying these bacteria seemed to be thriving rather than sick.


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or proanthocyanidins are thought to play diverse roles such as defense against herbivores and pathogens or ultraviolet protection.


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and local persistence of the pathogen in cattle has a distinct spatial signature--we believe that explaining this signature is the key to quantifying the role that badgers play in the persistence of bovine TB in Britain and Ireland.


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Two of these proteins are already being studied as potential drug targets against other pathogens. The team sequenced the genome of Haemonchus contortus


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These estimates rest on the recognition that all plants rely on microbial partners to secure nutrients deter pathogens


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An infection from a pathogen or parasite--even injuries burns or surgery--all cause an immediate decrease in testosterone.

In addition the Tsimane's regular exposure to pathogens and parasites requires additional calories for maintaining necessary immune function.


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Today methicillin-resistant S. aureus (MRSA) strain CC97 is an emerging human pathogen in Europe North and South america Africa and Asia.


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To identify the virus in this family that will most effectively control the Guatemalan potato moth The french-Ecuadorian research team have analysed the pathogens among moths from all over the world.


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#Irish potato famine-causing pathogen even more virulent nowthe plant pathogen that caused The irish potato famine in the 1840s lives on today with a different genetic blueprint

or sets of all genes of five 19th century strains of the Phytophthora infestans pathogen with modern strains of the pathogen

and 1880s were quite different from modern-day P. infestans genes including some genes in modern plants that make the pathogen more virulent than the historical strains.

In the areas of the genome that today control virulence we found little similarity with historical strains suggesting that the pathogen has evolved in response to human actions like breeding more disease-resistant potatoes.

Some of the differences between the European historical samples from the 1840s and the 1870s and 1880s suggest that the pathogen was brought to Europe more than once debunking the theory that the pathogen was introduced once

Ristaino's previous work pointed the finger at the 1a strain of P. infestans as The irish potato-famine pathogen

and attempts to control the pathogen Ristaino says. Late blight is still a major threat to global food security in the developing world she adds.

Knowing how the pathogen genome has changed over time will help modern-day farmers better manage the disease.


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The scientists also grew an oat variety unable to produce normal levels of avenacin a compound that protects roots from fungal pathogens.


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and 65 percent of the insect and pathogen invaders included in this study colonize hardwood tree species said Liebhold a research entomologist with the U s. Forest Service's Northern Research Station.

and pathogens in North america has likely been facilitated by the similarity of the flora among these three continents the study suggests.


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--which means that they have to withstand herbivores pathogens and competitors to persist in a community.


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Moreover the data provides fresh insights into the crop history of wheat and barley and their interaction with the mildew pathogen.


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and Agriculture indicate that inflammation-induced insulin resistance is in some cases an adaptive rather than pathological phenomenon.


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We hope this small study will lead to more extensive research to determine why we are seeing the levels of pathogens in these products

Cutter and Scheinberg speculate that interventions such as antimicrobial rinses can lower pathogen levels on poultry carcasses.

and federal regulations and emphasize the need for antimicrobial interventions to prevent a higher prevalence of pathogens.


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The virus has several highly unusual traits that paint a disquieting picture of a pathogen that may yet lead to a pandemic according to lead scientists from the National Institute of Allergy and Infectious diseases.


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When S. littoralis caterpillars drop from a plant they are highly vulnerable to predators and pathogens in the soil as well as to starvation.


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pathogens that cause BRD Mannheimia haemolytica increased over a three-year period. We have been seeing an increase in the number of antibiotic resistant bacteria that cause pneumonia (also called BRD) in cattle said Brian Lubbers assistant professor in the diagnostic lab based at Kansas State university.

They found that over that period a high percentage of M. haemolytica bacteria recovered from cattle lungs were resistant to several of the drugs typically used to treat that pathogen.

Because there are a limited number of antimicrobial drugs that can be used for treatment of BRD pathogens Lubbers said multidrug resistance in those pathogens poses a severe threat to the livestock industry.


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stem rust pathogen--called Ug99--that was discovered first in Uganda in 1999. The discovery may help scientists develop new wheat varieties

and strategies that protect the world's food crops against the wheat stem rust pathogen that is spreading from Africa to the breadbaskets of Asia

It recognizes the invading pathogen and triggers a response in the plant to fight the disease.

Wheat stem rust is caused by a fungal pathogen. According to Akhunov since the 1950s wheat breeders have been able to develop wheat varieties that are largely resistant to this pathogen.

However the emergence of strain Ug99 in Uganda in 1999 devastated crops and has spread to Kenya Ethiopia Sudan

However the discovery of the Ug99 race of pathogen showed that changes in the virulence of existing pathogen races can become a huge problem.

First they chemically mutagenized the resistant accession of wheat to identify plants that become susceptible to the stem rust pathogen.

and develop new approaches for controlling this devastating pathogen. Story Source: The above story is provided based on materials by Kansas State university.


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As E coli is used commonly as an indicator of fecal contamination with food-borne pathogens the practice of hygiene--availability of portable toilets

Because produce is consumed commonly raw it would be best to prevent pre-harvest contamination by food-borne pathogens all together


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Based on this study we would say not said Kylie Kavanagh D. V. M. assistant professor of pathology-comparative medicine at Wake Forest Baptist


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and helps defends a plant against pathogens among a variety of other functions. Teasing out the specific genes that perform each of these discrete functions from the many genes found to be activated by ethylene might allow scientists to produce plant strains that slow down growth

or pathogens says Katherine Chang the first author of the paper and researcher in Ecker's lab. In this way mapping interconnections between the hormone pathways may have implications in agriculture.


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and there are reports of increasing numbers of cases of skin inflammation in people bitten by deer keds Knut Madslien has monitored the spread pattern of deer keds in Fennoscandia produced a description of pathological hair loss

which can be favourable for the parasite and possible pathogens in the deer ked and its host.


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The study explores how large-scale pathogen outbreaks were much more infrequent in the past which suggests the human role in transporting pathogens to new locations such as the international seed trade is a major factor.

The temperate and boreal forests of Europe and North america have been repeated subject to pathogen outbreaks over the last 100 years said Martyn Waller from Kingston University.

Palaeoecology can potentially offer a long-term perspective on such disturbance episodes providing information on their triggers frequency and impact.


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but affect a broad range of species said entomologist Jeff Bloomquist a professor in UF's Emerging Pathogens Institute and its Institute of food and agricultural sciences.


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It is the first time scientists have decoded the genome of a plant pathogen and its plant host from dried herbarium samples.

This opens up a new area of research to understand how pathogens evolve and how human activity impacts the spread of plant disease.

and the US reconstructed the spread of the potato blight pathogen from dried plants. Although these were 170 to 120 years old they were found to have many intact pieces of DNA.

The researchers examined the historical spread of the funguslike oomycete Phytophthora infestans known as The irish potato famine pathogen.

The social upheaval during that time may have led to a spread of the pathogen from its center of origin in Toluca Valley Mexico.

Crop breeding methods may impact on the evolution of pathogens. This study directly documents the effect of plant breeding on the genetic makeup of a pathogen.

Perhaps this strain became extinct when the first resistant potato varieties were bred at the beginning of the twentieth century speculates Yoshida.

What is for certain is that these findings will greatly help us to understand the dynamics of emerging pathogens.


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Stephen J. Hamilton-Dutoit M d. Aarhus University Hospital Institute of Pathology Denmark; Jonas Bergh M d. Ph d. Karolinska Institute Sweden;


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#Substances in honey increase honey bee detox gene expressionresearch in the wake of Colony Collapse Disorder a mysterious malady afflicting (primarily commercial) honey bees suggests that pests pathogens

so beekeepers can enhance their bees'ability to withstand pathogens and pesticides. Although she doesn't recommend that beekeepers rush out


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The aim of this specialist was to find potatoes which brought together the features of the South american varieties (their colour resistance to pathogens

The four clones show certain resistance to the pathogens analysed such as the potato virus Y as well as the Pectobacterium atrosepticum bacteria


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We should not forget that more than 60%of human pathogens originate from animals. But raising awareness about these relatively unknown diseases is also crucial from an economic perspective.


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Wastewater can contain pathogens and dangerous metals like mercury chromium and arsenic said Pavlo Bohutskyi an environmental engineering doctoral student and leader of this team.

At the same time the pathogens in wastewater such as viruses fungi and bacteria could destroy the algae themselves

We found two strains that can grow well alongside pathogens and one that is already present in wastewater samples Bohutskyi said.


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and build protective coatings--are at work in the survival of the human pathogen Salmonella. One out of every six Americans becomes ill from eating contaminated food each year with over a million illnesses caused by Salmonella bacteria according to the Centers for Disease Control and Prevention.


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and how they affect cells in our bodies says Scott Kern M d. the Kovler Professor of Oncology and Pathology at the Johns hopkins university School of medicine.


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and does a dance in front of the other bees describing the location of what it's found which helps the hive decide collectively where the best source is said senior scientist Matthew Krummel Phd a UCSF professor of pathology.

and communicate essential information to each other in a similar way Krummel said thereby helping to coordinate immune responses directed against invading pathogens.

what they've discovered about the new pathogen or vaccine which in turn helps the immune system mount a coordinated response to the foreign matter Krummel said The discovery is said important Krummel

which the immune system recognizes a pathogen to which it had been exposed months or years previously. Without that long-term memory vaccines would be said useless Krummel.

The body wouldn't remember that it had been exposed to a particular pathogen such as measles or diphtheria and would not know how to successfully fight it off.


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As the most diverged wild relative of O. sativa (rice) O. Brachyantha has resistance against many rice pathogens and various stress environments.


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and others to study how livestock diet affected the transport of pathogens in field runoff from manure-amended soils.

Results from these studies have been published in Foodborne Pathogens and Disease Applied and Environmental Microbiology and Transactions of the ASABE.


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Advantages of using plants to produce therapeutic proteins include the ability to produce large quantities quickly and cheaply the absence of human pathogens the stability of the proteins and the ease with


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Both donor and receptor trees tested negative for other graft-transmissible pathogens of citrus. As controls five plants were mock-inoculated with pathogen-free healthy tissue.

Samples were collected at 10-and 14-week post inoculation/grafting for small RNA profiling. Leaves were collected also continuously at later points to ensure that the tissue used for srna libraries was from the diseased trees. srnas ranging from 18 to 28 nucleotides were isolated cloned


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and grow them better and more tolerant of environmental stress like heat and drought or pathogens?


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In experiments using human monocytes--cells involved in the first line of defense against an invading pathogen--the researchers examined

When a pathogen is recognized a series of molecules wake up from dormancy to create a process that activates the innate immune response.

not only attacks the pathogen but can also cause much more collateral damage. The researchers knew from previously published experiments that


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#Scientists identify genetic mechanism that contributed to Irish Faminewhen a pathogen attacks a plant infection usually follows after the plant's immune system is compromised.

A team of researchers at the University of California Riverside focused on Phytophthora the pathogen that triggered The irish Famine of the 19th century

The Genus phytophthora contains many notorious pathogens of crops. Phytophthora pathogens cause worldwide losses of more than $6 billion each year on potato (Phytophthora infestans) and about $2 billion each year on soybean (Phytophthora sojae.

The researchers led by Wenbo Ma an associate professor of plant pathology and microbiology focused their attention on a class of essential virulence proteins produced by a broad range of pathogens including Phytophthora called effectors.

The effectors are delivered to and function only in the cells of the host plants the pathogens attack.

The researchers found that Phytophthora effectors blocked the RNA silencing pathways in their host plants (such as potato tomato

Its effectors are the first example of proteins produced by eukaryotic pathogens--nucleated single -or multicellular organisms--that promote infection by suppressing the host RNA silencing process.

Our work shows that RNA silencing suppression is a common strategy used by a variety of pathogens--viruses bacteria

and shows too that RNA silencing is an important battleground during infection by pathogens across kingdoms.

The discovery by Ma's lab is the first to show that RNA silencing regulates plant defense against eukaryotic pathogens.

A similar motif is found in effectors of animal parasites such as the malaria pathogen Plasmodium suggesting an evolutionarily conserved means for delivering effectors that affect host immunity.

Next her lab will work on extensively screening other pathogens and identifying their effectors'direct targets

so that novel control strategies can be developed to manage the diseases the pathogens cause. Ma was joined in the study by UC Riverside's Yongli Qiao Lin Liu Cristina Flores James Wong Jinxia Shi Xianbing Wang Xigang Liu Qijun Xiang


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He said weanling pigs are more susceptible to pathogens and stress because they have to adjust to a new diet and a new environment.


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Salmonella are borne important food pathogens worldwide causing diarrhea vomiting nausea fever and abdominal pain. There are currently around 6 million cases of illness from Salmonella across the EU each year the majority


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#Amino acid studies may aid battle against citrus greening diseaseamino acids in orange juice might reveal secrets to the successful attack strategy of the plant pathogen that causes citrus greening disease also known as Huanglongbing or HLB.

With further research the profiles may prove to be a reliable rapid and early indicator of the presence of the HLB pathogen in an orchard according to Breksa.

For instance if the HLB pathogen were causing havoc with the trees'ability to create use

which suggests that the HLB pathogen may have interfered with the tree's conversion of phenylalanine to cinnamic acid.


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SBV is discovered a recently pathogen of livestock such as cattle sheep and goats. The researchers have laid bare important ways by which this virus causes disease.

The full report about the study publishes on January 10 in the Open Access journal PLOS Pathogens.


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and a professor of pathology and laboratory medicine and of internal medicine at UC Davis. But our research helps to dispel the myth that gluteal fat is'innocent.'


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