#Survey shows increase in resistance to drug therapies among bovine respiratory disease casesa survey of records of bovine respiratory disease cases at the Kansas State Veterinary Diagnostic Laboratory showed that drug resistance in one of the primary
However the contribution of multidrug resistance to limited or failed therapy in veterinary patients has received much less attention.
because their detoxification mechanisms and immune systems are developed not fully Llop concludes. Story Source: The above story is provided based on materials by Plataforma SINC.
and examined what type of bacteria was in the intestine through fecal samples and intestinal biopsies.
Both before and after meditation training the study participants'brain activity was examined using a special type of imaging--arterial spin labeling magnetic resonance imaging--that is very effective at imaging brain processes such as meditation.
By utilizing a high-resolution functional magnetic resonance imaging apparatus (fmri) Dr. Van der Linden and her colleagues can image the brains of live birds in a noninvasive environment.
Passive smoking at home or in the work place increases the risk of CVD by 30%However smoking bans lead to rapid and sizeable reductions in hospitalizations for acute myocardial infarction.
Specifically changing the bottle cap manufacturing process from injection molding to thermoforming may lower environmental impact.
Functional magnetic resonance imaging (fmri) scans conducted both before and after the four-week study period looked at the women's brains in a state of rest and in response to an emotion-recognition task in
and cutting to injection molding foaming and heating. Olivetti Kirchain and their colleagues found that for these small light components such processes are energy-intensive
and injection molding of parts of a sneaker's sole which expend large amounts of energy in the manufacture of small lightweight parts.
Dr Wenxin Wang is trying to uncover therapies for diseases such as diabetic ulcers and Epidermolysis Bullosa
GNVS can efficiently deliver a variety of therapeutic agents including DNA RNA (DIR-GNVS) proteins
and the subtropical fruit may revolutionize how medical therapies like anticancer drugs are delivered to specific tumor cells.
The researchers demonstrated that GNVS can transport various therapeutic agents including anticancer drugs DNA/RNA and proteins such as antibodies.
Our GNVS can be modified to target specific cells--we can use them like missiles to carry a variety of therapeutic agents for the purpose of destroying diseased cells he said.
The therapeutic potential of grapefruit derived nanoparticles was validated further through a Phase 1 clinical trial for treatment of colon cancer patients.
It made sense for us to consider eatable plants as a mechanism to create medical nanoparticles as a potential nontoxic therapeutic delivery vehicle.
and transmissibility of these H7n9 viruses and to develop effective vaccines and antiviral drugs so as to reduce their adverse effects upon human health.
The researchers led by Ram Sasisekharan the Alfred H. Caspary Professor of Biological Engineering at MIT also found that current flu vaccines might not offer protection against these strains.
From a pandemic-preparedness point of view we should potentially start including some of these H3 strains as part of influenza vaccines.
The researchers then exposed some of these strains to antibodies provoked by the current H3 seasonal-flu vaccines.
At Wake Forest Baptist we are now fighting cancer with state-of-the-art therapies including immunotherapeutics Powell said.
Currently there is no cure for Parkinson's but symptoms are treated with medications and procedures such as deep brain stimulation.
or if people who develop Parkinson's disease are simply less apt to use tobacco because of differences in the brain that occur early in the disease process long before diagnosis. For the present population-based study Dr. Susan Searles Nielsen
and wheezing at school you should see a board-certified allergist for proper testing diagnosis and treatment.
Some components of the nectar and pollen grains bees collect to manufacture food to support the hive increase the expression of detoxification genes that help keep honey bees healthy.
However honey bees have relatively few genes dedicated to this detoxification process compared to other insect species she said.
If you don't know what your next meal is going to be how does your detoxification system know which enzymes to upregulate?
Research had shown previously that eating honey turns on detoxification genes that metabolize the chemicals in honey
They identified p-coumaric acid as the strongest inducer of the detoxification genes. We found that the perfect signal p-coumaric acid is in everything that bees eat--it's the monomer that goes into the macromolecule called sporopollenin
Her team showed that p-coumaric acid turns on not only P450 genes but representatives of every other type of detoxification gene in the genome.
According to Berenbaum three other honey constituents were effective inducers of these detoxification enzymes. These components probably originate in the tree resins that bees use to make propolis the bee glue
#Identification of stem cells two separate roles raises possibility of therapies that could inhibit fat formation,
which could point the way to potential therapies. The findings are published in the April 27 online edition of Stem Cells and Development.
This is important because now we have the potential to develop therapies that can block the activity of Type 1 pericytes to form fat
We suggest that Type 1 pericytes could be used as a cellular target for therapy to diminish fat accumulation in the muscle.
Physicians can put these findings to use today through a blood test or even saliva test that measures genotype Dr. John Kostis said They can compare the patient's genetic background with the polymorphisms that have been identified in the study
whether or not to use vaccination to contain this disease so as to reduce the likelihood of exposure of humans to the H7n9 virus. APEIR studies on policy development showed the importance of having sound evidence on the merits
and pitfalls of vaccination so that these can be weighed up scientifically without outside interference. Although there is no evidence so far that this virus will result in a human pandemic this outbreak provides a reminder of the importance for all countries to ensure they have an appropriate stockpile of antiviral medication.
Developing a vaccine for the Schmallenberg virus is a possibility. One already exists for the similar Akabane virus
Scientists then used high-tech magnetic resonance imaging (MRI) devices to peer into the rats'brains seeking differences in activity between the rats-on-chips and the rats-on-chow.
Hoch explained that the team mapped the rats'brains using Manganese-Enhanced Magnetic resonance imaging (MEMRI) to monitor brain activity.
In diagnosing cancer nanoparticles with cancer-seeking properties might be injected into a patient before a medical scan.
and make it visible for early diagnosis and the best chances for recovery. For treating the disease nanoparticles would preferentially collect in
and destroy only the abnormal cells sparing healthy tissue from the damage that triggers side effects with existing cancer chemotherapy.
which kills round 40000 people each year with no vaccines or specific treatments currently available. There have been around 2400 cases of dengue infection in Northern Australia in recent years.
Emerging opportunities for water disinfection integrated urban water management and risk assessment1. Pedro J. Alvarez1 Phd Rice university Department of Civil and Environmental Engineering 6100 Main street MS 519 Houston TX 77005 United states 713-348-5903
alvarez@rice. eduthe extraordinary properties of some nanomaterials offer leapfrogging opportunities to develop next-generation applications for drinking water disinfection
and safer wastewater reuse (e g. photocatalytically-enhanced disinfection biofouling-resistant membranes and biofilm-and corrosion-resistant surfaces).
The whole situation is bedevilled by this primitive old-fashioned attitude that Schedule 1 drugs could never have therapeutic potential
The first session will be a low dose to check there are no adverse responses the second session will give a higher therapeutic dose
While they are under the influence of the drug the patients will have guided talking therapy to enable them to explore their negative thinking
For example we might associate Easter with chocolate or injections with fear. This suggests that other species not just bees may also use this logical process when learning from others.
One major question raised by the finding is why the Hepatitis a vaccine works so well to contain the infection.
The vaccine one of the most effective in use was thought to elicit neutralizing antibodies that attack the virus in the blood.
Since it is known now that the envelope surrounding the virus in the blood prevents this the vaccine cannot work as previously thought.
It makes us rethink completely the mechanism underlying the well-documented efficacy of Hepatitis a vaccine.
Future studies will investigate the mechanisms behind the vaccine's effectiveness Dr. Lemon said. While it was thought previously that vaccine-induced antibodies attacked the virus outside of the cell the new findings suggest antibodies may actually be able to restrict viral replication within a cell.
Understanding how this really good vaccine works will help us in the future to develop better vaccines for other viruses that we are having difficulty developing vaccines for said Dr. Lemon.
Story Source: The above story is provided based on materials by University of North carolina School of medicine. Note: Materials may be edited for content and length.
and plant pathologist John Sherwood of the University of Georgia. Mutschler-Chu said the collaboration will allow her to test her varieties in different regions
This exposure to the campfire makes chemical analysis of archaeological remains problematic. The forest's environmental and archaeological sites are vulnerable for a number of reasons.
The researchers believe this technology may function as a liquid biopsy revolutionizing conventional biopsy practices
Today's biopsies require the removal of tissue samples through a needle inserted into a solid tumor a procedure that is invasive and sometimes painful.
Biopsies are extremely difficult in metastatic prostate cancer because the disease often spreads to bone where the availability of the tissue is low.
This advancement will in principle allow us to track the genomic evolution of prostate cancer after we initiate a therapy
We hope the comprehensive understanding of cancer biology at the individual level will ultimately lead to better therapy choice for patients suffering from advanced cancer.
and may help doctors personalize therapies to a patient's unique cancer. To date CTC capture technologies have been able to do little more than count the number of CTCS which is informative but not very useful from a treatment planning perspective.
which was on par with their tests of p53 activity caused by a chemotherapy drug called etoposide.
#Functional ovarian tissue engineered in laba proof-of-concept study suggests the possibility of engineering artificial ovaries in the lab to provide a more natural option for hormone replacement therapy for women.
-or cell-based hormone therapy--essentially an artificial ovary-to deliver sex hormones in a more natural manner than drugs said Emmanuel C. Opara Ph d. professor of regenerative medicine and senior author.
The loss of ovarian function can be due to surgical removal chemotherapy and radiation treatments for certain types of cancer and menopause.
This family of genes has been found to be important for abiotic stress response especially in biosynthetic and detoxification pathways.
A control group received a saline injection while another was injected with the same amount of alcohol every day for three weeks.
and others showing no more of a change in locomotor activity than control mice given daily saline injections Weiner said.
#Higher soy intake prior to lung cancer diagnosis linked to longer survival in womensummary of a study being published online March 25 2013 in the Journal of Clinical Oncology reports that Chinese women who consumed more soy before being diagnosed with lung cancer
New results from a large observational follow-up study conducted in Shanghai China indicate that women with lung cancer who consumed more soy food prior to their cancer diagnosis lived longer than those who consumed less soy.
To our knowledge this is the first study to suggest an association between high soy consumption before a lung cancer diagnosis
Lung cancer is the leading cause of cancer-related death among women worldwide with only one in seven patients surviving for five years after diagnosis. Emerging evidence suggests that female hormones particularly estrogens
The median time between the first dietary assessment and cancer diagnosis was 5 8 years.
In this analysis patients were divided into three groups according to soy food intake prior to lung cancer diagnosis. The highest and lowest intake levels were equivalent to approximately 4 oz or more and 2 oz or less tofu
at twelve months after diagnosis. The risk of death decreased with increasing soy intake until the intake reached a level equivalent to about 4 oz of tofu per day.
and postmenopausal hormone replacement therapy use a factor that may negatively affect lung cancer prognosis. In addition the overall soy food intake is higher in Chinese women than in Western women.
whether consumption of soy food after diagnosis of lung cancer affects survival particularly among patients with early-stage disease who may benefit most from a nutritional intervention.
and a member of the Advanced Diagnostics & Therapeutics initiative (AD&T) at the University of Notre dame. And for these flies it can sometime turn out to be a difficult thing to do.
for patients during and after radiation therapy and beyond. Radiation treatment of organs with cancer is designed to give enough of a dose to be toxic to the cancer tumor with minimal impact to the surrounding tissue
The researchers then went back into the medical records to match participants to their individual radiation dose levels
if given by injection or in a purified pill form but when it is a part of the fruit of a plant it may be no different from a safety standpoint than the food in which it is contained
This study illustrates that simple Vitamin d blood tests and supplements have the potential to improve smokers'health.
#High-fat dairy products linked to poorer breast cancer survivalpatients who consume high-fat dairy products following breast cancer diagnosis increase their chances of dying from the disease years later according to a study by Kaiser permanente researchers.
The study published in the Journal of the National Cancer Institute is the first to examine the relationship between high-fat and low-fat dairy consumption following a diagnosis of breast cancer and long-term breast cancer survival.
Women entered into the cohort approximately two years after their breast cancer diagnosis. At the beginning of the study 1893 women completed a self-administered food-frequency questionnaire
but growing number that focus on the role of lifestyle factors after a breast cancer diagnosis For example the Pathways study of breast cancer survivorship based at the Division of Research is collecting
and lifestyle choices immediately after diagnosis. Findings from this study along with the LACE study are providing objective information to help guide women as they make decisions following a breast cancer diagnosis;
among these findings are that soy decreases the risk of breast cancer recurrence quality of life after diagnosis influences outcomes
and livestock should be vaccinated and animals should be monitored for novel viruses which could help predict
Daniel Lindner a research plant pathologist with the Forest Service's Northern Research Station led research that identified 35 species of Geomyces more than doubling the number of known species. Lindner
researcher saysthe immune system's T cells while coordinating responses to diseases and vaccines act like honey bees sharing information about the best honey sources according to a new study by scientists at UC
This discovery might lead to useful therapeutic interventions to fight disease according to Krummel. Results of the study were published online March 10 in Nature Immunology.
and sample foreign matter such as vaccines bacteria or viruses they come together as a group during what he and his team call the critical differentiation period.
what they've discovered about the new pathogen or vaccine which in turn helps the immune system mount a coordinated response to the foreign matter Krummel said The discovery is said important Krummel
how vaccines work. We know that they are effective for years after a vaccination but we don't know why.
It seems that T-cell aggregation is a profound part of the reason. Krummel's team found that the critical differentiation period is essential to the formation of
Without that long-term memory vaccines would be said useless Krummel. The body wouldn't remember that it had been exposed to a particular pathogen such as measles
In experiments with a mouse model of human immune function the scientists vaccinated mice for listeria a common bacterium that causes food-borne illness
as if the mice had never been vaccinated at all. Krummel said the work also opens up new paths of research in immunology
Currently there is no cure; sufferers have to let the virus run its course for a few days.
The new data also shows that people who report higher levels of secondhand tobacco smoke exposure also have the greatest evidence of coronary artery calcification a build up of calcium in the artery walls as seen on a low-dose computed tomography scan.
and makes it more likely that therapeutic interventions can be designed more rationally. To study the problem Kiang's lab worked closely with Moake's team at Rice's Bioscience Research Collaborative
and provide more clues about potential therapies. The research was supported by the National institutes of health the National Science Foundation the Alliance for Nanohealth the Welch Foundation the Mary R. Gibson Foundation and the Everett Hinkson Fund.
A weapon in the fight against kidney disease caused by high-fat dietsnew insight into grape seed extract as a therapeutic and preventative measure to fight obesity-induced kidney damage is presented in a new study.
#Research supports promise of cell therapy for bowel diseaseresearchers at Wake Forest Baptist Medical center and colleagues have identified a special population of adult stem cells in bone marrow that have the natural ability to migrate to the intestine
While there is currently no cure for IBD there are drug therapies aimed at reducing inflammation and preventing the immune response.
Because these therapies aren't always effective scientists hope to use stem cells to develop an injectable cell therapy to treat IBD.
Our hope is that a mixture of these cells could be used as an injectable therapy to treat IBD.
Two-thirds of them have received still not diagnosis and treatment. It is shown also that the risk of developing the disease can be reduced
Among them 69%were given blood tests. The blood samples were analysed for celiac disease and the children who had elevated levels were called to the nearest pediatric clinic for a small intestinal biopsy to check for disease suspicion.
In summary for a twelve year period starting in 1984 Sweden experienced a unique epidemic of celiac disease in the youngest children.
of which about 100000 have not yet received proper diagnosis and treatment. Increased attention is needed at all for so many victims as possible to get the proper diagnosis
and treatmentceliac disease is much more common in Sweden than in the rest of Europe
Two-thirds of them have received still not diagnosis and treatment. It is shown also that the risk of developing the disease can be reduced
Among them 69%were given blood tests. The blood samples were analysed for celiac disease and the children who had elevated levels were called to the nearest pediatric clinic for a small intestinal biopsy to check for disease suspicion.
In summary for a twelve year period starting in 1984 Sweden experienced a unique epidemic of celiac disease in the youngest children.
of which about 100000 have not yet received proper diagnosis and treatment. Increased attention is needed at all for so many victims as possible to get the proper diagnosis and treatmentstory Source:
The above story is provided based on materials by Ume㥠University. Note: Materials may be edited for content and length.
experts sayscientists say amending an EU directive on GMOS could help stimulate innovation in making cheaper vaccines pharmaceuticals
Advantages of using plants to produce therapeutic proteins include the ability to produce large quantities quickly and cheaply the absence of human pathogens the stability of the proteins and the ease with
This could be of huge benefit in developing countries where problems with storage can render vaccines useless.
and found that some of these tiny molecules could potentially be developed into early diagnosis markers for HLB.
and therefore early rapid and robust detective methods are required especially presymptomatic diagnosis. The study's author Dr Hailing Jin of The University of California Riverside explains srnas are important gene expression modulators some
Samples were collected at 10-and 14-week post inoculation/grafting for small RNA profiling. Leaves were collected also continuously at later points to ensure that the tissue used for srna libraries was from the diseased trees. srnas ranging from 18 to 28 nucleotides were isolated cloned
which means that they can potentially be developed into early diagnosis markers for the disease. This is important because
Body composition measures were assessed via computed tomography (CT). Results published online ahead of print in the American Journal of Clinical Nutrition found both increasing thigh intermuscular fat and decreasing thigh
#Researchers find potential new therapeutic target for treating non-small cell lung cancerresearchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer.
Since IKBKE kinase is induced by tobacco small molecular inhibitors of IKBKE could have a therapeutic drug potential for lung cancer explained lead author Jin Q. Cheng Ph d. M d. senior member
Current treatments for non-small cell lung cancer include surgery radiotherapy and chemotherapy. However patients eventually develop resistance to treatment.
and develop new gene-targeted therapies that can circumvent resistance said the authors. In this study the researchers also reported for the first time that IKBKE is a target of STAT3 a transcription factor that plays a key role in many cellular processes such as cell growth
The authors noted that the activation stage of STAT3 represents an attractive therapeutic potential because IKBKE is a STAT3 target.
While IKBKE induces chemotherapy resistance knocking down IKBKE sensitizes cancer cells to chemotherapy and reduces cancer cell survival.
Alkali supplementation therapy such as bicarbonate is used to treat CKD patients with severe metabolic acidosis but simply adding more fruits and vegetables
There might be therapeutic implications about giving supplemental zinc in a strategic manner to help improve some people with certain conditions.
and cures said Craft who joined the Wake Forest Baptist faculty in October after 18 years at the University of Washington in Seattle.
and related hospital care costs. Dr. Patel is an associate professor in pediatrics at Rush University Medical center.
In a New zealand study ischemic stroke and transient ischemic attack (TIA) patients were 2. 3 times more likely to have cannabis also known as marijuana detected in urine tests as other age
Determining how they interact is key to discovering cures for diseases. Simply put finding new therapies is akin to troubleshooting a broken mechanical assembly line
-if you know all the steps in the manufacturing process it's much easier to identify the step where something went wrong.
but a genetically altered version of the plant might provide a relatively inexpensive cure for the deadly rabies virus.
which is somewhat higher than the IPCC prognosis. But the researchers were surprised when they entered temperatures and other data from the decade 2000-2010 into the model;
But researchers at the University of Georgia have made a discovery that may soon lead to new therapies for this critically neglected disease that cause neither the risks nor the pain associated with traditional treatments.
Now that we better understand this critical pathway we may begin thinking about new therapies for sleeping sickness.
We hope that potential therapies will be equally applicable to animals and that it will have a positive impact on the area's economic outlook.
which may lead to new therapies for uncontrollable bleeding and trauma. These are fundamental discoveries about cell life
and in the lives of other organisms and we hope that these will lead to new therapies for a variety of disorders.
#Poultry vaccination responsible for dramatic fall in Salmonella infectionsmass poultry vaccination programmes introduced to combat Salmonella infections have led to a dramatic fall in the number of cases since the late 1990s according to a researcher at the University of Liverpool.
and disinfection procedures as well as a voluntary industry-led vaccination scheme that began in breeding flocks in 1994 and in laying flocks in 1998.
but the mass vaccination of poultry has continued by those breeders subscribing to the Lion Quality Code of Practice
The code of practice requires mandatory vaccination of all young hens destined to lay Lion eggs against Salmonella as well as traceability of hens eggs
Sarah O'brien Professor of Epidemiology and Zoonoses from the University's Institute of Infection and Global Health attributes a dramatic fall in the number of Salmonella cases in humans to this mass vaccination programme in poultry.
The decrease in laboratory confirmed human cases coincides quite closely with the introduction of vaccination programmes in breeder and laying flocks.
but the relationship between vaccination programmes and the reduction in human disease is compelling and suggests these programmes have made a major contribution to improving public health.
Dr. Maguire studied Vitamin d blood tests of 1896 health children under 6 years of age. The children were part of TARGET Kids!(
Using outpatient electronic medical records the researchers identified whether the participants developed cardiovascular disease diabetes mellitus hypertension (high blood pressure) and metabolic syndrome during the five-year period.
They investigated a set of genes preferentially expressed at the larval stage that contribute to odorant chemoreception food digestion and metabolic detoxification.
Insecticide tolerance or resistance may have contribution to the option of detoxification pathway in insect herbivores.
They identified in DBM obvious gene duplications of four gene families that participated in xenobiotic detoxification in insects including ATP-binding cassette (ABC) transporter families the P450 monooxygenases (P450s) glutathione
and carboxylesterase (COES). Notably the further analysis highlighted the potential role of ABC TRANSPORTERS in detoxification.
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