Genetic vectors

Chromosome (215)
Genome (2528)

Synopsis: 4. biotech: Genus: Genetic vectors:


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For foster parents, there are huge costs involved with no promise of passing on genes. Scientists have long been interested in adoption,


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because it is a genetically simple plant oe with two sets of chromosomes like us oe unlike,

She is looking for the crucial C4 players by over-expressing candidate genes in rice,

or by knocking out the gene in millet, to see what happens. If they do find the genetic code for C4,


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genes or the quantum states of atoms oe is linked closely to the field of thermodynamics, which was devised originally to understand how heat flows in engines and other machinery.


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Towards the back of the fish popsicle, Birck had cut a small square for sequencing a little bit of DNA called the CO1 gene oe also known as the"barcode of life Â. Normally Birck

copies the gene they're looking for and sequences it. They then compare the sequence they have with a database of animals and plants.

and analyse a small snippet of a gene that differs slightly but in a detectable way from species to species. The idea isn't terribly new:

the decision to use the CO1 gene as the"barcode  was made around 2003, mainly due to work by Paul Herbert at the University of Guelph in Ontario, Canada.

Herbert's group proposed that the CO1 gene could work as a barcode for several reasons:

as the gene is found outside the cell nucleus in structures called mitochondria. Herbert's team also showed that screening the gene can distinguish closely related species with 98%accuracy.

For them, it made sense to pick a small region to sequence, rather than spending considerably more time analysing the whole genome."

While the CO1 gene works most of the time, there are still species immune to barcoding.

Sturgeons, for example, simply can't be barcoded using the CO1 gene oe the gene hasn't evolved enough between different species oe so identifying their caviar through barcoding is impossible.

scientists don't use the CO1 gene at all; instead two little regions of DNA are used as"barcodes Â,

what different species'CO1 genes look like is kept. Right now, there are 112,547 animal species in the database,


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"Scientists seek big genes of bigfoot Â, read one. But the professor says that the response was to be expected.


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Building the protein components needed for life involves a complex set of machinery in our cells translating information encoded in our genes into a sequence of amino acids,


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However, this is not the only way of increasing photosynthesis. Scientists are also exploring the idea that genes from the ancestors of modern-day plants might boost the ability of crops to harness the sun. It is well known that primitive plants known as cyanobacteria have a talent

they achieved a 20%increase in tobacco plants after adding a single cyanobacteria gene called inorganic carbon transporter B (Ictb.

and colleagues from the University of Nebraska have carried out some initial tests on soybeans transformed with the same gene,

"The cost of meeting global regulatory requirements for a single gene engineered into a crop can run into many millions,

which has been engineered with genes from daffodils and bacteria to produce beta-carotene, a nutrient that the body can convert into Vitamin a.

But rather than importing genes from another organism researchers are now trying to find maize strains that naturally produce high levels of beta-carotene.

They then looked for any genes in these maize strains that resembled genes linked to high beta-carotene levels in other plants."

which carry a gene variant that slows down the conversion of beta-carotene to other substances,

when this sought-after gene variant is in place. Plant breeders are using the naturally occurring maize plants and those markers to breed new plants.


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In 1995, Ronald identified the first such receptor a rice gene known as known as Xa21 and in 1998

Beutler identified the gene for the first immune receptor in mammals a mouse gene known as TLR4.

The 1980s brought about an intense hunt for the genes that control production of the receptor proteins, followed by an oeavalanche of newly discovered receptor genes and mechanisms in the 1990s.


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It is likely that the gene transfer was mediated by a parasite or a pathogen. The debate over genetically modified organisms (GMOS) is heated.

One of the arguments against them is that it is unnatural to mix genes from different species. However, research in Lund, Sweden,

The research group on evolutionary genetics has discovered that a gene for the enzyme PGIC has been transferred into sheeps fescue (Festuca ovina) from a meadow grass, probably Poa palustris,

a reproductively distinct species. The DNA analyses also show that only a small part of a chromosome was transferred.

This is the first proven case of the horizontal transfer of a gene with known function from the nucleus of one higher plant to another. oeunfortunately

we dont know exactly how the gene jump between the species occurred, which is not surprising as it took place perhaps 700,000 years ago.

The most plausible explanation is that the gene was transmitted by a parasite or pathogen, such as a virus, perhaps with the help of a sap-sucking insect, says Professor Bengtsson.

If gene jumps can occur naturally between plants belonging to different species, does this mean that there is no longer any reason to oppose genetically modified crops?

or wrong in society. oemany fear genetically modified crops because they believe that they may lead to unwanted gene spread in nature.


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which genes are to be fine-tuned in the brains of workers and queens to produce their extraordinarily different behaviors.

more than 550 genes are marked differentially between the brain of the queen and the brain of the worker,


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DNA analysis showed the organically managed soils to have more total and unique genes, as well as greater genetic diversity.


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One reason for the size is that strains such as the Chinese spring wheat analyzed by Halls team carry six copies of the same gene (most creatures carry two.


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In fact, the Roundup-resistant gene is present in 95-percent of U s.-grown sugar beet plants


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policy director at the Soil Association, said the new technology is not worth the risk. oeonce you have bombarded an animal with other genes,


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By inserting the required genes from other fungi and bacteria it is possible to make a relatively inefficient transgenic strain that can ferment pentose sugars.


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#Scientists Incorporate Spiders Silk-Spinning Genes Into Goats Goats that produce spider silk protein in their milk could enable researchers to collect large quantities of the silk.

Researchers from the University of Wyoming have developed a way to incorporate spiders silk-spinning genes into goats,

and other researchers decided to put the spiders dragline silk gene into goats in such a way that the goats would only make the protein in their milk.

Like any other genetic factor, only a certain percentage of the goats end up with the gene.

three have tested positive for having the silk protein gene. When these transgenic goats have kids

or behavior compared to goats without the gene, the researchers said. In the future, the scientists plan to incorporate the silk genes into alfalfa plants,

which they say could produce even larger quantities of silk. They explain that not only is alfalfa widely distributed


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while 10 percent of the frogs exposed to atrazine were feminized completely their genes said they should be male,

In people, females have two X (sex chromosomes, while males have one X and one Y. For frogs,

the sex chromosomes are labeled as Z or W and females have dissimilar chromosomes (ZW), while males have matching ones (ZZ).

Frogs exposed to atrazine also had reduced testosterone levels, decreased fertility, and showed less mating behavior.


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In different seasons, they develop as asexual females who produce offspring with identical genes through parthenogenesis.

All its genes have evolved to allow it to exploit its feeding relationship, said Stern. oewe found a lot of genes 35,000 compared to 15,000 to 20,

000 in other insects and 25,000 in humans, said Richards, a corresponding author of the paper. oethus it seems that pea aphids (one among the 4,

500 other aphid species on the planet) have duplicated some of their genes, said Dr. Denis Tagu,

and that the second set can allow modifications by mutations. oemost of the mutations are probably neutral or negative for the genes, with no effect on the biology of the organism.

But some rare mutations might produce new functions for some of the genes that might help, in this case,

the pea aphid adapt to its environment. oeanother possibility is that maybe aphids require extra copies of genes


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This latest study has created a fuller picture of the arthropod family tree by using more species and more genes,

500 different combinations of PCR primers to find 62 protein-coding gene sequences that could be compared across all 75 species. Regier was an early proponent of using protein coding genes to sort out the arthropod tree,

Earlier studies had used not as many genes or as many species, making this study about four times larger than anything done previously. more via science news Share Thissubscribedel. icio. usfacebookredditstumbleupontechnorati u


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But the smaller genome of brachypodium makes it easier to find genes linked to specific traits, such as stem size and disease resistance.

which means scientists can insert foreign DNA into it to study gene function and targeted approaches for crop improvement in the transformed plants,

Vogel works at the ARS Genomics and Gene Discovery Research Unit in Albany, Calif. ARS geneticist David Garvin at the agencys Plant science Research Unit in St paul, Minn.

Vogel developed a method with a very high success rate for inserting genes into brachypodium.


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The breakthrough came after scientists at Melbournes St vincents Hospital were able to remove a section of pig DNA called the Gal gene,


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Two of the varieties contained genes for the Bt protein which protects the plant against the corn borer pest,


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more importantly, helps to identify those genes that are essential for such important agronomic traits as protein and oil content.

and his colleagues have identified more than 46,000 genes of which 1, 110 are involved in lipid metabolism. oethese genes

and their associated pathways are the building blocks for soybean oil content and represent targets that can be modified to bolster output

Of additional importance for soybean farmers is that the genome sequence has provided access to the first resistance gene for the devastating disease Asian Soybean Rust (ASR.


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Once you identify genes, the next step is to figure out what they do said Rami Dalloul, a poultry and immunology researcher at Virginia Polytechnic institute and State university in Blacksburg.

Wild turkeys have a gene that makes them resistant to a type of toxic fungus sometimes found in corn and soybeans.

If you can bring back that gene into the domestic population, then you can have these birds again more resistant to the toxin,


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The protein, extracted from rice plants containing human genes, could be used in hospitals to treat burns victims

#Dr Yang and his colleagues have developed a technique for inserting human genes into Asian rice using bacteria,

The latest work to introduce human genes into rice is likely to inflame opposition to GM technology further amid fears over the safety of genetically modified crops

and alarm at combining human genes with those from other species. Dr Yang said, however, that the protein produced by the genetically modified rice was identical to Human Serum albumin found naturally in Blood tests on rats also showed it did not produce any adverse reactions.


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and this has led experts to investigate methods of using pigs created with human genes, so that body parts grown in them can be harvested for use in patients without their immune systems rejecting them.


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My wife says it s The irish gene. A certain land hunger comes from being denied property ownership for so many generations.#


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The transgenic herd of 300 was bred by inserting human genes into cloned cow embryos which were implanted then into surrogate cows.


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because the risk of gene contamination in Oregons Willamette Valley was so great. According to Grist, Judge White warned that environmental impact statements on crops were being conducted too fast,


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As part of their research they studied a new breed of genetically-modified sheep that carry a detective gene that causes Huntingdons in people.


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the researchers introduced a new gene into them that manufactures a small decoy#molecule that mimics an important control element of the bird flu virus. The replication machinery of the virus is tricked into recognizing the decoy molecule instead of the viral genes


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#Genetically modified crops That Glow Green When Stressed Genetically altered Arabdopsis Thaliana plant, with green fluorescent protein (GFP) inserted near the on/off switches for anoxia and drought genes.

Cells expressing those genes glow green under a blue light (as shown. A group of University of Tennessee plant scientists has modified genetically tobacco plants


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says Gene Giacomelli, a plant scientist at the University of Arizona, who directs their the Controlled Environment Agriculture Center.


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the environmental impact of large-scale conventional farming and the potential public health threat if antibiotic-resistant bacterial genes jumped to human pathogens.


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In my research I discovered a unique group of genes necessary for a plant to determine if it s in the light or in the dark.

it appeared these genes were unique to the plant kingdom, which fit well with my desire to avoid any thing touching on human biology.

I later discovered that this same group of genes is also part of the human DNA.

This led to the obvious question as to what these seemingly plant-specific#genes do in people.

Many years later, we now know that these same genes are important in animals for the timing of cell division, the axonal growth of neurons,

But most amazingly, these genes also regulate responses to light in animals! While we don t change our form in response to light as plants do,

that mutant fruit flies that were missing some of these genes lost the ability to respond to light.

the longer term memories are based in epigenetics#changes in gene activity that don t require alterations in the DNA code,


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The brains of these novelty-seeking bees exhibit distinct patterns of gene activity in molecular pathways known to be associated with thrill-seeking in humans,

said University of Illinois entomology professor and Institute for Genomic Biology director Gene Robinson, who led the study.

They used whole-genome microarray analysis to look for differences in the activity of thousands of genes in the brains of scouts and non-scouts.

#The researchers found thousands of distinct differences in gene activity in the brains of scouting and non-scouting bees.

Among the many differentially expressed genes were several related to catecholamine, glutamate and gamma aminobutyric-acid acid (GABA) signaling,

The tools in the toolkit#genes encoding certain molecular pathways#may play a role in the same types of behaviors,


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About 80 percent of canola growing along roadsides in North dakota contains genes that have been modified to make the plants resistant to common weed-killers.

80%of canola growing along North dakota roadways actually contains genetically modified genes. Eighty percent. It was hoped this wouldn t happen.

and hunger, said gene technologies would undermine the nations capacities to feed themselves by destroying established diversity, local knowledge and sustainable agricultural systems.


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#oeit s just a marker to show that we can take a gene that was not originally present in the animal

The ultimate goal is to introduce beneficial genes into larger animals to create less costly and more efficient medicines.#

And a transgenic pig was able to pass on these genes by giving birth to two glowing piggies in 2008.


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RNA interference, for example, can turn genes off that promote disease and aging. New forms of gene therapy, especially in vitro models that do not trigger the immune system,

have the ability to add new genes. Stem cell therapies, including the recently developed method to create#oeinduced pluripotent cells#(IPCS) by adding four genes to your own skin cells to create the equivalent of an embryonic stem cell

but without use of an embryo, are being developed to rejuvenate organs and even grow then from scratch.


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goats with spider genes that produce super-strength silk in their milk; and synthetic bacteria that decompose trash

which typically involves swapping a few genes, the scientists are building entire genomes from scratch. Keeping bar-code-stamped vials in giant refrigerators at minus-80 degrees, the company s repository in Emeryville, Calif.,is one of the world s largest collections of living

Could they tinker with some genes in the yeast to create a biological machine capable of producing medicine?


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or letters of code#can shut down a gene involved in cholesterol uptake. The study had big implications for medicine and our food supply.


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#Genes do not go extinct. Recessive genes, like the gene for red or blonde hair color, can be carried from generation to generation without emerging as a hair color.

Source: Boing Boing. 6.)Hair and fingernails do not keep growing once someone dies. Instead, the skin shrinks, giving the appearance of further growth.

Source: Lecture Notes: Dermatology). ) 7.)The color of your snot doesn t indicate if you have a bacterial or viral infection.

) One gene does not equal one protein. Many genes make multiple different proteins, depending on how the mrna from the gene is sequenced

and cut up in the cell. Some genes don t make proteins at all. SOURCE: Annual Reviews Of Biochemistry.

22.)) Goldfish actually have pretty good memories. They can remember things for months, not seconds like most people say.

SOURCE: ABC News). 23. HIV probably didn t jump to humans through human-monkey sex,


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Such approaches could reduce the need to modify commercial crops with genes imported from other species#one of the practices that most disturbs critics of genetic modification.

a soya bean equipped with a bacterial gene that allows it to tolerate a Monsanto-made glyphosphate herbicide known as Roundup.

Putting the genes for this defense into wheat has created a crop that could trick the insects into thinking that they are in peril and drive them away.


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although genes play a key role in the development of asthma, changing a population s exposure to microbes#by protecting them from parasitic diseases,

#oeit can t all be due to genes, because if we look at the prevalence of asthma or diseases of inflammation over the past 50 years,

#oeit s some interaction between the genes and the environment that s causing these rates to skyrocket.#


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Epigenetic regulation refers to the turning on and off of genes by molecules not the genes themselves.

Any random cell could reasonably be expected to have some epigenetic abnormalities, but when all of the organism s cells are derived from the same cell,

For example, a series of cloned mice were shown to express an RNA molecule that inactivated one of the female s X chromosomes.


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and interferon for multiple sclerosis and crops like Monsanto s Roundup Ready soybeans was based on relatively crude methods for inserting a gene from one organism into another.

Although it s possible to insert a single gene from one species into another, it s much harder to cut the genetic code in specific places to make real copy-editing possible.

or around a gene that might cause a disease. Right now, it s hard to study them directly.

this could be done by changing the genes of a human stem cell (in the case of a Neanderthal)


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some pregnancies produce living offspring of the extinct species. 3.)Allele replacement for precision crossbreeding of a living species with an extinct species is a new genome-editing technique developed by Harvard


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Gene Sequencers 114. Treatment Monitors Micro-Colleges The systems used to create colleges centuries ago seems justifiably primitive by today s standards.


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There may be genes in that material that are gonna be of immense value in the future Mike Bonman told 60 minutes when the vault first opened in 2008.


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They strongly activated several genes that have been linked to IBD in humans. When it comes to such diseases


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It's all in their genes and their development and that is the adaptation that they have acquired to achieve these mass emergences.


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Genetic engineering or transplanting a foreign gene directly into a crop's genome has sparked fears of health and environmental havoc.

The benefits and the dangers of genetic modification are said overhyped he explaining that the practice focuses on one gene at a time

while many important traits such as drought tolerance depend on the influence of many genes within a plant.


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 The result is interesting as it provides provocative information to suggest that there might be lateralization in the bee brain as there is in vertebrate brains said Gene Robinson a researcher at the University of Illinois at Urbana-Champaign who wasn't involved in the study.


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Using animals as a method of seed dispersal is actually a useful form of mutualism the plants get to spread their genes


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The researchers obtained these results by applying a combination of high-tech gene sequencing techniques and analytical chemistry to a collection of hand-picked wild tomato relatives from the Andes mountains.

The Andean collection allowed the researchers to study how the gene responsible for turning on AT2 production varies depending on a plant's geographic location.

and the gene probably was inactivated multiple times says Last. This suggests the AT2 production genes evolved

and adapted as the wild tomato plants spread and encountered different environmental challenges. Eventually genes die

if they're not being used Last explains. However it appears that different pressures in the south caused the gene to actively protect the tomato from a variety of intruders.

This work and research through the NSF-funded Solanum Trichome Project will help agricultural planners devise new strategies to protect tomato crops.


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or small intestine of the bees to see which genes were activated. Bee immunity The bees that ate the honey chemicals showed activation in genes that are known to help bees fight parasites

and break down pesticides while those who ate the normal bee candy showed no such activation.

One particular chemical p-Coumaric acid in particular was tied to the gene activation. The findings suggest that honey isn't just providing bees with a quick source of fast food


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By suppressing that gene the scientists have tricked the plants into growing like Jack's beanstalk even the older leaves stay green and healthy.

By switching off a gene called UPBEAT1 the switchgrass never receives a signal to stop growing leading scientists to believe they can use the modified plant to create a higher-yielding biofuel crop.

By inserting a gene from bioluminescent marine bacteria researchers at Bioglow Inc. developed a tobacco plant with faintly glowing green leaves.


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which generates extremely large numbers of small DNA tags copied from the genes of organisms being examined.


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and has many more genes Torrey said. The microbe is known famously to infect rats and change their behavior causing them to be less afraid of the smell of cat urine.


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There are two main genes related to celiac disease. Ninety-five percent of people with celiac disease will have the HLA-DQ2 gene

and the other 5 percent have the HLA-DQ8 gene. Genetic testing is used often to calculate the risk for celiac disease.

However having the gene means that you are simply at risk for developing disease and is not a conclusive diagnosis. Positive genetic tests should be followed up with celiac blood panels

and possibly biopsies depending on the result of the blood panels. If the genetic tests return with negative results the patient can essentially rule out celiac disease.


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Polyphenols suppress the genes of bacteria that control the production of smelly compounds in the mouth Wu said.


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Imprinting takes place during embryo development and selectively silences certain genes from one parent or the other.


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Bacteria that were grown in the presence of cranberries did not produce as many of the genes needed to construct flagella.

Second cranberry powder also appeared to disrupt the bacteria's production of the urease accessory gene


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which uses the DNA sequence of a single gene to distinguish between closely related species

. But one gene never tells the whole story and when looking back to the beginning of metazoan evolution even multiple genes can lead us astray.

The breakthrough in today s paper is the sequencing of the entire genome of a Ctenophore known as the sea walnut (Mnemiopsis leidyi.

The sea walnut genome contained 16548 protein coding genes 44%of which shared homology-a type of ancestry-with non-Ctenophores.

but sponges do have required the genes for nervous system development and function. This means that the ancestor of all animals may have had advanced quite an nervous system

and these structures (but not their genes) were lost in the lineage that led to sponges.

The genes that support mesoglea development are completely unique and sufficiently different from bilaterian mesoderm to suggest an independently evolved three-layer system in these seemingly simple forms.

Genes responsible for cell signalling were present even before the evolution of multicellular animals. This suggests single celled organisms were communicating with each other before they decided to organise themselves into bodies with different types of cells.

The earliest multicellular animals evolved their own form of mesoderm independently with unique genes allowing sophisticated biological organisation.


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