Synopsis: 4. biotech: Genomics:


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it represents a fungal genome expressing fungal behavior through the body of an ant, the researchers noted in the paper.


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He was also a member of one of the teams that led the Human genome Project,


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from sequencing its genome to crossbreeding coffee plants with resistant strains. Caused by the fungus Hemileia vastatrix,

And in the United kingdom, Harry Evans is working on the genome of H. Â vastatrix at CABI in Egham.


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Genome reveals comb jellies'ancient originanimals evolved gradually, from the lowly sponge to the menagerie of tentacled,

This idea makes such intuitive sense that biologists are stunned now by genome-sequencing data suggesting that the sponges were preceded by complex marine predators called comb jellies.

a developmental biologist at the University of Washington in Seattle and a leading member of the team sequencing the genome of the comb jelly Pleurobrachia bachei.

Despite comb jellies'complexity, DNA sequences in the Pleurobrachia genome place them at the base of the animal tree of life, announced Swalla's colleague Leonid Moroz

Another team presented results from genome sequencing for the comb jelly Mnemiopsis leidyi, and found that the phylum lands either below,

Andy Baxevanis, a comparative biologist at the US National Human genome Research Institute in Bethesda, Maryland,

and a leader on the Mnemiopsis genome project, says that comb jellies are the only animals that lack certain genes crucial to producing microrna short RNA chains that help to regulate gene expression.


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Patents owned by Monsanto required the insertion of three different genes into the plant genome.


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or 10 percent of a genome and have that go to term, Lanza noted in an interview with Scientific American,


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Researchers hurriedly removed from public databases their recently published genome of the world s most famous cell line, Hela,


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Emerging preliminary analyses of the genome of the virus point to the possible spectre of a pathogen that might spread silently in poultry without causing serious disease.

since been racing to discover what clues the genome might hold  including the source of the virus,


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Pathogen genome tracks Irish potato famine back to its rootsthe great potato famine of the 1840s was a defining event in Ireland s recent history.

Working from 150-year-old dried leaves, two competing teams have sequenced now the genome of the single-celled organism that wreaked havoc on The irish potato crop.

It is the first ancient plant pathogen to have decoded its genome. In 2011, scientists reported the sequence of the plague-causing bacteria responsible for the Black death of the 1340s.

Mitochondrial genomes from the famine strains showed they were more closely related to the US-1 strain than the earlier research suggested

Weigel s team also found nothing in the nuclear genomes of the famine strains to explain their ferocity.

evolutionary geneticists at the University of Copenhagen, looked more closely at such genes after sequencing the nuclear genomes of five herbarium strains of P. infestans.


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a scientist at the University of Minnesota s Veterinary Diagnostic Laboratory, will publish the sequence of a virus genome taken from a Colorado farm.

And researchers still hope that they can elucidate the virus s international and domestic path by looking for subtle evolutionary changes in viral genome sequences of samples from Asia and different US states.


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Weeds warrant urgent conservationfaced with climate change, plant breeders are increasingly turning to the genomes of the wild, weedy relatives of crops for traits such as drought tolerance and disease resistance.


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When the team sequenced the two viruses genomes and compared them to other bird-flu strains,


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a bacterial pest that can insert DNA into plant genomes. In 2011, APHIS regulators announced that a herbicide-tolerant Kentucky bluegrass would not fall under their purview,

Some of that DNA is incorporated then into the genome. For Greg Jaffe, director of biotechnology at the Center for Science in the Public interest

such as zinc-finger nucleases enzymes that precisely target a region of the plant genome. In 2010, APHIS told Dow Agrosciences of Indianapolis, Indiana,

and in a manner more likely to damage other sites in the genome yet this remains the unregulated method."


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Missouri typically involves inserting genes into a crop s genome to boost EPSP-synthase production.


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by adding an antibody to fight rotavirus originally found in llamas in the rice genome.


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Genome centre On 19 september, the New york Genome Center officially opened the doors of its first dedicated research facility

Its aim is to provide nonprofit genome services and to foster collaborations between academia and industry.


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A team of researchers compared the genome sequences of nearly 400 samples of diarrhoea-causing Salmonella enterica collected from people and livestock in Scotland.

the team used whole-genome sequencing to trace the tiny evolutionary steps of the collected bacterial strains.


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Shrub genome reveals secrets of flower powera shrub with cream-coloured flowers that is the closest living descendant of Earth s first flowering plants has had its genome decoded.

"Phylogenetically, it s really the equivalent of the duck-billed platypus and monotremes, says Claude depamphilis, a plant evolutionary biologist at Pennsylvania State university in University Park, who co-led researchers on the Amborella Genome Project.

Just as the platypus genome yielded insights into the emergence of mammals, Amborella s gives a glimpse at changes that helped flowering plants,

Comparisons of the genomes of Amborella and those of other plants suggest that an early ancestor of flowering plants gained a duplicate copy of its genome

analysis of the Amborella genome reveals. About one-quarter of the genes involved in flowering lack obvious counterparts in the genomes of gymnosperms,

whereas the other three-quarters existed in the common ancestor of both plant lineages. His team s analysis also provides insight into the evolution of complex seeds, floral scents and other features of flowering plants.

Keith Adams, a plant molecular geneticist at the University of British columbia in Vancouver, Canada, thinks the idea that a genome duplication helped flowering plants to diversify is"an intriguing hypothesis

Botanists studying other plants should find the Amborella genome useful as a reference point to identify


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The wild Asian banana Musa acuminata malaccensis the genome of which was published last year (A. Â D Hont Nature 488,213-217;


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and discuss how genome analysis can aid clinical practice and patient care. go. nature. com/dqzhpa


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A 2005 genetic analysis of the 1918 pandemic virus pulled from a victim s preserved tissue concluded that it most closely matched viruses of avian origin2.


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Moreover sex allows an unrelated possibly inferior partner to insert half a genome into the next generation.

By exposing bdelloids to extremely high levels of ionizing radiation (a treatment that causes hundreds of physical breaks in DNA strands) one of Meselson's former graduate students Eugene Gladyshev showed that bdelloids can completely rebuild their genomes an unprecedented feat

It's known that about 50%of the human genome is of viral and bacterial but supressed origin.


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As more children have survived similarly we have a broader genome with sensitivities. The INDUSTRY does NOT test adjuvants for sensitivities.

and how they interact with the genome. So we may have a bigger pool of children sensitive to various adjuvants which many are put in just to lower the production costs not a true safety concern.

There are NEW studies showing new genome responses to many agents triggering reactions like autism. So for parents to TRUST vaccines NEW studies are needed.

Indeed parents may have to get their own genome mapped in order to know what is safe for them or not.


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Essentially the team managed to get a complete look at the genomes of both domestic and wild tomatoes and examined the effect of both natural evolution and artificial selection (the latter

Comparative genomics is used often on diseases to figure out the relationships between different strains but this is the first time it's been applied to tomatoes.


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which can be seen to increase the information in the genome. Here's a hint: anybody who can produce the FACTUAL proof to any of these simple questions will be the next Nobel prize winner.


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They've named the new strain HERB-1. This is the first time that scientists have decoded the genome of a plant pathogen from dried plants


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We can even screen the entire genome in great gulps of DNA at a time looking for the signature of rapid selection in our genes.


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See human genome project as an example...We learned the genes in the body and now have a good understanding of how they cause disease

and deeper the challenges fruits and risks of multi-billion dollar programs such as the Human genome Project and now the Brain activity Map require much deeper scrutiny.

because personal genomics and different environments have a huge impact on brain development and fine structure.

0) cleary u folks do not understand the contribution of projects like this and the human genome project.

Human genome project cost 3 billion dollars and returned 800 billion to the US economy through various ways.

Been a fan of genome mapping from it's inception. Clearly we know who gave us genome it wasn't Obama he gave us Solynda.

PS: Its refreshing to once again have a president in charge with big visions...nice...let me know how that works out for you.:


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The Greatest Genomes Sequenced In 2012click to launch the photo galleryclick to launch the photo galleryin the 10 years

since the complete human genome was published molecular biologists have been hard at work unraveling the genomic codes of multitudes of life forms.

In 2012 genome researchers sequenced the DNA of an unborn human baby the western lowland gorilla fruits and grains and livestock.

Click through our gallery to see the highlights. in 30%of the genome gorilla is closer to human

or chimpanzee than the latter are to each other. from a nature article on the gorilla genome...


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and incorporate it into the genome of the same species or a second one. They do this by either using bacteria to deliver the new genetic material or by shooting tiny DNA-coated metal pellets into plant cells with a gene gun.

While scientists can't control exactly where the foreign DNA will land they can repeat the experiment until they get a genome with the right information in the right place.

With GMOS we know the genetic information we are using we know where it goes in the genome

This allows for more precise changes to a plant's genome. Scientists at the University of California Berkeley are already working with it to create virus-resistant cassava.


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To do that requires a tremendous amount of genetic engineering says Lewis. Until scientists achieve a profound understanding of human and animal genomes superhuman hybrids will remain little more than a cinematic confection.

The technology that has revolutionized genetic analysis allowing for whole-genome sequencing of human DNA could also enable a precision pathogen of last resort.


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Its genome has been sequenced fully so scientists will be able to compare space rice with Earth rice to see


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On Sunday a large (seriously look at that list of authors) international team of scientists published the genome of the hot pepper for the first time.

The information that lies within the genome could mean a more efficient plant breeding process

and tomato the genome could also elucidate more about the evolution and adaptation of other delicious species. One of the study's co-authors Allen Van Deynze has been working with peppers for about 20 years.

With the genome the team of researchers learned more about capsaicin synthase which joins two pathways ne based on fatty acids


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DNA of storied plant provides insight into the evolution of flowering plantsthe newly sequenced genome of the Amborella plant addresses Darwin's abominable mystery--the question of why flowers suddenly proliferated On earth millions of years ago.

The genome sequence sheds new light on a major event in the history of life On earth: the origin of flowering plants including all major food crop species. On 20 december 2013 a paper by the Amborella Genome Sequencing Project that includes a full description of the analyses performed by the project as well as implications for flowering plant research will be published in the journal Science.

The paper is among three on different research areas related to the Amborella genome that will be published in the same issue of the journal.

Amborella (Amborella trichopoda) is unique as the sole survivor of an ancient evolutionary lineage that traces back to the last common ancestor of all flowering plants.

An effort to decipher the Amborella genome--led by scientists at Penn State university the University at Buffalo the University of Florida the University of Georgia

In the same way that the genome sequence of the platypus--a survivor of an ancient lineage--can help us study the evolution of all mammals the genome sequence of Amborella can help us learn about the evolution of all flowers said Victor Albert of the University

Scientists who sequenced the Amborella genome say that it provides conclusive evidence that the ancestor of all flowering plants including Amborella evolved following a genome doubling event that occurred about 200 million years ago.

Genome doubling may therefore offer an explanation to Darwin's abominable mystery--the apparently abrupt proliferation of new species of flowering plants in fossil records dating to the Cretaceous period said Claude depamphilis of Penn State university.

Comparative analyses of the Amborella genome are already providing scientists with a new perspective on the genetic origins of important traits in all flowering plants--including all major food crop species. Because of Amborella's pivotal phylogenetic position

it is an evolutionary reference genome that allows us to better understand genome changes in those flowering plants that evolved later including genome evolution of our many crop plants--hence it will be essential for crop improvement stressed Doug Soltis of the University of Florida.

As another example of the value of the Amborella genome Joshua Der at Penn State noted We estimate that at least 14000 protein-coding genes existed in the last common ancestor of all flowering plants.

Jim Leebens-Mack from UGA noted that The Amborella genome sequence facilitated reconstruction of the ancestral gene order in the'core eudicots'a huge group that comprises about 75 percent of all angiosperms.

As an evolutionary outsider to this diverse group the Amborella genome allowed the researchers to estimate the linear order of genes in an ancestral eudicot genome

or multiply within the genome (transposable elements) seem to have stabilized in the Amborella genome. Most plants show evidence of recent bursts of this mobile DNA activity

and function of protein-coding genes so the cessation of mobile DNA activity may have slowed the rate of evolution of both genome structure and gene function.

In addition to its utility in retrospective studies of the evolution of flowering plants the Amborella genome sequence offers insights into the history and conservation of Amborella populations.


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and sequencing the genome to confirm that they had the genetic ability to turn nitrogen into plant food.


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#Sugar beet genome sequenced and analyzeda new study published in Nature today describes the sugar beet reference genome sequence generated by researchers both from the Centre for Genomic Regulation (CRG) the Max Planck Institute for Molecular genetics and the University of Bielefeld in cooperation

with other centres and plant breeders. Sugar beet accounts for nearly 30%of the world's annual sugar production according to FAO and provides a source for bioethanol and animal feed.

The sugar beet genome sequence provides insights into how the genome has been shaped by artificial selection along time. What do foodstuff like muffins bread

Now a team of researchers from the Centre for Genomic Regulation (CRG) and the Max Planck Institute for Molecular genetics (Berlin Germany) lead by Heinz Himmelbauer head of the Genomics Unit at the CRG in Barcelona

The results of the study that will be published today in Nature shed also light on how the genome has been shaped by artificial selection.

Information held in the genome sequence will be useful for further characterization of genes involved in sugar production and identification of targets for breeding efforts.

which has sequenced its genome. This group encompasses other plants of economic importance like spinach or quinoa as well as plants with an interesting biology for instance carnivorous plants or desert plants. 27421 protein-coding genes were discovered within the genome of the beet more than are encoded within the human genome.

Sugar beet has a lower number of genes encoding transcription factors than any flowering plant with already known genome adds Bernd Weisshaar a principle investigator from Bielefeld University who was involved in the study.

The researchers speculate that beets may harbor so far unknown genes involved in transcriptional control

Many sequencing projects nowadays targeted at the analysis of novel genomes also address the description of genetic variation within the species of interest.

Commonly this is achieved by generating sequencing reads obtained from high-throughput sequencing technologies followed by alignment of these reads against the reference genome to identify differences explains Heinz Himmelbauer a principle investigator of this study.

and generated genome assemblies from four additional sugar beet lines. This allowed the researchers to obtain a much better picture of intraspecific variation in sugar beet than would have been possible otherwise.

In summary 7 million variants were discovered throughout the genome. However variation was distributed not uniformly: The authors found regions of high but also of very low variation reflecting both the small population size from

which has shaped the plants'genomes. Additionally gene numbers varied between different sugar beet cultivars which contained up to 271 genes not shared with any of the other lines as Juliane Dohm

or with disease resistance added Toni Gabaldon group leader in the CRG Bioinformatics and Genomics programme and ICREA research professor.

Finally the work also provides a first genome sequence of spinach which is a close relative of sugar beet.

Thanks to the sugar beet genome sequence made by the researchers and the associated resources generated future studies on the molecular dissection of natural


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The research was supported by the Tree Biosafety and Genomics Research Cooperative at OSU. Annual crops such as cotton and corn already are grown routinely as GMO products with insect resistance genes.


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#Work with Brazilian citrus greening genome could aid Florida industrya University of Florida researcher has mapped the DNA genome of a new strain of citrus greening that could further threaten Florida's beleaguered $9 billion citrus industry.

and map the genome of the most prevalent form of the disease in Florida and now he and colleagues have done the same for a new strain of the disease discovered in Brazil.

Gabriel said by having that roadmap of the bacteria genome they will be certain there are no surprises in the Brazilian species

What the genome does it lets you know everything that the organism has and doesn't have in its artillery for offense

The genome map is already available online at Genbank. To map the bacteria's DNA genome Gabriel's Brazilian colleagues first diced up

and crushed tissue from the veins of infected citrus trees where the organism was concentrated most highly.


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and cherries and other fruits in the United states Canada and Europe is itself being targeted thanks to groundbreaking genome sequencing at the University of California Davis

Officially published Dec 1 in the journal G3 (Genes Genomics Genetics) the open-access research has been available online for several weeks and drawing global attention.

To enable basic and applied research of this important pest Drosophila suzukii we sequenced the genome to obtain a high-quality reference sequence said molecular geneticist Joanna Chiu of the UC Davis Department of Entomology and Nematology.

and Ecology led the genomics team of collaborative researchers from four institutions. The posting of the genome and comparative sequence analysis on the publicly accessible Spottedwingflybase Web portal could lead to more species-specific weapons to combat the destructive pest Chiu said.

Scientists are looking at its biology behavior food and odor preferences and pesticide resistance. Many researchers are working hard to study the biology of this insect through basic and applied projects

and help facilitate everyone's research especially those who do not have expertise in genome

Zalom recently inducted as president of the nearly 7000-member Entomological Society of America said that the G3 article presents a high-quality reference sequence of Drosophila suzukii examination of the basic properties of its genome

and transcriptome and description of patterns of genome evolution in relation to its close relatives. The Spottedwingflybase Web portal has drawn more than 3000 page views from 20 countries including the United states France Italy Belgium China Spain Japan Germany and Great britain.

He also pointed out that the genome work may relieve the fears of countries wishing to import American fruit but not the pest.

and research technician Perot Saelao of the Begun lab. The Spottedwingflybase is dedicated a online resource for Drosophila suzukii genomics


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This research is an excellent example of how new genome technologies can enable major discoveries that in the past have been difficult says Associate professor Richard Macknight of the University of Otago Department of Biochemistry.


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The analysis of the Rhizophagus irregularis genome has revealed that this asexual fungus doesn't shuffle its genes the way researchers expected.

and including researchers from the Department of energy Joint Genome Institute (DOE JGI) reported the complete genome of R. irregularis (formerly Glomus intraradices) in a paper published online November 25 in the journal Proceedings of the National

This is the first sequenced genome of arbuscular mycorrhizae the type that is dominant on the planet said Igor Grigoriev one of the senior authors on the paper and lead for the Fungal Genomics Program at the DOE JGI.

In 2006 shortly after the DOE JGI sequenced the first tree genome Populus trichocarpa it became apparent that it took a village (of other organisms) to raise a poplar tree.

Rhizophagus irregularis is the next in this linage to be released by the DOE JGI it follows the ectomycorrhizal fungal symbiont Laccaria the poplar rust pathogen Melampsora and dozens of bacterial genomes.

Analysis of the R. irregularis genome also revealed several surprising details. The research team found that the genome is among the largest fungal genomes sequenced weighing in at 153 million base pairs (Mb.

For comparison the button mushroom (Agaricus bisporus) also sequenced and published by the DOE JGI has a genome of about 30 Mb.

Through several generations portions of R. irregularis's genome were duplicated invaded by repeated transposable elements famously known as'jumping genes'.

'Unlike many other fungi R. irregularis seems to lack mechanisms that can keep these transposable elements from running amok.

Among the expanded portions of its genome R. irregularis had several genes for phosphorus metabolism

Through analysis of this and other mycorrhizal genomes we can help to better understand interactions

The above story is provided based on materials by DOE/Joint Genome Institute. Note: Materials may be edited for content and length.


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and other institutes have succeeded in unraveling the whole genome sequence of desert poplar Populus euphratica and the genetic bases underlying poplar to against salt stress.

Considering the limitation of next-generation sequencing for assembling complex genome and the high heterozygosity of desert poplar researchers used a newly developed fosmid-pooling strategy to sequence

and assemble the genome of this tree species. All the efforts yielded a high-quality genome sequence of desert poplar with high contiguity coverage

and accuracy further demonstrating the feasibility of this fosmid-pooling approach for de novo sequencing and assembly of a complex heterozygous genome.

The genome of desert poplar is very similar to that of the closely related mesophytic congener P. trichocarpa.

Researchers investigated the differences between the two genomes and suggested that P. euphratica diverged from P. trichocarpa within the last 8 to 14 million years.

Although both species shared at least two whole-genome duplication (WGDS) and exhibited extensive collinearity across the gene space species-specific genes involved in stress tolerance such as ion transport ATPASE activity transcript factor activity

and/or positively selected in the P. euphratica genome. When studying the adaptation mechanisms to against salt stress researchers found that several gene families likely to be involved in tolerance to salt stress contain significantly more gene copies in the P. euphratica lineage.

The complete genome sequencing of desert poplar revealed the underlying genetic mechanisms of poplar to against salt stress laying a solid foundation for accelerating the genetic breeding of cultivated poplars for saline and desert fields. said Junyi


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The UCLA researchers'genetic analysis is published Nov 15 in the journal Science and featured on the journal's cover.

In related research last May Wayne and his colleagues reported at the Biology of Genomes meeting in New york the results of their comparison of the complete nuclear genomes of three recent wolf breeds (from the Middle east East asia

We analyzed those six genomes with cutting-edge approaches and found that none of those wolf populations seemed to be closest to domestic dogs Wayne said.

Mitochondria are tiny sub-cellular structures with their own small genome. By comparing this ancient MITOCHONDRIAL DNA with the modern mitochondrial genomes of 77 domestic dogs 49 wolves

and four coyotes the researchers determined that the domestic dogs were grouped genetically with ancient wolves or dogs from Europe--not with wolves found anywhere else in the world or even with modern European wolves.

While Wayne plans to pursue this follow-up research he said he does not expect a nuclear genome analysis to change the central finding.


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