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ScienceDaily_2013 06591.txt

#Substance that gives grapefruit its flavor and aroma could give insect pests the bootthe citrus flavor and aroma of grapefruit--already used in fruit juices citrus-flavored beverages and prestige perfumes and colognes--may be heading for a new use in battling mosquitoes ticks head lice and bedbugs thanks to a less expensive way of making large amounts of the once rare and pricey ingredient scientists say. A new product based on nootkatone would have multiple advantages over existing mosquito repellants based on DEET said Richard Burlingame Ph d. who presented the report. Nootkatone is a broad-spectrum ingredient that has been shown to be effective as a control agent for mosquitoes ticks and bedbugs. Nootkatone has been used for years to give beverages a grapefruit flavor. It is safe to eat has a pleasant citrus flavor is not greasy both repels and kills insects and should not have the toxicity concerns that exist for DEET. Burlingame who is with Allylix Inc. a renewable-chemical firm in Lexington Ky. spoke at a symposium entitled Biopesticides: State of the art and Future Opportunities. It includes presentations (abstracts appear below) on progress in developing new pesticides isolated from natural sources or patterned closely after natural products that are effective in pest control. The goal of the symposium is to discuss the science behind these products many of which are effective at lower doses and are less toxic to humans than conventional pesticides said James N. Seiber Ph d. of the University of California Davis. He co-organized the symposium with Aaron Gross and Joel Coats Ph d. both of Iowa State university and Stephen Duke Ph d. of the U s. Department of agriculture-Agricultural research service. Burlingame cited nootkatone as an excellent example of the potential for developing new pesticides based on natural sources. Nootkatone is a component of the oil in grapefruit and has been on the U s. Food and Drug Administration's list of substances generally recognized as safe for use in food. It has been in commercial use for years as a flavoring for foods and beverages and as a fragrance ingredient in perfumes. Those applications require only tiny amounts of nootkatone and price--$25 per ounce when extracted from grapefruit--was not a major concern. It was slightly less expensive when produced from a substance called valencene extracted from oranges. The need for a more economical source of nootkatone intensified after scientists at the U s. Centers for Disease Control and Prevention (CDC) discovered nootkatone's effectiveness in controlling ticks mosquitoes and other insects. Nootkatone extracted from grapefruit however would be too expensive for development of a consumer product. That use would require larger amounts of nootkatone. Allylix is now working with scientists at CDC to develop nootkatone for commercial use as an insect-control agent. Burlingame described how Allylix used proprietary technology to develop a way of producing valencene from yeast growing in industrial fermentation vats. Technicians harvest the valencene and use a chemical process to convert it into nootkatone. Allylix said the process made it possible to market nootkatone at a competitive price. The effects of nootkatone last much longer than those of repellents currently on the market he said. And nootkatone shows promise for being the most effective agent for the ticks that cause Lyme disease. Nookatone also works in a new way so it can be used against insects that develop resistance and shrug off conventional pesticides and yet would be very unlikely to harm people or pets. Allylix currently sells nootkatone only for use in flavor and fragrance applications. The next step involves getting approval from the U s. Environmental protection agency to sell nootkatone for insect control. They haven't approved it yet so no products currently on the market in the U s. include nootkatone as an active ingredient to control pests noted Burlingame. But in the future it could be a key ingredient in repellents for use on clothing or on skin as a spray or even as a soap or shampoo. Story Source: The above story is provided based on materials by American Chemical Society (ACS. Note: Materials may be edited for content and length h

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