#Nanowire implants offer remote-controlled drug delivery Abstract: Remote-controlled Eradication of Astrogliosis in Spinal cord Injury via Electromagnetically-induced Dexamethasone Release from"Smart"Nanowireswen Gao and Richard Borgenswe describe a system to deliver drugs to selected tissues continuously,
if required, for weeks. Drugs can be released remotely inside the small animals using pre-implanted,
and deposited onto a spinal cord lesion in Glial fibrillary acidic protein-luc Transgenic mices (GFAP-luc mice). Overexpression of GFAP is an indicator of astrogliosis/neuroinflammation in CNS injury.
The corticosteroid DEX, a powerful ameliorator of inflammation, was released from the polymer by external application of an Electromagnetic field for 2 hours/day for a week.
and non-invasively, opening the door to many other known therapies, such as the cases that dexamethasone cannot be applied safely systemically in large concentrations.
and wires required by other implantable devices that can lead to infection and other complications, said team leader Richard Borgens, Purdue University's Mari Hulman George Professor of Applied Neuroscience and director of Purdue's Center for Paralysis Research."
"This tool allows us to apply drugs as needed directly to the site of injury, which could have broad medical applications,
"Borgens said.""The technology is in the early stages of testing, but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
and avoid the terrible side effects of systemic treatment with steroids or chemotherapy.""The team tested the drug-delivery system in mice with compression injuries to their spinal cords
and administered the corticosteroid dexamethasone. The study measured a molecular marker of inflammation and scar formation in the central nervous system and found that it was reduced after one week of treatment.
A paper detailing the results will be published in an upcoming issue of the Journal of Controlled Release
Wen Gao, a postdoctoral researcher in the Center for Paralysis Research who worked on the project with Borgens
and transported a patch of the nanowire carpet on water droplets that were used used to deliver it to the site of injury.
The nanowire patches adhere to the site of injury through surface tension Gao said. The magnitude and wave form of the electromagnetic field must be tuned to obtain the optimum release of the drug,
Youngnam Cho, a former faculty member at Purdue's Center for Paralysis Research; and Jianming Li, a research assistant professor at the center.
GFAP is expressed in cells called astrocytes that gather in high numbers at central nervous system injuries. Astrocytes are a part of the inflammatory process and form a scar tissue,
A 1-2 millimeter patch of the nanowires doped with dexamethasone was placed onto spinal cord lesions that had been exposed surgically,
The lesions were closed then and an electromagnetic field was applied for two hours a day for one week.
###The research was funded through the general funds of the Center for Paralysis Research and an endowment from Mrs. Mari Hulman George. Borgens has a dual appointment in Purdue's College of Engineering and the College of Veterinary medicine.##
Cancer Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015news and information Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
New technique creates multilayered, self-assembled grids with fully customizable shapes and compositions June 23rd,
2015nanomedicine Nanoparticle'wrapper'delivers chemical that stops fatty buildup in rodent arteries Experimental therapy restores normal fat metabolism in animals with atherosclerosis June 23rd, 2015picosun ALD
breaks through in medical technology June 23rd, 2015nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd,
2015newly-Developed Biosensor in Iran Detects Cocaine addiction June 23rd, 2015discoveries Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
New technique creates multilayered, self-assembled grids with fully customizable shapes and compositions June 23rd,
2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015announcements Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
New technique creates multilayered, self-assembled grids with fully customizable shapes and compositions June 23rd,
2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Nanoparticle'wrapper'delivers chemical that stops fatty buildup in rodent arteries Experimental therapy restores normal fat metabolism
2015nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd,201 0
#Physicists fine-tune control of agile exotic materials: Tunable hybrid polaritons realized with graphene layer on hexagonal boron nitride Abstract:
to Detect Cyanogen Toxic Gas June 23rd, 2015imaging Robust new process forms 3-D shapes from flat sheets of graphene June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
and the Environment June 24th, 2015nanoparticle'wrapper'delivers chemical that stops fatty buildup in rodent arteries Experimental therapy restores normal fat metabolism in animals with atherosclerosis June 23rd,
4-D printing to advance chemistry, materials sciences and defense capabilities June 18th, 2015discoveries Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together
2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015materials/Metamaterials n-tech Research Issues Report on Smart Coatings Market
to Detect Cyanogen Toxic Gas June 23rd, 2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers n-tech Research Issues Report on Smart Coatings Market
2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015military Iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd,
2015scientists Create Synthetic Membranes That Grow Like Living Cells June 22nd, 2015discovery paves way for new kinds of superconducting electronics June 22nd,
its high concentration causes digestive malfunctions and results in the related diseases due to its toxicity.
reducing pollution caused by large consumption of toxic solvents due to the high surface area, and high sorption capacity.
chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015graphene flexes its electronic muscles: Rice-led researchers calculate electrical properties of carbon cones, other shapes June 30th,
2015researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th,
2015researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th,
2015researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th,
High-throughput bioactivity screening did not reveal increased toxicity of the particles when compared to an equivalent mass of metallic silver nanoparticles or silver nitrate solution.
"The researchers used the nanoparticles to attack E coli, a bacterium that causes food poisoning; Pseudomonas aeruginosa, a common disease-causing bacterium;
Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species; and Staphylococcus epidermis, a bacterium that can cause harmful biofilms on plastics-like catheters-in the human body.
The nanoparticles were effective against all the bacteria. The method allows researchers the flexibility to change the nanoparticle recipe in order to target specific microbes.
and decreasing the alkaline and acidic solubility without creating the cellular toxicity. Results of the research have applications in textile, polymer,
They can also be used in medical and military industries. Ultrasonic bath has been used in the finishing process of the fabrics.
if a poor state of health is caused by disease or a lack of water anyway,
They contribute to the early detection of diseases that affect grapevines, such as flavescence dore and black wood, declares Stefano Sgrelli, Ceo of Salt&lemon.
where they create clothing that kills bacteria, conducts electricity, wards off malaria, captures harmful gas and weaves transistors into shirts and dresses.
Marcia Silva da Pinto, postdoctoral researcher, works on growing metal organic frameworks onto cotton samples to create a filtration system capable of capturing toxic gas,
which could help in warding colds, flu and other diseases. Two of Hinestrozas students created a hooded bodysuit embedded with insecticides using metal organic framework molecules,
Malaria kills more than 600,000 people annually in Africa. While insecticide-treated nets are common in African homes
Other students have used MOFS to create a mask and hood capable of trapping toxic gases in a selective manner.
a bacterium that causes food poisoning; Pseudomonas aeruginosa, a common disease-causing bacterium; Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species;
and Staphylococcus epidermis, a bacterium that can cause harmful biofilms on plastics like catheters in the human body.
The nanoparticles were effective against all the bacteria. The method allows researchers the flexibility to change the nanoparticle recipe in order to target specific microbes.
Removing these toxic materials which include pesticides and endocrine disruptors such as bisphenol A (BPA) with existing methods is often expensive and time-consuming.
for Integrative Cancer Research. Eliana Martins Lima, of the Federal University of Goiás, is the other co-author.
Brandl says. hen we came up with the idea to use our particles to remove toxic chemicals, pollutants,
minimizing the risks of leaving toxic secondary products to persist in, say, a body of water. nce they switch to this macro situation where theye big clumps,
from environmental remediation to medical analysis. The polymers are synthesized at room temperature, and don need to be prepared specially to target specific compounds;
offering the example of a cheap testing kit for urine analysis of medical patients. The study also suggests the broader potential for adapting nanoscale drug-delivery techniques developed for use in environmental remediation. hat we can apply some of the highly sophisticated,
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
In particular, biomedical applications, an area where the use of biocompatible polycarbonates is established well, have been left out.
for example, could provide many more possibilities for biomedical applications n
#New material opens possibilities for super-long-acting pills (Nanowerk News) Medical devices designed to reside in the stomach have a variety of applications,
including prolonged drug delivery, electronic monitoring, and weight-loss intervention. However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
As such, they are designed usually to remain in the stomach for a limited time. Now, researchers at MITS Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern
and could allow for the development of long-acting devices that reside in the stomach, including orally delivered capsules that can release drugs over a number of days, weeks,
which is a medical emergency potentially requiring surgical intervention, says Koch Institute research affiliate Giovanni Traverso,
as there is a greater risk for fracture if a device is too large or too complex.
a professor of medical science and engineering at Brown University who was not involved with this study.
patients adherence to long-term therapies for chronic illnesses is only 50 percent in developed countries, with lower rates of adherence in developing nations.
Medication nonadherence costs the U s. an estimated $100 billion every year, the bulk of which comes in the form of unnecessary hospitalizations.
The researchers also say that single-administration delivery systems for the radical treatment of malaria
and other infections could significantly benefit from these technologies. In a March 2015 commentary piece in Nature("Perspective:
Special delivery for the gut"),Traverso and Langer wrote that the GI TRACT is an area rife with opportunity for prolonged drug delivery in tackling this global health problem.
they envision an emerging field of orally delivered devices that can maximize adherence and therapeutic efficacy y
and proof of principle,"says Harald Ott of Massachusetts General Hospital in Boston, who grew the limb."
"says Daniel Weiss at the University of Vermont College of Medicine in Burlington, who works on lung regeneration."
Hand transplants have also been successful, but the recipient needs lifelong immunosuppressive drugs to prevent their body rejecting the hand.
Results of hand transplants show that this happens through the recipient's nerve tissue penetrating into the hand
while muscle cells could come from biopsies from large muscles, such as in the thigh.""If you took about 5 grams, the size of a finger,
"At present, if you lose an arm, a leg or soft tissue as part of cancer treatment or burns,
but what about that time you had measles or was it chicken pox? Your blood knows:
It could also be used to identify links between viral infections and mysterious diseases like chronic fatigue syndrome.
our immune cells respond by producing antibodies that neutralise it when they bind to specific proteins on its surface.
These antibodies continue to be made long after the virus has been cleared from our body ready to mount a quicker response should it return.
If antibodies target it then the virus has infected the person in the past. var ord=window. ord Math. floor (Math. random()*10e12;
and could help doctors identify hidden infections.""A lot of people have hepatitis C, for example, without realising,"says Elledge.
You could imagine routinely screening people in this way, he says. To develop Virscan, Elledge and his colleagues used an international database to look up all viruses known to infect humans around 1000 strains from 206 viral species. Using this information,
any circulating antibodies latch on to the associated proteins on the bacteriophages. Sequencing these bacteriophages then reveals the person's viral history.
doctors have a pretty good idea of what you've got, "he says. Moreover, the immune system takes a
while to make antibodies, so you might not find a strong antibody response in the early stages of an infection.
The test would also not be able to distinguish between antibodies made as a result of an infection and those triggered by a vaccine.
Instead the technique might be useful in outbreaks of new viruses. Understanding how our immune system responds to other viral fragments might reveal clues as to
which family the new virus belongs to, says Pamela Vallely at the University of Manchester, UK."
For example, Elledge's team will be collaborating with another group to test people with chronic fatigue syndrome,
to see if they might have been infected with any of the same viruses."Multiple sclerosis is wheeled usually out as being linked to a virus,
He envisages screening wild populations of animals thought to be linked to emerging diseases.""You could test the wild bat population to get a good idea of
which could boost our ability to track the spread of diseases such as cancer. Humar and his colleagues developed three ways to get cells to emit visible light.
Viruses there contaminated a plant where bacteria were used to make drugs for two rare genetic disorders, Gaucher disease and Fabry disease, cutting off supplies.
so the only way to cut down on incidences of the disease is to decrease the number of mosquitoes that carry it.
reducing the population of the disease-carrying insects by 95 percent, according to a study published last week in PLOS Neglected Tropical diseases.
Since dengue is primarily spread through the mosquito species Aedes aegypti, Oxitec has engineered a male mosquito that, to female mosquitoes in the wild, looks just like the usual males.
or transmit the disease. Juazeiro, a city in northeast Brazil, was a great place to try them out.
dengue has been on the rise in Brazil, with an estimated 16 million new cases every year.
Many of the mosquitoes that carry the disease are also resistant to pesticides, which meant that Brazilians were left with few options to decrease dengue prevalence.
The neighborhood in which the researchers tested the modified mosquitoes was a low-income area with high rates of dengue infection
according to local public health officials. Over a one-year period, the researchers released the modified males into the local environment
and monitored the resulting eggs, looking for a characteristic fluorescent marker engineered into the malesgenome.
In the course of that year, the number of disease-carrying mosquitoes decreased by 95 percent as compared to a control group in a neighborhood next door.
This isn Oxitec first attempt to decrease the prevalence of disease-carrying mosquitoeshe company did another trial in the Cayman islands in 2010ut this test was the most successful.
The researchers hope to scale up their efforts to eradicate dengue and the insects that carry it in a larger area n
and reduce anxiety. They recently launched a Kickstarter campaign to turn their prototypes in to consumer-ready models,
and a microwave Carbon nanoparticles can be incredibly useful in the treatment of many types of disease,
and deliver medicine to wherever it's most needed in the body. They're also relatively easy to track as they move through the system,
and interfere with them as they deliver their medicine.""These tiny particles are camouflaged kind of, I would say,
"That clinical use involves the carbon spheres being coated with polymer-a polymer that can gradually release drugs into the system to fight cancer and other diseases.
"This is a versatile platform to carry a multitude of drugs-for melanoma, for other kinds of cancers and for other diseases,"says Rohit Bhargava."
"You can coat it with different polymers to give it a different optical response. You can load it with two drugs,
so you can do multidrug therapy with the same particles.""H/T: Techrada d
#World first underground urban farm opens for business in London The world first underground urban farm has started trading in London,
#Scientists are figuring out how to make medicinal marijuana, without the high Scientists have figured out how to separate the pain relieving qualities of medical marijuana from its psychological side-effects in an effort to offer people a new high-free option.
The research focussed on the main psychoactive ingredient in cannabis, known as THC (tetrahydrocannabinol), which is not only responsible for the high associated with the drug-plus hallucinations, delusions, memory loss,
and feelings of anxiety or calm-it also been shown to slow tumour growth in mice.
And now, scientists have figured out that the mechanisms by which the drug delivers its desired medical effects
"There has been a great deal of medical interest in understanding the molecular mechanisms at work in THC, so that the beneficial effects can be harnessed without the side-effects,"one of the team,
the researchers figured out that negative psychological side-effects of the drug, such as memory defects, mood swings, anxiety,
and paranoia, were triggered by a single pathway in the brain that was separate from the pathway that triggers the drug cancer-killing properties.
"The U s. EPA Mercury and Air Toxics Standards and the International Minamata Convention on Mercury, have focused on limiting the emissions of toxic air pollutants,
Doctors have begun routinely using a device known as the Pea pod to measure the body composition of the infants.
With this information health care workers can then personalize the baby's nutritional supplements to help with appropriate weight gain.
Charles Simmons, MD, chair of the Department of Pediatrics and director of the Division of Neonatology, says,
health care workers have performed hundreds of analyses of breast milk. Simmons, the Ruth and Harry Roman Chair in Neonatology in honor of Larry Baum said the information from both analyses should ultimately lead to healthier weight gain, better neurological outcomes and shorter hospital stays
for babies in the neonatal intensive care unit. Cedars-Sinai received the Pea pod in late spring and has begun just using it on a regular basis.
when babies were placed on their backs to reduce the risk of sudden infant death syndrome, the incidence of plagiocephaly--commonly known as flat head--have risen dramatically.
Ellen Mack, RNC, MN, neonatal clinical nurse specialist, said the babies are evaluated constantly to determine
because with the lower surface tension we expect less risk of head flattening and less risk for pressure ulcers."
or plan for the next one or rule out therapies that are unlikely to remain effective for long said Duke graduate student Pablo Gainza-Cirauqui who co-authored the paper.
and in humans to treat viral infections that antibiotics are powerless to cure. My kids are now 15 and 13
The percentage of infections caused by the bacterium Staphylococcus aureus that have proven resistant to treatment has risen steadily from just over 2 percent in 1975 and 29 percent in 1991 to more than 55 percent today--resulting in more than 11000 deaths in the U s. each year a higher death
The drugs called propargyl-linked antifolates show promise as a treatment for MRSA infections but have yet to be tested in humans.
The researchers are now using their algorithm to predict resistance mutations to other drugs designed to combat pathogens like E coli and Enterococcus.
We might even be able to coax a pathogen into developing mutations that enable it to evade one drug
Their computational approach could be especially useful for forecasting drug resistance mutations in other diseases such as cancer HIV
and influenza where raising resistant cells or strains in the lab is more difficult to do than with bacteria the researchers say.
The system could be tested with transplant patients at UPMC later this year. The findings, which were published online in the American Journal of Transplantation,
suggest that it's possible to use the technique of"machine perfusion"with a newly created cell-free oxygenated solution to expand the number of high-quality livers available for transplant,
explained senior investigator Paulo Fontes, M d.,UPMC transplant surgeon, associate professor, Starzl Transplantation Institute, Department of Surgery, Pitt School of medicine,
and easily moved around their pens just hours after they woke up from the surgery,
Professor Mahiran said in pharmaceuticals an innovation has produced successfully a drugs delivery method to penetrate the'blood brain barrier'especially for diseases that are associated with the brain such as Alzheimer Parkinson epilepsy and meningitis.
Gas sensors or implantable chips for medical applications which can gather information about blood sugar levels
--and can perhaps be used to target unsavory antibiotic resistance genes in bacterial pathogens and occasionally in beneficial bacteria.'
or even prevent many of the blunt-force injuries we see today.""Seepersad led the work along with UT Austin research scientist Michael Haberman.
and include medical diagnostics and fluorescence spectroscopy as well as UV curing and disinfection. A further application field is plant lighting, for
which the FBH has developed and manufactured a module enabling irradiation with UV-B light of a specific wavelength.
enabling in-situ measurements in various security and health relevant fields including biology, medicine, food control, and pharmacy.
Researchers develop a faster way to treat the heart after a heart attack Stem cell have been the main focus of healing therapy research
For healing after a heart attack, the ideal time to administer these therapies is when reopening the clogged blood vessel
While stem cells show promise for heart attack treatment, the process of harvesting and reintroducing the cells
A new study in the American Journal of Physiology--Heart and Circulatory Physiology reports a more practical approach called microsphere therapy that can be kept on hand
Heart attacks occur when the heart's blood vessel is blocked and blood flow stops, cutting off oxygen to the heart.
researchers from Erasmus Medical center in The netherlands used a biodegradable material called Polyactive, which keeps proteins intact,
and tested the microspheres'effectiveness in pigs with induced heart attacks. The researchers observed that the microspheres were not toxic
and stayed in the heart for at least 35 days. The treatment reduced inflammation that occurs after blood flow is restored
The therapy, however, did not improve heart function. It also did not decrease the size of the area damaged by the heart attack or the composition of the scar.
According to the researchers, while the method needs to be optimized, the study shows that microsphere therapy can potentially be an"off-the-shelf and immediate alternative to stem cell therapy"for treating heart attacks and potentially other diseases s
#Biodegradable, flexible silicon transistors Now researchers from the University of Wisconsin-Madison have come up with a new solution to alleviate the environmental burden of discarded electronics.
In addition, PLA is biocompatible and thus suitable for medical use, for instance in absorbable suture threads.
and Australian chemists have figured out how to unboil egg whites an innovation that could dramatically reduce costs for cancer treatments, food production and other segments of the $160 billion global biotechnology industry,
Shear stress within thin, microfluidic films is applied to those tiny pieces, forcing them back into untangled,
For example, pharmaceutical companies currently create cancer antibodies in expensive hamster ovary cells that do not often misfold proteins.
and make cancer treatments more affordable. Industrial cheese makers farmers and others who use recombinant proteins could also achieve more bang for their buck.
#Lawrence Livermore technology could help detect diseases in commercial swine industry Agricultural officials who seek to detect diseases affecting the commercial swine industry may gain a new ally a biological detection system developed by Lawrence Livermore
A study by LLNL and Kansas State university scientists found that the Lawrence Livermore Microbial Detection Array (LLMDA) could help identify diseases in the commercial swine industry.
which is published by the American Association of Veterinary Laboratory Diagnosticians. Many of the diseases affecting the commercial swine industry involve complex syndromes caused by multiple pathogens
including emerging viruses and bacteria. One pivotal advantage of the Livermore-developed LLMDA over other detection technologies is that it can detect within 24 hours any bacteria
said Raymond obrowland, professor of diagnostic medicine and pathobiology at Kansas State College of Veterinary medicine. t really the future of diagnostics for both humans and animals.
New infectious diseases in animal food production systems can create enormous impacts that can affect domestic consumption and exports
as well as public health in the case of diseases that can move from animals to humans, the paper authors wrote.
Two examples of new diseases introduced into the swine industry include theinfluenza A virus subtype H1n1 and Porcine epidemic diarrhea virus.
Two other foreign diseases, African swine fever and classical swine fever, remain constant threats to the U s. industry. he best assurance for the timely identification of known and unknown threats is to employ techniques
Currently, polymerase chain reaction (PCR) assays represent one technology widely used for pathogen detection but typically only a handful of microorganisms can be identified in a single test.
Another method of detecting pathogens, DNA sequencing, greatly expands the number of microorganisms that can be identified,
and requires significant expertise. he LLMDA can identify co-infections from a single sample, said LLNL biologist Crystal Jaing,
The array also can identify co-infections faster and cheaper than DNA sequencing. In their paper, the authors noted that as the LLMDA technology cost decreases and throughput increases
it becomes feasible to look at microarrays as everyday tools for use in the diagnostic laboratory. he beauty of the LLMDA is that it lets you identify unknown diseases that the researcher isn looking for,
and polymicrobial. hese multiple bacteria and viruses end up in a disease syndrome. Wee looking at a complex situation
and we need the tools that can give us a comprehensive look at the disease factors involved.
oral fluid and tonsils from pigs that have co-infections of porcine reproductive and respiratory syndrome virus (PRRSV) and Porcine circovirus-2 (PCV-2). The LLMDA easily identified PRRSV and PCV-2,
Clostridium and Staphylococcus. he use of the microarray technology could help the U s. detect the emergence of foreign animal diseases at their outset to prevent major disease outbreaks,
including clinical medicine, food safety testing, environmental monitoring and biodefense o
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