illness

Illness

Bone and muscular diseases (1)
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Illness (127)
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Infectious diseases (19)
Injuries (41)
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With common pathogens such as E coli and the pneumonia bug K. pneumoniae developing resistance to our antibiotics of last resort, leading pharmacologists, clinicians and epidemiologists say we risk being cast back to a time

when even routine surgery put Victorians at risk of fatal infection. It's no mystery

Light-switchable drugs have been explored in other fields such as cancer therapy, but not for antibiotics. Organic chemist Ben Feringa at Groningen and his co-workers used an existing light-switchable unit called azobenzene,

when swallowed, they tend to attack the"friendly#bacteria in the gut as well as pathogens. Drugs equipped with activation switches could be administered orally

blood pressure, core body and skin temperature, respiratory rate, blood oxygen levels, blood pressure and emotional stress levels.

once embedded under the skin monitors substances in the blood such as glucose and cholesterol so that chronic diseases like diabetes or the effects of treatments such as chemotherapy can be monitored.

and Monobaby, a device being developed to prevent Sudden infant death syndrome, also known as cot death, using an accelerometer attached to baby clothing.

and Oklahoma infrastructure in some states is scarce. o avoid feelings of range anxiety common in owners of CNG-only vehicles we made the Impala bi-fuel allowing our customers to drive on CNG when available and on gasoline

and island communities around the Mediterranean are affected by water-stress problems. According to the European environment agency (EEA), 16 to 44 million additional people will suffer water scarcity in Southern Europe by 2070.

and more effective route to the creation of vaccines to combat some of the most devastating diseases affecting farm livestock.

the PLAPROVA consortium focused on the use of plants proteins to produce vaccines against diseases such as avian flu, bluetongue, foot and mouth disease,

and porcine reproductive and respiratory syndrome. Plants have been used to produce pharmaceuticals in the past, but the crucial element at the heart of the three-year PLAPROVA project was a technique for doing this much more quickly than previously possible an advance

usually in a matter of months from the time the strain of disease is first indentified.

#ACTINOGEN#Uncovering a hidden source of new antibiotics In recent years, the emergence of multiple-drug-resistant bacteria has created a major health threat, for example through hospital-acquired infections from drug

-resistant'superbugs'such as MRSA (Methicillin-resistant Staphylococcus aureus) and the rapidly emerging multi-drug resistant Gram negative hospital infections.

It has allowed also the resurgence of'old'diseases that we thought were things of the past,

such as new strains of tuberculosis against which existing drugs are powerless. It was to meet the unaddressed need for new antibiotics that the ACTINOGEN research project began in 2005

#The eaves of death for malaria mosquitoes EU-funded researchers have developed three new tools to kill malaria-carrying mosquitoes.

They are now working to bring their low-cost innovations to market quickly a boost to the global battle against this deadly disease.

Over the past two decades global efforts to prevent malaria and treat its victims have contributed to reduce infection dramatically

and save millions of lives. Even so, each year around 200 million people catch malaria, and 600 000 die from the disease, mostly children and women in Africa, according to the World health organization.

Prevention through insecticide-treated bednets and indoor sprays, is one of the best ways to win the battle.

But mosquitoes are becoming resistant to insecticides potentially reversing the gains made so far. In response, the EU-funded MCD project has developed three new weapons against them a special coating that transfers insecticides effectively to mosquitoes landing on it,

The netherlands-based research company specialises in developing products to control disease-transmitting insects. have been working in the field of malaria research for the past 22 years,

and bricks on up to 7 000 houses one that would yield solid scientific evidence that these tools can be deployed broadly to reduce the burden of malaria.

and scan for infection for exampleâ##synthetic gene circuits are especially useful for detecting things like contaminants pesticides heavy metals and counterfeit drugs.##

bandages that signal when a wound is infected with antibiotic-resistant bacteria; or smart clothing that tells a runner she s getting dehydrated.##

and has been shown to cause cancer. Because biochar can be produced from various waste biomass including agricultural residues this new technology provides an alternative

and sarin gas Scientists are developing a way to prevent brain damage among people exposed to poisonous chemicals found in pesticides and chemical weapons.

potentially minimizing dangerous side effects such as blood clots and uterine cancer. The gel was tested on women diagnosed with noninvasive cancer ductal carcinoma in situ (DCIS) in

which abnormal cells multiply and form a growth in a milk duct. Because of potential side effects

says lead author Seema Khan, professor of surgery and professor of cancer research at Northwestern University Feinberg School of medicine.

which should avoid potential blood clots as well as an elevated risk for uterine cancer. Women who have completed surgery

For a new study published in Clinical Cancer Research, researchers conducted a phase II clinical trial to compare the effects of the gel, 4-OHT, with oral tamoxifen.

The National Cancer Institute of the National institutes of health and BHR Pharma, LLC supported the research

#Wireless pacemaker is much smaller than a penny Engineers have built an electronic pacemaker that smaller than a grain of rice

and lead to a type of medicine where physicians treat disease and alleviate pain with electronics instead of drugs. e need to make these devices as small as possible to more easily implant them deep in the body

and create new ways to treat illness and alleviate pain, says Ada Poon, assistant professor of electrical engineering at Stanford university.

The discovery of a certain genotype might indicate the potential for a genetic disease and suggest that diagnostic testing be done.

and has been shown to cause cancer. ecause biochar can be produced from various waste biomass including agricultural residues this new technology provides an alternative and cost-effective way for arsenic removalsays Bin Gao associate professor of agricultural

which can run for years without needing to be wound manually. The new system works like this:

and pathogens that can have an environmental impact if not properly managed. While turning the manure into clean water makes environmental sense

For example sophisticated vintners use precise irrigation to put regulated water stress on grapevines to create just the right grape composition for a premium cabernet or a chardonnay wine.

reduces stress, and makes the milking station less of a bottleneck because there isn't a whole herd trying to get in at the same time.

and pen of the Astronaut 4 are equipped also with sensors to detects signs of mastitis.

We are prepared not to deal with an outbreak of pathogens such as E coli and salmonella in tainted foods.

The crisis is attributed generally to a mixture of disease, parasites, and pesticides. Other scientists are pursuing a different tack:

and even pest and disease resistance. There is potential for these multifunctional techno-greenhouses built around LED grow lights to increase the quality of the food we eat

Of course, the disease-eradicating, condom-reinventing Microsoft cofounder didn actually drink human excrement Sedro-Woolley-produced sewage sludge at its finest.

The vaccine could prevent future outbreaks of the disease, and potentially lead to new treatments for polio and other human diseases.

Bryan Charleston, head of the Livestock Viral Diseases Programme at the Pirbright Institute in Woking, UK,

and his colleagues used computer simulations to create a model of the protein shell of the virus that causes the disease,

then reconstructed it from synthetic protein components. The synthetic shell contains no genetic material and so it cannot infect the animals.

it could also be used to create vaccines for human diseases that are caused by viruses of the same family, such as hand, foot and mouth disease,

because we are so close to ending this disease. JEFF J MITCHELL/REUTERSA 2001 outbreak of foot and mouth disease led to the slaughter of huge numbers of sheep and cows.

and Charleston that the new vaccine is unable to cause an infection or outbreak. Marvin Grubman, an animal-disease researcher at the US Department of agriculture in Orient Point, New york, says that the new vaccine"is a good piece of work,

#Gene-analysis firms reach for the cloud For Chaim Jalas at the Center for Rare Jewish Genetic disorders in New york,

and identify mutations that might be causing the undiagnosed diseases that afflict his clients families.

and finds those most likely to cause disease. Personalis, down the road in Menlo Park, offers sequencing services and interpretation for clinicians and pharmaceutical and biotechnology companies.

to explore the variants roles in disease. The company will outsource the sequencing to Illumina,

then the cable can get taut and fracture, which is really bad news . So we wanted to understand what was underlying those patterns.

#A new way to model cancer Sequencing the genomes of tumor cells has revealed thousands of mutations associated with cancer.

They have shown that a gene-editing system called CRISPR can introduce cancer-causing mutations into the livers of adult mice enabling scientists to screen these mutations much more quickly.

In a study appearing in the Aug 6 issue of Nature the researchers generated liver tumors in adult mice by disrupting the tumor suppressor genes p53 and pten.

They are now working on ways to deliver the necessary CRISPR components to other organs allowing them to investigate mutations found in other types of cancer.

The sequencing of human tumors has revealed hundreds of oncogenes and tumor suppressor genes in different combinations.

Tyler Jacks director of MIT s Koch Institute for Integrative Cancer Research and the David H. Koch Professor of Biology is the paper s senior author.

Gene disruptioncrispr relies on cellular machinery that bacteria use to defend themselves from viral infection.

To investigate the potential usefulness of CRISPR for creating mouse models of cancer the researchers first used it to knock out p53 and pten

Previous studies have shown that genetically engineered mice with mutations in both of those genes will develop cancer within a few months.

and pten the researchers were able to disrupt those two genes in about 3 percent of liver cells enough to produce liver tumors within three months.

Using CRISPR to generate tumors should allow scientists to more rapidly study how different genetic mutations interact to produce cancers as well as the effects of potential drugs on tumors with a specific genetic profile.

This is a game-changer for the production of engineered strains of human cancer says Ronald Depinho director of the University of Texas MD Anderson Cancer Center who was not part of the research team.

Enhanced potential of this powerful technology will be realized with improved delivery methods the testing of#CRISPR/Cas9 efficiency in other organs and tissues and the use of CRISPR/Cas9 in tumor-prone backgrounds.

The research was funded by the National institutes of health and the National Cancer Institute u

#A new way to detect leaks in pipes Explosions caused by leaking gas pipes under city streets have made frequently headlines in recent years,

as well as serve as plant-based biosensors and stress reducers. By adapting the sensors to different targets,

pesticides, fungal infections, or exposure to bacterial toxins. They are also working on incorporating electronic nanomaterials, such as graphene, into plants. ight now,

the two lead authors, are former postdocs in the laboratory of Robert Langer, the David H. Koch Institute Professor at MIT Koch Institute for Integrative Cancer Research.

and to aid our understanding of a range of diseases, "explained Professor Evans. Aside from biological applications,

or to create artificial noses for the early detection of disease or simply to advise you that the milk in your fridge has gone off."

This transformative technology enables highly specific low-power high-throughput physiological sensing that can be multiplexed to detect a number of significant disease-specific factors in real time commented Scott Hammond executive director of UCSB's Translational Medicine

and brain signaling with the potential to transform our understanding of how the brain worksnd how to treat its most devastating diseases.

This could get around a lot of serious health problems in neurodegenerative diseases in the future.""These disorders, such as Parkinson's, that involve malfunctioning nerve cells can lead to difficulty with the most mundane and essential movements that most of us take for granted:

This inability to see what's happening in the body's command center hinders the development of effective treatments for diseases that stem from it.

which are affected in some neurodegenerative diseases. And it's at this level where the promise of Lieber's most recent work enters the picture.

#Supercomputers reveal strange stress-induced transformations in world's thinnest materials (Phys. org) Interested in an ultra-fast unbreakable and flexible smart phone that recharges in a matter of seconds?

and break under stress. Fortunately researchers have pinpointed now the breaking mechanism of several monolayer materials hundreds of times stronger than steel with exotic properties that could revolutionize everything from armor to electronics.

In this study DFT calculations revealed the materials'atomic structures stress values vibrational properties and whether they acted as metals semiconductors or insulators under strain.

These toxic liquid solvents raise many issues for concern including environmental pollution, high cost of disposal, health problems and poisoning during the disposal process.

or DNA sequence from one animal into the genome of another plays a critical role in a wide range of medical researchncluding cancer, Alzheimer's disease, and diabetes.

-which might not actually manage to develop into a human even under the right conditions-than of individuals who suffer daily with crippling diseases that were thrust upon them by chance

Stem cell research is an incredibly valuable source of information concerning real diseases that real humans are really suffering from right at this very moment.

Stem cell-derived organs might in future provide accurate disease models for screening of pharmaceutical compounds reducing the requirement for animal testing

and while many of these are beneficial, some can cause disease. For example, some reports have linked Crohn disease to the presence of certain strains of E coli. e like to be able to remove specific members of the bacterial population

and see what their function is in the microbiome, Lu says. n the longer term you could design a specific phage that kills that bug

so that simplifies that workflow in the lab. he new approach also overcomes an important hurdle in using bacteriophages to treat disease,

which makes it difficult to choose the right phage for the right infection, if such a phage is available at all,

and gastrointestinal infections, including pneumonia, sepsis, gastritis, and Legionnairesdisease. One advantage of the engineered phages is that unlike many antibiotics,

Lu says. e aim to create effective and narrow-spectrum methods for targeting pathogens. u

as well as treating human disease. Another advantage of this approach is that all of the phages are based on an identical genetic scaffold,

However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.

Now, researchers at MIT Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern

as there is a greater risk for fracture if a device is too large or too complex.

The researchers also say that single-administration delivery systems for the radical treatment of malaria

and other infections could significantly benefit from these technologies. In a March 2015 commentary piece in Nature, Traverso and Langer wrote that the GI TRACT is an area rife with opportunity for prolonged drug delivery in tackling this global health problem.

With this new material which can be used to create extended-release systems via swallowable ills,

Most commercial sunblocks are good at preventing sunburn, but they can go below the skin surface

the researchers tested their sunblock against direct ultraviolet rays and their ability to cause sunburn.

the researchersformulation protected equally well against sunburn. They also looked at an indirect and much less studied effect of UV LIGHT.

Saltzman and Girardi are affiliated with the Yale Cancer Center. Source: William Weir, Yale Universit C

#3d printed Tadpole Endoscope device can improve cancer diagnoses Sep 15, 2015 By Kiratadpoles. Very recently, we reported on 3d printed icrofishrobots that can be injected directly into our blood to perform complex medical tasks.

A team from the Institute of Precision Engineering at the Chinese University of Hong kong as developed 3d printed tadpole-like devices that can improve diagnosis of various cancers by entering the patient stomach

A traditional procedure for diagnosing cancers of the gastrointestinal (GI TRACT which rank as the second most prevalent among all types of cancers in the world,

is endoscopy, wherein a long, flexible tube with a light and camera attached to its end passes through a person digestive system.

and relatively noninvasive solution that could improve the very way we diagnose cancers. Developed to be swallowed just like a large pill (it is a bit bigger than a small coin),

when it comes to cancer diagnosis. Once the stomach has been checked thoroughly, the device wimsinto the lower GI TRACT aided by natural peristaltic actionhat is,

Researchers in professor Margaret Frey lab create fibers hundreds of times thinner than a human hair that can capture toxic chemicals and pathogens.

and will diagnose diseases without requiring specialized laboratories particularly useful in regions with limited access to doctors and hospitals.

and allows it to time-release. y allowing rapid detection of disease and preventing agricultural chemical release into the environment,

#Nanoporous Gold Sponge Detects Pathogens Faster This novel technique enables sensitive DNA detection in compound biological samples e g.,

According to UC Davis researchers, these sponge-like nanoporous gold hold the potential for enabling new devices to detect agents responsible for causing disease in both plants

It almost like a natural sieve. arly identification of disease biomarkers and pathogenic microbes is possible with the swift and sensitive detection of nucleic acids.

Going forward, the team anticipates that their research will be useful in the progress of mini point-of-care diagnostic systems for clinical and agricultural applications. he applications of the sensor are quite broad ranging from detection of plant pathogens to disease biomarkers,

For instance, in human sepsis cases, the illness can be detected early on, thereby preventing any needless treatments as doctors can now establish bacterial contamination much more rapidly than ever before.

if pathogens are present. Pallavi Daggumati, Zimple Matharu, and Ling Wang in the Department of Electrical and Computer engineering at UC Davis were the other authors of the papers.

#Nanoporous Gold Sponge Detects Pathogens Faster This novel technique enables sensitive DNA detection in compound biological samples e g.,

According to UC Davis researchers, these sponge-like nanoporous gold hold the potential for enabling new devices to detect agents responsible for causing disease in both plants

It almost like a natural sieve. arly identification of disease biomarkers and pathogenic microbes is possible with the swift and sensitive detection of nucleic acids.

if pathogens are present. Pallavi Daggumati, Zimple Matharu, and Ling Wang in the Department of Electrical and Computer engineering at UC Davis were the other authors of the papers.

a make-or-break figure for those who are struggling with stunted production and less or no profit due to the disease. uring the past 15 years,

The disease starves the tree of nutrients damages its roots and the tree produces fruits that are green and misshapen, unsuitable for sale as fresh fruit or, for the most part, juice.

and the disease has affected already millions of citrus trees in North america. It has recently been found twice in California.

to combat disease for filtering fresh drinking water, and much more. Now, researchers from MIT and the Federal University of Goias in Brazil have developed a new technique that uses ultraviolet (UV LIGHT to extract man-made pollutants from soil and water.

Lead author Nicolas Bertrand, a former professor at MIT Koch Institute for Integrative Cancer Research, told Laboutlook that he

Drug delivery and beyondthe power of nanoparticles is also being harnessed to fight life-threatening lung diseases, such as cystic fibrosis.

stopped brain cancer in rats by delivering gene therapy through nanoparticles. The nanoparticles deliver genes for an enzyme that converts a prodrug called ganciclovir into a glioma cell killer.

There is no reliable treatment for glioma which has a 5-year survival rate of 12 percent.

As in cystic fibrosis, a current delivery method of gene therapy relies on using a virus, which can pose significant safety risks.

Challenges remainbertrand and other lead author Ferdinand Brandl both left MIT to join pharmacy schools in Quebec city, Canada and Regensburg, Germany, respectively.

Researchers propose to do by making the plants better at handling stress. Now I know what you might be thinking tress limate changeit sounds like it time to call the plant acupuncturist.

when the plant detects stress. Beneath this superficially crude mechanism lie untold layers of regulatory nuance.

#Tadpole-like endoscope swims through gastrointestinal tract in search of cancer Endoscopes are essential tools for the medical examination of many organs of the human body,

With cancers of the gastrointestinal (GI TRACT such as esophageal cancer, stomach cancer, and colon cancer, being some of the most commmon of all cancers in the world,

a range of procedures are necessary to physically examine all parts of the GI for maximum diagnostic effect.

Of these, gastroscopy is used to help diagnose esophageal and stomach cancer, whilst intestinal and coleorectal cancers can be determined with the use of capsule endoscopy and colonoscopy, respectively.

Unfortunately, all of these procedures are costly to perform and can place a great deal of stress on someone who may already be quite ill.

The new Tadpole Endoscope (TE on the other hand, is a relatively noninvasive device that is simply swallowed like a large pill

and then remotely guided around inside the patient's stomach by a doctor. Created by engineers from the Institute of Precision Engineering at the Chinese University of Hong kong,

and function after a heart attack Though sufferers of heart attacks may survive the initial event, they cause permanent damage to the organ in the form of scar tissue,

which affects its ability to pump blood. Scientists around the world are working on this problem, with hydrogels,

In pigs that had suffered from a heart attack, blood pumped out of the left ventricle was reduced from the normal 50 percent to 30 percent.

the lab-based manufacturing approach wouldn't be vulnerable to weather and disease, the way poppy crops are--allowing millions of people around the world who do not have sufficient access to painkilling drugs to get the medications they need.

If you've lost a healthy bone to an accident or illness, or if you were born with bones that aren't the right shape,

what it sees as a foreign object, leading to infections or defective transplants after these operations.

the late American film critic who lost his jawbone to cancer, is autograft. This is basically a euphemism for cutting a piece of bone out of one part of the body

but applying these chemicals to the surface of wounds has its limits. To best stem blood loss, those chemicals need to be able to find their way deep into a wound.

There may now be a solution, however, and it comes in the unlikely form of fizz, reports Wired.

propelling them deep into a wound as they pop. The new concoction is composed of powdered marble, tranexamic acid

Water from the blood is the catalysis that sets it fizzing. f you can get the particles in the general area of the wound,

all the way to the damaged internal blood vessels feeding the wound. By clotting so deep into the lesion, the clot was shown to be more stable.

Right now the fizzing agent is a bit messy. While chemicals do get deeper into the wound,

they pop off in every other direction too. Eventually researchers hope to make the delivery process more efficient,

Proof-of-concept study conducted in mice a key step toward better treatments for lung diseases August 3rd,

and charge to some part of another molecule--such as the binding site of a human protein involved in some physiological process that goes awry in a given disease.

Orbital angular momentum of neutron waves can be controlled September 25th, 2015liquid crystals show potential for detection of neurodegenerative disease September 24th, 201 0

He worries more about gremlins that plague today's reverse osmosis membranes--growths on membrane surfaces that clog them (called"biofouling)

leading to the rapid synthesis of drug derivatives for treating Parkinson's disease. Nagoya, Japan-Yutaro Saito, Yasutomo Segawa and Professor Kenichiro Itami at the Institute of Transformative Biomolecules (ITBM

which is an anticholinergic drug used in the treatment of Parkinson's disease.''Parachuting'boron onto the para-position of a benzene ring by a bulky iridium catalyst.

Caramiphen, an anticholinergic agent used for the treatment of Parkinson's disease contains a monosubstituted benzene moiety along with ester and amine groups.