The complex sugar structure in glycoprotein can be subtly different between samples from healthy and diseased patients.
which has specific sugars in a specific location in the molecule. Professor Mendes added""Biomarkers such as glycoproteins are essential in diagnostics as they do not rely on symptoms perceived by the patient,
the sugar part of the prostate cancer glycoprotein is reacted with a custom-designed molecule that contains a boron group at one end (the boron linkage forms a reversible bond to the sugar).
The glycoprotein is then bound to the surface via its sugar groups, before the rest of the surface is blocked with a third molecule.
Within that cast, there was a special area with boron-containing molecules that can recognise a specific set of sugars.
so there's a clear need for more accurate diagnosis. By focussing on the sugar, we appear to have hit the'sweet spot'for doing just that.
push large quantities of salt water through and the salt will be rejected on the basis of size
In that case, both the plastic and the oil-based sauce are hydrophobic and interact together.
from lipstick to ice cream. Yet it has helped also to give its source country the dubious distinction of being the world third-largest greenhouse gas emitter after China and the US as well as a leading source of hazardous smoke haze.
They have modified genetically yeast to perform the complicated chemistry needed to convert sugar to morphine.
then you are relying on microscopic yeast that turns sugars into alcohol. But by borrowing DNA from plants, scientists have been genetically engineering yeasts that can perform each of the steps needed to convert sugar into morphine.
One stage of the process-the production of an intermediary chemical called reticuline-had been a stumbling block.
which is a cheap sugar source, and have the yeast do all the chemical steps required downstream to make your target therapeutic drug."
Biofuel sweetspot"We've identified a new route of chemistry with its source from sugars in sugarcane plus some of the so-called waste material called bagasse"
Prof Bell acknowledged that certain crops as feedstock for the sugar-derived process would be problematic:"
-in order to make it available for growing sugar plantations, and you get rid of that vegetation by burning it then you are putting a big pulse of CO2 into the atmosphere."
#Hackers steal data using pitta bread Secret encryption keys can be stolen using a cheap gadget so small it could be concealed inside some pitta bread.
and make the main cell types of neurological systems-the central nervous system and the peripheral nervous system-in a dish that is specialised for each patient.'
From sugars to viral invaders to nerve impulses all cellular traffic passes through the cell membrane, and likely interacts with the proteins embedded there, such as neurotransmitter and hormone receptors.
to use CRYO EM to visualize the structure of the body receptors that sense the spiciness of chili peppers and, in work reported last month, wasabi.
they decided to incorporate these balls of sugar-sensing, insulin-releasing material into an array of tiny needles.
After that, the Gates Foundation took interest. t wasn just a pie-in-the-sky idea anymore wee really treating patients
including sugars, which allow the bacteria to be controlled by the food that is eaten by the host,
In lab dishes, the group assembled Cas9 ribonucleoproteins, or RNPS, which combine the Cas9 protein with single-GUIDE RNA.
and mustard) and later with sugarcane the team introduced genes that boost natural oil production in the plant.
That's where we get out secret sauce from.""Behaviosec's tech plugs directly into banks apps and websites,
To ice the cake, based on the lab work so far, it appears the material could be manufactured at a commercial scale more easily than other graphite replacement materials,
but adding sugar to the mix would create soft, weak, concrete. In the end, Jonkers chose calcium lactate,
The secret sauce consists of specially placed rows of bacterial spores dotted onto strips of double-sided plastic tape.
These permeable silicone beads could be sliced a-bread'breakthrough for CO2 capture--efficient easy-to-handle minimal waste
because the robot had not been trained on some objects, such as tofu.""By having flexible robots, we're contributing to the next phase of automation.
"The beauty of this work is that it can serve as a test bed for clinical trials in a dish,
But the science which warned us off eating eggs along with other high-cholesterol foods such as butter, shellfish,
bacon and liver could have been flawed, a key report in the US has found. Foods high in cholesterol have been branded a danger to human health
and saturated fat and focusing concern on sugar as the biggest dietary threat. The Daily mail's GP Martin Scurr predicts that advice will change here in the UK too.
because it's easy to convey to the public that fatty foods like butter, cheese and red meat are furring up their arteries.
In fact there are many other risk factors involved but somehow we've become obsessed with cholesterol.'
'London-based cardiologist Dr Aseem Malhotra, science director of campaign Group action On Sugar, wrote in The british Medical Journal that it was time to'bust the myth of the role of saturated fat in heart disease'.
'He added that the food industry had contributed effectively to heart disease by lowering saturated fat levels in food and replacing it with sugar.
and codeine from a common sugar, boosting the prospect of'home-brew'drug supply. But whether making morphine in bubbling vats of yeast will be commercially viable-either for drug companies
#Beauty Is Only (3-D Printed) Skin Deep Global cosmetics giant L'oréal has waged a battle against gravity for more than a century, with countless creams, peels and potions as its weapons.
whether theye tossing more cookies or muffins. That datand the high-quality fertilizeras turned Chapman into a WISERG evangelist. e will put them in as many stores as we possibly can,
Foodspotting users recommend dishes. The app is searchable by specific foods. Move over lattes. The hottest hot beverages in Manhattan are the sippable one brothsfrom Brodo single-service window, with add-ins like Calabrian chili oil, shiitake mushroom tea and fermented beet juice.
and sign up for unique off-menu dishes and exclusive events at local restaurants. The Scio handheld spectrometer instantly analyzes foods and pharmaceuticals at a molecular level;
Cold butter meets its match with the Butterup knife. Your bread will thank you c
#Meet Amelia, the AI Platform That Could Change the Future of IT Her name is Amelia,
and she is the complete package: smart, sophisticated, industrious and loyal. No wonder her boss, Chetan Dube, can get her out of his head. y wife is convinced I having an affair with Amelia,
In the future, though, Schoellhammer hopes he can create the needles out of crystallized sugar. The mpill took an estimated three years to go from concept to prototype
crying about the need for a greater slice of the tax revenue and service fee pie,
If Microsoft can get a piece of that massive pie, all the better for its shareholders. With free access to Office and free upgrades to Windows 10, Microsoft is bowing to market realities.
Lest the reader think that this is all just pie in the sky, we should give some hard numbers.
and prior attempts to use DNA to make nanoscale sculpture have required high levels of magnesium salt to keep the final shape from unraveling.
Maggi case should begin new era of food vigilancea leading food safety official has urged India government to view the recent Maggi noodles affair as the beginning of a new era of food safety vigilance.
and lead in Maggi noodles should initiate a campaign against unhealthy food in general. He also called for greater self-regulation by manufacturers and better awareness among the public about how much food safety testing takes place behind the scenes. he heated discussion on the presence of lead in food products,
#Flavour delivery particle can cut sugar by half and is cheaper than sugar Developed by inventor
and Douxmatok CEO Avraham Baniel-who used to be part of Tate and Lyle's Splenda team-along with the Warner Babock Institute for Green Chemistry,
a carrier particle is coated with sugar molecules using non-covalent bonding. This increases the surface area meaning the same sweetness can be achieved using less sugar.
Joint CEO Eran Baniel told Foodnavigator that because Douxmatok which means twice as sweet in French
and Hebrew-uses sugar, rather than artificial or alternative sweeteners, consumers'taste expectations are satisfied and there are no aftertaste issues. ee not about reformulation.
"The sensory profile of Douxmatok is literally the same as sugar.""The carrier particle has been approved for use in food
and two issued in the EU. Taste is king for the consumer cost for the companyat a tasting session in Israel Foodnavigator tried out Douxmatok's tomato ketchup with 54%less sugar,
But, according to Baniel, this only poses a problem for manufacturers of dark chocolate. Despite reducing the calorie content,
and this is a very important issue for the industry. f youe the same price as sugar all you get is compliments and nothing else.
such as cocoa in chocolate, could be costly for manufacturers of certain products. But this is something the R&d team is working to overcome,
and teach them how to use the technology as some culinary methods need to be adapeted-Douxmatok's sugar needs to be added to a product at very specific moments
and taste-tested for candy, chocolate, baked and dairy products and pharmaceutical syrups, while a second generation particle called S2 can be used in beverages.
The R&d team is looking into using the technology for salt reduction, while a carrier particle for Xylitol, Malitol and Erithrytol has also been developed
In this case, the robot is being used in the bakery sector to decorate gingerbread. Michael Beising, CEO, EVT,
to detect wrong particles in chocolate or 3d to determine the outline of a package,
such as the surface texture of gingerbread figures. Beising added due to the baking process, the gingerbread becomes slightly uneven
and has to be measured again separately one by one. The robot needs the orientation and height information for the subsequent sugar icing decoration of the pastry.
VT develops machine vision software and sensor systems for different industries. Our products read codes e g.
and place or to fill the right candies at the right position in a candy box. he next project for EVT is developing sensor fusion,
designed for products like liquid and pastelike confectionery, dairy products, dressings and condiment sauces. By developing the Evoguard aseptic valves,
but it would be impossible to match the flavor exactly without a precise knowledge of the recipe. reating Unique Colorsthere are three different ngredientmolecules present in these inks one of these ingredients is common household sugar.
#IBM and Bon Appétit's Chef Watson app cooks up some surprising dishes Meet Chef Watson, the most versatile culinary genius around.
to create dishes using the 10,000 recipes from Bon Appétit database that have been fed to Watson. hen we got started on this idea about a year ago,
Over a five-day period, ICE and IBM treated passersby to dishes that were prepared using Watson database of recipes from the culinary school.
Watson suggests different dishes using those combinations, presenting the user with Bon Appétit recipes that use those ingredients.
While superficially, the app can be used to create interesting, delicious dishes, Rivera suggested that it is most impactful as a lifestyle guide that can help people make better informed decisions about
what are the best dishes Abrams and Rivera have prepared through Chef Watson? Abrams demurred and said that he best Chef Watson dish is the one that has yet to be created. or Rivera,
But researchers at Duke university and Microsoft Research think they have a solution that'll let gamers have their on-demand cake
In late 2014, Global Bioenergies started up the fermentation unit for a pilot program to produce gaseous isobutane from renewable biomass sugars such as corn-derived glucose.
and the peripheral nervous system-in a dish that is specialized for each patient, "says Bhatia.""Nobody has done ever this with adult blood.
but also using gels, pastas and thick fluids. Other efforts around the globe to print metals are also beginning to bear fruit,
but also using gels, pastas and thick fluids. Other efforts around the globe to print metals are also beginning to bear fruit,
like how to bake a cake or brew a pot of coffee, as well as more complex tasks,
or it can be incorporated with cells in a dish and then injected to stimulate tissue growth,
The device is around the same mass as a 000-size gelatin capsule and powered by a capacitor that is charged up before use.
when the actual budget sausage gets made. A potential compromise might see projects started before the end of 2016 get grandfathered in or result in a more gradual stepdown of the ITC.
The three each captured 8 percent of the greentech VC pie, according to the data company report, he 2014 U s. Venture capital Year in Review.
a long chain of sugar molecules found in plant cell walls that bestows wood with its strength.
Lancaster noticed off-hand that her cultured brain cells weren sticking to the bottom of the dish as usual instead,
allowing it to separate the proteins of a boiled egg and take it back to how it was before it was cooked.
when sugar levels are too high or too low, or when an alarm on the pump is addressed not quickly by the user.
This was done by first growing the two types of cells in separate compartments within the dish.
Simply measuring how long the fluorescence lasts provides an estimation of the sugar level in the blood below.
#Lamp runs on nothing but saltwater A lamp that requires just two tablespoons of salt and a glass of water in order to work could make lighting affordable for people around the world.
In the event that you don't carry a bag of salt with you, and don't want to use your drinking water,
He assembles sandwiches of graphene and boron nitride with various horizontal orientations.""The tricks we would use were making cleaner devices,
The plastic materials, called organic photovoltaics, are organized typically like a plate of cooked pasta a disorganized mass of long, skinny polymer paghettiwith random fullerene eatballs.
The UCLA technology arranges the elements more neatly like small bundles of uncooked spaghetti with precisely placed meatballs.
Some fullerene meatballs are designed to sit inside the spaghetti bundles, but others are forced to stay on the outside.
The plastic materials, called organic photovoltaics, are organized typically like a plate of cooked pasta a disorganized mass of long, skinny polymer paghettiwith random fullerene eatballs.
The UCLA technology arranges the elements more neatly like small bundles of uncooked spaghetti with precisely placed meatballs.
Some fullerene meatballs are designed to sit inside the spaghetti bundles, but others are forced to stay on the outside.
and sugars were meant simply to be in life March 11th, 2015thin films Researchers synthesize new thin-film material for use in fuel cells:
And these long flat noodles grow together in a very specific way: In the oven used for the synthesis, temperatures stay just below the melting point of tin oxide.
Thus, the noodles find specific interconnection points by kinetics instead of thermodynamics. Each junction is forced into a well-defined angle following strict geometric principles,
The structural design of the tin oxide 3d network, meaning the grown-together noodles, was investigated in detail using transmission electron microscopy.
and dipping it into a solution containing metal salts. These molecules then glom onto the self-assembled polymer,
The complex sugar structure in glycoprotein can be subtly different between samples from healthy and diseased patients.
which has specific sugars in a specific location in the molecule. Professor Mendes added""Biomarkers such as glycoproteins are essential in diagnostics as they do not rely on symptoms perceived by the patient,
the sugar part of the prostate cancer glycoprotein is reacted with a custom-designed molecule that contains a boron group at one end (the boron linkage forms a reversible bond to the sugar).
The glycoprotein is then bound to the surface via its sugar groups, before the rest of the surface is blocked with a third molecule.
Within that cast, there was a special area with boron-containing molecules that can recognise a specific set of sugars.
so there's a clear need for more accurate diagnosis. By focussing on the sugar, we appear to have hit the'sweet spot'for doing just that.
to enable clean printing with metals, gels, pastas or extremely thick fluids s
#Engineers'synthetic immune organ produces antibodies Cornell engineers have created a functional, synthetic immune organ that produces antibodies
It is made from gelatin-based biomaterials reinforced with nanoparticles and seeded with cells, and it mimics the anatomical microenvironment of lymphoid tissue.
The plastic materials, called organic photovoltaics, are organized typically like a plate of cooked pasta a disorganized mass of long, skinny polymer spaghetti with random fullerene meatballs.
The UCLA technology arranges the elements more neatly like small bundles of uncooked spaghetti with precisely placed meatballs.
Some fullerene meatballs are designed to sit inside the spaghetti bundles, but others are forced to stay on the outside.
she had no idea how to remove salt from groundwater to make it more palatable, nor had she ever been to India,
and dipping it into a solution containing metal salts. These molecules then glom onto the self-assembled polymer,
they decided to incorporate these balls of sugar-sensing, insulin-releasing material into an array of tiny needles.
"builds on recent research by the same team that previously identified a fat-and-sugar molecule called GSL as the chief culprit behind a range of biological glitches that affect the body's ability to properly use, transport
It wasnt just a pie-in-the-sky idea anymore were really treating patients Cima says.
"In their structure, the crystals resemble sandwiches with a thickness of three atoms (around 4 angstroms:
or lipids, instead of sugars, or glucose, using synthetic biology and metabolic engineering tools to redirect the path of carbon in the cell.
Beliaev's team was able to direct the bacteria to make less sugar and more lauric acid,
In that case, both the plastic and the oil-based sauce are hydrophobic and interact together.
physiological salt concentrations that are more suitable for biological applications of DNA NANOSTRUCTURES, explains Dr Hgberg.
The solution was to flat-pack the components by building the 3d shape layer-by-layer, much like a miniature exercise in cake decoration.
The physicists in Ralph Ernstorfers group now want to experiment further with precisely these sandwiches of different materials.
and how the energy can flow away in sandwich structures, says Ralph Ernstorfer. In this way, he and his colleagues want to bring GST into a position where it can act as a light switch for optical data processing as well e
Tesla's pie-in-the-sky ideas admittedly led to some pretty amazing breakthroughs in energy technology.
Vitamin c should ideally come from a diet rich in fresh fruits and vegetables. However this diet isn't typical for most.
Acrylate, a type of salt also known as waterlock, is the substance that gives nappies their sponginess.
multilayered retinal tissue in a dish. A RIKEN team has succeeded in developing a culture method that allows human embryonic stem cells to be efficiently
and help contribute to retinal tissue growth in the culture dish. This degree of cellular organization is the closest scientists have yet come to building self-growing retinal tissue from stem cells. ur results are consistent with the current view that the retinal pigment epithelium
professor of cellular microbiology. he sensing component of the artificial neuron senses a change in chemical signals in one dish,
This electrical signal is translated next into the release of the neurotransmitter acetylcholine in a second dish,
Shining red light on skin or cells in a dish gives an instant energy boost that could help heal wounds,
A microbial contamination on a contact agar plate with a 405-nm light source in the background.
By filling a metallic waffle-like nanostructure with liquid crystal, and sandwiching it between layers of plastic,
The amount of voltage applied to the liquid crystal sitting in the waffle wells alters its molecular orientation,
#Terminator-Like Vision Could Help Robots Do Our Dishes If the above gif looks familiar it probably because it looks eerily similar to this:
while they navigate our complex world. deally we want robots to be cleaning our dishes at some point in the future.
The SALT (Sustainable Alternative Lighting) lamp offers a healthier solution with a saltwater-powered battery.
One way is to have a sandwich comprising a surface that is conducting juxtaposed with a bulk that is insulating.
#Audi has made a synthetic, high-grade fuel from plant sugars Just last month, German car manufacturer Audi invented a carbon-neutral diesel fuel,
the fuel is produced by converting corn-derived glucose-a renewable source of biomass sugar-into isobutane gas.
or soup for 10 minutes, remove from the heat, and add a generous dash of lemon juice to foster iron absorption.
Schouenborg is also working on his own gelatin-based'needle'for delivering electrodes into the brain a
"The sensing component of the artificial neuron senses a change in chemical signals in one dish,
"This electrical signal is translated next into the release of the neurotransmitter acetylcholine in a second dish,
and mustard leaf. A pesticide free farming process-the results of 18 months of research and preparation-has been designed to produce crops with the least amount of energy expenditure possible.
#Alzheimer's plaques reduced by targeting sugar attachment to the BACE1 enzyme A major factor contributing to Alzheimer's disease is the formation of pathogenic A?
and Naoyuki Taniguchi at RIKEN in collaboration with Tamao Endo and Shigeo Murayama at the Tokyo Metropolitan Institute of Gerontology showed that much of the BACE1 found in the brains of Alzheimer's disease patients is modified by the attachment of a particular sugar with the help of the enzyme
because BACE1 without the sugar is destroyed and cannot interact with APP. Using a difficult procedure called subcellular fractionation they determined that sugared BACE1 is located near APP within cells.
However if the sugar is attached not to it it is found further from APP and closer to lysosomes--subcellular structures that degrade unneeded molecules.
This research highlights the importance of glycosylation--the modification of proteins by sugars. Far from being rare it is the most common way in
although a sugar change is considered often just a marker for disease or a specific cell type our team has demonstrated clearly the functional role of a glycan during AD development.
The sections are stacked then with solid electrolytes in between for a multilayer sandwich with multiple microsupercapacitors.
which involves a com bi na tion of ther a pies with neg a tive side effects.
or salt-and-pepper patterns seen in some organisms when cells tell their neighbors to be not
Published in Proceedings of the National Academy of Science the paper details how lack of the Ngly1 protein results in the incomplete removal of the sugar portion of glycoproteins--a process called deglycosylation.
which can be changed through the addition or subtraction of sugar chains. When proteins are made not correctly they are sent to be broken down in the cytosol.
NGLY1 is a cytosolic enzyme that removes the sugar chains from specific types of glycoproteins
and ENGASE is another cytosolic enzyme in animal cells that degrades the free sugars left behind.
and how much of the undegraded portion still had attached sugar chains. As expected they found sugar chains were removed not from the model protein in the double knockout cells
First removal of sugar chains by ENGASE appeared to have created a form of the protein that in the absence of Ngly1 could not be degraded properly.
when the model protein was sugared de by ENGASE one sugar molecule remained attached to the protein.
as long as the incomplete removal of sugars by ENGASE was prevented. People with the NGLY1 mutation have many severe symptoms from delayed development
features fermentation and ethanol yields that set a new standard for conversion of biomass sugars from pretreated corn stover--the non-edible portion of corn crops such as the stalk--converting up to 97 percent
of the plant sugars into fuel. Researchers announced that while conventional yeast leaves more than one-third of the biomass sugars unused in the form of xylose,
Mascoma's C5 FUEL#efficiently converts this xylose into ethanol, and it accomplishes this feat in less than 48 hours.
and convert sugars from lignocellulosic biomass has accelerated greatly the translation of basic research outcomes to a commercial product,
"Although cellulosic biomass such as corn stover, wheat straw and bagasse (the fibrous remains after sugar is extracted from sugarcane
because of recalcitrance--a plant's resistance to releasing sugars for conversion to alcohol--it is much more difficult to utilize than corn.
While most processing methods simply convert cellulose to sugar, this new approach also converts hemicellulose,
which significantly increases overall sugar yield and thereby increases the level of ethanol produced. In fact
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