Colitis

Celiac disease (12)
Colitis (15)
Crohn's disease (11)
Diarrhea (28)
Gastroenteritis (15)
Irritable bowel syndrome (10)
Liver diseases (92)
Nausea (13)
Pancreatitis (10)

Synopsis: Domenii: Health: Health generale: Illness: Gastrointestinal diseases: Colitis:

and colitis but the drugs have never been tested as possible cancer treatments. What our study really says is that these drugs could have an entirely new second life in combination with chemotherapy says Yaffe who is a member of MIT s Koch Institute for Integrative Cancer Research.

The researchers found that a sealant they had developed previously worked much differently in cancerous colon tissue than in colon tissue inflamed with colitis. The finding suggests that for this sealant

However, it performed worse in tissue inflamed with colitis than in healthy tissue. Further studies of the molecular interactions between the adhesive

suggesting that SAP-1 plays a protective role against colitis. In addition, carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 20,

Suppression of CEACAM20 functions via dephosphorylation was suggested to contribute to preventing colitis. By shedding light on the anti-inflammatory mechanism of the intestinal epithelial cells, Prof.

These changes in bacterial expression triggered chronic colitis in mice genetically prone to this disorder,

10.1038/nature14232#Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome#Authors: Benoit Chassaing, et a e

and patients with colitis may benefit from this approach, "stated co-author James Willson, M d, . associate dean of oncology programs at UT Southwestern Medical center and co-author on the current study."

and may also be a treatment for colitis."The findings from this study were published recently in Science through an article entitled"Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration."

and prevented colitis symptoms. In mice where two-thirds of their livers had been removed surgically, SW033291 accelerated regrowth of new liver nearly twice as fast as normally happens without medication.

For those suffering the debilitating impact of colitis, accelerating tissue growth could heal colon ulcers more quickly,

which in turn could allow patients to take lower dosages of other medications that treat colitis some

Yang and Bae, now at Inje University in Korea, worked in the Markowitz laboratory on studies of colitis (Yang) and on liver regrowth after surgery (Bae.

Fink and Tiwari, both of Case Western Reserve, completed the work on the colitis mouse model.

who played a role in the success of the colitis experiments in mice, and Mark Chance, who contributed proteomics expertise for studies that showed how SW033291 works.

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