compared with just 8%for regularly stem cell therapies. The team did not invent a treatment for this heart disease,
This comes soon after a separate team from Harvard university announced their porous hydrogel could also achieve huge increases in the effectiveness of stem cell therapies.
and a company called VAR2 Pharmaceuticals has been spun out of this research to bring the therapy to market.
And the sheer demand for medication therapy is only going to rise, as chronic health conditions worsen:
and therapies that might work in humans. Genetically matched kidney organoids without disease-linked mutations showed no signs of either disease,
#Drug combo shows promise for skin cancer n transitnew melanoma research finds a combination therapy is highly effective at treating patients with skin metastases.
The treatment, interleukin (IL)- 2 combined with imiquimod and topical retinoid therapy, is a promising option for patients with so-called n-transit metastases.
t unclear if the recently developed targeted melanoma therapies that have revolutionized management of patients with internal melanoma metastases are useful in patients with metastatic disease limited of the skin,
Davis. ur results demonstrate that intralesional therapy with a protein that causes immune cells to divide,
or stage IV melanoma who had history of treatment with IL-2 therapy combined with imiquimod and a topical retinoid.
TWO YEARS LATER The data indicate that all patients achieved complete clinical response to the treated lesions within one to three months of starting the intralesional IL-2-based therapy.
otherwise, including powerful hormone-based therapies.""Unlike prior approaches to this design problem, ours is based a selection method,
First identified by Dr. Friedman in 1994 as a satiety hormone that switches off hunger, leptin initially failed as an obesity therapy,
Leptin on its own and in an unmodified state isn't ideal as a therapy because it doesn't last long in the bloodstream."
offering the possibility of directly testing potential avenues for therapy on the patient's own tissues. ur work, the Development article concluded, rovides a unique platform to produce human cones for developmental, biochemical,
"This could open the door to as yet unknown new therapies and preventions.""Knothe Tate has used already the system to demonstrate a link in osteoarthritic guinea pigs between disease status and molecular transport through blood, muscle, and bone.
Not everyone with ovarian cancer would benefit from this particular combination of therapies. The good news is these two types of cells are present in about 50%of ovarian cancer patients who would be candidates for this dual treatment.
"When we make the leap into therapies for humans, I think we have shot a better with noninvasive sonogenetics approaches than with optogenetics."
which will use a combined therapy of romidepsin with a HIV vaccine to kill the infected cells. ombination studies are of highest interest now.
there is no proven drug therapy for treating losses in episodic memory, which has led scientists to find ways of training the brain through computer-based games. e need a way of treating the cognitive symptoms of schizophrenia, such as problems with episodic memory,
used in conjunction with medication and current psychological therapies, this could help people with schizophrenia minimise the impact of their illness on everyday life. i
If the drug in question is the backbone of a specific therapy, laboratories need increased access to confirm efficacy
It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.
and therapies that might work in humans. Genetically matched kidney organoids without disease-linked mutations showed no signs of either disease,
Pollock became the first subject in a UCLA experiment that set out to meld electrical stimulation therapy with a robotic exoskeleton that effectively walks for paralyzed patients.
Others are developing stem-cell therapies, such as those from Stempeutics, Novadip or Bonus Biogroup. In this method
Therapy using implanted organic bioelectronicsource: Linköping University i
#First 3d printed Drug Approved by FDA Youl rarely see medication news on the pages of Medgadget,
The specific FDA approval is for SPRITAM (levetiracetam) that used as a therapy for epileptics to help control partial onset seizures, myoclonic seizures,
#Implantable Electrical Stimulation Therapy for Treating Scoliosis Some scientists believe that in many people scoliosis develops because of the unequal pressure that muscles on the sides of the spinal column tend to exert.
though there are no clinical trials that have confirmed this therapy or how to use it properly.
#White blood cell Mediated Therapy for Neurons in Patients with Parkinson Disease Scientists at the University of North carolina at Chapel hill have begun researching the delivery of neurotropic factors to the brain as a potential therapeutic for Parkinson disease.
However, one potential therapy is the development of smarter immune cells that deliver neurotropic factors to neurons damaged by the disease.
Delivering the protective proteins through immune cells is a breakthrough in GDFP therapy. This new macrophage mediated protein delivery system could potentially provide a therapy for patients who are afflicted by this debilitating disease e
#New Self-Positioning Transcatheter Mitral valve Developed by National University of Singapore Transcatheter heart valve replacements have become life savers for many frail patients who are unsuitable for open heart surgery.
Such sensors could also be used to monitor the effectiveness of stem cell therapies, Jasanoff says. s stem cell therapies are developed,
it going to be necessary to have noninvasive tools that enable you to measure them, he says.
#Gold-diamond nanodevice for hyperlocalised cancer therapy: Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells,
which can potentially be applied to thermal cancer therapy. Pei-Chang Tsai from the Institute of Atomic and Molecular Sciences, at the Academia Sinica, Taipei,
therefore act as switchable nanoheaters for therapies based on delivering intense and precise heat to cancerous cells,
#Advance in photodynamic therapy offers new approach to ovarian cancer The findings were published just in the journal Nanomedicine:
and the University of Nebraska takes existing approaches to photodynamic therapy and makes them significantly more effective by adding compounds that make cancer cells vulnerable to reactive oxygen species,
"Photodynamic therapy is a different approach that can be used as an adjunct to surgery right during the operation,
and genetic therapy, composed of"small, interfering RNA,"are attached to what researchers call"dendrimer-based nanoplatforms,
Compared to existing photodynamic therapies, this approach allows the near-infrared light to penetrate much deeper into abdominal tissues,
Using photodynamic therapy alone, some tumors in laboratory animals began to regrow after two weeks. But with the addition of the combinatorial genetic therapy to weaken the cancer cell defenses,
there was no evidence of cancer recurrence. During the procedures, mice receiving the gene therapy also continued to grow
We believe a key to the success of this therapy is that it takes away those defensive mechanisms."
is associated with invasion, metastasis, resistance to cancer therapies, and overall cancer cell survival. That excess of DJ1 is silenced by the genetic therapy composed of sirna.
The findings of this research, Taratula said, could also build upon some other recent advances in photodynamic therapy, in
which a different compound called naphthalocyanine could be administered prior to surgery, causing the cancer cells to"glow
"The tumors exposed to a single dose of a combinatorial therapy were eradicated completely from the mice
it also has broad implications for targeted therapy for other diseases such as cancer and neurological disorders,"said Chien.
and help design new drug therapies against pathogens by targeting enzymes that interact with DNA."
or find protein properties that would be ideal targets for drug therapies.""For example, viral genes code for their own proteins that process their DNA,
or if you want to modulate the immune system using nucleic acids, for vaccines or systemic suppression therapies,
#Novel nanoparticle therapy promotes wound healing (w/video)( Nanowerk News) An experimental therapy developed by researchers at Albert Einstein College of Medicine of Yeshiva University cut in half the time it takes to heal
Details of the therapy, which was tested successfully in mice, were published online in the Journal of Investigative Dermatology("Fidgetin-like 2:
"e envision that our nanoparticle therapy could be used to speed the healing of all sorts of wounds,
Dr. Sharp and project co-leader Joshua Nosanchuk, M d.,professor of medicine at Einstein and attending physician, infectious diseases at Montefiore Medical center, developed a wound-healing therapy that uses
Dr. Sharp plans to start testing the therapy on pigs, whose skin closely resembles that of humans, within months a
and describes how the research team used nanotechnology to watch tumor stem cells respond to therapy. ee never been able to directly observe the actions of potential cancer treatments this way before,
while developing new imaging tools at the single-cell level to visualize the course of therapies needed to eradicate these cells,
while counteracting these effects, with a protein-bound version of the drug called Abraxane currently the leading therapy.
it could be a game-changer for cancer therapy.""In future work, Chilkoti and coworkers will begin applying the packaging system to other cancer drugs with the goal of developing a"one size fits all"technology to improve the effectiveness of many other cancer drugs s
This would represent a quantum leap in antiviral therapy, says Fussenegger, who was involved not in the study.
The only current therapy that treats their causes is allergen-specific immunotherapy or allergy shots
In order to develop a safer, more direct, cause-based therapy, researchers have developed nanoparticles that envelop an allergen
and help design new drug therapies against pathogens by targeting enzymes that interact with DNA"There are other single-molecule tools around,
or find protein properties that would be ideal targets for drug therapies.""For example, viral genes code for their own proteins that process their DNA,
"The two therapies were tested together in laboratory experiments using human immune cells and in mice that were engineered to have a human immune system.
as any patient prescribed URMC-099 would also be taking antiretroviral therapy. The goal was to determine
Much to Gelbard and Gendelman surprise, URMC-099 increased the effectiveness of the nanoformulated drug. ur ultimate hope is that wee able to create a therapy that could be given much less frequently than the daily therapy that is required today,
& Technology (TVST), open up new areas of research in the pursuit of neuroprotective therapies. Glaucoma is a neurodegenerative disease where patients lose seemingly random patches of vision in each eye.
much like multi-drug therapy, may ultimately benefit patients with impaired mobility in a wide variety of rehabilitation settings.
DARPA portfolio of neurotechnology programs includes the Restoring Active Memory (RAM) and Systems-Based Neurotechnology for Emerging Therapies (SUBNETS) programs,
No effective therapy for Alzheimer exists. And scientists have yet to completely identify the cause,
possibly paving the way for new therapies that can either hone the pathway cancer-killing role or reduce its role in inflammation
San francisco. his opens up the possibility for new types of therapies that target blood coagulation factors, upstream of autoimmune processes.
The researchers are now attempting to block fibrinogen using biological and small-molecule approaches as potential new therapies to suppress autoimmunity directed against the brain,
because the therapy has been shown to delay and even reverse disease progression of Parkinson disease in preclinical models.
#iphone leak reveals new parts The video at Unbox Therapy shows what is claimed to be leaked parts of the Apple iphone 6s,
although it said it was xtremely rarethe Unbox Therapy video out today shows the backplate for the iphone 6s,
They probably wouldn trap enough cells to work as an anticancer therapy says Shea, but the implant could boost people chances of survival by identifying early on that cancer cells are on the move allowing the patient to begin chemotherapy right away.
Simple stem cell therapies are finally making their way towards the clinic, and a treatment for wounds caused by Crohn disease could be the first off-the-shelf therapy to get European union approval.
Hard-to-treat wounds near the anus afflict around 50,000 people in Europe every year. In a phase III trial, a treatment developed by Tigenix in Belgium improved the chances of healing such wounds by 50 per cent and apparently with no adverse side effects.
The therapy uses stem cells derived from donated liposuction tissue which have extremely low levels of the proteins that trigger immune reactions,
In need of relief New therapies are needed desperately. Triptans don work for half the people who try them,
#World first trial of stem cell therapy in the womb Their bones are so brittle that they fracture while in the womb.
Now a clinical trial of stem cell therapy in the womb aims to help babies born with brittle bone disease start life with stronger skeletons. o our knowledge,
or can predict the response to a therapy. The Fraunhofer FIT will make the first public demonstration of the system alongside its ZETA imaging software that is used in drug research at the forthcoming BIOTECHNICA expo in Hanover, Germany, between October 6 8, 2015.
"The two therapies were tested together in laboratory experiments using human immune cells and in mice that were engineered to have a human immune system.
as any patient prescribed URMC-099 would also be taking antiretroviral therapy. The goal was to determine
"Our ultimate hope is that we're able to create a therapy that could be given much less frequently than the daily therapy that is required today,
It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.
was approved for oral use as a prescription adjunctive therapy in the treatment of epilepsy, the company said on Monday.
The findings also open the possibility of new therapies aimed at measuring and preventing dangerous imbalances in cells.
#Normalization Of Testosterone Level After Testosterone Replacement Therapy Patients with low testosterone levels who have gone then on to have testosterone replacement therapy (TRT) could be at lower risk of cardiovascular events such as heart attack or stroke,
but offers hope in finding new therapies.""""Understanding the mechanisms used by cancer cells to adapt to their environment creates new possibilities to treat this deadly disease,
Chinese scientist Youyou Tu was awarded jointly the Nobel prize in Physiology or Medicine for her discovery of a new malaria therapy.
which suggests that it could work as a targeted cancer therapy. And for some reason, the NK cells also didn't seem to attack all cancer types-only their former brethren.
But they're pretty keen to get the therapy into clinical trials soon.""We're in discussions with pharmaceutical companies to take this straight into humans after the appropriate preclinical toxicity studies,
#Possible progress against Parkinson's and good news for stem cell therapies Parkinson's, which affect as many 10 million people in the world,
and how it relates to disease or response to drug therapies.""Gersbach added, "Not only can you start to answer those questions,
and a viable, more cost-effective alternative to current radiotherapy and photodynamic therapy (PDT) treatments.
when using LTP treatment is different from other therapies. The active agents in the LTP break up DNA
This is different to some current therapies which cause apoptosis, where cells are prompted to die through natural mechanisms that can result in treatment resistance.
In the case of early stage organ confined tumours, patients may be treated with a focal therapy, for example cryotherapy, photodynamic therapy,
we have presented the first experimental evidence promoting the potential of LTP as a future focal cancer therapy treatment for patients with early stage prostate cancer.
and developed as a whole new class of cancer therapy, especially for cancer stem cells, "he said."
not a well-defined pocket seen in other druggable proteins targeted by many current cancer therapies."
and drug discovery--aiming to translate discovery in the lab into clinical therapy, to help cancer patients and their families,
"We hope to find a better therapy--and eventually a cure--for cancer
#Study revises theory of how PTEN, a critical tumor suppressor, shuts off growth signals Today,
which can be essential to choosing the most appropriate therapy, supports the need for molecular profiling strategies that are more accessible to providers, clinical investigators and patients;
The replacement of these cells through bone marrow transplantation is the only widely established therapy involving stem cells in human patients.
"Currently, there are no disease modifying therapies and much attention has been focused upon prevention and early diagnosis,"said Ole A. Andreassen, MD, Phd,
and cancer, opening the door to new therapies. Experiments in mice and human cells have shown that the protein promotes the proliferation of cytotoxic T cells,
we hope we can provide a robust treatment for patients. ext we will test the therapy in mice,
and see if it can be combined with other therapies. If all goes well, we hope to be ready to carry out human trials in about three years.
"Preclinical studies suggested that this combination therapy would have better outcomes than those elicited by their individual
and Immunotherapeutics Service at MSK, found that the same concurrent combination of therapies generated notably positive responses in previously treated patients."
"It was apparent following that trial that the combination should be tested as a first line therapy for metastatic melanoma,
The Phase 2, double-blind trial enrolled 142 patients with advanced melanoma who had received not prior therapy.
while melanoma patients with the mutant BRAF gene can be treated with a targeted therapy, the majority
Patients with BRAF mutations had similar outcomes for each of the therapies. The combination therapy also induced effects that continued well after the last administration of the therapy.
Of those patients who died, 25 in the combination group (27%)and 17 in the monotherapy group (37%)died from progressive disease.
Notably, three of the deaths in the combination group were determined to have been combined related to the therapy."
"In general, and as might be expected, side effects were more prevalent in patients who received the combination therapy,
But we also look forward to following up with the patients who benefitted from the combination therapy to assess the durability of the responses we have observed
Current multiple sclerosis therapies aim to slow further myelin destruction by the immune system, but the Case Western Reserve team used a new approach to create new myelin within the nervous system.
Their work offers great promise of developing therapies that reverse disabilities caused by multiple sclerosis or similar neurological disorders."
to produce these advanced therapy products, to work with international teams and to manage the regulatory aspects of the trials in France and abroad.
which existing therapies are either unsatisfactory or unavailable
#Printing silicon on paper, with lasers Recently, a group of researchers at Delft University of Technology,
It is normally very sensitive to estrogen-targeting therapies because of high expression of the estrogen receptor protein,
"Figuring out specific differences that are not visible under the microscope allows us to intervene with more appropriate and potentially lifesaving therapy.
we have an opportunity to identify anticancer therapies that would specifically target that abnormality and that would otherwise not be given to those patients who could benefit.
the opportunity exists to provide tailored therapies for patients,"notes Lorna Rodriguez, MD, Phd, director of the precision medicine initiative at the Cancer Institute and professor of obstetrics, gynecology and reproductive sciences
such findings can also aid in developing the next generation of therapies through clinical trials. It is our aim at Rutgers Cancer Institute of New jersey to build upon this work,"notes senior author of the work, Shridar Ganesan, MD, Phd, associate director for translational science at the Cancer Institute
"Current therapies focus on stopping immune system attacks, slowing the progression of the disease. Our research is focused on trying to repair the brain itself,
"These networks can also be useful for understanding how various therapies work and to help with developing new therapies."
and might be a good target for therapy. Ubiquitin-proteasome inhibitors have already been used successfully in cancer therapy and clinical trials.
Therefore, this research might provide molecular bases and insights for developing additional therapeutic strategies in the future,"explained Ed Seto, Ph d.,senior member of the Cancer Biology and Evolution Program at Moffitt t
2015 in Molecular Cell, offer guidance for improving stem cell therapies. The new work also reveals more about certain cancers that arise
and optimizing the efficiency of stem cell therapies.""When they looked closer at the genes that both pathways activated,
so that preventive therapies can be given. But exercise stress testing is inappropriate for diagnosis in hemodialysis patients who have multiple complications including muscle weakness, osteoporosis and peripheral arterial disease."
so that preventive therapies can be given. But exercise stress testing is inappropriate for diagnosis in hemodialysis patients who have multiple complications including muscle weakness, osteoporosis and peripheral arterial disease."
and lay the foundation for the next era of cancer therapy, "said corresponding author Jinghui Zhang, Ph d.,a member of the St jude Department of Computational biology."
There are currently dozens of active clinical trials evaluating vaccines for cancer therapy. Approximately 235,000 new diagnoses of breast cancer were made last year,
In this case, HER2 is both a naturally occurring hormone receptor and an antigen target for therapy.
World health organization guidelines recommend antiretroviral therapy for individuals with a CD4+T cell count of less than 500 cells/ml.
"At some point in the future, this approach may be suitable for modeling individual patient response to cancer therapies to inform clinical treatment,
Various sight recovery therapies are being developed by companies around the world, offering new hope for people who are blind.
what vision would be like after two different types of sight recovery therapies. Lead author Ione Fine,
This new discovery could open the way to incorporating sulfur into other natural products, potentially advancing new therapies for indications beyond cancer."
#Better way to engineer therapeutic proteins into antibodies Some proteins exist so fleetingly in the bloodstream that they can't be given effectively as therapies.
and diagnostic compounds that would not have been possible otherwise--including powerful hormone-based therapies.""Unlike prior approaches to this design problem,
First identified by Friedman in 1994 as a satiety hormone that switches off hunger, leptin initially failed as an obesity therapy,
Leptin on its own and in an unmodified state isn't ideal as a therapy because it doesn't last long in the bloodstream."
and food insecure people with HIV are less able to take anti-HIV therapies, make clinic visits,
Participants were HIV positive individuals between 18 and 49 years old on anti-HIV therapy
The finding was confirmed in samples from patients receiving high-dose interleukin 2 therapy to treat metastatic melanoma."
Currently, many RNA-based therapies are under investigation worldwide. The MIME method can make a significant contribution to this research by helping to identify the appropriate RNA segments.
This multi-device approach, much like multi-drug therapy, may ultimately benefit patients with impaired mobility in a wide variety of rehabilitation settings."
"A therapy based on these inhaled drugs may help deal with new viral and bacterial strains that are resistant to conventional vaccines
and therapies that could change the infectious disease landscape.""The investigators say they are currently testing an oral small molecule immune modulator in phase 2 clinical trials that acts like volatile anesthetics to help reduce secondary infections after someone becomes sick with the flu u
and guide the development of new therapies.""The study reveals the most rigorously validated classification system for pancreatic ductal adenocarcinoma to date.
"Basal-like tumors also trended toward a better response to adjuvant therapy.""If we know that your tumor is aggressive,
then it may be important to treat your whole body first with neoadjuvant therapy, which is given therapy prior to surgery,
as opposed to just trying to remove the tumor with surgery at the outset, "said Yeh, who,
which respond to therapies differently than other tumor subtypes, so we are interested very in seeing
"For pancreatic cancer in particular, it's a race against the clock, every therapy counts, so you want your first therapy to work,
"she said.""With this cancer, you don't have a lot of time to try different therapies. If a patient is given a therapy that is unsuccessful, that is time in
which the patient's disease has progressed. So the goal is to start patients on the right therapy from the get-go
#New molecule found to prevent preterm birth Premature births are linked intimately with inflammation of the uterine tissue, a biological response
which induces contractions and preterm labor. In their search for a mean to prevent this phenomenon
#Filling a void in stem cell therapy Stem cell therapies are limited often by low survival of transplanted stem cells
Stem cell therapies bear tremendous hopes for the repair of many tissues and bone or even the replacement of entire organs.
and function correctly at the site of injury to be useful for clinical regenerative therapies.
and no curative therapies available. The UK10K project has measured genetic variations in 10,000 individuals in great detail,
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011