A surgeon, for instance, will be able to work on a virtual brain physically, with the full tactile experience,
Their work, published online July 8 by the journal Science Translational Medicine, could pave the way for gene therapy in people with hearing loss caused by genetic mutations."
precision medicine treatment injected into their ears to restore hearing, "Holt says. Sound transducers: How TMC works Holt's team showed in 2013 that TMC1
actually gives impulses through the brain into the muscles, then the muscles contract,"orthopaedic surgeon and director of research and development at Ossur,
though-the lens developed by Gareth Webb is inserted into the eye via a painless procedure that takes less than 10 minutes (Webb says the process is a lot like cataract surgery).
dedicated to helping organisations that provide eye surgery in developing countries. Funds have also been earmarked for eye research institutes across the world d
Publishing the results in Science Translational Medicine, the team observed no serious side effects. Studies on mice and rats showed the drug could also be used to prolong survival in particularly severe pneumonia,
while previous research published last year in Nature Medicine has shown this class of drugs could also be effective in treating tuberculosis.
Amgen, is to get approval from the FDA and the European Medicines Agency. The drug is administered once every two weeks for up to 18 months
According to the study, published in The Journal of Clinical Oncology, of the 436 patients with inoperable melanoma, 16.3 percent of them were still in remission six months after the treatment,
and his colleagues could lead to new ways to treat neurodegenerative diseases and paralysis, as well as mapping out the brain in greater detail than ever before.
and improve survival outcomes after surgery and injury.""We are excited very,"lead researcher Sanford Markowitz,
an oncologist from Case Western Reserve University in the US, said in a press release.""We have developed a drug that acts like a vitamin for tissue stem cells,
or liver surgery but in the future they hope to see whether it could more broadly speed up the repair of tissues around the body."
The gadget has been developed by ophthalmologist Andrea Russo together with and Italian tech development firm Si14 Spa.
and deliver medicine to wherever it's most needed in the body. They're also relatively easy to track as they move through the system,
and interfere with them as they deliver their medicine.""These tiny particles are camouflaged kind of, I would say,
"The device was created by medical company, Second sight, and works through an electronic device that's implanted onto a patient's retina-the layer of light-sensing cells at the back of the eye.
and only 11 adverse events, most of which arose shortly after surgery and were treated successfully. Only one device had to be removed after it became damaged
which have been published in the journal Ophthalmology, will allow them to begin testing the device in an even broader range of subjects,
#Scientists are figuring out how to make medicinal marijuana, without the high Scientists have figured out how to separate the pain relieving qualities of medical marijuana from its psychological side-effects in an effort to offer people a new high-free option.
"There has been a great deal of medical interest in understanding the molecular mechanisms at work in THC, so that the beneficial effects can be harnessed without the side-effects,"one of the team,
In late-stage patients who had received already surgery, the blood test could also predict their chances of survival and relapses.
surgical oncologist David Linehan from the University of Rochester Medical centre in the US told Elaine Schattner at Forbes. The key to the new blood test is a tiny,
and how likely it was to progress after surgery, based on how much of the protein was being carried by the exosomes.
The company lists medical monitoring, sportswear clothing and even connected cars as potential use cases for its technology-bend
This is the first time movement has been restored voluntarily without surgery.""These encouraging results provide continued evidence that spinal cord injury may no longer mean a lifelong sentence of paralysis and support the need for more research,"Roderic Pettigrew,
"The potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
"Non-destructive manipulation of cells over time and in the correct environment is a key enabling technology highly needed within the biology and medical research communities,
Chair in Surgery and director of the Pfleger Liver Institute and Dumont-UCLA Transplant and Liver Cancer Centers presented the study during the annual meeting of the Southern Surgical Association.
The study appears in the early online edition of the peer-reviewed Journal of the American College of Surgeons.
The retrospective study included 865 liver cancer patients who had transplants between 1984 and 2013 said study first author Dr. Vatche G. Agopian an assistant professor of surgery in the division
and the existing American Joint Committee on Cancer pathologic TNM staging system giving transplant physicians and oncologists more information to work with in deciding how often to monitor for recurrence and whether or not adjuvant treatment
For most patients who are diagnosed with liver cancer it generally is advanced too to treat with surgery.
For patients with underlying liver dysfunction who are unable to undergo surgery to remove the tumor liver transplantation is the best way to treat the patient.
#Rate of investment in medical research has declined in U s. increased globally From 2004 to 2012,
the rate of investment in medical research in the U s. declined, while there has been an increase in research investment globally, particularly in Asia, according to a study in the January 13 issue of JAMA.
For the last century medical research including public health advances has been the primary source of and an essential contributor to improvement in the health and longevity of individuals and populations in developed countries.
Few previous analyses have compared medical research in the United states with other developed countries according to background information in the article.
and who supports medical research as well as resulting patents publications and new drug and device approvals.
Reduced science investment The largest increase in biomedical and health services research funding in the U s. occurred between 1994 and 2004
The share of U s. medical research funding from industry accounted for 46 percent in 1994
medicines currently in clinical trials. Underfunding of service innovation Health services research (which examines access to care the quality
in comparison with total medical research funding. Private insurers ranked last (0. 04 percent of revenue) and health systems 19th (0. 1 percent of revenue) among 22 industries in their investment in innovation.
The analysis underscores the need for the United states to find new sources to support medical research
Restore the U s. Lead in Biomedical Researchto achieve a new strategic vision for research the United states will need a roadmap that sets priorities describes needed structural and organizational changes
and creates an environment that enables innovation write Victor J. Dzau M d. of the Institute of Medicine Washington D c. and Harvey V. Fineberg M d. Ph d. of the University of California San francisco in an accompanying editorial.
and efficiency the United states can retain its leadership position in biomedical research h
#Glass for battery electrodes In this regard researchers are diligently looking for new materials that exhibit a greater energy density
and fears among those affected and their families says lead investigator Uzma Samadani MD Phd assistant professor in the Departments of Neurosurgery Psychiatry Neuroscience and Physiology at NYU Langone.
and professor and chairman of the Department of Neurological Surgery at University of Washington Medicine and co-chair of the Head Neck and Spine Committee of the National Football league.
Traumatic brain injury is one of the most common causes of neurologic morbidity in the world today Dr. Ellenbogen says.
That study published Dec 16 in Journal of Neurosurgery looked exclusively at military veterans. Dr. Samadani's future work aims to replicate eye-tracking's diagnostic potential for head injuries on a larger scale in Iraq
Also lending third-party support for Dr. Samadani's research is M. Sean Grady MD the Charles Harrison Frazier Professor and Chairman of the Department of Neurosurgery at the Perelman School of medicine at the University
who is also a researcher at the Research Institute of the MUHC and a Professor of Human genetics, Paediatric Surgery and Ophthalmology at Mcgill University."
Similar design strategies have great potential for use in a wide variety of human-made systems, from biomedical devices to microelectromechanical components, photonics and optoelectronics, metamaterials, electronics, energy storage
"Potential applications range from battery anodes, to solar cells, to 3d electronic circuits and biomedical devices.""The 3d transformation process involves a balance between the forces of adhesion to the substrate and the strain energies of the bent,
This opens up new therapeutic possibilities for patients suffering from neurological trauma or disorders, particularly individuals who have become paralyzed following spinal cord injury,
"These include materials science, electronics, neuroscience, medicine, and algorithm programming. I don't think there are many places in the world where one finds the level of interdisciplinary cooperation that exists in our Center for Neuroprosthetics."
#New algorithm will allow better heart surgery experts say A new technique to help surgeons find the exact location of heart defects could save lives,
meaning patients have to spend extra time in the theatre as the surgeon finds the problem.
The more time taken in surgery the more likely problems are to develop, adding extra danger for patients and expense for the NHS.
which will enable medics to exactly find the area of concern before any surgery takes place.
cutting the amount of time in surgery for some patients. In a paper published in PLOS Computational biology,
"The standard way we do electrocardiograms does not provide sufficient information to enable medical professionals to focus in clearly to the area of concern."
That means more time in surgery, more chance for things to go wrong and worse outcomes for patients."
GI & Liver the work brings surgeons one step closer to helping human patients using this regenerative medicine technique.
Tissue-engineered small intestine (TESI) grows from stem cells contained in the intestine and offers a promising treatment for short bowel syndrome (SBS) a major cause of intestinal failure particularly in premature babies and newborns with congenital intestinal anomalies.
Tracy C. Grikscheit MD a principal investigator in The Saban Research Institute of CHLA and its Developmental biology and Regenerative medicine program is also a pediatric surgeon at Children's Hospital Los angeles and an assistant professor of surgery at the Keck School of medicine
However in those initial studies--published in July 2011 in the biomedical journal Tissue Engineering Part A--only basic components of the intestine were identified.
since medical staff can identify and isolate confirmed Ebola cases more rapidly, "said Dr. Christiane Stahl-Hennig, the Head of the Unit of Infection Models."
which could lead to new drug design for psychiatric and neurodegenerative diseases, has been discovered by researchers at Georgia State university.
Their findings are published in the journal Nature Communications this week. The research team has been studying a metabolic pathway called the tryptophan kynurenine pathway,
which is linked to psychiatric and neurodegenerative disorders, including depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's disease, AIDS dementia complex, asphyxia in newborns and epilepsy.
The medical potential of this pathway warrants detailed study to provide information about the pathway's enzymes and their regulation.
This pathway produces several neurotransmitter regulators and is responsible for metabolizing nearly 99 percent of the tryptophan in the body.
"This pathway is associated highly with neurodegenerative diseases and depression.""The researchers took a high concentration of the purified protein,
They will partner with Dr. Andy Miller, director of psychiatry at Emory University, to determine the physiological application of this pathway in humans s
"These same technologies can now be used to study the brains of people who died from unexplained neuropsychiatric diseases to determine
Co-first author Alice Eunjung Lee, Phd, from the lab of Peter Park, Phd, at the Center for Biomedical Informatics at Harvard Medical school, developed the study's retrotransposon analysis tool,
Srishti Bhagat and Nicole Calakos of Duke Neurology Department; Louis-Jan Pilaz and Debra Silver of Duke's Molecular genetics and Microbiology Department;
and Daniel Wilton and Beth Stevens of Boston Children's Hospital Department of Neurology Harvard Medical school.
Ruth Tuttle Freeman Research Professor of radiation oncology and radiology and co-director of the Center for Molecular Imaging at the University of Michigan Medical school. ub1 is well-known for its role in cell division.
Charles Simmons, MD, chair of the Department of Pediatrics and director of the Division of Neonatology, says,
Simmons, the Ruth and Harry Roman Chair in Neonatology in honor of Larry Baum said the information from both analyses should ultimately lead to healthier weight gain, better neurological outcomes and shorter hospital stays
I. Shulman the George R. Cowgill professor of medicine and cellular & molecular physiology--developed a novel method to measure the rate of triglyceride production from fatty acids in three types of animals:
when we can use ipscs for human therapy aren't that far away says Zhaohui Ye Ph d. an instructor of medicine at the Johns hopkins university School of medicine.
Linzhao Cheng Ph d. a professor of medicine and oncology in the Johns hopkins university School of medicine; and their colleagues pitted CRISPR against TALEN in human ipscs adult cells reprogrammed to act like embryonic stem cells.
"explains senior author Evan Rosen, MD, Phd, of the Division of Endocrinology, Diabetes and Metabolism at BIDMC and Professor of Medicine at Harvard Medical school."
However, epidemiological and molecular data have suggested that events leading to insulin resistance might also take place in the nucleus,
#Byproducts from bacteria awaken dormant T-cells HIV viruses Dental and medical researchers from Case Western Reserve University found another reason to treat periodontal disease as soon as possible.
The researchers reported similar results in a study of breast cancer at the 2013 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.
and chief of dermatology at UC San diego School of medicine and colleagues have uncovered a previously unknown role for dermal fat cells known as adipocytes:
The emergence of antibiotic-resistant forms of S. aureus is a significant problem worldwide in clinical medicine.
Biomolecular interaction analysis a cornerstone of biomedical research is accomplished traditionally using equipment that can cost hundreds of thousands of dollars said Wyss Associate Faculty member Wesley P. Wong Ph d. senior author
Wong who is also Assistant professor at Harvard Medical school in the Departments of Biological Chemistry & Molecular Pharmacology and Pediatrics and Investigator at the Program in Cellular and Molecular Medicine at Boston Children's Hospital calls the new
Biomedical researchers all over the world can start using this new method right away to investigate how biological compounds interact with their targets using commonly-available supplies at very low cost t
Distinguished Professor of Orthopaedic Surgery at the MU School of medicine.""The benefit to patients is that more graft material will be available
This will allow us as surgeons to provide a more natural joint repair option for our patients."
In traditional preservation methods, donated tissues are stored within a medical-grade refrigeration unit in sealed bags filled with a standard preservation solution.
"said study co-author James Cook, director of MU's Comparative Orthopaedic Laboratory and the Missouri Orthopaedic Institute's Division of Research."
schedule surgery and get the graft to the surgeon for implantation.""Stannard, who also serves as chair of MU's Department of Orthopaedic Surgery
and medical director of the Missouri Orthopaedic Institute, said that patients with metal and plastic implants often are forced to give up many of the activities they previously enjoyed
in order to extend the life of their new mechanical joints.""For patients with joint problems caused by degenerative conditions,
However, the method of preserving the grafts themselves has limited the amounts of quality donor tissue available to surgeons.
Cook, who also serves as the William and Kathryn Allen Distinguished Professor in Orthopaedic Surgery at the MU School of medicine,
because this brain abnormality cannot be detected by current neurological exams or electroencephalography (EEG). Temporal lobe epilepsy (TLE) or limbic epilepsy is a common adult epileptic disorder characterized by spontaneous recurrent seizures that may also spread to other brain regions triggering secondary severe generalized seizures.
Aside from neurosurgery which benefits only a small population of TLE patients there are no other effective treatments or preventive strategies.
Nicolas Bazan Boyd Professor and Director of the LSU Health New orleans Neuroscience Center of Excellence and Alberto Musto Assistant professor of Research Neurosurgery and Neuroscience found that brief small electrical microbursts
or even reversing the disease in preclinical models. Treating fat tissues with IL-33 restored normal Treg cell levels
The approach opens up new possibilities for the study of biomedical processes as well as for applications in biotechnology, chemistry, and pharmacy."
and medicine,"says Schiller. With the help of chemical reactions that were previously impossible in the cell,
but it also promotes remarkable neurological recovery from the most frequent form of stroke in humans s
#Using 3-D printing clinicians repair tracheal damage Mr. Goldstein a Phd candidate at the Hofstra North Shore-LIJ School of medicine has been working with a team of surgeons at the North Shore
Lee Smith MD chief of pediatric otolaryngology at Cohen Children's Medical center and David Zeltsman MD chief of thoracic surgery at Long island Jewish Medical center both part of
and Daniel A. Grande Phd director of the Orthopedic Research Laboratory at the Feinstein Institute and asked
With 3d printing we were able to construct 3d printed scaffolding that the surgeons could immediately examine
The advantage of PLA is that it's used in all kinds of surgical implant devices says Dr. Smith.
and Dr. Zeltsman at The Society of Thoracic Surgeons illustrate how the 3d printed windpipe or trachea segments held up for four weeks in an incubator.
Medical research can take years to move from bench to bedside as can US Food and Drug Administration (FDA) approval.
and tools to improve the lab. He is the presenting author on a paper being presented to thousands of surgeons
making it easier for surgeons to repair the aorta without opening the chest and easier for patients to recover.
The approach was described today at the 51st Annual Meeting of The Society of Thoracic Surgeons.
The surgeons performed the entire procedure using only a small incision in the groin (inner thigh.
While our study only addressed aneurysms, the results have implications for cardiothoracic surgeons who perform procedures to repair tears in the ascending aorta (type A dissection),
the Breast cancer Risk Assessment Tool (BCRAT), are published in the Journal of Clinical Oncology.""Physicians routinely perform biopsies to evaluate concerning findings in the breast,
for the presence of a breast cancer,"says Amy Degnim, M d.,a surgeon at Mayo Clinic and a senior author of the study."
Developed by the National Cancer Institute and the National Surgical Adjuvant Breast and Bowel Project, BCRAT is currently the most commonly used model for predicting breast cancer risk in women with BBD.
Moreover, around 25%of survivors develop neurological complications and cognitive impairment. Lead authors Pedro Mejia and J. Humberto Treviño-Villarreal
and turns out to be a major bad actor in promoting neurological symptoms and death. Remarkably, Mejia, Treviño-Villarreal and colleagues showed that reducing leptin using a variety of means,
In their animal model, treating mice with the mtor inhibitor rapamycin protected them against the neurological complications of cerebral malaria.
#Device for guided surgery of deviations in long bones patented CEU-UCH Cardenal Herrera University patented a device that can be applied in surgeries to correct deviations in long bones.
and enables a surgeon to set the cutting angle that best suits the bone, and, also, to set the location
and could have applications in orthopedic surgery on humans. Angular deviations in the bones of body extremities cause physical overload that, in the case of dogs and other animals that develop those bones in the course of only a few months,
can only be corrected through a surgical intervention. After mandatory medical criteria have been met, the device our university patented could have applications in adult humans,
so that a specific deviated bone can be realigned through surgery. To determine the suitable formula, the bone that is to be operated on is reconstructed first in 3d on the basis of an CT SCAN,
the personalized device that the surgeon uses to determine the optimal points and cutting angles is designed and produced.
has so far been used in seven orthopaedic surgical interventions on dogs in which Iván Serra,
These surgeries, which in three dimensions corrected deviations in bones, yielded some very satisfying results.
International dissemination of the investigation This new device for surgery of angular deviations in long bones was presented to experts in engineering and veterinary medicine at two international congresses.
The results of the first surgical interventions on dogs were presented in the presence of UCV professor of Veterinary medicine Iván Serra, at the 17th European Society of Veterinary Orthopaedics and Traumatology Congress,
"Going forward, Huang said there are numerous possibilities for the material to control elastic waves including super-resolution sensors, acoustic and medical hearing devices,
Abnormalities in these brain regions are associated with neurological and mental health disorders. According to Professor Donohoe: For years scientists have been fascinated by the development of different brain structures and how this changes in brain-based disorders.
and to understanding the basis of neurodevelopmental and neurodegenerative disorders such as schizophrenia Alzheimer's disease and epilepsy.
Because the antibiotics are present on the particulate matter with bacteria the selective pressure for bacteria to retain their resistance remains during their flight said Greg Mayer an associate professor of molecular toxicology at the institute.
explained senior investigator Paulo Fontes, M d.,UPMC transplant surgeon, associate professor, Starzl Transplantation Institute, Department of Surgery, Pitt School of medicine,
and easily moved around their pens just hours after they woke up from the surgery,
Joining forces with dermatologists and oncologists from the University Hospital in Zurich and backed by the University Research Priority Program"Translational Cancer Research,
and funded by the Robert Wood Johnson Foundation--published online-first by the New england Journal of Medicine.
and parent study principal investigator, Karin V. Rhodes, MD, MS, director of the department of Emergency Medicine's Center for Emergency Care Policy and Research."
The discovery could lead to targeted therapies and interventions for Alzheimer's disease, autism and other neurological conditions.
creating 12 research hubs across the United states to improve the utility of biomedical data. USC's two BD2K centers of excellence, including ENIGMA,
"The ENIGMA Center's work uses vast datasets as engines of biomedical discovery; it shows how each individual's genetic blueprint shapes the human brain,
and kidneys explained senior investigator Timothy Billiar M d. professor and chair of surgery Pitt School of medicine.
If hypoglycemia develops in these premature babies and persists for over an hour, it can affect brain development.
A different method to previous sensors Glucolight spares the premature babies blood samples and enables the blood sugar level to be monitored permanently thanks to the sensor's novel measuring technology,
The computer then uses these two different readings to calculate the premature baby's blood sugar level.
#Connection between childhood adversity psychiatric disorders seen at cellular level Mitochondria convert molecules from food into energy that can be used by cells
and psychiatric disorders but the research is limited very and no prior work has examined the relationship of MITOCHONDRIAL DNA to psychosocial stress.
and psychiatric conditions are associated with inflammation and health conditions like diabetes and heart disease. Identifying the changes that occur at a cellular level due to these psychosocial factors allows us to understand the causes of these poor health conditions
and possibly the overall aging process. said Audrey Tyrka MD Phd Director of the Laboratory for Clinical and Translational Neuroscience at Butler Hospital and Associate professor of Psychiatry and Human Behavior at Brown University.
Participants completed diagnostic interviews to assess psychiatric disorder diagnosis and assess childhood adversities including parental loss and childhood abuse and neglect.
and some psychiatric disorders are linked to important cellular changes that may represent advanced cellular aging.
and prevention options for stress-related psychiatric and medical conditions and may shed light on the aging process itself. said Dr. Tyrka also the director of research for Butler Hospital l
#Scientists invent system to improve effectiveness of cancer surgery With the goal of making it easier for surgeons to detect malignant tissue during surgery
scientists have invented a new imaging system that causes tumors to ight upwhen a hand-held laser is directed at them. surgeon goal during cancer surgery is to remove the tumor,
Our goal is to provide better real-time information to guide the surgery. Published online ahead of print in IEEE Transactions on Biomedical engineering (TBME),
Mohs and co-authors report on their prototype system that combines a fluorescent dye that localizes in tumors with a real-time imaging system that allows the surgeon to simply view a screen to distinguish between normal tissue and the ightedmalignant tissue.
Current technology allows cancer surgeons to scan tumors prior to surgery with magnetic resonance imaging and other systems.
However, to scan the tumor during surgery involves moving the patient from the operating table and into the machinery hich prolongs the surgery. eing able to quickly scan a tumor during surgery to visualize tumor tissue from non-tumor tissue is an unmet clinical need,
said Mohs. athology techniques that examine tumor tissue during surgery can take up to 20 minutes
and they focus on the tissue removed during surgery, not the tissue that remains in the body.
In TBME, the authors noted that the ideal system would find tumor boundaries with high sensitivity,
have minimal impact on operative time and surgical technique, present findings in an intuitive manner and avoid the use of ionizing radiation or a specialized imaging environment, such as MRI machines.
A surgeon-controlled laser can be directed at any area of interest. In addition an imaging system with three cameras sits above the surgical field.
The images recorded by both systems are processed to display a composite image. Using this system,
a surgeon would scan the tumor prior to surgery to determine its boundaries. The tumor would then be removed surgically
Recently, Mohs was awarded a $1. 37 million research grant from the National Institute of Biomedical Imaging
Edward Levine, M d.,Surgical Sciences Oncology; Frank Marini, Ph d, . and Graca Almeida Porada, M d.,Ph d.,Institute for Regenerative medicine;
Wake Forest School of medicine, an established leader in medical education and research; and Wake Forest Innovations,
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