such as materials used for biomedical purposes. This new method of radical polymerization doesn involve heavy metal catalysts like copper.
either or both of these processes could be faulty in neurodegenerative diseases such as Alzheimer, Amyotrophic lateral sclerosis (ALS),
said Raymond obrowland, professor of diagnostic medicine and pathobiology at Kansas State College of Veterinary medicine. t really the future of diagnostics for both humans and animals.
including clinical medicine, food safety testing, environmental monitoring and biodefense o
#Nature Inspires First Artificial Molecular Pump Using nature for inspiration, a team of Northwestern University scientists is the first to develop an entirely artificial molecular pump, in
These encouraging results from in vitro tests in humans and in vivo tests in mice were published in the Annals of Neurology. e believe we have identified the first therapy that will impact the quality of life of people with multiple sclerosis by significantly reducing the disability and the disease progression
as well as facial deformation and neurodegeneration. Cockayne syndrome is caused by mutations in either of two genes involved in the repair of DNA damage induced by ultraviolet (UV) rays.
Until now, neurodegeneration and aging have largely been attributed to the damage inflicted on cells by mitochondrial free radicals.
and make the main cell types of neurological systems the central nervous system and the peripheral nervous system in a dish that is specialized for each patient,
particularly neuropathic pain, said Akbar Panju, medical director of the Michael G. Degroote Institute for Pain Research and Care,
a clinician and professor of medicine. his research will help us understand the response of cells to different drugs and different stimulation responses,
or personalized medical therapy for patients suffering with neuropathic pain. ource: Mcmaster Universit i
#Controlling a robotic arm with a patient intentions Giving himself a drink for the first time in 10 years,
In a clinical trial, the Caltech team and colleagues from Keck Medicine of USC have implanted successfully just such a device in a patient with quadriplegia
the Caltech team collaborated with surgeons at Keck Medicine of USC and the rehabilitation team at Rancho Los Amigos National Rehabilitation Center.
The surgeons implanted a pair of small electrode arrays in two parts of the PPC of a quadriplegic patient.
After recovering from the surgery, the patient was trained to control the computer cursor and the robotic arm with his mind.
such as those of the Andersen Lab at Caltech, to human patients, ultimately turning transformative discoveries into effective therapies, says center director Charles Y. Liu, professor of neurological surgery, neurology,
and biomedical engineering at USC, who led the surgical implant procedure and the USC/Rancho Los Amigos team in the collaboration. n taking care of patients with neurological injuries and diseasesnd knowing the significant
We have created a unique environment that can seamlessly bring together rehabilitation, medicine, and science as exemplified in this study,
it like going to the dentist and having your mouth numbed. It very hard to speak without somatosensory feedback.
says Professor Geoff Woods from the Cambridge Institute for Medical Research at the University of Cambridge,
The researchers believe that the device has enormous potential for use in point-of-care medical diagnostics,
Goldys believes that we will see rapidly increasing use of smartphone technology in the field of biomedical diagnostics, particularly in resource poor areas.
as a significant step toward advancing personalized medicine. The ability to accurately find mutations that are biomarkers for disease will help clinicians determine treatment paths for patients,
a mark oncologists often use as a proxy for cure in immunotherapy. Importantly, responses to treatment were pronounced most in patients with less advanced cancers (stage IIIB, IIIC,
and is published in the Journal of Clinical Oncology. T-VEC is modified a form of herpes simplex virus type-1
, in Bristol School for Cellular and Molecular Medicine, and the study lead author, said: hile inflammation is critical to prevent infection,
The results of the findings were published recently in the Journal of Clinical Oncology. Uofl was one of the major sites for the phase III clinical trial involving 436 patients who received the viral immunotherapy, talimogene laherparepvec (T-VEC.
The U s. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) are considering findings from the trial to make the treatments available to more patients with advanced melanoma.
More Researchthe Journal of Clinical Oncology report comes on the heels of Chesney findings from another study published this month in the New england Journal of Medicine.
and other neurological conditions. Whether memories lost to amnesia are erased completely or merely unable to be recalled remains an open question.
the study first author and an assistant professor of surgery in UCLA division of liver and pancreas transplantation. his device is best single predictor of organ survival in our patients,
#Injectable electronics New system holds promise for basic neuroscience, treatment of neurodegenerative diseasesit a notion that might be pulled from the pages of science-fiction novel electronic devices that can be injected directly into the brain,
and treat everything from neurodegenerative disorders to paralysis. It sounds unlikely, until you visit Charles Lieber lab. A team of international researchers, led by Lieber, the Mark Hyman, Jr.
a process common to delivery of many species in biology and medicine you could go to the doctor
or record neural activity. hese type of things have never been done before, from both a fundamental neuroscience and medical perspective,
The advance could mean a giant step forward in efforts to tailor medical treatment plans to individual patients.
Led by Shigeki Miyamoto, a professor of oncology at UW-Madison, and David Beebe, the John D. Macarthur Professor and Claude Bernard professor of biomedical engineering at UW-Madison, the researchers published news of the advance May 1, 2015, in the Royal Society
Faster regrowth and healing of damaged tissues Research focuses on select tissues injured through disease, surgery and transplants,
the Ingalls Professor of Cancer Genetics at the university School of medicine and a medical oncologist at University Hospitals Case Medical center Seidman Cancer Center. e have developed a drug that acts like a vitamin for tissue stem cells,
and individuals having liver surgery. The goal for each is the same: to increase dramatically the chances of a more rapid and successful recovery.
as well as the Asa and Patricia Shiverick-Jane Shiverick (Tripp) Professor of Hematological Oncology. Case Western Reserve research associate Amar Desai, Phd, worked between the Markowitz
in some cases today, physicians are unable to perform surgery because the amount of the liver to be removed would be so great as to pose severe risk to the patient.
But having a drug to accelerate the liver regrowth could make surgery a viable option.
Yang and Bae, now at Inje University in Korea, worked in the Markowitz laboratory on studies of colitis (Yang) and on liver regrowth after surgery (Bae.
according to Restorative Neurology and Neuroscience reporthuman stem cells can be differentiated to produce other cell types, such as organ cells, skin cells, or brain cells.
In a new study published in Restorative Neurology and Neuroscience, researchers report successfully growing multiple brain structures
Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field,
ranging from fundamental science to medicine. In astronomy, it will boost the performance of adaptive optics, a technology at the heart of the European Extremely Large telescope (E-ELT.
more effective Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible
while keeping crucial brain tissue intact and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient brain showing
which areas are and are not cancer. A summary of the research appears June 17 in Science Translational Medicine. s a neurosurgeon,
I in agony when I taking out a tumor. If I take out too little the cancer could come back;
says Alfredo Quinones-Hinojosa, M d.,a professor of neurosurgery, neuroscience and oncology at the Johns hopkins university School of medicine and the clinical leader of the research team. e think optical coherence tomography has strong potential for helping surgeons know exactly where to cut.
First developed in the early 1990s for imaging the retina, optical coherence tomography (OCT) operates on the same echolocation principle used by bats and ultrasound scanners,
thought OCT might provide a solution to the problem of separating brain cancers from other tissue during surgery.
and the surgeon could look at a screen to get a continuously updated picture of where the cancer is
the team has tested the system on fresh human brain tissue removed during surgeries and in surgeries to remove brain tumors from mice.
The researchers hope to begin clinical trials in patients this summer. If those trials are successful
it will be a big step up from imaging technologies now available during surgeries, says Quinones-Hinojosa. ltrasound has a much lower resolution than OCT,
She is working on combining OCT with a different imaging technique that would detect blood vessels to help surgeons avoid cutting them s
Dr Perriman from Bristol School of Cellular and Molecular Medicine said: rom our preliminary experiments, we found that we could produce these artificial membrane binding proteins
#New tool on horizon for surgeons treating cancer patients Surgeons could know while their patients are still on the operating table
and proteins would harness the diagnostic value of validated immunohistochemistry approaches for surgical decision-making, Kertesz said.
rapidity and specificity of our method, there is great potential for our technology to assist surgeons in the detection of cancer from tissue biopsy samples,
and co-first author Crystal S. Conn, Phd, a postdoctoral fellow in the UCSF Department of Urology,
said principal investigator Arturo Alvarez-Buylla, UCSF professor of neurological surgery, Heather and Melanie Muss Endowed Chair and a principal investigator in the UCSF Brain tumor Research center and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. t may be unwelcome
news for those who thought of adult neural stem cells as having a wide potential for neural repair.
A joint effort between diabetes doctors and biomedical engineers could revolutionize how people with diabetes keep their blood sugar levels in checkpainful insulin injections could become a thing of the past for the millions of Americans who suffer from diabetes, thanks to a new invention
More preclinical tests and subsequent clinical trials in humans will be required before the patch can be administered to patients,
which could have broad medical applications, Borgens said. he technology is in the early stages of testing,
But bacteriophages can also cause potentially harmful side effects, according to James Collins, the Termeer Professor of Medical Engineering and Science in MIT Department of Biological engineering and Institute of Medical Engineering and Science,
and the new findings suggest that parasite calcineurin should be a focus for the development of new antimalarial drugs. ur study has great biological and medical significance, particularly in light of the huge disease burden of malaria,
says Ian Macdonald, a professor of ophthalmology with the Faculty of medicine & Dentistry at the University of Alberta,
a surgeon detaches the area to be injected in the patient retina, then injects the viral vector through a narrow needle into the back of the eye.
I got the call that I qualified for the surgery. he viral vector, known as AAV2-REP1, was provided by Nightstarx Ltd.,
Oxford research is ongoing under the direction of ophthalmologist Robert Maclaren. Funds, support and equipment for the Canadian trial have been provided by various governmental and private agencies,
and reattach the retina within hours of surgery. he human body is doing its work. Wee just helping it. ource:
current director of pipeline research of Emergent biosolutions. here are multiple filoviruses that threaten our communities, front line medical workers and defense personnel,
and on the results of using the material in preclinical models of wound healing. e are interested very in engineering strong,
and can be activated using light. ydrogels jellylike materials that can mimic the properties of human tissue are used widely in biomedicine,
Further investigation in preclinical models will be needed to test the material properties and safety before approval for use in humans e
which opens up new perspectives for the treatment and prevention of neurodegenerative diseases. The article describing their discovery is published in AAASFIRST open access online-only journal Science Advances. n higher organisms DNA is bound with proteins in complexes called the nucleosome.
and to the development of various diseases, including neurodegenerative, e g. Alzheimer disease. A group of researchers, lead by Vasily M. Studitsky, studied the mechanism of detection of single stranded-dna DNA breaks at
and a professor of radiology and of medicine at Weill Cornell Medical College. f physicians can accurately predict who is at risk,
Min said. t embodies the goal of precision medicine, namely, to precisely identify and exclude the patients who have
he continued. e have medicine that saves lives; we just need to identify earlier the right patients
but inside the clear chip lies the potential to improve how medicine and medical research is done. f you can integrate
and automate an analysis technique into a chip, it opens doors to great applications, said Janssen, a postdoctoral researcher in the Sumita Pennathur Lab at UC Santa barbara. With only a minimal amount of human plasma,
particularly in remote areas where people don have access to a full medical lab, as well as data gathering for clinical trials or epidemiological studies.
For the impact his project will have in the field of translational medicine, the postdoctoral scholar has been awarded the 2015 Lindros Award from the UCSB Translational Medical Research Laboratory (TMRL).
t very awesome, Janssen, a recent transplant from The netherlands, said of the award. It feels like a recognition of his effort,
and methodologies in all of medicine, said Dr. Scott Hammond, executive director of TMRL. orking with the Pennathur Lab, Kjeld Janssen research is intended to bring real-time detection to the world of medicine.
This technology, said Hammond, allows for the identification of specific DNA markers in an advanced microfluidic device. urther,
or medicine necessary to monitor or treat patients. Efforts to study and combat highly infectious diseases,
said UCSB mechanical engineering professor Sumita Pennathur. t a big step forward in terms of bringing out nanofluidic technology to real biomedical applications of disease diagnosis
#Gene therapy restores hearing in deaf mice Proof-of-principle study takes a step toward precision medicine for genetic hearing loss.
Their work, published online July 8 by the journal Science Translational Medicine, could pave the way for gene therapy in people with hearing loss caused by genetic mutations. ur gene therapy protocol is not yet ready for clinical trialse need to tweak it a bit moreut in the not-too-distant
precision medicine treatment injected into their ears to restore hearing, Holt says. Holt team showed in 2013 that TMC1
said Dr. Wen H. Shen, the study lead investigator and an assistant professor of cell biology in radiation oncology at Weill Cornell. ased on our research,
HMS professor of medicine and director of the Center for Virology and Vaccine Research at Beth Israel Deaconess. e are encouraged very by the results of this latest preclinical HIV-1 vaccine study
Based on these preclinical data, the HIV-1 version of this vaccine regimen is now being evaluated in an ongoing international clinical study sponsored by Crucell Holland BV
remote medicine and a wide variety of other business, civil and military uses. 3d Tau SSE technology is designed to be embedded directly into a new generation of screens for televisions, movie theaters, computer displays, game
a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco. his technology could help us quickly screen for drugs likely to generate cardiac birth defects,
it requires medical personnel with technical skills and brings the risk of needle-related diseases and injuries.
It is also easy to use without the need for trained medical personnel, making it ideal for use in developing countries,
Its development was funded partially by the National institutes of health. t unplugs a world of possibilities for scientists to learn how brain circuits work in a more natural setting. said Michael R. Bruchas, Ph d.,associate professor of anesthesiology and neurobiology at Washington University School of medicine and a senior author
Both options require surgery that can damage parts of the brain and introduce experimental conditions that hinder animalsnatural movements.
University of Illinois at Urbana-Champaign and a senior author. ltra-miniaturized devices like this have tremendous potential for science and medicine. ith a thickness of 80 micrometers and a width of 500 micrometers,
Since 2012 the oncological guidelines prescribe that doctors have to choose an individualized approach, where the risk of recurrence of the disease in a specific patient has to determine the follow-up course of action.
According to Joost Klaase, surgeon at the Medical Spectrum Twente (MST) and involved with the research, the medical world has need a for the system. he nomogram for risk of breast cancer recurrence gives us a tool to create a tailor-made follow-up for breast cancer patients:
Alden Chadwick via flickr. com, CC BY 2. 0. In order to help medical professionals combat this deadly affliction,
a researcher involved in the study. his type of sensing platform offers a large variety for medical diagnostics,
researchers are already hailing it as an important innovation in medical diagnoses. The sensor has shown yet its value in detecting cholera without error,
a Professor in the Faculty of medicine Department of Laboratory Medicine and Pathobiology. ee now discovered the DNA mbulanceand the road it takes. ekhail discovered this DNA ambulance,
#New technology helps personalized medicine by enabling epigenomic analysis with a mere 100 cells A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as
This epigenomic characterization potentially allows medical doctors to create personalized treatment of diseases by understanding the state of a patient,
The innovative approach may lead to more effective therapies with fewer side effects, particularly for diseases such as cancer, heart disease and neurodegenerative disorders.
which is a medical emergency potentially requiring surgical intervention, says Koch Institute research affiliate Giovanni Traverso,
a professor of medical science and engineering at Brown University who was not involved with this study. his is a very smart approach.
are an obvious candidate for medical applications of the technology, as these cells not only stand at the center of many disease processes,
and medicine. t been great to be part of this exciting collaboration, and I look forward to seeing the insights from this work used to help patients in the future,
It is believed to be the first time voluntary leg movements have ever been relearned in completely paralyzed patients without surgery.
neurobiology and neurosurgery. Edgerton said although it likely will be years before the new approaches are widely available,
The research was funded by the National institutes of health National Institute of Biomedical Imaging and Bioengineering (grants U01eb15521 and R01eb007615), the Christopher and Dana Reeve Foundation,
director of the National Institute of Biomedical Imaging and Bioengineering. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
It a wonderful example of the power that comes from combining advances in basic biological research with technological innovation. dgerton estimates that cost to patients of the new approach could be one-tenth the cost of treatment using the surgical epidural stimulator
because no surgery is required, it would likely be more easily available to more patients. The study co-authors were conceived Gerasimenko,
as well as Daniel Lu, associate professor of neurosurgery, researchers Morteza Modaber, Roland Roy and Dimitry Sayenko, research technician Sharon Zdunowski, research scientist Parag Gad, laboratory
and Adam Ferguson, assistant professor of neurological surgery at UC San francisco. Edgerton and his research team also plan to study people who have severe,
The cells thus behaved in a similar manner than in the patient, offering attractive possibilities for translational medicine.
director of the National Institute of Biomedical Imaging and Bioengineering at NIH. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
believing it could greatly expand the number of paralyzed individuals who could potentially benefit from spinal stimulation. here are a lot of individuals with spinal cord injury that have gone already through many surgeries
whether undergoing surgery to implant a stimulator is warranted. Alternatively, Edgerton speculates it may be possible early after an injury for noninvasive stimulation to help patients achieve a certain level of motor control that then allows them to continue to improve with physical rehabilitation
and avoid surgery altogether. ll patients are going to need something slightly different, and maybe noninvasive stimulation is going to be best in some cases and epidural stimulation in others,
Further down the road, the concept could lead to a better way to deliver therapeutic stimulation to address neurodegenerative diseases,
The results could have implications for medical research, said Babu. For example, n the human population you have many individuals that carry single nucleotide polymorphisms
Instead, the team suggests in a study published today (June 25) in the neurology journal Brain,
and director of Northwestern Cognitive Neurology and Alzheimer Disease Center, said in a statement. Neuroscientist Carl Wernicke discovered in 1874 that some stroke victims with damage to the left sides of their brains suffered language impairment,
and the other on a neurodegenerative disease that attacks mostly brain cells in cortex rather than the region as a whole, Mesulam said in the press release.
who developed the technique working with the company Cinogy and the Department of Dermatology, Venereology and Allergology at the University Medical centre Göttingen.
such as in medical diagnostics for example. Their results are published in Nature Communications. Three-dimensional structures in materials and biological samples can be investigated using X-ray tomography,
space exploration and medical applications abound for low-density, nontoxic structural shielding materials Lightweight composite metal foams can absorb energy from impacts
The discovery means the materials could be useful in spacecraft, the nuclear industry and in medicine.
#Tiny'wrist'to assist needle surgery A tiny flexible wrist component for needle-sized surgical equipment could enable surgeons to perform operations in tiny spaces
which would involve incisions so small that they could be sealed just with surgical tape, rather than sutures.
which would form part of the suite of equipment for a type of minimally invasive technique known as needlescopic surgery,
Needlescopic surgery, also known as mico-laproscopy, uses instruments about the size of a sewing needle inserted through incisions that are typically 5-10mm long.
is developing a surgical robot for needlescopic surgery, which a surgeon would operate remotely, like the Da vinci robot which is used now mainly for abdominal operations such as prostate surgery. he Da vinci uses a wire
-and-pulley system that is extremely difficult to miniaturise any further, so it won work in smaller spaces like the head and neck, said Webster.
Instead of Da vinci rigid rods tipped with pulley-operated instruments Webster team is working on a robot
the surgeon can move the tip of the needle to the site of surgery with great accuracy.
when the surgeon gets the needle tip where it needs to go. Without a riston the end of the needle, it hard for the the surgeon to cut
or remove tissue, or repair damage. Most microlaproscopy uses sharp-edged rings or heated wires on the end of the needle to scrape
Combined with a pincer on the end of the wrist, this could allow surgeons to make precise cuts
a professor urology surgery at Vanderbilt who is consulting on the project. here are a myriad of potential applications in some really exciting areas such as endoscopic neurosurgery,
This would allow us to do surgeries that at present require much larger incisions and may even enable us to perform operations that are not feasible at present. he team is now working on the user interface and control software for the device,
and hopes to test it first in transnasal surgery, which aims to remove tumours at the base of the skull by inserting instruments through the nose. t should be useful for a number of other operations as well,
said Webster. e think once we give this tool to surgeons they will find all kinds of applications we haven thought of.
#White house unveils $215 million plan to develop patient-specific medical treatments The White house unveiled a"Precision Medicine Initiative"today a $215 million investment that will go toward building a database containing genetic information
"Most medical treatments have been designed for the verage patient, according to A white house statement. As a result, treatments can be very successful for some patients,
"The Precision Medicine Initiative will leverage advances in genomics, emerging methods for managing and analyzing large data sets while protecting privacy,
and health information technology to accelerate biomedical discoveries.""The White house investment is split in four parts.
If that's the case, then precision medicine"will be useless, "as basic medicine is where all the ideas for how to use that information is produced.
Eisen also told The Verge that the money will be flushed down the toilet "if the databases developed through this initiate are constructed poorly."
"The potential for precision medicine to improve care and speed the development of new treatments has begun only just to be tapped,"according to the White house statement.
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