Korean Scientists at the Center for Nanoparticle Research, Institute for Basic Science (IBS) in Seoul,
and Bioengineering have designed a nanoparticle transport system for gene delivery that destroys deadly brain gliomas in a rat model,
The nanoparticles are filled with genes for an enzyme that converts a prodrug called ganciclovir into a potent destroyer of the glioma cells.
"The ability to successfully deliver genes using these biodegradable nanoparticles, rather than potentially harmful viruses, is a significant step that reinvigorates the potential for gene therapy to treat deadly gliomas as well as other cancers."
Biodegradable nanoparticles have shown recently promise as a method to deliver genes into cells. Their use for delivery avoids many of the problems associated with viral gene delivery.
the first goal of the group was to develop a nanoparticle that could efficiently carry DNA encoding a gene known as HSVTK into cells.
the HSVTK-encoding nanoparticles were 100%effective in killing both of the glioma cell lines grown in the laboratory.
Because it is important that the nanoparticles spread throughout the entire tumor, they were infused into the rat gliomas using convection-enhanced delivery (CED).
which efficiently disperses the nanoparticles throughout the tumors. To test the tumor-killing ability of the system,
then CED was used to infuse the HSVTK-encoding nanoparticles into the rat gliomas, and systemic ganciclovir treatment continued for eight more days.
"Next steps will include enhancing the efficiency of this nanoparticle delivery system and evaluating the technology in additional brain cancer animal models."
and whether the nanoparticles could be administered successfully systemically --which could broaden the use of the therapy for a wide range of solid tumors and systemic cancers s
#Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions Scientists have designed nanoparticles that release drugs in the presence of a class of proteins that enable cancers to metastasize.
In mice treated with the nanoparticles coated with peptides that are impervious to MMPS or given saline,
#Nanoparticles used to prevent inflammatory acne through slow-released nitric oxide GW researcher and dermatologist, Adam Friedman, M d,
This research, published in the Journal of Investigative Dermatology, identified that the nanoparticles were effective at killing Proprionobacterium acnes,
which the nanoparticles could be a new way to tackle Acne, one of the most common dermatologic diseases affecting between 40-50 million people each year.
"Given the advent of computing resources like Aurora and the wide gamut of the available two-dimensional materials and nanoparticle types,
And Yellow fever Researchers in the US have developed a silver nanoparticle-based paper test to simultaneously detect dengue, yellow fever and Ebola.
The test is made from strips of paper containing antibodies attached to triangular silver nanoparticles of varying size according to the disease they recognize
Silver nanoparticles appear as different colours according to their size, so when a patient serum sample migrates through the device,
#Engineering Phase changes in Nanoparticle Arrays Scientists at the U s. Department of energy Brookhaven National Laboratory have taken just a big step toward the goal of engineering dynamic nanomaterials
In a paper appearing innature Materials, they describe a way to selectively rearrange the nanoparticles in three-dimensional arrays to produce different configurations,
Introducing eprogrammingdna strands into an already assembled nanoparticle array triggers a transition from a other phase,
Such phase-changes could potentially be used to switch a material properties on demand. ne of the goals in nanoparticle self-assembly has been to create structures by design,
DNA-directed rearrangementthis latest advance in nanoscale engineering builds on the team previous work developing ways to get nanoparticles to self-assemble into complex composite arrays,
they started with an assembly of nanoparticles already linked in a regular array by the complementary binding of the A t, G,
or a combination of these forces between particles. e know that properties of materials built from nanoparticles are strongly dependent on their arrangements,
the reprogramming DNA strands adhere to open binding sites on the already assembled nanoparticles. These strands exert additional forces on the linked-up nanoparticles. y introducing different types of reprogramming DNA strands,
we modify the DNA shells surrounding the nanoparticles, explained CFN postdoctoral fellow Yugang Zhang, the lead author on the paper. ltering these shells can selectively shift the particle-particle interactions,
either by increasing both attraction and repulsion, or by separately increasing only attraction or only repulsion.
the team demonstrated that they could switch their original nanoparticle array, the otherphase, into multiple different daughter phases with precision control.
and accompanying theoretical analysis confirm that reprogramming DNA-mediated interactions among nanoparticles is a viable way to achieve this goal. ource:
The solvent system could improve the combined use of metallic nanoparticles and DNA based materials. In the typical aqueous solvents where DNA NANOTECHNOLOGY is performed,
nanoparticles are prone to aggregation. The solvent low volatility could also allow storage of assembled DNA structures without the concern that a water-based medium would dry out.
These images show differential conductance through the quantum dot as a function of the gate voltage that controls the number of electrons in the dot (x-axis) and the applied magnetic field (y-axis).
It is made from gelatin-based biomaterials reinforced with nanoparticles and seeded with cells, and it mimics the anatomical microenvironment of lymphoid tissue.
The engineers reinforced the material with silicate nanoparticles to keep the structure from melting at the physiologically relevant temperature of 98.6 degrees.
A protein nanoparticle called OD-GT8 60mer which already proved to help immunity of mouse models to cope with HIV,
During it scientists tested a protein nanoparticle designed to bind and activate B cells needed to fight HIV.
#New way to produce carbon nanoparticles found only honey and microwave needed Researchers at University of Illinois have created a new inexpensive and simple way to produce carbon nanoparticles.
They are small enough to evade the body immune system, reflect light in the near-infrared range for easy detection,
However, when usual methods to produce carbon nanoparticles are rather complex and can take days,
and time that these carbon nanoparticles can virtually be made at home. Dipanjan Pan bioengineering professor one of authors of the study, said that you just have to mix honey
but that is nanoparticles with high luminescence This method is extremely simple and highly scalable for eventual clinical use.
These carbon nanoparticles produced in such a simple and inexpensive way have several attractive properties.
Finally, carbon nanoparticles are rather small, less than eight nanometres in diameter (in comparison, a human hair is 80,000 to 100,000 nanometres thick).
The team of researchers tested the therapeutic potential of these carbon nanoparticles by loading them with an anti-melanoma drug
so they used vibrational spectroscopic techniques to identify the molecular structure of the nanoparticles and their cargo.
The experiment showed that the carbon nanoparticles did not release the drug payload at room temperature
Study showed that cancer cells were affected positively by drugs delivered by these carbon nanoparticles. These carbon nanoparticles,
despite being made from honey in the microwave, are very useful indeed. They can be used to carry a variety of different drugs into a human body.
having in mind that currently production of carbon nanoparticles requires expensive equipment and purification processes that can take days.
Once the researchers designed these ntelligent insulin nanoparticles, they had to figure out a way to administer them to patients with diabetes.
Gu created these icroneedlesusing the same hyaluronic acid that was a chief ingredient of the nanoparticles,
The bright dot on the end of the nanowire is used the gold nanoparticle to seed the nanowire growth.
The researchers found that it was possible to combine the gel with silica nanoparticles microscopic particles previously found to stop bleeding to develop an even more powerful barrier to promote wound healing. his could allow us to immediately stop bleeding with one treatment
Taking advantage of cotton irregular topography, Hinestroza and his students added conformal coatings of gold nanoparticles,
Synthesizing nanoparticles and attaching them to cotton not only creates color on fiber surfaces without the use of dyes,
similar to the working principle of a quantum dot gated by an external electrode. In our case, the charged atoms nearby provide the electrostatic gate potential that regulates the electron flow
his intriguing behavior goes beyond the established picture of charge transport through a gated quantum dot.
#Environmentally Friendly Lignin Nanoparticle reenssilver Nanobullet to Battle Bacteria North carolina State university researchers have developed an effective
NC State engineer Orlin Velev and colleagues show that silver-ion infused lignin nanoparticles, which are coated with a charged polymer layer that helps them adhere to the target microbes,
As the nanoparticles wipe out the targeted bacteria, they become depleted of silver. The remaining particles degrade easily after disposal because of their biocompatible lignin core,
limiting the risk to the environment. eople have been interested in using silver nanoparticles for antimicrobial purposes, but there are lingering concerns about their environmental impact due to the long-term effects of the used metal nanoparticles released in the environment,
said Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the paper corresponding author. e show here an inexpensive and environmentally responsible method to make effective antimicrobials with biomaterial cores. he researchers used the nanoparticles
to attack E coli, a bacterium that causes food poisoning; Pseudomonas aeruginosa, a common disease-causing bacterium; Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species;
The nanoparticles were effective against all the bacteria. The method allows researchers the flexibility to change the nanoparticle recipe in order to target specific microbes.
Alexander Richter, the paper first author and an NC State Ph d. candidate says that the particles could be the basis for reduced risk pesticide products with reduced cost
Electron microscope images showing the formation of a nickel silicide nanoparticle (colored yellow) in a silicon nanowire.
as well as development of the devices that deliver the stream of nanocrystals. The work is based on a team effort of ASU faculty Wei Liu
is pushing pretty hard for. he group is now working to use the plasmonic structure to create a single photon source necessity for extremely secure quantum communicationsy sandwiching a single quantum dot in the gap between the silver nanocube and gold foil.
During testing, the coral-like plates removed 2. 5 times as much mercury from water than traditional aluminium oxide nanoparticles.
who worked with Petta in his lab. Prof Petta added that a double quantum dot was capable of only transferring one electron at a time.
The paper, Semiconductor double quantum dot micromaser, was published in the Science journal yesterday d
#Graphene sheaths could boost processor signal speeds by 30 per cent Scientists at Stanford have found a new use for graphene that will significantly increase the speed of standard computer processors.
Quantum dots are nanocrystals, which are made of semiconductor materials that are small enough to exhibit quantum mechanical properties.
and researching the role of nanoparticles in blood in diseases detection. Clinical trials have revealed that the spoon reduces shaking by about 76 percent.
< Back - Next >
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011