The company provides a layer of so-called biometric security that lets banks tell who you are just from the way you type,
Prakash, an assistant professor of bioengineering at Stanford, is the proprietor of"frugal science, "a term he coined to explain the movement toward building cheap versions of high tech tools.
which is an online biohacking store, has simplified the process of hacking the body by selling kits packed with the necessary supplies
and biohacking is one way to accomplish this, he said. To date, Dangerous Things has sold several thousand implants
biohacking in general, because people look at the body and because we know so much more about it now,
whether the safety of concrete could be improved using a biological solution. This manufacturing query turned out to be the right question asked at the right time.
a microbiologist, the cracks that form in concrete are not just unpleasant to look at, they can eventually lead to structural failures. he problem with cracks in concrete is said leakage
Jonkers said he hopes his concrete could be the start of a new age of biological buildings.
#Biomimicry Wave Energy Device Ready To Leave The Nest A new bio-inspired method of harvesting energy from the ocean has completed its shakedown on land,
However, kelp is pretty much on the money in terms of biomimicry. The Biowave wave energy device was inspired by the way that kelp sways and pivots with the movement of ocean swell waves.
led by Nenad Bursac, Duke university associate professor of biomedical engineering, and postdoctoral researcher Lauran Madden.""The beauty of this work is that it can serve as a test bed for clinical trials in a dish,
and is made from biocompatible materials, IFLSCIENCE reports. The patch tiny, painless needles are packed with insulin
Cosmetics firm has teamed with bioengineering experts to develop tissue By Sarah Griffiths for Mailonline Published:
13:07 GMT, 20 may 2015 Cosmetics giant Lreal is joining forces with a bioengineering firm to print human skin.
for use in medical research. he technology will leverage Organovo proprietary Novogen Bioprinting Platform and Lreal expertise in skin engineering to develop 3d printed skin tissue for product evaluation and other areas of advanced research,
Elsewhere the lens is made of'inert biocompatible polymeric materials that do not cause biophysical changes within the eye.
Minority report-style tech can be used up to 40ft away Biometric technologies are on the rise.
We have researched this area by presenting people with potential future scenarios that involved biometrics. We found that,
when their biometrics are being read.''I feel negatively about a remote iris scan because
For example, implementing biometric identification in smart phones and other everyday objects such as computers or cars could make people see the technology as useful and easy to operate.
and governmental usage of biometric identification than the average citizen might be comfortable with. As one participant put it:'
'The implementation of biometric systems is not just dependent on user acceptance or resistance. Before iris-scanning technology could be introduced in the EU,
Biometric data, such as iris scans, are treated often as special due to the sensitivity of the information they can contain.
Dr Ivan Poon, a molecular biologist at La Trobe University who led the work, said they may have uncovered a key part of the immune systems defence mechanism.
Professor Banfield and her colleagues sequenced the genomes of organisms found in ground water at a site beside the Colorado river in Rifle Colorado.
They then assembled the millions of DNA pieces into eight complete bacterial genomes from four new and one previously studied phyla.
They also produced draft genomes more than 90 per cent complete for a further 789 other bacteria.
the protein-based machinery that translate genetic information into proteins. They have placed them into an entirely new branch of the tree of life they have called the'candidate phyla radiation'due to their similarities to each other.
Christopher Brown, a microbiologist who was part of the team who took part in the study at the University of California Berkeley,
They have extremely small genomes and appear to be stripped down'forms of life with just enough genes needed to survive.
The team has named now 20 the new phyla they identified after award-winning microbiologists and one was called Berkelbacteria-after University of California Berkeley.
'There is a lot of biology that we haven't been able to understand from our current methods.'
Can we take some inspiration from biology and create a skin-like display?''The team is able to change the colour on an ultrathin nanostructured surface by applying voltage.
Alicia Jackson, the deputy director of Darpa Biological Technologies Office In virginia, made comments alluding to the technology at a biotech conference on Monday. or the first time
On earth, most synthetic biology projects use just two at the moment-e coli and yeast. want to use any organism that has properties
dubbed the oogle Maps of genomes, will help scientists correlate information on organisms. And the ultimate goal is to choose organisms with specific genes to create something with certain characteristics.
But understanding the genetics means it is now possible to engineer a microbe like yeast to do the job.
reported in the journal Science on Thursday, provides the missing piece in the biosynthesis puzzle.
'said Matias Ison, Lecturer in Bioengineering, University of Leicester.''But the astonishing fact was that these changes were dramatic,
Gene therapy that restores hearing in mice could be used on humans in just five years By Ellie Zolfagharifard For Dailymail. com and Reuters Published:
01:22 GMT, 9 july 2015 Gene therapy to treat hereditary human deafness could be available within five years.
Separately, a similar Novartis gene therapy trial is under way to help restore hearing in people who have become deaf through damage or disease.
when safety scares set back research, gene therapy is enjoying a renaissance. The technique has had positive clinical results recently in conditions ranging from blood diseases to blindness.'
'It's an exciting time for gene therapy in hearing.''A key element in current optimism is the development of better and safer viral delivery systems for getting corrective genes into the body.
Within a month, around half the mice with the mutation showed brainwave activity consistent with hearing
'said Kevin Healy, a UC Berkeley professor of bioengineering, who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco.'
'This technology could help us quickly screen for drugs likely to generate cardiac birth defects, and guide decisions about
'Published in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate
'This spatial differentiation happens in biology naturally, but we demonstrated this process in vitro, 'said study lead author Zhen Ma, a UC Berkeley postdoctoral researcher in bioengineering.'
'The confined geometric pattern provided biochemical and biophysical cues that directed cardiac differentiation and the formation of a beating microchamber.'
'Modeling early heart development is difficult to achieve in a petri dish and tissue culture plates,
Pictured, the side panels light up The model uses biometric technology to visualise the physical and emotional connection shared by man and machine when at the wheel.
The model uses biometric technology to visualise the physical and emotional connection shared by man and machine when at the wheel.
which is used for biometrics, access to devices and social media tagging, for example. At the moment, facial recognition systems tend to rely on matching clear and well-lit photos
#Harvard Yale scientists develop technique to make GMOS safer A new milestone has been reached by scientists at Ivy League universities Yale and Harvard;
they have discovered a method to prevent genetically modified organisms (GMOS) from escaping into the wild. This technique is a powerful breath through in the mission to build stable, synthetic life forms.
The cells that carry an alternative genetic code will make them dependent on an artificial nutrient not available in nature.
George Church, a genetics professor at Harvard Medical school oversaw one of the studies that was published Wednesday in the journal Nature,
and compered the study to putting GMOS n a leash. The ability to alter an organisms genetic composition has been entertained one long by scientists and the plot of dozens of sci-fi movies and novels.
#Pop-up silicon 3d structures mimic biological structures A way to make pop-up silicon structures which can mimic the shape of biological structures like the veins
and brain cells has been found by researchers at Northwestern University, Illinois and the University of Illinois at Urbana-Champaign.
Complex three-dimensional (3d) structures in biology (e g.,, cytoskeletal webs, neural circuits, and vasculature networks) form naturally to provide essential functions in even the most basic forms of life.
L'oréal USA, the largest arm of The french cosmetics company, recently announced that it is teaming up with a San diego-based bioprinting startup called Organovo Holdings to print actual skin tissue.
though never via 3-D bioprinters before. Now, it looking to Organovo --which has worked with Merck to successfully 3-D print multicellular human liver
The 3-D printed skin tissue will be produced using Organovo Novogen Bioprinting Platform. Using microscopic building blocks from human skin cells,
Aside from using bioprinted skin to improve product assessments, 3-D printed skin tissue is already being tested in clinical trials as a treatment for burns
spent two years using a PCC store as a iving laboratory to understand how food waste is created in a retail grocery environment. n 2010 the WISERG teamith the help of biologists, computer programmers and engineerseveloped a solution:
despite a vast number of examples in the biological world. The potential of evaporation to power engineered systems is neglected largely.
since DNA cages and bunny rabbits don have to act as genetic material for a cell, they have a much narrower list of chemical requirements than natural DNA.
incubated from an idea that struck Manu Prakash, an assistant professor of bioengineering at Stanford university, when he was a graduate student.
on-GMO ot treated with growth hormone o added preservatives Our 35%obesity rate in the US,
which approved the first GMO in 1980. Unhealthy, or even unsafe, became collateral damage in the ar on Poverty Ironically,
As per BBC News, authors of a study distributed in the Nature journal sequenced the genomes of 120 different birds of 17 species. Darwin backed his Theory of Natural selection with the finches,
as their beaks developed to better devour the food around them. his is an exciting case where mild mutations in a gene that is vital for typical development prompts phenotypic observable advancement,
lead analyst Leif Andersson, a professor of functional genomics at Uppsala University, the Swedish University of Agricultural sciences, said in a press release.
the research is a major step forward in pharmacology and builds on earlier work in optogenetics, a technology that makes individual brain cells sensitive to light
and demonstrated an implantable, cellular-scale microfluidic and micro-optical interface to biology, with application opportunities not only in the brain but in other parts of the nervous system and other organs as well, says the study other co-principal investigator, John A. Rogers, professor of materials science and engineering at the University of Illinois. For now,
and observe and study the biological and medical significance of RNA misregulation. Previous technologies made it possible to attain static snapshots of RNA location
Mirkin is professor of chemistry in the Weinberg College of Arts and Sciences and professor of medicine, chemical and biological engineering, biomedical engineering and materials science and engineering.
Nanoflares have been very useful for researchers that operate in the arena of quantifying gene expression. Aurasense, Inc.,a biotechnology company that licensed the Nanoflare technology from the university,
and EMD-Millipore, another biotech company, have commercialized Nanoflares. There are now more than 1, 700 commercial forms of Nanoflares sold under the Smartflare name in more than 230 countries.
The Sticky-flare is designed to address limitations of Smartflares most notably their inability to track RNA location and enter the nucleus. The research team believes Sticky-flares are poised to become a valuable tool for researchers who want to understand the function of RNA in live cells.
professor of stem cell biology. linical trials are still in the very early stages. However with this kind of product,
says lead author Satya Dandekar, who chairs the department of medical microbiology and immunology at University of California,
That finding dispels concerns that the genetic material will quickly degrade in rain and sunlight. In the proof-of-principle study researchers wanted to answer
Geneticists have used the technique to silence specific genes examine what functions are lost and hence learn that gene purpose.
Ronald laboratory has been studying rice genetics and disease resistance for more than two decades and in 1995 announced that a gene called Xa21 confers resistance to the bacterial blight pathogen.
associate professor of cell biology and physiology at Washington University School of medicine in St louis. y finding the mutation,
They looked for mutations in the FMR1 gene that might impair the protein but not eliminate it entirely.
To see what effect this mutation might have, geneticist Stephen T. Warren and colleagues at Emory University replicated it in mouse brain cells
and tested it for the widely known functions of FMRP. To their surprise, this mutated FMRP appeared to work normally.
who is also an associate professor of biomedical engineering. his patient presents a case of partial fragile X syndrome associated with mutated, rather than absent, FMRP.
What does this mutation impair to cause only two symptoms of fragile X? To find out, Warren replicated the mutation in fruit flies.
Surprisingly, the fruit fly studies indicated that this single mutation increased the number of transmitters in brain cells, implicating a fundamental problem in
which the brain cells send out too many signals. To verify the mechanism in mammals, they turned to Klyachko lab,
researchers were able to verify the same effect from just the mutation and link it to human disease.
This single mutation in FMRP has the same overactivating effect on transmissions as the total loss of the protein.
The scientists say they can rule out the possibility that additional problems also are caused by this mutation
which can make the implants more biocompatible. Researchers had discovered already that cells interact better with rough
In many cases, genetic mutations that cause cancer involve chemical changes to individual building blocks of DNAREATING DNA ADDUCTS."
And it impossible to determine the exact location where a building block in the genetic code has been altered into an adduct.
The technology, called the Missouri Osteochondral Allograft Preservation System (MOPS), more than doubles the storage life of bone
says medical entomologist Gregory Lanzaro, professor in the pathology, microbiology and immunology department at University of California,
biological agentsncluding mosquito-killing bacteria and fungind genetic manipulation of mosquitoes aimed at either killing them
and director of the campus Center for Bioengineering. Whether inflammation is a byproduct of the disease
The Shire-NPS deal comes less than two weeks before NPS faces a key decision from the FDAHETHER to approve its biologics license application (BLA) for Natpara
"The acquisition of NPS Pharma is a significant step in advancing Shire's strategy to become a leading biotechnology company, Shire CEO Flemming Ornskov, M d,
Amgen markets cinacalcet HCL as Sensipar in the U s. and as Mimpara in the EU;
cellular, and developmental biology at CU-Boulder. Apoptosis is a natural process that kills billions of cells in a typical human body each day.
well-known genome and short life span of just a few days.""This makes drug screening much easier,
Jerry W. Shay, Ph d.,professor and vice chairman of cell biology at UT Southwestern, and colleague, Woodring E. Wright, M d.,Ph d.,professor of cell biology and internal medicine, found that 6-thio-2'-deoxyguanosine could stop the growth of cancer cells in culture and decrease the growth of tumors in mice.
Drs. Shay and Wright are co-senior authors of the study nduction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2deoxyguanosineappearing in Cancer Discovery. reatment with 6-thio
wrote the investigators. n A549 lung cancer cellased mouse xenograft studies, 6-thio-dg caused a decrease in the tumor growth rate superior to that observed with 6-thioguanine treatment.
because cells in any one tumor have chromosomes with different telomere lengths and any one cell's telomeres must be shortened critically to induce death. 6-thiodg is used preferentially as a substrate by telomerase
#Ultra-Fast Software Developed to Scan the Human genome Researchers at Nationwide Children's Hospital say they have developed an analysis pipeline that cuts the time it takes to search a person's genome for disease-causing variations from weeks to hours.
an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetic variation in clinical and population-scale genomics appears in Genome Biology."
and $3 billion to sequence the first human genome,"notes Peter White, Ph d.,principal investigator and director of the biomedical genomics core at Nationwide Children's and the study's senior author."
After a genome is sequenced, scientists are left with billions of data points to analyze before any truly useful information can be gleaned for use in research and clinical settings."
Churchill allows efficient analysis of a whole genome sample in as little as 90 minutes, explains Dr. White."
Churchill allows computationally efficient analysis of a high-depth whole genome sample in less than two hours,
000 Genomes raw sequence dataset in a week using cloud resources
#Inflamed Brain Is depressed a Brain Researchers at the Centre for Addiction and Mental health (CAMH) in Toronto have found a possible link between inflammation in the brain and clinical depression.
Marc Lecuit, M d.,Ph d.,Head of the Biology of Infections Unit at the Pasteur institute and senior author on the study,
has revealed several genetic mutations that may trigger the development of testicular cancer, in addition to uncovering a gene that may aid tumors in promoting resistance to existing drug therapies.
They report previously unidentified chromosome duplications and confirmed data from earlier findings that associated these tumors with the KIT gene,
says Clare Turnbull, Ph d.,senior author and team leader in predisposition and translational genetics at ICR.
Their preliminary finding of a link between XRCC2 and platinum drug resistance was validated once they sequenced a sample from an additional platinum-resistant tumor. e have identified new potential driver mutations for this type of cancer
and provided new evidence of a link between mutations in the gene XRCC2 and platinum treatment-resistant tumours.
director of the center at Newcastle University. his novel approach would allow women who carry these mutations greater reproductive choice. e
and the Biotechnology industry Organization (BIO) ignaled support for sharing clinical trial data beyond recent industry norms,
a funder of bioethics research. ur recommendations attempt to balance the interests of different stakeholders with the public interest in having the best information possible regarding the effectiveness and safety of therapies.
"Dr. Toner and his colleagues anticipate that the Cluster-Chip will have an increasingly important role in stimulating new research on CTC cluster biology,
and to develop even better technologies to understand their biology in cancer metastasis. t
#Inexpensive Technique Developed to Manufacture Nanofibers Scientists at the University of Georgia say they have developed an inexpensive way to manufacture nanofibers,
or liquefied in a solution is mixed with biocompatible iron oxide or another magnetic material and placed inside a hypodermic needle.
published in Nature Genetics, could have implications for the development of new methods of pain relief.
Using detailed genome mapping two teams of researchers collaborated to analyze the genetic make-up of 11 families across Europe
Most often the majority of prostate cancer is thought of as an organ-confined disease with little genetic variation.
"The findings from this study were published recently in Nature Genetics through an article entitled patial genomic heterogeneity within localized, multifocal prostate cancer.
From this group, whole genome sequencing was performed on samples from five patients whose prostates were removed surgically.
"This discovery of a new prostate cancer-causing gene gives researchers a new avenue to explore the biology of the disease
"By showing that mutations in prostate cancer vary spatially in different regions of a tumor,
"Interestingly, the researchers determined that half of all prostate patients have either C-MYC or LMYC mutations,
Dr. Bristow thinks that this study takes an important step forward in identifying new biomarkers for prostate cancer and developing novel treatment options for patients."
the company immediately added Abbvie Viekira Pak to its National Preferred Formulary as the exclusive option for patients with genotype 1 hepatitis Cust three days after the FDA approved the drug.
Express Scriptsindependent Pharmacy & Therapeutics Committee concluded that Viekira Pak was at least clinically equivalent to two Gilead sciences drugs, Harvoni (ledipasvir and sofosbuvir) and Sovaldi (sofosbuvir.
and only covers Sovaldi for non-genotype 1 hepatitis C. ur clients will save more than $1 billion this year on hepatitis C medications,
Representatives of two other top-selling cancer drug developers, Celgene and Amgen, at deadline had responded not to GEN queries on indication pricing
If a mutation occurs in one of them, the person develops the disease. Scientists introduced a mutated human gene (TDP-43 or FUS) into C. elegans.
noted Veriepe. orms with an immune deficit resulting from the tir-1 gene's mutation were in better health
thus streamlining a challenging step in the biologics manufacturing process within a small operating footprint. The technology will complement Pall's STAXTM depth filtration products to enable continuous clarification of cell culture, enabling integration of the bioreactor with downstream processing
according to Michael Egholm, president of Pall Biopharmaceuticals. The AWS technology works by applying acoustic forces across a flow channel to generate a three-dimensional standing wave.
When a cell culture passes through the flow channel, the cells are trapped at the nodes of the acoustic waves
The company recently acquired the Biosmb multicolumn continuous chromatography platform from Tarpon Biosystems.""This approach helps to bridge the critical gap between bioreactor and the downstream processing train,"points out Egholm."
"The AWS products will eliminate the reliance on centrifugation for cell culture clarification, and will provide a continuous feed stream for direct integration with the Biosmb platform.
and GMP scale to match pilot and production bioreactor volumes, with predictable and reproducible performance over a wide range of cell densities. e
"15-PDGH is a key enzyme responsible for the biological inactivation of a group of signaling molecules, called eicosanoids,
"explained co-author Dr. Joseph Ready, Ph d.,professor of biochemistry and member of the Simmons Cancer Center at UT Southwestern Medical center.
#Novel Epigenetic Technique Opens Door to Combatting Virulent Strains of Bacteria Researchers from the Icahn School of medicine at Mount sinai say they have developed a novel method to more precisely analyze bacterial populations
and reveal epigenetic mechanisms that can drive virulence. The new technique holds the promise of a potent new tool to offset the growing challenge of antibiotic resistance by bacterial pathogens, according to the team.
The study (ingle molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes appears in Nature Communications,
Beyond their participation in host defense, increasing evidence suggests that these modifications also play important roles in the regulation of gene expression, virulence,
existing methods for studying bacterial methylomes rely on a population-level consensus that lack the single-cell resolution required to observe epigenetic heterogeneity. e created a technique for the detection
We found that a typical clonal bacterial population that would otherwise be considered homogeneous using conventional techniques has epigenetically distinct subpopulations with different gene expression patterns"said Gang Fang, Ph d,
. assistant professor of genetics and genomics at the Icahn School of medicine at Mount sinai and senior author of the study. iven that phenotypic heterogeneity within a bacterial population can increase its advantage of survival under stress conditions such as antibiotic treatment,
as it enables de novo detection and characterization of epigenetic heterogeneity in a bacterial population.
demonstrating the new technique reveals distinct types of epigenetic heterogeneity. For Helicobacter pylori, a pathogenic bacterium that colonizes over 40%of the world population
the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.
This may have contributed to the increasing rate of antibiotic resistance of H. pylori. he application of this new technique will enable a more comprehensive characterization of the functions of DNA methylation and their impact on bacterial physiology.
both of which present significant epigenetic heterogeneity. c
#Novel Tissue Scaffold Technique Marks Milestone in Regenerative medicine Researchers say they have developed a new tissue scaffold technology that could one day enable the engineering of large organs.
and paint the cells without affecting their biological function, said Adam Perriman, Ph d.,from the University of Bristol school of cellular and molecular medicine."
but also for other tissue such as cardiac muscle or bone, according to the University of Liverpool Anthony Hollander, Ph d.,head of integrative biology."
and paint the cells without affecting their biological function, said Adam Perriman, Ph d.,from the University of Bristol school of cellular and molecular medicine."
but also for other tissue such as cardiac muscle or bone, according to the University of Liverpool Anthony Hollander, Ph d.,head of integrative biology."
and gene therapies to prevent drug relapses, "explains Dr. Dietz.""If we can control this pathway,
. Purdue's Walther Professor of Cancer Structural biology and professor of biological sciences and chemistry who leads the research team."
Implications for nsp5 regulation and the development of antivirals, June 8 in the Journal of Biological Chemistry.
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