certain cancer biomarkers cling to the surface of the tiny particles, increasing their size and causing them to clump together.
"Timothy Reddy, assistant professor of biostatistics and bioinformatics at Duke, has spent the better part of a decade mapping millions of these enhancers across the human genome.
"Reddy found that specificity by teaming up with Gersbach, his neighbor within Duke's Center for Genomic and Computational biology,
This catalyst is a stable carbon aerogel, or foam, with pores ranging from 2 to 50 nanometers in diameter, providing enormous surface area and room for the battery electrolyte to diffuse.
They polymerized molecules of the organic compound aniline into long chains in a phytic acid solution, then freeze-dried the three-dimensional hydrogel into an aerogel."
To do that, the researchers heated the aerogel to 1, 000 degrees Celsius in the absence of oxygen.
when a specific disease biomarker is present--is enough to ensure it remains immobilized and therefore stable.
#Researchers find protein that may signal more aggressive prostate cancers Biomarkers in the body are analogous to the warning lights in cars that signal something might need repairing.
"In the context of prostate cancer) there's a big interest in trying to find biomarkers to discriminate between aggressive and nonaggressive disease,
Franceschi and colleagues recently discovered a biomarker that they believe achieves this differentiation. Prostate cancer can grow so slowly the carrier dies of natural causes before the cancer spreads,
"If this biomarker does indeed control the growth of prostate cells, it's a new signal that's not been seen before
"It could also be a potential biomarker to discriminate between fast and slow growing tumors."
The new SEG can be applied to a wide-variety of wearable energy harvesters to transduce biomechanical-stretching energy from the body (or machines) to electrical energy.
#New biomarker for uterine cancer discovered Researchers at Uppsala University have, together with researchers from Turku and Bergen, discovered a new biomarker
which makes it possible to identify women with uterine cancer who have a high risk of recurrence.
By searches in the public protein atlas database the researchers were able to identify ASRGL1 as a potential new biomarker.'
"By combining biocompatible light-capturing nanowire arrays with select bacterial populations, the new artificial photosynthesis system offers a win/win situation for the environment:
have developed a biocompatible micropump that makes it possible to deliver therapeutic substances directly to the relevant areas of the brain.
"said corresponding author Jinghui Zhang, Ph d.,a member of the St jude Department of Computational biology.""In this study of the tumor and normal genomes of 43 patients, CONSERTING identified copy number alterations in children with 100 times greater precision and 10 times greater precision in adults."
or biofilms, already growing on the bone fragments. They demonstrated this by first allowing bacteria to colonize the bone
#Urine test for early stage pancreatic cancer possible after biomarker discovery A team at Barts Cancer Institute, Queen Mary University of London, has shown that the three-protein'signature'can both identify the most common
while to secure proof of principle funding in 2008 to look at biomarkers in urine, but it's been worth the wait for these results.
This is a biomarker panel with good specificity and sensitivity and we're hopeful that a simple,
if the 3-biomarker signature is present during the latency period--the time between the genetic changes that will cause the cancer to develop and the clinical presentation."
because it has high biocompatibility, and is known a biomaterial used in implantable devices.""We investigated preparation of a silk base scaffold for a microneedle, quantitatively analyzed needle stiffness,
#Bringing the Tasmanian devil back to mainland Australia would restore ecosystem health Reintroducing Tasmanian devils to the mainland could improve biodiversity by limiting the spread of red foxes
"Combining the new dynamical biomarkers we created a test which, based on the number of subjects tested to date,
An international research team involving bioinformatics researcher Max von Kleist has produced ground-breaking findings that could, among other things
Through mathematical and statistical calculations developed by bioinformatics researcher Max von Kleist the functional consequence of every possible mutation can be quantified.
"In the old days, pharmaceutical companies would have done bioassays on extracts from all 10,000 species, "Metcalf said.
The team included Georg Duda, Ph d.,who a Wyss Associate Faculty member and the director of the Julius Wolff Institute and Professor of Biomechanics and Musculoskeletal Regeneration at Charité--Universitätsmedizin Berlin,
a biostatistician who is Senior Investigator at the Lady Davis Institute and Associate professor at Mcgill University,
and other biomarkers that reflect muscle wasting.''''According to recent studies, the prevalence of cachexia is high,
It was also able to remove bacterial biofilms that typically cause dental disease and was effective at removing soft tissue from bones,
Starstream's effectiveness was demonstrated further with the publication of two additional papers--further results on its effectiveness against dental biofilms were published in the Journal of Dental Research,
Jens Biegert and his colleagues at ICFO are currently investigating molecular sensitivity for the identification of cancer biomarkers on the single cell level using all optical techniques in the mid-wave infrared wavelength range g
The researchers used mouse embryonic fibroblast cells to determine biocompatibility; that, along with the fact that the stretchability of gold nanomesh on a slippery substrate resembles the bioenvironment of tissue
Researchers at Unit 1121"Biomaterials and Bioengineering"(Inserm/Strasbourg university) have succeeded in creating a biofilm with antimicrobial, antifungal and anti-inflammatory properties.
A biofilm invisible to the naked eye It is within this context that researchers at the"Bioengineering
and Biomaterials"Unit 1121 (Inserm/Strasbourg University) with four laboratories1 have developed a biofilm with antimicrobial and anti-inflammatory properties.
Hyaluronic acid, a natural component of the body, was chosen also for its biocompatibility and inhibiting effect on bacterial growth.
Indeed, bioinformatic analysis led him to predict the existence of a mysterious protein: COCO, a"recombinational"human molecule that is normally expressed within photoreceptors during their development.
#Biomarker finder adjusts on the fly A Rice university laboratory has developed a continuously tunable method to find and quantify DNA and RNA biomarkers.
Rice bioengineer David Zhang and his colleagues have developed a unique way to adjust their nucleic acid probe reagents on the fly
But finding a specific biomarker in a massive amount of genetic code is hard. Zhang and his team at Rice's Bioscience Research Collaborative have become specialists in finding such needles in haystacks.
there may be two biomarker sequences of interest, but the high expression of one would outshine the low expression of another.
Because the unit brightness of each biomarker can be adjusted, the researchers'new method allows the simultaneous and accurate observation of many biomarkers."
"In principle, we should be able to tune indefinitely, "he said.""But we'd be trading off time and labor and cost versus what people actually need.
/Probe design is complicated by the fact that researchers often look for many biomarkers at once, and that those biomarkers interact with each other,
Zhang said.""In an age of advancing science and big data, we want to look at hundreds or thousands or millions of different DNA biomarker signatures."
"Researchers have to decide in advance whether to measure how sensitive the target sequences are to their probes,
One of the researchers'goals is to design noninvasive cancer diagnostics that detect DNA biomarkers in blood samples for early screening and early recurrence detection.
Believed to be the first kit of its kind dedicated to the portable measurement of cancer biomarkers,
A new affordable and disposable microfluidic test strip--comprising of tiny tubes about the size of a human hair--is used specifically for the quick measurement of different types of cancer biomarkers in a whole blood sample.
Dr Reis said the microfluidic test strip is versatile enough to measure several cancer biomarkers simultaneously from one whole blood sample. 1 World health organization World Cancer Report 201 1
"We wanted a device which could identify a biomarker in a sample of saliva, and it had to emit fluorescent light so a cell phone camera could records it,
Afterwards it was considered to make it visible through an enzymatic reaction where the biomarker is fluorescent
"Another of our goals is to use calcium phosphate fibers and biocompatible plastics to design surgical implants."
Within this structure a biocide reservoir is formed and the outermost layer releases the ions. This is beneficial because it prevents direct contact between the tissue and the silver particles,
the IFAM researchers demonstrated that the Dentaplas coating is not only antimicrobial but also fully biocompatible and sterilizable.
And identifying OSCS in heparin currently requires methods such as high performance liquid chromatography combined with NMR and mass spectrometry,
Timothy Reddy, assistant professor of biostatistics and bioinformatics at Duke, has spent the better part of a decade mapping millions of these enhancers across the human genome.
Reddy found that specificity by teaming up with Gersbach, his neighbor within Duke Center for Genomic and Computational biology,
memory and motor skills were involved. ur work represents one of the first attempts using fmri to define a neurofunctional biomarker of a subtype in very young ASD toddlers,
is one of the world great centers of biodiversity. There are places where you can as many kinds of butterflies in a day as live in all of the eastern United states
but also in the blood, said Bergers. simple blood test would give us a noninvasive biomarker to check on the state of myeloid activation.
Right now, one of the major issues in anti-VEGF therapy is that there are no biomarkers for response and relapse. t
By combining biocompatible light-capturing nanowire arrays with select bacterial populations, the new artificial photosynthesis system offers a win/win situation for the environment:
have developed a biocompatible micropump that makes it possible to deliver therapeutic substances directly to the relevant areas of the brain.
Or they might alter materials for greater biocompatibility temperature stability, or water resistance. his is like going from building boats only out of wood,
Engineering professor Jeffrey La Belle use of biomarkers in saliva could replace current tests that require individuals with TYPE II DIABETES to draw blood samples each day.
ASU Engineering professor Jeffrey La Belle use of biomarkers in saliva could replace current tests that require individuals with TYPE II DIABETES to draw blood samples each day.
Arizona State university engineering professor Jeffrey La Belle use of biomarkers measurable indicators of wellness or disease in body fluids to diagnose
and expand the use of tear fluid as a means of detecting various ocular (eye) disorders by measuring certain biomarkers it contains.
The sensor then wirelessly sends data about telltale biomarkers to an external eaderdevice, allowing doctors to better monitor a patient progress
Once implanted, the sensor wirelessly sends data about biomarkers to an external eaderdevice, allowing doctors to better monitor a patient progress
on-demand data concerning two biomarkers linked to a tumor response to treatment: ph and dissolved oxygen.
The sensor housing, made of a biocompatible plastic, is small enough to fit into the tip of a biopsy needle.
revealing changes in the targeted biomarkers. ith these devices, it like taking blood pressure. It a simple measurement.
#Researchers discover cancer markers may be visible early during human development Researchers at the Virginia Bioinformatics Institute have uncovered a link between the genomes of cells originating in the neural crest
and those beneath normal skin. ombining the new dynamical biomarkers we created a test which,
#Telltale biomarker detects early breast cancer in NIH-funded study Researchers have shown that magnetic resonance imaging (MRI) can detect the earliest signs of breast cancer recurrence and fast-growing tumors.
the biomarker is enhanced, generating enough signal for MRI detection of small, high-risk cancer and micrometastases.
biocompatible polymer film made out of polyvinylidene fluoride, or PVDF. To improve the material energy harvesting ability, they added DNA,
and is biocompatible and biodegradable. Their device was powered with gentle tapping, and it lit up 22 to 55 light-emitting diodes
and non-invasively saliva biomarkers holds considerable promise for many biomedical and fitness applications, said Wang.
and contains many different biomarkers, researchers needed to make sure that the sensors only reacted with the uric acid.
and electronics to make sure that they are indeed completely biocompatible. The next iteration of the mouth guard is about a year out,
and form biofilms. This is where the project began, as a collaboration with orthopedic surgeon Dr. Alex Mclaren and his team member and bioengineer Dr. Ryan Mclemore of Banner Good samaritan Medical center, Phoenix,
The team included Georg Duda, Ph d.,who a Wyss Associate Faculty member and the director of the Julius Wolff Institute and Professor of Biomechanics and Musculoskeletal Regeneration at Charité Universitätsmedizin Berlin,
#Researchers find biomarker for autism that may aid diagnostics By identifying a key signaling defect within a specific membrane structure in all cells, University of California,
they have found both a possible reliable biomarker for diagnosing certain forms of autism and a potential therapeutic target.
There are also no current, reliable diagnostic biomarkers for ASD. Genetic research has identified hundreds of genes that are involved,
present a biohazard and may damage cells. Now a team of researchers has developed a cell sorter based on acoustic waves that can compete with existing fluorescence-activated cell sorters
they have very low biocompatibility. The cell-sorting process can reduce cell viability and functions by 30 to 99 percent for many fragile or sensitive cells such as neurons, stem cells, liver cells and sperm cells.
and biohazard concerns remain factors that have prevented this technology from being even more widespread. Microfluidic cell sorting is revolutionary for the fields of cell biology and immunology
Jingyou Yu, a doctoral student in MU pathobiology graduate program, conducted experiments to show that IFITM proteins, particularly IFITM2 and IFITM3, block HIV cell-to-cell transmission.
who is also a graduate student in pathobiology, and discovered that IFITM proteins specifically interact with the HIV-1 envelope glycoprotein
Indeed, bioinformatic analysis led him to predict the existence of a mysterious protein: COCO, a ecombinationalhuman molecule that is normally expressed within photoreceptors during their development.
Trajan Chief executive officer Stephen Tomisich said Trajan is driven by a passion to develop technologies that will impact human wellbeing. hilst this first iteration of the hemapen provides a DBS format ready for Liquid Chromatography-Mass Spectrometry (LC-MS) analysis,
#Biomarker finder adjusts on the fly A Rice university laboratory has developed a continuously tunable method to find and quantify DNA and RNA biomarkers.
Rice bioengineer David Zhang and his colleagues have developed a unique way to adjust their nucleic acid probe reagents on the fly
But finding a specific biomarker in a massive amount of genetic code is hard. Zhang and his team at Rice Bioscience Research Collaborative have become specialists in finding such needles in haystacks.
there may be two biomarker sequences of interest, but the high expression of one would outshine the low expression of another.
Because the unit brightness of each biomarker can be adjusted, the researchersnew method allows the simultaneous and accurate observation of many biomarkers. n principle,
we should be able to tune indefinitely, he said. ut we be trading off time and labor and cost versus what people actually need.
Probe design is complicated by the fact that researchers often look for many biomarkers at once, and that those biomarkers interact with each other,
Zhang said. n an age of advancing science and big data, we want to look at hundreds or thousands or millions of different DNA biomarker signatures. esearchers have to decide in advance
whether to measure how sensitive the target sequences are to their probes, or how specific they will be when binding,
One of the researchersgoals is to design noninvasive cancer diagnostics that detect DNA biomarkers in blood samples for early screening and early recurrence detection.
assistant professor of biostatistics and bioinformatics at Duke. inding a change in sequence or gene activity is relatively straightforward
who all work together in adjacent laboratories and offices in Duke Center for Genomic and Computational biology, for help with these more specialized techniques.
Ovastasis focuses on protein biomarkers that are specific to the reproductive cells, in this case, the egg.
The difference is that Ovastasis plans to use those protein biomarkers as targets for a novel female birth control medication. he identification of drug targets that are selective to the egg
It was through the same research into egg biomarkers that Herr and his team uncovered a fundamental,
and acquire their own unique set of biomarkers as they begin to form specific organs.
Like Ovastasis, Neoantigenics is focused on creating a targeted drug that will affect only those cells identified by the correct cell surface biomarkers.
the biomarker that is found only on growing eggs and tumor cells. The monoclonal antibodies to SAS1B can be thought of as a homing mechanism to guide a miniscule warhead selectively to the surface of cancer cells.
The same biomarkers that will help limit the area of impact for Ovastasis birth control will also help Neoantigenics confine the toxic effects of cancer treatment to growing egg and tumor cells.
and Ronald Harty in the Department of Pathobiology of the University of Pennsylvania School of veterinary medicine demonstrates a way to do that,
which requires the highest levels of biocontainment. There, researchers carried out experiments similar to what had been done with the VLP assays.
and the Medical Research Council, have developed also a biomarker test to identify SETD2 mutated tumours,
"In nature, a great number of microorganisms, like diatoms, can assemble biominerals into intricate hierarchical three-dimensional architectures with great structural control,
According to NC State, the technology consists of an elastic film that is studded with biocompatible microcapsules.
and will later launch other authentication services based on biometrics, the company said.""Going forward, we plan to not target hardware manufacturers that make smartphones,
but to instead provide our biometric solutions to online service and security companies,"said a Samsung SDS spokesperson."
"We plan to offer clients that need biometrics solution with various business models and offer differentiated authentication services."
"Samsung's self-developed biometrics authentication solution has received certification from the Fast IDENTITY Online (FIDO) Alliance, an international standard setter for online authentication,
FIDO-backed biometric authentications will become the de facto standard of the future, "said the spokesman.
Samsung SDS did not elaborate on how its biometrics solutions work, but said it includes the use of fingerprint-,iris,
which means it is biocompatible and less toxic to patients than systems that use synthetic materialssays Dr. Zhen Gu senior author of a paper on the work and an assistant professor in the joint biomedical engineering program at NC State and UNC
and studied it using bioinformatic techniques. We demonstrated for the first time in a patient with an adrenal cortex tumor
and metal--and also suppressed biofilm formation in a study reported in Nature Biotechnology. But that's not All the team implanted medical-grade tubing
The work was done in collaboration with MIT's Laboratory for Computational biology and Biophysics led by Mark Bathe senior co-author of the paper.
and may provide a resource for discovery of beta cell therapies that promote survival or regeneration of beta cells and development of screening biomarkers to monitor beta cell health and survival to guide therapeutic
it will help identify many more genes that hold potential as genetic biomarkers of disease progression
biocompatible fluid based on medicinal white oil is used in place of the wire cable. To control the attached instruments and orient the tip of the endoscope,
"Ultimately this could provide another biomarker in the toolkit for identifying those at greatest risk of developing diseases such as Alzheimer's."
"said Ranjan J. Perera, Ph d.,associate professor and scientific director of Analytical Genomics and Bioinformatics at Sanford-Burnham's Lake Nona campus in Orlando."
importantly, broaden the opportunity to use lncrnas as biomarkers to detect prostate cancer.""The study profiled the lncrnas in three distinct groups:(
but not all of the study samples, suggesting that reliance on a single biomarker may be insufficient for prostate cancer detection,
Bacteria behaving badly Das first became interested in diagnostics as an otolaryngology resident during research to find potential biomarkers of sinusitis in the blood.
"Research has shown that people with chronic sinusitis often have bacteria in their sinuses that have created biofilms--communities of bacteria with sticky protective covers that help them evade antibiotics and flourish unchecked.
These properties also give biofilms a unique biochemical fingerprint. Thinking that biofilms could be part of the solution, in 2008,
Das received a KL2 trainee award from Ohio State's Center for Clinical and Translational Science (CCTS) to start working with one of the nation's leading bacteriologists, Lauren Bakaletz, Phd.
had made already several critical discoveries about a type of biofilm-building bacterium called nontypeable Haemophilus influenzae (NTHI),
Bakaletz and Das started searching for the unique biochemical signature of NTHI's biofilm. In the process, they developed a novel chinchilla model of bacterial sinusitis following a viral infection.
After looking at hundreds of proteins secreted by NTHI biofilms, they landed on two candidates:
outer membrane protein (OMP) 2 and 5--proteins that were predominantly present within biofilms formed by NTHI.
With the biofilm signature in hand, the two scientists then invented a technology that reacts to the presence of NTHI proteins by changing color, much like a rapid strep or pregnancy test.
"The future of freshwater biodiversity is linked inextricably to land and water infrastructure management,"writes N Leroy Poff of Colorado State university in his guest editorial for ESA Frontiers, in
These large complex molecules form slimy biofilms and bind waterborne organic matter into larger particles in which disease-causing microorganisms can become embedded
Secondly the polymers help to form sticky biofilms which can trap the T. gondii egg cells and coat kelp on which marine snails graze.
They have found new biomarkers: molecules whose increased presence or absence in tissue suggests the development of tumorous cells.
They concluded that especially SOCS2 could be a very sensitive early diagnostic biomarker. Further analysis also revealed that this protein could even give an early prediction of the cancer's severity.
tough and biocompatible. Recently, the A*STAR team demonstrated that laser surface melting of these alloys enhances their corrosion resistance as a result of a notable enhancement in the surface concentration of aluminum.
and a host of other diseases in people using promising new biomarkers called exosomes. Indeed Popular Science magazine named exosome-based cancer diagnostics one of the 20 breakthroughs that will shape the world this year.
which is a key setback in clinical development of exosomal biomarkers. Now Zeng and colleagues from the University of Kansas Medical center and KU Cancer Center have published just a breakthrough paper in the Royal Society of Chemistry journal describing their invention of a miniaturized biomedical testing device for exosomes.
and better sensitivity of analysis when compared with the conventional bench-top instruments now used to examine the tiny biomarkers.
Such knowledge would help develop better predictive biomarkers and more efficient targeted therapy to improve the clinical outcome.
Biomarker reveals cancer cause The expression of the protein CLIP2*provides information on whether a papillary thyroid carcinoma was induced by radiation
With this discovery, scientists from the Helmholtz Zentrum München have identified a new biomarker for the diagnosis of the cancer cause.
In their investigations, the scientists developed a standardized method to determine the CLIP2 biomarker status."This biomarker allows us both to draw conclusions about the mechanisms involved in the development of such tumours
lonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes, Nature Medicine, 2015;
The multidisciplinary team drawing on their expertise in genetics, cancer, computational biology, pharmacology, and other disciplines also tested the response of tumor cells with specific mutations to anticancer drugs.
You can think of it as being biocompatible with our planet. But if this material gets put in your garden or on the side of the road,
It s getting broken into biocompatible stuff. It ll help improve the soil in your area.
including biometric smartwear that can monitor an athlete's health (like the ones made by Hexoskin,
and Dexcom have developed biocompatible coatings as well as sensors with multiple electrochemical sites that can be polled to see which ones no longer work properly.
The only exotic component is the carbon nanotube aerogel sheet used for the fiber sheath
#The First White Laser Scientists and engineers at Arizona State university, in Tempe, have created the first lasers that can shine light over the full spectrum of visible colors.
And while biometric alternatives such as fingerprint readers are finding their way onto more consumer electronics devices they are not without their limitations either.
So what about tightening the security screw further by applying a continuous biometric such as a keyboard that knows who typing on it in real-time
After testing it Mick Watson a bioinformatics researcher at the Roslin Institute in Scotland says nanopore sequencing is a disruptive technology that could potentially dominate the sequencing market for years to come.
To make the device even more efficient Walsh is studying human biomechanics and testing people s energy consumption as they use it.
Biometric researchers from Michigan State university have developed a fingerprint-scanning system for children under five years old that could replace ineffective paper vaccination records.
Until now biometrics experts believed fingerprints of babies and toddlers were too unreliable because image sensors are designed for the ridges and valleys of adult fingertips.
They intend to present a paper detailing their work at a biometrics conference later this month.
Fingerprints are a better biometric trait than the iris of the eye or palm and footprints because they are easier to record from young children
The Michigan State university researchers plan to do further tests potentially in India where already there is a national biometric ID program.
Privacy groups have warned that biometric data can be misused or faked. However people in developing countries typically do not voice concerns over privacy
and security with biometric data says Mark Thomas the executive director of Vaxtrac a nonprofit that worked with the Benin trials.
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