| Acetylcholine (32) |  |
| Dopamine (52) | |
| Gaba (23) | |
| Neurotransmitter (83) | |
| Serotonin (47) | |
| Acetylcholine (32) | |
| Dopamine (52) | |
| Gaba (23) | |
| Neurotransmitter (83) | |
| Serotonin (47) | |
The authors said the drug likely improved working memory function by boosting levels of the neurotransmitter acetylcholine.
which is required to make the neurotransmitter acetylcholine. With optogenetic tools that allowed the team to tune the firing frequency of these Chat+neurons up and down with laser light,
During culture, myobundles maintain functional acetylcholine receptors and structurally and functionally mature, evidenced by increased myofiber diameter and improved calcium handling and contractile strength.
For small molecule detection, Tao's team used membrane proteins that detect acetylcholine--a model system that has been studied widely.
In particular, acetylcholine, which was the first neurotransmitter to be discovered, is involved in cognition and motor functions.
Although much is known about the synthesis and secretion of this critical neurotransmitter, the spatial and temporal regulation of acetylcholine synthesis remains unclear.
where it subsequently recruits another enzyme Chat for acetylcholine synthesis. This ACL-transporting protein, called BNIP-H, was linked first to Cayman ataxia,
triggering the targeted release of acetylcholine. Using mass spectrometry, the researchers showed that expressing more BNIP-H in cultured cells could increase acetylcholine secretion while knockdown of BNIP-H reduced acetylcholine secretion.
The BNIP-H-induced increase of acetylcholine in turn launches a positive feedback loop involving the MAPK/ERK signalling pathway that ultimately promotes growth of neurites,
which are projections from neurons.""BNIP-H defines the precise localisation, duration and strength of acetylcholine signalling that determines the growth of neurons
and the coordination of body movements,"explained Assoc Prof Low, the corresponding author of the paper.
The study also provides the first experimental data solidifying the link between dysfunctional cholinergic (acetylcholine) secretion and Cayman ataxia.
suggesting that the loss of acetylcholine secretion resulting from BNIP-H mutation could explain some of the symptoms of Cayman ataxia.
Their work also serves as a foundation for further studies into acetylcholine-related diseases, and may lead to new treatments that involve BNIP-H."Our findings could provide new direction to better understand causes of cholinergic-related diseases, such as Alzheimer's disease, Down's syndrome, ataxia and schizophrenia.
In particular, acetylcholine, which was the first neurotransmitter to be discovered, is involved in cognition and motor functions.
Although much is known about the synthesis and secretion of this critical neurotransmitter, the spatial and temporal regulation of acetylcholine synthesis remains unclear.
where it subsequently recruits another enzyme Chat for acetylcholine synthesis. This ACL-transporting protein, called BNIP-H, was linked first to Cayman ataxia,
triggering the targeted release of acetylcholine. Using mass spectrometry, the researchers showed that expressing more BNIP-H in cultured cells could increase acetylcholine secretion while knockdown of BNIP-H reduced acetylcholine secretion.
The BNIP-H-induced increase of acetylcholine in turn launches a positive feedback loop involving the MAPK/ERK signalling pathway that ultimately promotes growth of neurites,
which are projections from neurons.""BNIP-H defines the precise localisation, duration and strength of acetylcholine signalling that determines the growth of neurons
and the coordination of body movements,"explained Assoc Prof Low, the corresponding author of the paper.
The study also provides the first experimental data solidifying the link between dysfunctional cholinergic (acetylcholine) secretion and Cayman ataxia.
suggesting that the loss of acetylcholine secretion resulting from BNIP-H mutation could explain some of the symptoms of Cayman ataxia.
Their work also serves as a foundation for further studies into acetylcholine-related diseases, and may lead to new treatments that involve BNIP-H."Our findings could provide new direction to better understand causes of cholinergic-related diseases, such as Alzheimer's disease, Down's syndrome, ataxia and schizophrenia.
This electrical signal is translated next into the release of the neurotransmitter acetylcholine in a second dish,
Changes of 20 M glutamate or acetylcholine triggered diffusive delivery of acetylcholine, which activated cells via receptor-mediated signalling.
Alternatively, conversion of glutamate-induced descending neuromuscular signals into acetylcholine-mediated muscular activation signals may be obtained
"This electrical signal is translated next into the release of the neurotransmitter acetylcholine in a second dish,
This electrical signal is translated next into the release of the neurotransmitter acetylcholine in a second dish,
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