and children who suffer from certain types of seizures caused by epilepsy. The tablet is manufactured through a layered process via 3d printing
The FDA has approved previously medical devices including prosthetics made with 3d printing. An agency spokeswoman confirmed the new drug is the first prescription tablet approved that uses the process.
including more neurological drugs. The company is owned privately. Doctors are increasingly turning to 3d printing to create customised implants for patients with rare conditions
and injuries, including children who cannot be treated with adult-size devices. The FDA held a workshop last year for medical manufacturers interested in the technology o
#iphone 6s will be announced in a month The rumoured September 9 (September 10 in Australia) reveal date lines up well with Apple usual September event,
with the device usually going on sale two weeks later. There still debate on whether Apple 2015 device will be called the iphone 7
#iphone leak reveals new parts The video at Unbox Therapy shows what is claimed to be leaked parts of the Apple iphone 6s,
although it said it was xtremely rarethe Unbox Therapy video out today shows the backplate for the iphone 6s,
self-driving cars, Google glass, internet balloons, health care, GOOGLE TV mobile payments, home automation and its Google+social network, among others.
in the longest US isolation experiment yet aimed at helping NASA prepare for a pioneering journey to Mars. The crew includes a French astrobiologist, a German physicist and four Americans a pilot, an architect, a doctor/journalist and a soil
The projects include self-driving cars, Google glass, internet balloons, drones, health care, GOOGLE TV, mobile payments, home automation and its Google+social network, among others.
Dogs wagging their tails to the left were found to be expressing negative emotions such as fear, anxiety and aggression,
"It could be that these trigger settings in the embryo that affect the risk of obesity or diabetes in life,
in the hope of encouraging more hospitals to adopt it. The approach involves inserting a slim,
When used to monitor the brains of people in intensive care after a stroke or head injury,
it warns doctors if glucose starts to dip which can cause brain damage. The probe can theoretically monitor almost any molecule,
but Rostami says the most useful parameters are glucose, which shows if there is a good blood supply,
although the bleeding had stopped, the woman brain glucose levels had fallen, probably caused by other blood vessels constricting.
what going on in the brain after injury is a good thing, says Karim Brohi a trauma specialist at the Royal London Hospital.
But he cautions that there are no figures as yet on whether such monitoring improves survival rates.
Sometimes a second probe is placed near the original site of injury, to provide more information t
in the hope that more hospitals would adopt it. The approach involves inserting a 1-centimetre-long probe directly into the brain.
When used on people in intensive care after a stroke or head injury, it warns doctors
if glucose starts to dip which can cause brain damage. The tool is widely available, but it is not clear yet
whether the information it provides saves lives, meaning it is used largely for research instead. But Rostami believes her use of the probe helped to save a woman life last year.
The woman was in intensive care after a stroke that involved bleeding on the surface of her brain.
although the bleeding had stopped, the woman brain glucose levels were falling, probably because other blood vessels had constricted.
what going on in the brain after injury is a good thing, says Karim Brohi, a trauma specialist at the Royal London Hospital.
But he cautions that there are no figures yet on whether such monitoring does improve survival rates.
and slashed energy prices, there is a risk that toxic compounds in the fracking fluid can get into shallow aquifers via fractures in the bedrock.
or to sculpt scar tissue over wounds in a more seamless way. Designer tissue ach case that a surgeon would be presented with is going to be unique,
says team member Miles Montgomery at the University of Toronto, Canada. ou could build it in situ, almost like designer tissue.
#Cancer trap grabs wandering tumour cells to warn of early spread The trouble with cancer is it spreads sometimes even before someone knows they are ill.
A small implant that traps cancer cells as they migrate through the blood could make a lifesaving early-detection system. his could be the canary in the coal mine,
then once it is in place the implant could be scanned for cancer cells while inside the body either by doctors,
Shea devised the approach along with Jacqueline Jeruss, a breast cancer surgeon. Jeruss had noticed how common it was for her patientsfirst symptom to be breathlessness as the cancer had already spread to their lungs.
They and their colleagues devised an implant made from an inert porous material already used in medical devices,
and loaded it with a signalling molecule called CCL22. This attracts certain immune cells, which encourages cancer cells to follow suit.
the team showed that cancer cells could be detected in the implant while it was still in place, via a new scanning system called optical coherence tomography (OCT). This technique,
In mice, the implants cut the number of tumour cells that migrated to secondary sites like the lungs.
They probably wouldn trap enough cells to work as an anticancer therapy says Shea, but the implant could boost people chances of survival by identifying early on that cancer cells are on the move allowing the patient to begin chemotherapy right away.
The main challenge, says Shea, will be getting the OCT scanner to penetrate human skin, which is thicker than rodent skin.
The new implant should in theory attract a wide range of cancer cells although so far the team have shown only it works for one tumour type other than breast cancer,
such as those who have had already surgery to remove a tumour and might experience a recurrence.
the implant could even be removed and the cells analysed to see which cancer drugs they are most susceptible to.
Gerhardt Attard of the Institute of Cancer Research in London says there is growing interest in personalising cancer treatments by testing cancer cells in the blood. his could be a very powerful way of risk stratifying patients for treatment
#Donated liposuction stem cells could heal difficult wounds IT a quiet revolution. Simple stem cell therapies are finally making their way towards the clinic,
and a treatment for wounds caused by Crohn disease could be the first off-the-shelf therapy to get European union approval.
Hard-to-treat wounds near the anus afflict around 50,000 people in Europe every year. In a phase III trial, a treatment developed by Tigenix in Belgium improved the chances of healing such wounds by 50 per cent and apparently with no adverse side effects.
The therapy uses stem cells derived from donated liposuction tissue which have extremely low levels of the proteins that trigger immune reactions,
says Tigenix head Eduardo Bravo. This means that the treatment, should it be approved after the full results are published next year,
can be given off-the-shelf the stem cells from a single person could be used to treat 2500 people.
By contrast, the only stem-cell-based medicinal product that is currently approved for use in the EU a cornea treatment involves removing cells from each individual eye
And bone-marrow transplants, which also involve stem cells and have been performed for decades, require a matched donor t
and insulin pump can make life a lot easier for people with type 1 diabetes. he sense of potential freedom is amazing,
if a bionic pancreas could free diabetics from the daily routine of monitoring and regulating their glucose levels (New england Journal of Medicine, doi. org/7s4).
Type 1 diabetes is caused by destruction of beta cells in the pancreas that make insulin to control how much sugar circulates in the blood.
When the pancreas is no longer in control, a person risks coma and death from plunging glucose levels.
A glucose sensor and insulin pump, both attached to the abdomen, are used by some people with type 1 diabetes to manage their condition,
so they based the brain on detailed images of the professor grey matter. e could foresee a future in which, before brain surgery,
the surgeon 3d prints a brain out of hydrogel and then practises on it, says Angelini. hen the surgeon knows exactly how that surgery is going to happen. heye made,
I think, a significant advance, says Jennifer Lewis of Harvard. t a beautiful piece of work. One of the limitations, she says,
Analysing those natural vibrations might help spot tumours and other abnormalities, and now an algorithm normally used to study earthquakes has been adapted to do just that.
Lumps can be a sign of cancer, of course, and stiffness in certain organs can indicate disease.
Ultrasound scans that measure the elasticity of the liver, for example, can show up cirrhosis. It is more difficult to measure the elasticity of the brain.
Ultrasound isn an option because it can pass through the skull. Doctors are limited to touching the brain directly
when a section of the skull has been removed during surgery. octors can only feel a few centimetres deep,
so only have information about the elasticity of the surface of the brain, says Stefan Catheline at INSERM in Paris, France.
But such devices haven made it to the clinic yet, in part because they aren very comfortable to use,
says Armando Manduca at the Mayo Clinic in Rochester, Minnesota. here could potentially be great value in using
and diagnosis. Catheline hopes his technique will eventually help doctors diagnose diseases and monitor the success of their treatment.
The plaques found in some forms of dementia, for example, have more elasticity than normal brain tissue the new technique might be able to detect those differences.
This can be useful before surgery he says: while a soft mass can be sucked swiftly away,
or too much stress but their underlying cause has remained a mystery. Now researchers have found that a migraine may be triggered by a protein deep in the brain that stimulates the neurons controlling facial sensations.
The discovery creates a potential new target for safer migraine medicines and adds weight to the theory that neurons,
they found that they could cause a headache or migraine about two hours later. Both peptides widen blood vessels,
which are known to trigger a headache. The pair measured the electrical activity of these neurons in anaesthetised rats
the neurons responsible for a headache no longer surged with activity. hese receptors could genuinely represent a new therapeutic target for migraine,
In need of relief New therapies are needed desperately. Triptans don work for half the people who try them,
#World first trial of stem cell therapy in the womb Their bones are so brittle that they fracture while in the womb.
Now a clinical trial of stem cell therapy in the womb aims to help babies born with brittle bone disease start life with stronger skeletons. o our knowledge,
Brittle bone disease or osteogenesis imperfecta, is caused by mutations in the gene for making collagen a tough,
and fix any fractures. hey home to any site of injury, says Anna David of University college London,
By comparing the number of fractures in each group, they should be able to determine
and new neurons grown by asthma drug IT as good as new. An asthma drug has rejuvenated rat brains,
making old rats perform as well as young ones in tests of memory and cognition. Our brains slowly degenerate as we age.
And age-related inflammation of the brain is implicated in many brain disorders. To tackle both problems in one go,
A drug called montelukast (Singulair), regularly prescribed for asthma and allergic rhinitis, blocks these receptors, so Aigner and his colleagues tested it on young and old rats.
The team used oral doses equivalent to those taken by people with asthma. The older animals were 20 months old perhaps between 65 and 75 in human years.
says James Nicoll, a neuropathologist at the University of Southampton, UK. Aigner agrees he will start by testing the drug in people with Parkinson disease,
he says p
#AI tool scours all the science on the web to find new knowledge It the proverbial needle in a haystack.
says Oren Etzioni, director of AI2. f youe a medical researcher, you could ask hat the latest on these drug interactions?
Or even a query in natural language like, hat are papers saying about middle-aged women with diabetes and this particular drug?'
or technique that they could use, in a medical case, to save somebody life. AI2 is not the only organisation intent on digitising
codenamed Big Mechanism, to read all the scientific papers on certain types of cancer and use that knowledge to identify potential treatments.
#Genetically Modified Yeast Yields Narcotics, Raises Regulation Questions When bioengineer Christina Smolke started her own research lab,
yeast that can literally brew narcotic drugs. Achieving that, she knew, could open the door to the quick development of better medications of all sorts."
these modified yeast strains should make it much easier and cheaper to manufacture new painkilling medicine
"We can leverage this technology to reduce some of the narcotics'side effects, or make medications that are less addictive,
Those microbes produce tiny quantities of narcotic, and only do it under highly-controlled conditions not in your average garage.
and is designed to treat seizures in people suffering from epilepsy. It's a new version of a seizure medication that's been on the market for years."
"The FDA had approved previously medical devices made with 3-D printing. The company that makes Spritam says the 3-D-printed version of the drug allows it to dissolve more quickly,
#Engineers Make Narcotics With Yeast. Is Home-brewed Heroin Next? When bioengineer Christina Smolke started her own research lab,
yeast that can literally brew narcotic drugs. Achieving that, she knew, could open the door to the quick development of better medications of all sorts."
these modified yeast strains should make it much easier and cheaper to manufacture new painkilling medicine
"We can leverage this technology to reduce some of the narcotics'side effects, or make medications that are less addictive,
where there's a terrible shortage of pain medicine, Smolke says. Still, the genetically modified yeast strains have triggered a heated debate about how to regulate these organisms and the possibility of"home-brewing morphine.""
Those microbes produce tiny quantities of narcotic, and only do it under highly-controlled conditions not in your average garage.
Doctors in Spain say this is the world's first 3-D-printed rib cage, made entirely from titanium.
And they've already implanted the device into the chest of a 54-year-old cancer patient.
The man lost his sternum and pieces of four ribs when doctors removed a large tumor.
The perforated center section of the implant is the prosthetic sternum. Four thin rods on the left mimic ribs.
The eight clamps on either side attach the implant to bone. Screws hold the clamps in place.
Surgeons at Salamanca University Hospital reported the man's case and how they made the prosthesis last month in the European Journal of Cardio-Thoracic Surgery.
Engineers at Anatomics in Melbourne, Australia, custom-designed the device using CT SCANS of the man's chest.
They manufactured the implant with a $1. 3 million metal printer at a government-run lab. The printer uses an electron beam to melt titanium powder,
"But for complex and customized implants, the cost to print them is more affordable and the time to produce it is shorter than with traditional manufacturing,"Crystal Ladiges,
so will printed 3-D implants. Surgeons typically use a combination of flat plates, bars and mesh to build an artificial rib cage and sternum for patients.
The 3-D printing technology allowed the surgeons to create an implant that"fitted like glove"in the man's chest, Dr. Jose Aranda
of Salamanca University Hospital, said in a statement. He and his colleagues hope the better fit will mean fewer complications in the long run.
But the surgical team admits that such a complex prosthesis is probably helpful only for extreme cases,
when extensive reconstruction of the sternum and rib cage are needed e
#4-D laser printing: holograms and beyond Novel tech that manipulates light has applications beyond holograms,
The new imaging method could make future medical applications more cost-effective and space-efficient than is possible with today technologies.
The researchers say that their technology is articularly interesting for medical applications as it can distinguish between differences in tissue density.
Cancer tissue, for example, is less dense than healthy tissue. The method therefore opens up the prospect of detecting tumors that are less than 1mm in diameter in an early stage of growth before they spread through the body
and exert their lethal effect. For this purpose however, researchers must shorten the wavelength of the X-rays even further
in order to be able to diagnose diseases earlier, to find new active ingredients faster and more reliably,
The developers say the system can be used to identify biomarkers that are early indicators of a disease
or can predict the response to a therapy. The Fraunhofer FIT will make the first public demonstration of the system alongside its ZETA imaging software that is used in drug research at the forthcoming BIOTECHNICA expo in Hanover, Germany, between October 6 8, 2015.
the team led by Ghent Dries Van Thourhout suggests that electrical injection-a necessity for true photonic integration-could be achieved readily with the incorporation of a suitable blend of narrow-bandgap semiconductor material in the future.
Van Thourhout and colleagues outlined how these challenges could be met. he in-plane laser configuration employed makes it straightforward to adopt well-studied electrical injection schemes,
predicts the team. his also forms a route towards electrical injection for the device. Cutting data center power consumption They suggest that a wide range of applications stand to benefit from the kind of low-cost,
IMEC says that efforts are focused now on growing the more complex semiconductor layer stacks needed for electrical injection of the lasers and emission in the 1300 nm wavelength range d
#3d printed Pills Could Bring Bespoke Drugs to a Hospital Near You It a development that could spell the end of horse pills,
an existing anticonvulsant used to treat epilepsy that has been available as a generic in the U s. since 2008.
and shipped them to hospitals and for the first time this process means we can produce tablets much closer to the patient,
Today, most bespoke drugs are formulated at specialized compounding pharmacies that are frequently miles away from the hospitals and clinics in
which they are used. 3d printing could bring those capabilities into hospitals and clinics, cutting time off delivery and making custom pharmaceuticals easier to obtain b
#New uper-Tomatocan Fight Cancer, Heart disease, Diabetes and Alzheimer Scientists said that they have invented a uper-tomatowhich can fight cancer, heart disease, diabetes and Alzheimer.
The makers of this unique tomato said it has high quantities of disease-fighting antioxidant plant chemicals.
whereas genistein could help in prevention of some cancers, including breast cancer. The study published in the journal Nature Communications said that the super-tomatoes contain a protein called Atmyb12,
and potentially production of other products derived from aromatic amino acids Martin further said their work could be used effectively in a number of areas including plant and microbe engineering, medicinal plant natural products,
The researchers also hope that the similar technique can be used to manufacture other compounds that form the basis of many medicines a
For example, the material could be engineered to detect specific pollutants, toxins or pathogens, with the results instantly visible through color emission.
The findings could help identify ways to repair damaged neural connections in patients with spinal cord injuries or neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), also known as Lou gehrig's disease.
That's a key finding for research on how to treat spinal cord injuries and ALS,
Integrated into an injection molding system, the device is capable of generating more than 1. 7 million bar code configurations on anything from cellphones to pills.
"While our system has been developed initially for products made from plastics or composites through injection molding,
produced using an injection molding process, into which 3d bar codes could be incorporated e
#Fiber Sensors Improve Robot Touch Sensitivity Fiber optic sensors could give robots the sensitivity needed to handle delicate objects and work safely alongside humans.
#UV Catheter Plugs Holes in Hearts With help from UV LIGHT, a new catheter device could provide a way to repair defects in hearts and other organs without surgery.
It was developed jointly by researchers from Boston Children's Hospital, Harvard university and Brigham and Women's Hospital."
"said Dr. Pedro del Nido, chief of cardiac surgery at Boston Children's Hospital. The catheter is inserted through a vein in the neck or groin and directed to the area of the defect.
As the glue cures, pressure from the balloons secures the patch it in place. Finally, both balloons are deflated
"This really is a completely new platform for closing wounds or holes anywhere in the body,"said Harvard professor Dr. Conor Walsh."
While medical devices that remain in the body may be jostled out of place or fail to cover the hole as the body grows,
The adhesive was developed in the lab of Dr. Jeff Karp, a bioengineer at Brigham and Women's Hospital.
The french company Gecko Biomedical, of which Karp is a founder, plans to test the adhesive in humans later this year r
#Antibiotic-Resistant Bacteria Are No Match For Medieval Potion Bloodletting, mercury cures, holes drilled in the headany ancient medical remedies seem ill-advised based on our modern understanding of medicine.
But researchers recently found that a thousand-year-old Anglo-saxon treatment for eye infections works as an antibiotic against one of today most notorious bacteria, Methicillin-resistant Staphylococcus aureus (MRSA.
The british researchers will present their findings this week at an annual microbiology conference held in the United kingdom. Christina Lee,
and is one of the earliest known medical textbooks. The researchers prepared four batches of the recipe,
The researchers tested the concoction on cultures of MRSA bacteria in synthetic wounds as well as in rats.
Blind rats without the digital implants never achieved more than a 50 percent chance of guessing the correct branch.
they've developed software that can gauge the speed at which a typist is tapping the keyboard to help diagnose Parkinson disease.
(which slows all motor skills) and diseases that affect the central nervous system, including Parkinson. For the first version of this study, the researchers were looking at typing patterns that indicated
#Glowing Tumor Paint Shows Surgeons Where To Cut Brain surgery is complicated notoriously. Before surgeons go in to remove a tumor,
they study the size and location of the tumor. But once theye in, they have to rely on their fingers
and eyes to distinguish tumor cells from healthy brain cells. Now researchers have developed a"paint"that can be injected into a patient's veins to make tumor cells glow.
After a number of successful studies in mice and dogs, the paint is now being tested in humans in California.
The paint is made from two chemicals. The first is chlorotoxin a protein derived from scorpion venom,
which targets the chloride receptors on the surface of tumor cells. The protein carries a second,
Researchers injected the tumor paint into the patients'veins and it was successfully able to cross the blood-brain barrier,
The first few test subjects had tumors that were deep in the brain so the surgeons had to remove a piece of the tissue before shining a light on it.
T he question was, 'Does it glow?''And when we saw that it glows, it was just one of those moments...
Chirag Patil, one of the researchers behind the test at Cedars Sinai Medical center in Los angeles, told NPR.
The paint may also be used for other types of tumors in the future. Ideally, doctors wouldn be using surgery at all to eliminate tumors--it still a rudetechnique,
as one researcher said. But while surgery is still a standard treatment, tumor paint could help surgeons be much more precise m
#A 3d printed, Battery-Powered Rocket engine Nothing demonstrates engineering prowess and technical knowhow quite like rocket science.
Theres also nothing quite as expensive either. To launch even a lightweight rocket into space, the cost is easily upwards of $100 million
or fracture in the earth's crust. There are many different types of faults. A thrust fault, like the one that caused the earthquake Saturday,
or some combination of the three, not to mention the numerous people who desperately need medical care. Faced with scenes of such devastation
because people need malaria meds. You feel like you've spent time in these places after spending hours digitizing aerial imagery.
--but a transfusion of the wrong blood type can be fatal. For example, the immune system of a type O individual will launch a massive attack on the"invading cells"of a type A individual
called an antigen. The result: The blood is more like type O, the universal donor. This isn the first time that researchers have produced blood with fewer antigens in the lab,
but this attempt has worked better than any other. The researchers used a technique called directed evolution;
Though this enzyme works pretty well to remove most antigens, it not perfect. That means that the treated blood isn a perfect type O,
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