Young men with cancer could be helped by the process s
#From reel to real: Potter-style invisibility cloak a reality now WASHINGTON: Scientists have developed a Harry Potterstyle ultra-thin invisibility cloak that can conform to the shape of tiny objects
#Protein system can detect viral infection, kill cancer cells MIT engineers have developed a modular system of proteins that can detect a particular DNA sequence in a cell
"said Shimyn Slomovic, a postdoc at Massachusetts institute of technology's Institute of Medical Engineering and Science (IMES) and the paper's lead author."
The researchers can programme the system to produce proteins that alert immune cells to fight the infection, instead of GFP."
#Paraplegic man walks using only his brain power A brain-to-computer echnology that can translate thoughts into leg movements has enab ed a man paralysed from the waist down by a spinal cord injury to become the first such
doctors n Southern California reported on Wednesday. The slow, halting first steps of the 28-year-old paraplegic were documented in a preliminary study published in The british-based Journal of Neuroengineering and Rehabilitation,
along with a Youtube video. The feat was accomplished using a system allowing the brain o bypass the injured spinal cord
and spinal injury victims regain some mobility. Dr An Do, a study co-author, said clinical applications were many years away.
brain-controlled walking after a complete spinal cord injury,"said biomedical engineer Zoran Nenadic, who led the research.
#Paraplegic man walks using only his brain power A brain-to-computer technology that can translate thoughts into leg movements has enabled a man paralysed from the waist down by a spinal cord injury to become the first such patient to walk without the use of robotics,
doctors in Southern California reported on Wednesday. The slow, halting first steps of the 28-year-old paraplegic were documented in a preliminary study published in The british-based Journal of Neuroengineering and Rehabilitation,
along with a Youtube video. The feat was accomplished using a system allowing the brain to bypass the injured spinal cord
and spinal injury victims regain some mobility. Dr An Do, a study co-author, said clinical applications were many years away.
brain-controlled walking after a complete spinal cord injury,"said biomedical engineer Zoran Nenadic, who led the research.
accurate detection of Ebola infections is needed to control outbreaks. Laboratory tests using preparations of Ebola virus
Virologists at Texas Biomedical Research Institute in San antonio prepared the viral samples for testing. The system combined a microfluidic chip for sample preparation and an optofluidic chip for optical detection.
and patch, eliminating the need for open heart surgery. Pedro delnido, contributing author on the study, said,
Catheterisations are preferable to open heart surgery because they don't require stopping the heart, putting the patient on bypass,
As the glue cures, pressure from the positioning balloons on either side of the patch help secure it in place.
#Two-step therapy for breast tumour shows promise Disabling a cancer-causing pathway and administering an immune-molecule-based'mop-up'therapy can eradicate a type of breast tumour in mice,
according to researchers who said that the treatment could slash the amount of chemotherapies required in humans to half."
"This line of research is important to future therapy for Her2-positive breast cancers because it defines a way to make the current treatment better
which is needed to make the targeted therapy work. This therapy, when translated for use in humans,
would be beneficial in reducing toxicity because the amount of antibody could be decreased by two-thirds and the amount of chemotherapy by at least half.
so that individuals previously not able to afford targeted therapy will be able to do so.""All of the therapeutic agents used in this preclinical study are approved
and we expect to try ordered therapy plus interferon in clinical trials soon, "Greene said.
Interferon-gamma is a small protein called a cytokine normally produced by T cells as part of the immune response.
but is used not by oncologists so much because of other side effects. It works by rendering the tumour cells more susceptible to Her-2 inhibitors
In addition, this combination therapy also augments host tumour immunity which can be a good advantage for this therapy,
researchers said. In a series of experiments in breast cancer cell lines and transgenic mice that develop breast cancer as adults,
and reduction of tumour size in the mice when the therapy is combined with a typical chemotherapeutic agent.
#Cure for cancer might accidentally have been found, and it could be malaria Scientists might have made accidentally a huge step forward in the search for a cure for cancer discovering unexpectedly that a malaria protein could be an effective weapon against the disease.
Danish researchers were hunting for a way of protecting pregnant women from malaria, which can cause huge problems
because it attacks the placenta. But they found at the same time that armed malaria proteins can attack cancer, too an approach
which could be a step towards curing the disease. that can then bury into cancer cells and release the toxin,
killing them off. The scientists have found that in both cases the malaria protein attaches itself to the same carbohydrate.
It is the similarities between those two things that the cure could exploit. The carbohydrate ensures that the placenta grows quickly.
and a tumor,"said Ali Salanti from University of Copenhagen.""The placenta is an organ,
In a manner of speaking, tumors do much the same, they grow aggressively in a relatively foreign environment."
"The process has already been tested in cells and on mice with cancer, with the findings described in a new article for the journal Cancer cell.
because the protein appears to only attach itself to a carbohydrate that is only found in the placenta and in cancer tumors in humans."
"In the tests on mice, the animals were implanted with three different types of human cancers.
It reduced non-Hodgkin's lymphoma tumours to about a quarter of their size, got rid of protstate cancer entirely in two of six mice
and kept alive five out of six mice that had metastatic bone cancer compared to a control group all of
which died.""We have separated the malaria protein, which attaches itself to the carbohydrate and then added a toxin,
"said Mads Daugaard, a cancer researcher at Canada's University of British columbia and one of the scientists that worked on the research."
"By conducting tests on mice, we have been able to show that the combination of protein
#Blood cancer develops from prior blood disorder Researchers have discovered how an incurable type of blood cancer develops from an often symptomless prior blood disorder.
and ways to identify those most at risk of developing the cancer. All patients diagnosed with myeloma,
a cancer of the blood-producing bone marrow, first develop a relatively benign condition called'monoclonal gammopathy of undetermined significance'or MGUS."
"Our findings show that very few changes are required for a MGUS patient to progress to myeloma as we now know virtually all patients with myeloma evolve from MGUS,
"A drug that interferes with these initial metabolic changes could make very effective treatment for myeloma,
and only progresses to cancer in approximately one in 100 cases. However, currently there is no way of accurately predicting which patients with MGUS are likely to go on to get myeloma.
It specifically affects antibody-producing white blood cells found in the bone marrow, called plasma cells. For the study, the researchers compared the cellular chemistry of bone marrow
and blood samples taken from patients with myeloma, patients with MGUS and healthy volunteers. Surprisingly, the researchers found that the metabolic activity of the bone marrow of patients with MGUS was significantly different to plasma from healthy volunteers,
but there were very few differences at all between the MGUS and myeloma samples. The research team found over 200 products of metabolism differed between the healthy volunteers
and patients with MGUS or myeloma, compared to just 26 differences between MGUS patients and myeloma patients.
The findings suggest that the biggest metabolic changes occur with the development of the symptomless condition MGUS and not with the later progression to myeloma.
The researchers believe that these small changes could drive the key shifts in the bone marrow required to support myeloma growth.
The study was published in Blood Cancer Journal l
#Premature birth may weaken brain connections Premature birth may result in weakened connections in brain networks linked to attention, communication and the processing of emotions, thereby increasing risk of neurological and psychiatric disorders,
new research has found.""We found significant differences in the white matter tracts and abnormalities in brain circuits in the infants born early,
compared with those of infants born at full term, "said principal investigator Cynthia Rogers, assistant professor of child psychiatry at Washington University School of medicine in St louis. White matter tracts in the brain are made of axons that connect brain regions to form networks.
The researchers used functional magnetic resonance imaging and diffusion tensor brain imaging to compare 58 babies born at full term with 76 infants born at least 10 weeks early.
Each premature baby meanwhile, received a brain scan within a few days of his or her due date.
offering an explanation for why children born prematurely may have elevated an risk of psychiatric disorders. The researchers also found differences in preemies'resting-state brain networks,
These brain circuit abnormalities likely contribute to problems that materialize as the children get older,
which could improve vision in older people with presbyopia and cataracts. As people age, their lenses lose flexibility and elasticity.
This leads to a condition known as presbyopia, common in people over 45 years old, and can require optical aids, such as reading glasses.
and intra-ocular lens implants to rejuvenate sight. Mistry is currently researching and developing the lens in the lab
Eye surgeons would make an incision in the cornea and use ultrasound to break down the old lens.
The lens could also have application in tackling cataracts-the clouding of natural lenses -which affect many people in later life and
"Given the impact of atrophy on astronauts in space, I wondered if a suit like the one worn by Freeman could fool the body into thinking it was on the ground rather than in space,
a dissolvable tablet that treats seizures While wee seen a lot of interesting 3d printed medical applications appear in surgery rooms already think about 3d printed titanium implants
However, one New jersey-based Farmaceutical company called Aprecia is hard at work pioneering another 3d printed medical application:
What more, Aprecia have just been awarded FDA approval for the first of 3d printed drug of its kind, the epilepsy drug Spritam.
It a prescription adjunctive therapy in the treatment of partial onset seizures myoclonic seizures and primary generalized tonic-clonic seizures in adults and children with epilepsy,
they write. This is good news for the large number of patients suffering from epilepsy-related afflictions,
of which there are an estimated three million in the US alone (of which about a sixth are children).
Surely epilepsy drugs already exist? Well you would be absolutely right, but the company argues that many patients have reported finding it difficult swallowing the large pills necessary. n my experience,
Ohio-based doctor Marvin H. Rorick in the company release. specially for children and seniors, having an option for patients to take their medication as prescribed is important to managing this disease. nd that where 3d printing comes in.
Aprecia uses a technology they call Zipdose 3d printing which essentially revolves around Powder-liquid 3d printing to create porous structures that rapidly disintegrate
Aprecia is developing formulations of medicines that rapidly disintegrate with a sip of liquid, even at high dose loads,
they mysteriously say about the exact way the technology works. y combining 3dp technology with a highly-prescribed epilepsy treatment,
this could increase the effectiveness of medical treatment. Doctors in the US already have access to a government-sponsored 3d printing repository, through
which they can share designs to aid in medical treatment, and 3d printed drugs could be a welcome addition to that system.
In short, Spritam is definitely paving the way for a new generation of 3d printed drugs. Posted in 3d printing Applications (adsbygoogle=window. adsbygoogle.
#Shanghai Children Medical center opens China first pediatric 3d printing medical research unit When it comes to applications for 3d printing in the medical industry,
Chinese doctors have been among the most prominent supporters of the technology as of late and have used it for a myriad of medical-related purposes.
Within the past few months alone, Chinese doctors have used 3d printing to aide in a highly-complex hip-replacement surgical procedure for a 42-year-old woman,
remove a tumor from a 60-year-old woman kidney and to help repair a 28-year-old woman atlantoaxial dislocation condition.
Thanks to the continued success of using 3d printing to aid in surgical procedures the country-along with 3d printing giant Materialise-proudly unveiled their first pediatric-specific 3d digital medical research facility in Shanghai at the Shanghai Children Medical center on Thursday, August 13th.
Among other projects, the new Pediatric 3d printing Unit at the hospital will focus on pediatric medical imaging, digital modelling, 3d fabrication,
and the researching new ways of using 3d printing in a number of clinical applications. According to Kim Francois, a spokeswoman from Materialise, the company will contribute with training for digital modeling and 3d printing procedures, clinical software development and technology support.
By creating a 3d printed organ replica in advance of a potentially life-threatening surgery, doctors can both practice their procedure with the replica as well as use it as a reference during the actual surgery. or example,
when we are working out treatment for a child with congenital heart disease we can create a 3d dissection model of the patient
which provides a clear view of the situation and promotes further analysis, said the research center director Liu Jinfen.
According to experts from Materialise, a majority of the 3d printing applications for the pediatric unit will focus on complex diseases including congenital heart disease, premature skull formations and congenital bronchial softening.
In addition to helping support the doctors in advance of a surgery, the models can also be recycled and used as reference in medical classes, too.
Assuming that the new Pediatric 3d printing Unit is a success, it will likely only be a matter of time before other hospitals around the world open up their own 3d printing labs,
too t
#3d4md turns solar powered suitcase 3d printer into medical tool for saving lives in third world and on Mars As regular readers will have noticed doubtlessly,
3d printing technology is already steadily making a name for itself as a genuine and very useful medical technology.
But despite all the 3d printed organ replicas, bioprinted innovations and even plastic hand prosthetics out there, the reality is that very few are available to a broad public.
People across the third world have very little access to basic medical care, let alone to 3d printed tools and prosthetics themselves.
But that could be changing in the near future as one Canadian doctor recently founded a startup that is employing 3d printers for medical care in hard to reach places.
Called 3dmd and led by dr. Julielynn Wong, this fantastic initiative uses multipurpose solar-powered suitcase 3d printers that can be used to manufacture all sorts of medical tools in the remote corners of the world and even in space by astronauts.
This inspiring 3d printing venture has been developed by actual public health physician dr. Wong, who realized that 3d printers are making life in the west much easier,
while people in the rest of the world haven even completed previous medical steps yet.
So why not combine the two into a single package? ver one billion people lack access to electricity.
and can take weeks to months to arrive in the hands of medical staff. 3d4md brings technologists,
healthcare professionals and patients together to create affordable 3d printable medical solutions to positively impact over one billion lives,
Our mission is to use 3d printers to deliver the highest standard of medical care in the most challenging places to those who need it the most.
Recently publishing a medical article called"Solar-Powered Suitcase 3d printer Makes Medical Supplies"in the September issue of the Aerospace medicine Human Performance journal,
say, doctors without borders, can take these suitcase 3d printers to any remote village in Africa that hasn even been put on the grid yet. his 3d printing system is capable of making a range of medical supplies,
including custom splints, scalpel handles, and dental instruments. Designing this system to fit inside a carry on suitcase allows safer handling of fragile parts
My father carried a doctor's bag containing medical equipment when he made house calls. I began to imagine how doctors could use portable 3d printers to make medical supplies for patients during visits,
she says. As she goes on to explain, the current second edition of the 3d printer has been made entirely with off-the-shelf components. he entire system has to be within the maximum size limits for carry on baggage to allow safer handling of delicate parts
and pressing play is the only thing that is needed to print a wide range of tested medical supplies.
I decided to use solar energy to power my 3d printer to make medical supplies during my simulated Mars mission.
I had printed my medical supplies tested by clinic staff to see if they worked properly.
In short, this 3d4md kit is quickly becoming the machine that doctors throughout the world and beyond it need.
#More revealed about 3d printed Acetabular Cup formally approved for hip surgery in China Chinese scientists
and surgeons have been at the forefront of 3d printed medical applications over the last few years,
and regular readers will have noticed doubtlessly a lot of 3d printed components being used in surgeries in Chinese hospitals. And last week, we learned that this number is doubtlessly set to skyrocket,
and Cai Hong of Peking University Third Hospital in cooperation with AK Medical, a Chinese private medical company.
where hip disease and other issues (necrosis, dysplasia, fractures, and bone diseases such as arthritis) necessitating hip replacement is becoming more and more common.
As dr. Zhang Ke recently pointed out, joint replacement surgery is very common in China about 400,000 took place in 2014,
of which at least two thirds is focused specifically on hip replacement. Depending on the domestic or imported artificial joints used, an operation costs about 50,000-100,000 RMB,
Doctors send data to the manufacturing enterprise, where an engineer builds 3d models with it.
Professor Zhang Ke and doctor Cai Hong went to Sweden for an academic meeting and encountered a metal 3d printer.
From his long-term clinical experience in the medical field Zhang Ke realized that it can be used widely in medical applications.
After returning to China, he received support from Liu Zhongjun, Director of the bone department at the Beijng University Third Hospital.
For the next step, Zhang Ke began leading the Group of Orthopedic Joints team to develop the first Chinese 3d printed hip products.
However, as tests revealed, 3d printing does more than reduce prices. Just a few weeks ago, Cai Hong office replaced an existing Chinese-made artificial acetabular cup with a 3d printed one.
Cai Hong explained after leading the revision surgery which cost the patient another 100,000 yuan (after paying 40,000 for the previous surgery).
The difference is that the common cast cup has a smooth surface, while the 3d printed version is rough
So far, dozens of patients have received 3d printed hip replacement surgery, and ll the clinical results were very good,
Cai Hong explained. hina's 3d printing implant registration and approval process is relatively long; to get our research and development of artificial hip joints from clinical research finally approved took 40 months,
Also problematic is customized that 3d printed orthopedic implants are restricted still officially in use. Cai Hong expressed regret that, at the present,
drafts on the individual customization of the medical devices regulations will be introduced for comment, he adds. That will hopefully bode very well for the future d
#3d printed Tadpole Endoscope device can improve cancer diagnoses Very recently, we reported on 3d printed icrofishrobots that can be injected directly into our blood to perform complex medical tasks.
Now, yet another aquatic creature has inspired scientists and 3d engineers within the medical community. A team from the Institute of Precision Engineering at the Chinese University of Hong kong as developed 3d printed tadpole-like devices that can improve diagnosis of various cancers by entering the patient stomach
and wirelessly transmitting images of what it sees. A traditional procedure for diagnosing cancers of the gastrointestinal (GI TRACT
which rank as the second most prevalent among all types of cancers in the world,
is endoscopy, wherein a long, flexible tube with a light and camera attached to its end passes through a person digestive system.
This can be done either through the mouth and back of the throat, as in gastropy,
doctors can get a firsthand view of the patient organs and assess the damage. While the procedure has been invaluable in diagnosing stomach, intestinal, esophagus and colon cancers
it requires a great deal of skill on behalf of the doctor, and can be uncomfortable, painful, and stressful for the patientot to mention prohibitively expensive.
and relatively noninvasive solution that could improve the very way we diagnose cancers. Developed to be swallowed just like a large pill (it is a bit bigger than a small coin),
which allows it to be guided deftly around the entire stomach by the doctor, and the ingeniously 3d printed shell,
when it comes to cancer diagnosis. Once the stomach has been checked thoroughly, the device wimsinto the lower GI TRACT aided by natural peristaltic actionhat is,
and eventually be implemented successfully in medical applications i
#American Wind turns wind-generated electricy on its head with 3d printed Microcube Aerospace engineer Robert Yost has developed
durable 3d printed plastic parts and assembles that are indistinguishable from injection molded-product parts in all aspects except for time and money:
and could be useful for tissue engineering, providing invaluable aid to neurosurgeons and cancer researchers.
The gel, similar to common hand sanitizer, minus alcohol and perfume, is able to rapidly switch from a solid to liquid state in response to stress.
Its applications range from medicine, advanced energy, electronics, aerospace design and many others. Despite these groundbreaking characteristics,
#New 3d printed Lamellar Titanium Technology encourages bone growth with spinal implants There a reason the expression o be the backbone ofexists.
Unfortunately, a number of injuries, infections and conditions directly affect the backbone and spine, limiting movement or at times even the very functioning of our bodies.
K2m, a global medical device company focused on developing complex and minimally invasive spine solutions for patients suffering from the most complicated spinal pathologies
which uses advanced 3d printing techniques to create spinal implants out of a porous and rough biomaterial that actually promotes bone growth activity.
K2m 3d Lamellar Titanium Technology uses advanced 3d printing technology to mimic lamellar structures and rowspinal implants with titanium powder and a high-energy laser beam.
unlike smooth titanium or other biomaterials such as PEEK, has been associated in preclinical data with bone growth (osteoblastic) activity.
The technology also incorporates 500 micron diameter pores that run through the walls of the implant,
This means that the patient own bone could grow within and throughout the bioprinted implant.
spinal implant lines offered in a range of sizes uniquely designed to accommodate the vertebral anatomy.
CASCADIA AN and TL Interbody Systems spinal implants"With 3d printed Lamellar Titanium Technology, an innovative alternative to many traditionally manufactured PEEK and titanium designs now exists in the interbody space,
"said Tom Morrison, MD, a neurosurgeon at Polaris Spine & Neurosurgery Center in Atlanta, Georgia."I'm excited about the CASCADIA platform
and porosity that may allow the bone to grow into the implant.""The announcement was made today at the 2015 North american Spine Society (NASS) Annual meeting in Chicago and offers an unprecedented application for 3d printing in spinal implants and the treatment of complex spinal pathologies
#Researchers develop new metal materials through 3d printing Wee heard of new materials being developed for 3d printing use
and more fracture resilience than regular metals because of the lack of pattern in their composition, so to speak.
Their eyes have caused defects largely by refractive errors, cataract, or glaucoma. They don see the world as the rest of the seeing world does and, due to the high costs of healthcare or unavailability of medical facilities,
they probably never will. 80%of all visual impairment can be prevented or cured, but 90%of these people live in developing countries,
Earlier in May, he delivered a talk at TEDX Auckland on his journey in fighting for preventable blindness
3d printed Wearable If a Makerbot Replicator 3d printer can be used in pharmacological research labs for advances studies on how to administer cancer fighting drugs,
#3d Systems Demos Virtual Surgeries and Soft 3d printed Models in New orleans On top of its massive 3d printing portfolio and Quickparts services, 3d Systems also has an extensive medical design and 3d printing wing.
Today, the company has announced two significant programs that could foreshadow the future of medicine altogether:
the release of irst-ever virtual reality robotic prostatectomy simulation training as well as patient-specific 3d printed kidney models for surgical planning and training, developed in partnership with Tulane University School of medicine.
According to the American Cancer Society, more than 220,000 men in the US will be diagnosed with prostate cancer this year,
prostatectomy procedures remove the entire prostate gland. 80%of these procedures in the US are, the National Cancer Institute states,
To step in and train the surgeons that will perform this surgery is 3d Systems with its Robotix Mentor training module.
The Robotix Mentor allows trainees to practice the surgery in a virtual environment using step-by-step guidance, performance metrics, anatomy recognition,
The additional LAP Mentor Express simulator even provides laparoscopic assistants training to aid the primary surgeon in the virtual procedure. 3ds Vice president
he addition of the Prostatectomy Module changes the future of Robotic Urology training. 3d Systems is committed to supporting medical advancements that ultimately affect patient safety by providing innovative products that range from virtual reality training
In addition to their new Robotix system, 3ds has developed also a new series of soft, 3d printed kidney models for surgical training.
the models developed by 3ds in tandem with surgeons at Tulane University School of medicine actually have the texture and consistency of the kidneys on
doctors are able to create a soft and flexible model via multi-material 3d printing. The kidney model can then be used to train med-students
plan surgeries, or practice procedures before operation. Dr. Jonathan Silberstein, Assistant professor of Urology and Chief of Urologic Oncology at Tulane, says of the technology,
ndividualized patient-specific soft tissue 3d printing allows surgeons and trainees the opportunity to operate on a model that looks
and feels just like their patient kidney tumor. This technology has the potential to reinvent the way we teach
and train our young surgeons and for experienced surgeons adapting to a new technology such as robotics,
it will flatten the learning curve. o me, what these technologies represent, in addition to the future of surgery planning,
is 3d Systemsgrasp of the evolving reality computing ecosystem, which encompasses 3d scanning, 3d printing, VR,
and haptic devices, all of which can be found in the company growing healthcare division. Both pieces of tech will be on display at the Annual Meeting for the American Urological Association in New orleans from today until May 19.
When these tools become widespread through the medical community, however, remains to be seen t
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