#3d printing in the Vacuum of Space Now Possible from Made In Space At the end of last year,
and delivering medicinal products to hard-to-reach places within the body. The leaders of this project, Professors Shoachen Chen and Joseph Wang, recognized that most microrobots that have already been produced are unable to perform more advanced tasks due to their simply-shaped designs and inorganic physical make-ups.
will be able to serve as both a detoxification device and a toxin sensor too, and, hopefully,
and detoxification is monitored easily due to the red light that is emitted on the device when nanoparticles are introduced to the particular toxins.
helping medical professionals gather their diagnosis from swimming throughout the body with these microfish. 3d printing enthusiasts are amazed oftentimes by
This means that the full injection-molded-transparent-plastic-bottle to 3d printed-transparent-plastic-bottle-cycle is now a real opportunity for the 3d printing industry as a whole,
#3d4md Puts a 3d printer in the Doctor Bag of the Future As the technology progresses,
assess and provide 3d printing of medical supplies where it is needed most, turning the knowledge she acquired to her own field of expertise.
and off-the-shelf components to 3d print medical and dental devices, using either a solar power-charged battery or solar panels as power sources.
and customized medical resources at a Mars analogue research station. This study describes a 3d printer with a PV system improvised on-site by providing a detailed components summary.
and evaluating three case study prints appropriate for providing medical care on a Mars mission. The findings from this work were used to design an ultraportable, plug-and-play, solar-powered 3d printing system suitable for transport to,
Some more doubts may concern the actual efficacy of the medical items that were 3d printed.
and published the results, in collaboration with the University of Aveiro (Portugal), in the Journal of Biomedical Materials Research.
and that was approved FDA for use in implants: polycaprolactone, or PCL. The ceramic phase material was hydroxyapatite,
the Principal investigator in charge of the project. hese types of materials are designed with different shaping methods for obtaining implant pieces
by adding conducting CNTS into the bioprinted polymer and mineral prosthetic bone implant, you can stimulate the regrowth of the actual bone cells.
and scaffolds for regenerative biomedicine that will speed up bone regrowth, while the polymer-based support dissolves efficiently.
Mercedes explained. believe that this technique is the future for tissue replacements as it allows tailored solutions by capturing the anatomical information of the patient wound by computed tomography and magnetic resonance, for example,
to obtain a personalized and unique implant. There is already a large trend being developed for introducing and testing these products as future solutions and
#Cancer Patient Receives 3d printed Sternum and Ribs in First of its Kind Surgery Only months after Australia scientific research arm launched its $6 million 3d printing facility,
CSIRO Lab 22 has begun already making a significant impact, helping to improve the life of one Spanish cancer patient.
With a 3d printed titanium sternum and rib implant, designed and manufactured by Lab 22 and Melbourne-based Anatomics,
an international collaboration has aided a 54-year-old patient diagnosed with a chest wall sarcoma.
When a Spanish surgical team made up of Dr José Aranda, Dr Marcelo Jimene and Dr Gonzalo Varela from Salamanca University Hospital decided to remove the patient sternum and part of his rib cage,
the team knew that the geometries of his chest cavity would prove finding a suitable implant difficult.
Dr Aranda explains, e thought, maybe we could create a new type of implant that we could fully customise to replicate the intricate structures of the sternum and ribs.
We wanted to provide a safer option for our patient, and improve their recovery post-surgery.
However, 3d printing has been increasingly proven as the ideal method for creating complex, patient-specific implants.
In turn, they crossed paths with Aussie medical device company Anatomics. Anatomics CEO Andrew Batty realized that the only process for producing such an implant was through metal 3d printing
saying, e wanted to 3d print the implant from titanium because of its complex geometry and design.
While titanium implants have previously been used in chest surgery, designs have not considered the issues surrounding long term fixation.
Flat and plate implants rely on screws for rigid fixation that may come loose over time.
This can increase the risk of complications and the possibility of reoperation. First, Anatomics produced a 3d reconstruction of the patient chest wall and tumor with high-resolution CT SCANS, with
which the doctors were better able to plan their surgery and the necessary implant. Batty elaborates
rom this, we were able to design an implant with a rigid sternal core and semi-flexible titanium rods to act as prosthetic ribs attached to the sternum.
To print the resulting component, the team turned to CSIRO newly launched facility, which houses a variety of metal 3d printers and other additive technologies.
Alex Kingsbury, Research Group Leader of Additive manufacturing at CSIRO, explained the benefits of 3d printing in surgical-grade titanium,
e built the implant using our $1. 3 million Arcam printer. The printer works by directing an electron beam at a bed of titanium powder
in order to melt it. This process is repeated then building the product up layer-by-layer until you have a complete implant. 3d printing has significant advantages over traditional manufacturing methods, particularly for biomedical applications.
As well as being customisable, it also allows for rapid prototyping which can make a big difference
if a patient is waiting for surgery. The implant was shipped then off to Spain, where it was implanted into the patient.
Dr. Aranda says, he operation was very successful. Thanks to 3d printing technology and a unique resection template, we were able to create a body part that was customised fully
Minister Macfarlane said. his collaboration crossed disciplines and international boundaries, with a clear benefit for both this individual patient and for surgical practice.
3d printing in the medical sector is climbing towards a peak of hypeability and nothing could be more hype-worthy than the regeneration of nerves after an injury.
A team of researchers from the University of Minnesota, Virginia Tech, University of Maryland, Princeton university,
a affliction suffered by more than 200,000 people worldwide due to disease and injury. The Mayo Clinic suggests that
due to the complexity of nerve regeneration, nerve damage can be permanent; however, according to a study published in the journal of Advanced Functional Materials,
his represents an important proof of concept of the 3d printing of custom nerve guides for the regeneration of complex nerve injuries.
and printer right at the hospital to create custom nerve guides right on site to restore nerve function.
you may never have to hear your uncle complain about his sciatica ever again v
without corners, we have rounded edges that you can really stress. And we were able to print them in half-rings.
and tissues that the surgeons are going to operate on. Other applications include tissue engineering, flexible electronics, particle engineering, smart materials,
Veena's team perfected the technique of'polymer injection'for electric arc furnaces. In Australia alone, this technology has resulted so far in over two million used car tyres being converted from waste into a valuable feedstock for steel production.
Researchers writing recently in The british Dental Journal argue dentists shouldn't remove impacted wisdom teeth that are not giving any symptoms.
Dentists often remove impacted wisdom teeth to avoid the risk of problems such as pain, gum inflammation and decay.
they advise dentists keep a close eye on the teeth to see if they develop problems.
surgery itself can lead to complications such as nerve damage, damage to other teeth, infection, swelling,
bleeding, pain or affect a patient's ability to open their mouth fully. Tennant and colleagues, including graduate student Abed Anjrini,
previously found 527 per 100,000 Australians were admitted to hospital for impacted wisdom teeth removal in 2008/09--a rate seven times higher than in the UK
by their dentists, to decide whether they want to take the risk of keeping their impacted wisdom teeth.
when you have your wisdom teeth out the more likely you will suffer complications from the surgery,
and will result in an increasing rate of surgical complications. Although, he adds, we won't know
However he was excited most about the technology's potential in treating diseases such as cancer by delivering drugs more efficiently."
Mazdiyasni says future plans include investigating the technology for other engine components including coated parts and fracture critical parts s
#Spot Glaucoma With Your Smartphone Researchers from the Indian Institute of Science, Bangalore, have developed a method to diagnose glaucoma from smartphone images.
Scientists at the Indian Institute of Science (IISC), Bangalore, have announced the development of a new and simple method to detect glaucoma early enough to prevent blindness.
Glaucoma is usually the result of increased pressure in the eye, resulting in damage to the optic nerve,
which carries information to the brain. Since the symptoms of glaucoma do not show up until very late stages,
early detection by a procedure called fundus imaging is advised. Fundus imaging involves taking photographs of the retina
professor of electrical engineering at the IISC and leader of the team that developed the new method. his pre-screening tool can detect glaucoma with 90 percent accuracy,
This is useful when hospitals, government healthcare units or NGOS conduct healthcare camps, he says. The IISC team has not,
Sudipto Pakrasi, chairman of the ophthalmology division at Medanta, Gurgaon, Haryana, tells Scidev. Net that currently available technologies for detection of glaucoma are expensive
while the new method is not only cheap, but will also help with mass-screening for glaucoma.
About 12 percent of India 1. 2 billion people are estimated to be affected by glaucoma. amage to the optic nerve due to glaucoma is not reversible.
If we detect it early then it is possible to halt the progression of glaucoma by appropriate medications or surgery,
Pakrasi says. ision may be preserved at nearly normal levels if glaucoma is detected and treated early. c
#ab-In-A-Needledetects Liver Toxicity In 30 Minutes The researchers are currently working on a prototype that miniaturizes a test lab into the size of a needle.
It is the brainchild of a joint research team from Singapore Nanyang Technological University (NTU Singapore), SIMTECH and the Houston Methodist Hospital Research Institute.
such as ejector pins for iphones, watch springs for expensive hand-wound watches, trial medical implants,
#Telomeres Implicated In Premature Aging Scientists have established successfully a comprehensive model of rare accelerated aging disorder, Hutchinson-gilford progeria syndrome (HGPS), opening up the possibility of treatment for the rare disease.
HGPS is an extremely rare genetic disease which causes patients to start aging rapidly when they are around one year old.
Symptoms include stunted growth and joint abnormalities, and patients often die of heart failure by their teenage years.
One in four million children suffer from HGPS, which currently has no effective treatment. The syndrome is caused by a mutated protein called progerin
which induces DNA damage, triggers premature cellular aging and slows down cell proliferation, resulting in accelerated aging.
Therapies incorporating LAP2ALPHA may be administered to early-diagnosis HGPS patients to minimise telomere damage, while older patients, who have undergone already telomere damage,
and vaccines traditionally given by injection. Cheap, lightweight and portable, the advanced nebulizer delivers precise drug doses to patients with life-threatening
or debilitating lung conditions including cancer, tuberculosis, asthma and cystic fibrosis. But the Respitetm nebulizer also has the potential to be used to administer insulin to people with diabetes
or to painlessly vaccinate infants currently subjected to needles. Professor Leslie Yeo, Director of RMIT University Micronanophysics Research Laboratory, said the Respite technology had the potential to revolutionize how patients were treated with drugs
including people with lung cancer whose poor survival rates have stayed stable despite significant therapeutic advances in recent years. nything we can nebulize,
we can potentially deliver, Yeo said. Yeo commented that conventional puffers only manage to get 30 percent of the drugs into the lungs,
Respitetm allows allows the dose to be adjusted based on a patient's size, age, gender, physiological profile and disease severity.
Recent trials in Melbourne also showed sheep given a DNA flu vaccine via a nebulizer had comparable immune responses to animals injected with the vaccine.
despite the significant therapeutic advances achieved in recent years and currently, there are no personalized delivery devices for inhaled cancer drugs to improve these clinical outcomes,
shift work and, perhaps, seasonal affective disorder. The study also provides a mathematical model that accurately predicts the behavior of the clock under different circumstances.
to provide transplanted organs or future artificial organ implants with the necessary connections to the rest of the body,
giving us endless possibilities in sensing, diagnosis and therapy. And all of this thanks to tiny structures that are up to 1, 000 times smaller than a human hair."
Perhaps in the future it may be possible for doctors to apply flexible bandages to severely burnt skin to reprogram the cells to heal that injury with functional tissue instead of forming a scar.
Alternatively, we may see surgeons first applying the nanoneedle bandages inside the affected region to promote the healthy integration of these new organs and implants in the body.
#Microbubble Technology for Delivery of Nanoparticles to Tumours Biomedical researchers led by Dr. Gang Zheng at Princess Margaret Cancer Centre have converted successfully microbubble technology already used in diagnostic imaging into nanoparticles that stay
trapped in tumours to potentially deliver targeted, therapeutic payloads. The discovery, published online today in Nature Nanotechnology, details how Dr. Zheng and his research team created a new type of microbubble using a compound called porphyrin-a naturally occurring pigment in nature that harvests light.
In the lab in preclinical experiments, the team used low-frequency ultrasound to burst the porphyrin containing bubbles
potentially overcoming one of the biggest translational challenges of cancer nanotechnology. In addition, we have demonstrated that imaging can be used to validate
"says Dr. Zheng, Senior Scientist at the Princess Margaret and also Professor of Medical Biophysics at the University of Toronto.
and therapeutic properties once they burst, he says, in a blink-of-an-eye process that takes only a minute
organic nanoparticle delivery platforms capable of transporting cancer therapeutics directly to tumours. Source: http://www. uhn. ca a
Yet local ph changes can provide invaluable early signals of many pathologies. For example, the ph around a cancer cell is slightly lower than normal,
the presence of an unseen tumor or show whether an infection has developed around a surgical implant."
which GEMS can be employed for biomedical uses.""That would require, among other things, further miniaturization.
That would open up many additional biomedical applications. One of the most significant features of GEMS is that they can be tuned"in fabrication to respond to different biochemical states
to better differentiate between different pathologies, "Zabow says.""We think that these sensors can potentially be adapted to measure a variety of different biomarkers,
New materials for energy application, new concepts for medical surfaces, new surface materials for tribological systems and nano safety and nano bio.
which can be a complication of cataract surgery. The company envisions a wide application of this immunodepletion strategy in other fibrotic diseases and cancer,
and has completed recently in-licensing intellectual property and additional assets for targeting Myo/Nog cells for therapeutic purposes from LIMR Development Inc. LDI),
a for-profit subsidiary of the Lankenau Institute for Medical Research where an early stage of the technology was developed.
Myo/Nog cells were discovered in the laboratory of Dr. Mindy George-Weinstein, and named for their ability to form muscle (Myo) and their production of Noggin,
a disease that typically occurs in approximately 30%of adults and greater than 70%of children after cataract surgery.
Additional studies testing this formulation in rabbits undergoing cataract surgery are ongoing with Drs. Liliana Werner and Nick Mamalis, Co-Directors of the Intermountain Ocular Research center at the University of Utah.
"Dr. Mindy George-Weinstein, Professor of Biomedical sciences at the Cooper Medical school of Rowan University, stated,"Myo/Nog cells have also been found in a variety of tumors,
where we predict they contribute to tumor growth. This targeted 3dna immunodepletion strategy may be useful as an adjuvant therapy to reduce tumor expansion and recurrence."
"Dr. Robert Getts, Chief Science Officer of Genisphere, said, "Since the antibody has broad utility
doctors and researchers use stains or dyes that stick to the particular structure or molecule they are looking for.
Doctors also have to choose which things to test for, because it not always possible to obtain multiple samples for multiple stains from one biopsy.
The new, advanced infrared imaging technique uses no chemical stains, instead scanning the sample with infrared light to directly measure the chemical composition of the cells.
and now is a professor at the University of Houston. ne of the bottlenecks in automated pathology is the extensive processing that must be applied to stained images to correct for staining artifacts and inconsistencies.
which can then be used for other tests. his approach promises to have immediate and long-term impact in changing pathology to a multiplexed molecular science in both research and clinical practice,
The Carle Foundation Hospital in Urbana, Illinois, and the University of Illinois Cancer Center at the University of Illinois at Chicago were partners in this work e
#Ingenious Microfluidic Device to Detect and Extract Biomolecules from Fluid Mixtures Employing an ingenious microfluidic design that combines chemical and mechanical properties,
and could lead to better technologies for medical diagnostics and chemical purification. A team of Harvard scientists has demonstrated a new way of detecting
Aizenberg said. his new approach holds promise for the next-generation, energy-efficient separation and purification technologies and medical diagnostics.
and produces planetariums, eyeglass lenses, camera and cine lenses and binoculars as well as solutions for biomedical research, medical technology and the semiconductor, automotive and mechanical engineering industries.
thus having the capacity of becoming a standard method of quality control of stem or pluripotent cells before their use in cell therapy or research in biomedicine.
who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical school and Boston Children's Hospital and Professor of Bioengineering at Harvard SEAS."
"This advance offers an entirely new approach with which to confront a broad range of problems in fields ranging from energy to medicine."
#Researchers Determine Molecular Structure of Nanobody-P Domain Complex for Norovirus Infection with highly contagious noroviruses,
while not usually fatal, can lead to a slew of unpleasant symptoms such as excessive vomiting and diarrhea.
This makes the development of an effective vaccine to protect against infection, as well as antiviral therapy to combat already-existing infections,
particularly challenging",says Dr. Grant Hansman, a virologist who leads the CHS Research Group on Noroviruses at the German Cancer Research center (Deutsches Krebsforschungszentrum, DKFZ) and Heidelberg University.
Hansman's research team recently discovered that a"nanobody"called Nano-85 was able to bind to intact norovirus-like particles (VLPS) in culture.
this could be a very promising lead in developing norovirus antiviral therapy. This could be especially beneficial to immunosuppressed individuals such as cancer patients.
Administering a vaccine to protect against infection would overwhelm the patient's immune system. However, if he or she has the option of receiving an antiviral to eliminate the infection,
the norovirus becomes much less dangerous.""Source: http://www. dkfz. d d
#Canatu Announce Multitouch, Button-Free Automotive Panels with Carbon nanobud Films Canatu, a leading manufacturer of transparent conductive films, has in partnership with Schuster Group
and Display Solution AG, showcased a pioneering 3d encapsulated touch sensor for the automotive industry. The partnership is delivering the first ever,
then back-molded by injection molding, resulting in a unique 3d shape with multitouch functionality.
as they are attached to the skin with a biocompatible, medical-grade adhesive. Users can therefore decide where they want to position the sensor patch
#Lab on a Chip Acoustofluidic Sputum Liquefaction Device for Safe Asthma and Tuberculosis Diagnostics A device to mix liquids utilizing ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis
of sputum from patients with pulmonary diseases such as tuberculosis and asthma. The device, developed by engineers at Penn State in collaboration with researchers at the National Heart, Lung,
or around 19 million people, have asthma, and in undeveloped regions where TB is still a widespread
and often deadly contagion. o develop more accurate diagnosis and treatment approaches for patients with pulmonary diseases,
we have to analyze sample cells directly from the lungs rather than by drawing blood,
different drugs are used to treat different types of asthma patients. If you know what a person immunophenotype is
you can provide personalized medicine for their particular disease. There are several issues with the current standard method for sputum analysis. The first is that human specimens can be contagious,
With the lab on a chip system a nurse can operate the device with a touch of a few buttons
Stewart J. Levine, a Senior Investigator and Chief of the Laboratory of Asthma and Lung Inflammation in the Division of Intramural Research at NHLBI, said his on-chip sputum liquefier is a significant advance regarding our goal
This will allow health care providers to individualize asthma treatments for each patient and advance the goal of bringing precision medicine into clinical practice.
This research was supported by the American Asthma Foundation Scholar Award the National Science Foundation, and the NHLBI Division of Intramural Research.
or diagnose substances at a molecular level. ur system can do chemistry, biology, biochemistry, molecular biology, clinical diagnosis,
and chemical analysis, said company president and cofounder Fanqing Frank Chen. nd our system can be implemented very cheaply,
or an advanced nanophotonic automated system, with sensitivity to the level of a single molecule, far superior to sensors on the market today. oday detection and diagnosis methods are far from perfectetection limits are in PPM (parts
including food safety, environmental monitoring (of both liquids and gases), medical diagnosis, and chemical analysis. Optokey customers include a major European company interested in food safety,
and a German company interested in point-of-care diagnosis. think wee at the cusp of a really major transition in the field,
and it can go into schools, restaurants, factories, hospitals, ambulances, airports, and even battlefields. he next market Chen is targeting is the smart home,
Trained at Los alamos National Laboratory and Mount sinai Hospital at NYU, Chen started out as a biochemist working on biomedical devices.
After he joined Berkeley Lab around 2000, he learned about quantum dots, which are nanocrystals with peculiar properties,
and accurately detect a biomarker for prostate cancer, which has a high rate of false positives using conventional diagnostic tools.
#Packaging Cancer drug into Nanoparticles Double Tumor Destroying Efficacy Researchers have packaged a widely used cancer drug into nanoparticles,
more than doubling its effectiveness at destroying tumors. The drug paclitaxel has been used for decades to fight breast, ovarian, lung and other cancers.
But its effectiveness has been limited by its small molecular size and insolubility in water--properties that allow the body to clear the drug too quickly,
reducing its accumulation in tumors. Many molecular packaging systems have been developed to deliver the drug while counteracting these effects, with a protein-bound version of the drug called Abraxane currently the leading therapy.
But Ashutosh Chilkoti professor and chair of the Department of Biomedical engineering at Duke university, thought his team could do better.
the Duke team doubled tumor exposure to the drug compared to Abraxane while simultaneously reducing its effects on healthy tissue.
This kept mice with tumors alive significantly longer and, in some cases, completely eradicated the tumors.
and accumulate in tumors where they take advantage of a tumor's acidic environment.""The chemical bonds holding the polypeptide cage together are stable in blood,
but dissolve in a tumor's lower ph levels,"said Jayanta Bhattacharyya, senior researcher in Chilkoti's lab and first author on the paper."
"This delivers the drug directly to the tumor and helps prevent it from randomly absorbing into healthy tissue, reducing side effects."
A second group of mice had human prostate tumors growing under their skin. Similarly, while they did not survive past 60 days
with some experiencing a complete cure. As the mortality rates suggest the Duke technology showed a higher concentration of paclitaxel in the tumors with more staying power than Abraxane,
while simultaneously showing much lower levels throughout the rest of the mice's bodies.""Clearly in the animal model there is a night and day difference,
"said Neil Spector, an oncologist at Duke Medicine familiar with the work.""But it's not just the increase in clinical efficacy
it could be a game-changer for cancer therapy.""In future work, Chilkoti and coworkers will begin applying the packaging system to other cancer drugs with the goal of developing a"one size fits all"technology to improve the effectiveness of many other cancer drugs s
when releasing lithium. his expansion and contraction of aluminum particles generates great mechanical stress, which can cause electrical contacts to disconnect.
Researchers in professor Margaret Frey lab create fibers hundreds of times thinner than a human hair that can capture toxic chemicals and pathogens.
processes done in a medical testing lab for example, purifying samples, mixing ingredients, capturing bacteria can be done with material about the size of a deck of cards.
and will diagnose diseases without requiring specialized laboratories particularly useful in regions with limited access to doctors and hospitals.
and allows it to time-release. y allowing rapid detection of disease and preventing agricultural chemical release into the environment,
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