and think it holds promise for delivering a variety of drugs targeting cancer and other diseases. he paper ocoon-Like Self-Degradable DNA-Nanoclew for Anticancer Drug Deliverywas published online Oct 13 in the Journal
In this disease the body produces too much of the hormone cortisol. Now for the first time a mutation of ARMC5 has been characterized as the cause behind the growth of meningeal tumors.
and the number of cells in the tumor increases the blood cortisol level rises in the course of the disease says Dr Schneider.
#Computerized surveillance system quickly detects disease outbreaks among preschoolers A web-based system that allows preschools
and child care centers to report illnesses to local public health departments could improve the detection of disease outbreaks
Oct 11 at the American Academy of Pediatrics (AAP) National Conference & Exhibition in San diego. Researchers who designed the biosurveillance system will describe how it can be used to track illness trends
In addition, if child care providers see that larger centers in their community are reporting flu-like illness,
Previously some public health departments have found that school absenteeism as a marker for illness was delayed imprecise
"However, child care or preschool absences are typically more likely to be associated with illness and most young children continue to need child care for most of the year,
"Most illness reporting methods used by many public health departments are based slow, paper and inefficient, "says Hashikawa.
They entered data on illness type and symptoms in seven categories commonly seen in preschoolers:
fever, influenza-like illness, pink eye, stomach illnesses (gastroenteritis), cold or respiratory symptoms, ear infections and rash.
Researchers sent data electronically to the public health department weekly or more frequently if spikes in illness cases were seen.
Results showed centers reported 188 individual episodes of illness from Dec 10, 2013, through March 28, 2014.
and in turn contribute to cancers and other diseases. Adding a twist to this idea however is the fact that not every histone is the same.
The researchers believe that finding new targets in the gastrointestinal tract could lead to new therapies for many more diseases. hat one of the fun things in scienceow we get to follow up on these different avenues,
They were considering various exotic diseases and I said'Antibiotics.''Antibiotics are crashingin his last position as managing director of the Center for Molecular Discovery at Yale university Kinch had assembled a huge database of information about drug discovery and development in the pharmaceutical industry.
The ability to mold inorganic nanoparticles out of materials such as gold and silver in precisely designed 3d shapes is a significant breakthrough that has the potential to advance laser technology microscopy solar cells electronics environmental testing disease
#Lung cancer can stay hidden for over 20 years UK scientists have discovered that lung cancers can lie dormant for over 20 years before suddenly turning into an aggressive form of the disease according to a study published in Science*today (Thursday.
They found that after the first genetic mistakes that cause the cancer it can exist undetected for many years until new additional faults trigger rapid growth of the disease.
and the Rosetrees Trust--highlights the need for better ways to detect the disease earlier.
Two-thirds of patients are diagnosed with advanced forms of the disease when treatments are less likely to be successful.
By revealing that lung cancers can lie dormant for many years the researchers hope this study will help improve early detection of the disease.
Survival from lung cancer remains devastatingly low with many new targeted treatments making a limited impact on the disease.
By understanding how it develops we've opened up the disease's evolutionary rule book in the hope that we can start to predict its next steps.
But as the disease evolved these became less important with the majority of faults now caused by a new process generating mutations within the tumour controlled by a protein called APOBEC.
and despite some positive steps being made against the disease it remains one of the biggest challenges in cancer research with fewer than 10 per cent surviving for at least five years after diagnosis. Building on this research will be a key priority for the recently established Cancer
If we can nip the disease in the bud and treat it before it has started travelling down different evolutionary routes we could make a real difference in helping more people survive the disease.
Building on this work Cancer Research UK is funding a study called TRACERX which is studying 100s of patient's lung cancers as they evolve over time to find out exactly how lung cancers mutate adapt
"for detecting and characterizing even trace amounts of chemicals and biologically important molecules-from explosives, chemical warfare agents and environmental pollutants to disease markers.
"For example, Tian noted, the plasmonic paper can be used to detect target molecules that serve as indicators for diseases such as kidney cancer."
dedicated his career to finding a cure for the disease, said he hopes to have human transplantation trials using the cells to be underway within a few years."
strategies for all stages of the disease.""Melton expressed gratitude to both the Juvenile diabetes Research Foundation and the Helmsley Trust, saying"their support has been,
and memory but relatively little is known about the molecular pathways affected by these diseases. A study published by Cell Press October 9th in the American Journal of Human genetics shows that neurodevelopmental disorders caused by distinct genetic mutations produce similar molecular effects in cells suggesting that a one-size-fits-all therapeutic approach could be effective
but the genetic factors responsible for these diseases are very complex. For example whereas common variants in the same gene have been associated with two
or more different disorders mutations in many different genes can lead to similar diseases. As a result it has not been clear
and psychiatric problems and mutations in euchromatic histone methyltransferase 1 (EHMT1) cause similar symptoms in a disease known as 9q34 deletion syndrome.
Our study suggests that one fundamental cause of disease is that neural stem cells choose to become full brain cells too early Ernst says.
This could affect how they incorporate into cellular networks for example leading to the clinical symptoms that we see in kids with these diseases s
offering a possible strategy for treating this lethal disease. The study was published today in the online issue of Cell.
combined with the researchers'sophisticated computer models of cellular regulation, is a powerful method for identifying genetic drivers of a wide range of diseases."
"This algorithm adds a new dimension to our ability to identify the genetic causes of complex disease.
it will help identify many more genes that hold potential as genetic biomarkers of disease progression
whose individual or synergistic activity is necessary for disease to develop and persist. However, these models provided no information on the key genetic mutations that presumably drive the abnormal activity of these master regulators.
"Conventional techniques, like genome-wide association studies, must test all possible genetic mutations and variants in a disease cell, compared with a normal cell,
"The new approach was tested on mesenchymal glioblastoma, the most aggressive subtype of the disease, by jointly analyzing the gene expression
as a master regulator of the disease, so the researchers focused on KLHL9, which had never been tied to this or any other form of cancer.
DIGGIT may be applicable to other complex diseases. In further studies by the Califano team, the algorithm identified 35 genes as drivers of breast cancer.
that had not been connected previously with the disease and that are currently being investigated.""It's important to stress that this constitutes an important improvement over traditional gene-association studies.
The latter can identify statistical associations between mutations and disease, but cannot explain how the mutation drives that effect,
"Because DIGGIT identifies disease-causing genes by tracing their aberrant activity through the regulatory network of the cell,
it provides direct information on the specific molecular interactions through which a genetic mutation causes disease--the'mechanism.'
which these mutations likely work to drive disease, adding significant new knowledge that can be tested rapidly in the lab"Dr. Chen said a
whether defects in these mechanisms might even contribute to human disease. tory Source: The above story is provided based on materials by Whitehead Institute for Biomedical Research.
#Mining big data yields Alzheimers discovery Scientists at The University of Manchester have used a new way of working to identify a new gene linked to neurodegenerative diseases such as Alzheimer's.
which is linked to a group of neurodegenerative diseases. The study has just been published in the journal BMC Genomics.
"Ultimately this could provide another biomarker in the toolkit for identifying those at greatest risk of developing diseases such as Alzheimer's."
but also the networks it uses to influence a disease like Alzheimer's. We believe this information will be incredibly useful for future studies looking at treatments and preventative measures."
advancing our knowledge of diseases and ultimately improving detection and treatment
#RNA molecules found in urine, tissue that detect prostate cancer Researchers at Sanford-Burnham Medical Research Institute have identified a set of RNA molecules that are detectable in tissue samples and urine of prostate cancer patients,
Since most men with prostate cancer have indolent (nonaggressive) disease for which conservative therapy or surveillance would be appropriate treatment,
and are reported increasingly as contributing to a range of diseases, including cancer.""We have identified a set of lncrnas that appear to have an important role in prostate cancer diagnostics,
"There is a tremendous unmet clinical need for better noninvasive screening tools for early detection of prostate cancer to reduce the overtreatment and morbidity of this disease,"added Dr. Patel."
The participants received a questionnaire every two years regarding disease outcomes and lifestyle behaviours, such as smoking status and medication use.
#Slime-producing molecules help spread disease from cats to endangered sea otters The spread of diseases from land animals to sea otters
These large complex molecules form slimy biofilms and bind waterborne organic matter into larger particles in which disease-causing microorganisms can become embedded
Using the parasite Toxoplasma gondii as a model they showed how these sticky polymers increase the chance that disease-causing organisms would be picked up by marine snails
Findings from the new study will be published Oct 8 in the journal Proceedings of the Royal Society B. Discovering the role that these invisible polymers play in disease transmission in the ocean is a tremendous step forward in helping us better understand
Contamination of coastal waters with disease-causing microorganisms is known to pose a threat to the health of both humans
and animals but the mechanisms by which diseases are transmitted in marine ecosystems has remained until now a mystery.
when the snails are eaten by otters completing the intricate chain of disease transmission from land-based cats to the endangered coastal sea otters Other researchers on the study were Colin Krusor Patricia A. Conrad John L. Largier
and select the best population of stem cells that we can use for treating different diseases such as brittle-bone disease
and to aid our understanding of a range of diseases, "explained Evans. Aside from biological applications,
or to create artificial noses for the early detection of disease or simply to advise you that the milk in your fridge has gone off."
and a host of other diseases in people using promising new biomarkers called exosomes. Indeed Popular Science magazine named exosome-based cancer diagnostics one of the 20 breakthroughs that will shape the world this year.
and colleagues have shown that a lentivirus encoding let-7 injected into mouse neurons promotes the autophagic turnover of toxic misfolded proteins associated with neurodegenerative disease. e also demonstrate that treatment with anti-let-7 can block autophagy
Understanding how it becomes active can help uncover new ways to treat disease. Dr Hildebrand said the research team found that a particular part of the protein became'unlatched
#New pathway discovered regulating autoimmune diseases The main function of the immune system is to protect against diseases and infections.
which can result in diseases such as multiple sclerosis type 1 diabetes lupus or rheumatoid arthritis. There are currently no existing cures for these diseases.
Now in a new study by researchers at Brigham and Women's Hospital (BWH) a potential treatment maybe on the horizon.
The molecule is also able to reverse disease progression by restoring damaged tissue caused by the autoimmunity process.
Mice receiving CD4+T cells along with NAD+present had delayed a significant onset of disease as well as a less severe form
The Helmholtz Zentrum München focuses its work in health research on major widespread diseases. In addition to diabetes and lung diseases, this also includes cancer.
The objective of the Helmholtz Zentrum München is the rapid further development of the results of basic research
#Non-coding half of human genome unlocked with novel sequencing technique An obscure swatch of human DNA once thought to be nothing more than biological trash may actually offer a treasure trove of insight into complex genetic-related diseases such as cancer
We know that there is hidden variation there like disease proclivities or things that are evolutionarily important
and disease and finding personalized therapies Maggert said. However this topic is incomplete unless biologists can look at the entire genome.
The optimal drug therapies we have today often aren't enough to manage this disease for some patients
and purification of bone marrow-derived stem cells for tissue repair in human patients suffering from a range of tissue-degenerative diseases The team is now working on high-speed methods for separating MSCS.
and when disrupted it can lead to neurodegenerative diseases, "said Dr. Perlson.""Understanding how an organism such as rabies manipulates this machinery may help us in the future to either restore the process
the researchers hope their findings will allow scientists to control the neuronal transport machinery to treat rabies and other neurodegenerative diseases.
Disruptions of the neuron train system also contribute to neurodegenerative diseases, like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS.
#Artificial membranes on silicon Artificial membranes mimicking those found in living organisms have many potential applications ranging from detecting bacterial contaminants in food to toxic pollution in the environment to dangerous diseases in people.
because they offer the possibility of containing membrane proteins--biological molecules that could be used for detecting toxins diseases and many other biosensing applications.
hold great promise for treating cancer and other diseases. However, several inefficiencies have limited their translation to the clinic
a professor of microbiology at the University of Iowa Carver School of medicine and director of the school Center for Immunology and Immune-Based Diseases, says that this paper presents a reative new approach with considerable potential in the development
and putting them back into your body to fight your disease, whatever that may be, Sharei says.
and other metabolic diseases. Harvard Stem Cell Institute (HSCI) scientists have found a way to both make more energy-burning human brown fat cells
and other metabolic diseases. Unlike energy-storing white, or ad, fat cells, oodbrown fat cells make a protein called UCP1 that converts energy stored in glucose
and metabolic disease, said Chad Cowan, an HSCI principal faculty member who, among other things, also studies the therapeutic potential of brown fat cells.
The breakthrough could be important in developing effective molecules for use in a wide range of industries everything from the development of safer new drugs and disease diagnosis to less toxic pesticides.
In addition to the development of effective new drugs and diagnosis methods for diseases including cancer, it could potentially lead to new reenpesticides using pheromones tailored specifically to attract pollinators
Such devices could be used to diagnose diseases, especially skin conditions, or to detect environmental pollutants and food conditions,
and a member of the Broad Stem Cell Research center. e also think this approach could possibly be extended to other diseases.
As a result, HIV infection causes disease similar to that in humans. The researchers found that the CAR-carrying blood stem cells successfully turned into functional T cells that could kill HIV-infected cells in the mice.
Their findings shed light on an important mutation in this deadly disease, and may lead to more targeted anticancer therapies.
the Yale team conducted a comprehensive analysis using whole-exome sequencing of more than 200 melanoma samples from patients with the disease.
and fluid supplements to deal with the symptoms of the disease. Doctors also sometimes administer cancer drugs to help the immune system rebound.
so those with the disease must work hard to mimic that organ function. If blood sugar goes too low,
there a lot we can do to affect disease management. For instance, doctors could mine the data for patterns in which patients suffer from low blood sugar,
#Kinsa Raises $9. 6m Series A For A Smart Thermometer That Tracks The Spread Of Illness Kinsa the company behind the world s first app-enabled FDA-approved smart thermometer
which lets Kinsa track the spread of illness at schools and in other small communities.
or tapping in rhythm to test for Parkinson Disease. Users will decide how to share their data
The touch screen can feel people tapping in rhythm to detect inconsistencies that may signal a disease.
to external factors gleaned by scraping public data such as weather info, disease seasonality and even local events
picking out new diseases as theye coming to the area so we can start helping different systems
and also to reproduce the functional and biochemical signals of diseases especially rare ones and those that make taking muscle biopsies difficult.
and it looks like it will be a real boon for researchers trying to figure out the effects of various diseases and drugs on the body.
As science links these variants to disease risk, the idea has been that genotypes could predict your chance of getting cancer or heart disease
or lower, their risk for drug reactions, common diseases, or personality traits such as a lack of empathy.
Promethease makes little effort to combine the genetic risks for any one disease into a single comprehensible number.
adding a link to a New yorker article that discussed the gene and its role in a rare childhood disease.
#Gene-Silencing Drugs Finally Show Promise The disease starts with a feeling of increased clumsiness.
The disease is caused by malformed proteins produced in the liver so one treatment is a liver transplant.
and it only slows the disease down. Now after years of false starts and disappointment it looks like an audacious idea for helping these patients finally could work.
because it suggested a way to shut down the production of any protein in the body including those connected with diseases that couldn't be touched with ordinary drugs.
fight diseases like FAP by using RNAI to eliminate bad proteins (see The Prize of RNAI and Prescription RNA.
The combination of low cost and ease-of-use is allowing Alnylam to go after more common diseases not just the rare ones that patients will go to great lengths to treat.
Because we ve made incredible improvements in the delivery strategy Meyers says we can now go after big diseases where we can treat millions of patients potentially.
he had been searching for the next great delivery mechanism one that could greatly expand the diseases that can be treated by RNAI.
Alnylam sees the potential for billions of dollars in revenue from liver-related diseases. Yet most diseases involve other tissues in the body.
Dahlman and his colleagues at MIT are some of the leaders in the next generation of RNAI delivery targeting delivery to places throughout the body.
which are associated with a wide variety of diseases. The studies showed that the method could be used to reduce tumor growth in lung cancer for example.
Compared to the status quo of not getting vaccinations for life-threatening diseases mothers are not asking these questions
we didn know a single gene related to these psychiatric diseases, not a single pathway, said Eric Lander, Broad director.
as well as adults and children with rare diseases. Because all Britons are members of the National Health service,
or disease could change the impedance properties of the wearer wrist, requiring the device to be recalibrated,
for Systems-Based Neurotechnology for Emerging Therapies. e want to understand the brain networks in neuropsychiatric illness,
Genome editing technology is considered a promising new tool for curing disease. For decades gene therapy has meant that a virus delivers a functional copy of a gene that is dysfunctional in a patient.
Second, some diseases, such as Huntington can be treated this way because the broken copy of the gene causes harm.
and some suffered leukemia-like diseases as a side effect (see he Glimmering Promise of Gene therapy.
or other protein known to be involved in a disease. Pharmaceutical companies may use robotics to test many chemical reactions in parallel.
whether it for deep-brain stimulation in Parkinson disease, or retinal implants for the blind, there is already neural damage,
drug like this must be reserved for serious diseases and not given to general practitioners to spread around like aspirin
Researchers claim that those suffering from the disease have reduced GSH as compared to the healthy individuals."
Also, it can help predict the disease much before its onset, "said Dr Pravat Mandal, a professor at NBRC and associate professor (adjunct) at the John Hopkins University, Maryland, USA.
not only provide clinical insight about the disease's pathophysiology but also expedite the drug development process,
about one in 85 individuals over the age of 65 years will suffer from the disease s
"In this particular disease, we think a mutation in the ATF6 gene disrupts the UPR process
because this (UPR) is a new pathway found to be involved in this disease, "he said d
%but also prevent recurrence of the disease by 55%.%The innovation is an'extra cut'-a dissection in medical parlance-along the neck to detect
%but also prevent recurrence of the disease by 55%.%The innovation is an'extra cut'-a dissection in medical parlance-along the neck to detect
"Plus the amputation is tied often to a traumatic experience like an accident or illness, and the mind keeps reliving these memories,
"Plus the amputation is tied often to a traumatic experience like an accident or illness, and the mind keeps reliving these memories,
and in elder care homes, where the disease is transmitted easily by environmental contamination, "said Clyde Manuel, a doctoral student of North carolina State university, Raleigh."
Several earlier studies have established that copper is very effective against a host of bacteria that cause a variety of human diseases including stomach ailments, pneumonia,
hepatitis Researchers have developed a highly sensitive nanomechanical sensor that can detect cancerous tumours as well as viral disease markers for HIV,
The sensor can detect viral disease markers, which appear when the immune system responds to incurable
or hard-to-cure diseases, including HIV, hepatitis, herpes, and many others. The sensor will also enable doctors to identify tumour markers,
The highly sensitive sensor will allow for diagnosing diseases long before they can be detected by any other method,
HIV Researchers have developed a highly sensitive nanomechanical sensor that can detect cancerous tumours as well as viral disease markers for HIV,
The sensor can detect viral disease markers, which appear when the immune system responds to incurable
or hard-to-cure diseases, including HIV, hepatitis, herpes, and many others. The sensor will also enable doctors to identify tumour markers,
The highly sensitive sensor will allow for diagnosing diseases long before they can be detected by any other method
Researchers have developed a highly sensitive nanomechanical sensor that can detect cancerous tumours as well as viral disease markers for HIV,
The sensor can detect viral disease markers, which appear when the immune system responds to incurable
or hard-to-cure diseases, including HIV, hepatitis, herpes, and many others. The sensor will also enable doctors to identify tumour markers,
The highly sensitive sensor will allow for diagnosing diseases long before they can be detected by any other method
"Muscle stem cells are the ultimate way to cure muscle-related wounds or diseases, "Hu said,
with the goal of preventing disease outbreaks in humans. Project Premonition, launched by American tech company Microsoft,
Project Premonition could eventually allow health officials to get a jump start on preventing outbreaks of a disease like dengue fever
whether or not it is a disease spread by mosquitoes, researchers said. It will do that by relying on what Ethan Jackson
calls'nature's drones'-mosquitoes-to look for early signs that a particular illness could be on the move.
Until recently, the idea of culling through mosquitoes to try to find diseases that are known both
with the goal of preventing disease outbreaks in humans. Project Premonition, launched by American tech company Microsoft,
Project Premonition could eventually allow health officials to get a jump start on preventing outbreaks of a disease like dengue fever
whether or not it is a disease spread by mosquitoes, researchers said. It will do that by relying on what Ethan Jackson
calls'nature's drones'-mosquitoes-to look for early signs that a particular illness could be on the move.
Until recently, the idea of culling through mosquitoes to try to find diseases that are known both
Some people with dwarfism say it is not a disease that needs treatment. But about 80%of children with achondroplasia are born to parents of normal stature,
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