Many of the most threatening diseases are transmitted by so-called RNA VIRUSES, such as HIV, influenza, and hepatitis C. What they have in common is that the genome does not consist of DNA, but RNA.
"We need to expand the clinical toolbox available for people with spinal cord injury and other diseases."
and treatment in developing countries that often lack the resources to address the life-threatening disease,
a disease that the World health organization estimates was responsible for 584,000 deaths in 2013, along with an estimated 198 million new cases in that span of time.
as a result of misdiagnoses can results in new, drug-resistant strains of the disease in addition to increasing costs for malaria medications, Coté notes.
Researchers discover a gene variant that provides a delaying mechanism for Alzheimer's disease Medical research has yet to discover an Alzheimer's treatment that effectively slows the disease's progression,
These individuals have a rare gene mutation that leads to full-blown disease around age 49. However, in a few outliers, the disease manifests up to a decade later."
"We wanted to study those who got the disease later to see if they had a protective modifier gene,
"said co-author Kenneth S. Kosik, co-director of UCSB's Neuroscience Research Institute and a professor in the Department of Molecular, Cellular and Developmental biology."
We hypothesized the existence of gene variant actually pushes the disease onset as much as 10 years later."
then we can modify the level of eotaxin in individuals to treat the disease. But our results must be replicated
#Mathematical'Gingko trees'reveal mutations in single cells that characterize diseases A new interactive analysis program called Gingko has been released that reduces the uncertainty of single-cell analysis
disease can occur. Such mutations have been linked not only with cancer but a host of other illnesses, including autism and schizophrenia.
Adjusting the landscape of the human body to remove the mechanism that allows pathogens to cause disease.
and at that point there's no plan B. This could be the plan B--targeting the human genes that enable the parasite to cause disease."
mortality due to disease can be prevented by manipulating characteristics of the host t
#Super-stretchable metallic conductors for flexible electronics Washington state University researchers have discovered how to stretch metal films used in flexible electronics to twice their size without breaking.
#Pancreatic cancer subtypes discovered in largest gene expression analysis of the disease to date Dense surrounding tissue can block drugs from reaching pancreatic cancer tumors,
And the researchers say that could be particularly important for a disease that has only a 7 percent five-year survival rate."
which the patient's disease has progressed. So the goal is to start patients on the right therapy from the get-go
which the team named argolaphos, was found to be most potent against three types of bacteria that cause illness:
according to the Active Bacterial Core surveillance report by the Centers for Disease Control and Prevention.
According to estimates cited by the Centers for Disease Control and Prevention, antibiotic resistance is a problem that adds around $20 billion annually to health care costs in the U s."The biggest question scientists have to ask to tackle antibiotic resistance is,
Lung transplantation is often the only option for patients with end stage lung disease, but is limited by a shortage of donor organs.
but not in later stages of the disease after the plaques have accumulated.""Clearing tissue with Scales followed by 3d microscopy has clear advantages over 2d stereology or immunohistochemistry,"states Miyawaki."
and pinpointing structural changes that characterize other brain diseases
#Biodiesel made easier, cleaner with waste-recycling catalyst Researchers at Cardiff University have devised a way of increasing the yield of biodiesel by using the waste left over from its production process.
#Microbiologists describe new insights into human neurodegenerative disease Microbiology researchers at the University of Georgia studying a soil bacterium have identified a potential mechanism for neurodegenerative diseases.
you end up with diseases such as Alzheimer's and Parkinson's. HSD10 potentially prevents this by removing these damaged lipids before they have a chance to act."
#Loss of cellular energy leads to neuronal dysfunction in neurodegenerative disease model A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria--the brain's cellular power plants--can deplete cellular energy levels
and cause neuronal dysfunction in a model of neurodegenerative disease. A link between mitochondria, energy failure,
Using a model of Leigh's disease, a genetically inherited neurodegenerative disorder that affects mitochondria,
They found that the genetic mutation associated with Leigh's disease compromised ATP levels, and this reduction of ATP was enough to cause significant cellular dysfunction."
in the model of Leigh's disease, the cells did not have enough ATP to complete this step.
if boutons lacking mitochondria will still be able to function properly in diseases that disrupt the distribution of mitochondria.
in order to comprehend changes in disease, "he explains.""It's worth taking the time to study these underlying biological processes
so this opens up a brand new pathway to pursue in developing drugs to block the disease,"Dr. Richards,
Osteoporosis is a common disease that will lead to fractures in between one-third and one-half of all women over the course of their lives.
allowing researchers to correlate rare genetic changes with human disease by comparing the DNA of healthy individuals with those who have health problems.
This particular study also stands as proof of principle that uncommon genetic variants can have a significant impact on common diseases."
"The hypothesis is that the genetic sequencing being done by UK10K will expose previously unknown genetic factors underlying disease,
and are more frequent among those with common diseases. This is precisely what has been revealed in the case of EN1
that sophisticated analysis of the genome would reveal those genes associated with disease. The promise for the contribution genetics can make to human health lies in the discovery of novel compounds that can counter the effect of deleterious genetic variants influencing these genes s
They observed whether such mice were resistant to muscle wasting induced by a high level of cortisol--a stress hormone released in your body any time you have a stressful situation such as an illness or a surgery.
It was also able to remove bacterial biofilms that typically cause dental disease and was effective at removing soft tissue from bones,
Their work also serves as a foundation for further studies into acetylcholine-related diseases, and may lead to new treatments that involve BNIP-H."Our findings could provide new direction to better understand causes of cholinergic-related diseases, such as Alzheimer's disease, Down's syndrome, ataxia and schizophrenia.
Changing the activity of BNIP-H or/and its downstream effectors might be used to treat those diseases caused by dysregulation of cholinergic neurotransmission,
"said Assoc Prof Low w
#Novel role of mitochondria identified in immune function Scientists at The Scripps Research Institute (TSRI) have discovered a new role for an enzyme involved in cell death.
The groundbreaking research has the potential to help more than 200,000 people annually who experience nerve injuries or disease.
Because of this complexity, regrowth of nerves after injury or disease is very rare according to the Mayo Clinic.
Their work also serves as a foundation for further studies into acetylcholine-related diseases, and may lead to new treatments that involve BNIP-H."Our findings could provide new direction to better understand causes of cholinergic-related diseases, such as Alzheimer's disease, Down's syndrome, ataxia and schizophrenia.
Changing the activity of BNIP-H or/and its downstream effectors might be used to treat those diseases caused by dysregulation of cholinergic neurotransmission,
"said Assoc Prof Low w
#'Safepay':'First anti-fraud system to use existing credit card readers From large-scale data breaches such as the 2013 Target case to local schemes that use skimming devices to steal data at the gas pump,
While treating diseases using this system is likely many years away, it could be used much sooner as a research tool,
and fatigue has been a deadly disease for metals, "the researchers wrote.""We weaken the constraint of the substrate by making the interface between the Au (gold) nanomesh and PDMS slippery,
"Using the smart particle for immunotherapy would involve tagging its outer surface with molecules designed to teach the body's disease-fighting cells to recognize
The discovery is a potential game-changer in Type 2 diabetes research, leading to a new way of thinking about the disease and its future treatment."
--and how they can fail--could lead to new ways to treat the disease, delaying or even preventing diabetes,
The Canadian Diabetes Association reports that more than 20 Canadians are diagnosed newly with the disease every hour of every day.
an aging population and heightened awareness of the disease stemming from the 2011 death of Apple Inc. cofounder Steve jobs. Zajac-Kaye's group discovered that a single protein is behind the process that allows pancreatic neuroendocrine tumors to thrive.
This can have important implications for identifying human disease-causing mutations because this study indicates that a mutation does not have to change amino acid identity to cause a disease.
In fact, most mutations in human DNA do not result in amino acid change.""Therefore, our study indicates that the new"code"--the speed limit of assembly--within the genetic code can dictate the ultimate function of a given protein,
and while many of these are beneficial, some can cause disease. For example some reports have linked Crohn's disease to the presence of certain strains of E coli."
and Legionnaires'disease. One advantage of the engineered phages is that unlike many antibiotics, they are very specific in their targets."
as well as treating human disease. Another advantage of this approach is that all of the phages are based on an identical genetic scaffold,
Results from the METEOR trial Patients with advanced kidney cancer live for nearly twice as long without their disease progressing
the current standard treatment for the disease. Analysis of results in July 2015 showed that the estimated median (average) progression-free survival time for patients with advanced clear cell kidney cancer,
This has resulted in a significant reduction in the rate of disease progression or death in the cabozantinib arm as compared with the everolimus arm.
81%of patients with stage I disease, in which the tumour is confined to the kidney,
with only around eight percent of patients with stage IV disease surviving for five years.
Their disease had to have progressed within six months of receiving prior treatment with VEGFR tyrosine kinase inhibitor (TKI) therapy.
or are suffering from multiple chronic diseases are not suitable for the treatment. Although current mitral valve interventions delivered via a small incision through the skin could be a viable alternative treatment
offering hope that treatments may be developed for currently non-curable degenerative diseases, like Stargardt disease and ARMD."
Beyond the clinical applications, Professor Bernier's findings could enable the modelling of human retinal degenerative diseases through the use of induced pluripotent stem cells,
Preclinical studies using mouse models of bladder cancer have demonstrated the efficacy of the mycobacterium M. brumae in the treatment of this disease.
The test accounts for many risk factors for the deadly disease and has the potential to be adapted by physicians nationwide to assess teenagers'future risk
meaning that the disease is entirely preventable. These modifiable risk factors include high blood pressure, high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets and smoking.
and their risk for future disease and use it as a motivator for individuals to try to change their risk
or get medication to reduce their metabolic syndrome severity and their future risk for disease, "Deboer said d
#Groundbreaking computer program diagnoses cancer in two days In by far the majority of cancer cases, the doctor can quickly identify the source of the disease, for example cancer of the liver, lungs, etc.
which--on the basis of a biopsy from a metastasis--can with 85 per cent certainty identify the source of the disease
Many diseases involve structural changes in tissues which are reflected in a change in their mechanical properties, such as elasticity.
From this, they will also be able to identify distinct subsets of the disease to stratify patients for precision therapy based on their unique mutations and the inhibitors available for those mutations s
and can lead to diseases such as cancer.""Using the Australian Synchrotron, Dr Mace, Dr Murphy and colleagues were able to obtain detailed three-dimensional images of Trib1."
Gelbard, director of UR's Center for Neural development and Disease, developed URMC-099 to treat HIV-associated neurocognitive disorders or HAND,
reduce side effects and help people manage the disease, because they won't have to think about taking medication every day
especially mutations, has become critically important for the detection of diseases and design of therapies to treat them.
The finding points towards developing a powerful malaria vaccine in the hope of eradicating this debilitating and often fatal disease.
and several hundred million suffer from this disease across the globe. To add to the disease burden,
the malaria parasite is increasingly becoming resistant to commonly used antimalarial drugs. Development of an antimalarial vaccine is an integral part of an effort to counter the socioeconomic burden of malaria.
which could provide a treatment target for'switching off'the gene in people with neurodegenerative diseases such as Parkinson's disease.
Current treatments for Parkinson's only treat symptoms of the disease rather than its underlying causes,
play an important role in a number of diseases that affect the nervous system, including Parkinson's.
"Although we are currently looking at neurodegenerative disease, there is potential for the technology to be expanded to psychiatric diseases, chronic pain,
seizure disorders and many other conditions affecting the brain and nervous system down the road.""Using nasal mucosal grafting,
because the therapy has been shown to delay and even reverse disease progression of Parkinson's disease in preclinical models.
"Brain diseases are notoriously difficult to treat due to the natural protections the body builds against intrusion,
as there are multiple diseases of the brain that do not have good therapeutic options, "Dr. Bleier said."
. Since there are no effective treatments for the deadly disease, University of California, San diego researchers developed a new computational strategy to search for molecules that could be developed into glioblastoma drugs.
and created a new strategy for drug design--one that we expect many other researchers will immediately begin implementing in the development of drugs that target similar proteins, for the treatment of a variety of diseases."
"We were able to use the blood tests to map out the disease as it progressed. We now need to see if this works in more patients and other cancer types,
and has the potential to give doctors valuable clues about a patient's disease without having to take repeated tumour samples."
where we'll use less invasive techniques to track the disease in real time
#Sound waves levitate cells to detect stiffness changes that could signal disease Utah Valley University physicists are literally applying rocket science to the field of medical diagnostics.
With a few key changes, the researchers used a noninvasive ultrasonic technique originally developed to detect microscopic flaws in solid fuel rockets, such as space shuttle boosters,
to successfully detect cell stiffness changes associated with certain cancers and other diseases. Brian Patchett, a research assistant and instructor within the Department of physics at Utah Valley University, will describe the group's method,
and how they change during the process of cancer and disease development.""The stiffness of the cell is the primary change detected with our high-frequency ultrasound;
and how it changes in certain diseases, "Patchett said. The group's method can also help distinguish between different types of cancer--such as aggressive breast cancer vs. less aggressive forms."
and characterize cancer or other diseases.""Our method identifies aggressive types of breast cancer, for example, while in the operating room,"Patchett noted."
which is part of the immune response to an illness.""We're collaborating with the Huntsman Cancer Institute--part of the University of Utah healthcare system--to explore various types of breast tissues under levitation to refine our pathology detection methods,
personalized medical treatments based on our ability to quickly and effectively detect cancers and diseases in patients
Waterborne diseases, such as typhoid or diarrhoeal illnesses, kill 1. 5 million people a year globally.
including low testosterone, erectile dysfunction and Peyronie disease. He is recognized also a expert in treating male infertility,
researchers opened a door to similar tests on a range of childhood diseases. The Mito Test uses near infrared spectroscopy, a special type of light beamed through the skin
Augusta and elsewhere to study other childhood diseases that may affect muscle mitochondria.##This is the start of a collaboration;
Professor of Metabolic Disease at NTU Lee Kong Chian School of medicine and senior principal investigator with the National Cancer Centre Singapore. ur work has important clinical implications,
n this work we have begun to crack open the question of why residual disease persists after targeted therapy.
or eliminate residual disease. i
#Engineers gain control of gene activity; new therapies may be ahead Duke researchers have developed a new method to precisely control
then you have said the disease Isaac Hilton, postdoctoral fellow in the Gersbach Lab and first author of the study. ut many diseases, like cancer,
cardiovascular disease or neurodegenerative conditions, have a much more complex genetic component. Many different variations in the genome sequence can affect your risk of disease
and this genetic variation can occur in these enhancers that Tim has identified, where they can change the levels of gene expression.
and how it relates to disease or response to drug therapies. Gersbach added, ot only can you start to answer those questions,
The research findings open new opportunities for developing novel treatment solutions for patients suffering from memory loss due to dementia-related conditions such as Alzheimer and even Parkinson disease.
GLDC caught the researchersattention as they investigated diseases known as nborn errors of metabolism which occur when cells are missing certain metabolic enzymes.
he said. ut this trial in newly diagnosed disease is a different kettle of fish. Because this trial clearly shows an improvement both in time until the tumor starts growing but more importantly in overall survival.
which is a major control mechanism for disease, explained co-senior author Kun Ping Lu, HMS professor of medicine and director of translational therapeutics in the Cancer Research Institute at Beth Israel Deaconess. in1 is a common key regulator in many types of cancer
#New transitional stem cells discovered Preeclampsia is a disease that affects 5 to 8 percent of pregnancies in America.
Complications from this disease can lead to emergency cesarean sections early in pregnancies to save the lives of the infants and mothers.
what causes diseases like preeclampsia and other prenatal problems. Embryonic stem cells are pluripotent, meaning they can develop into a number of different types of cells such as muscle cells, bone cells, skin cells, etc.
May be Possible to Predict Disease Progression It is the first time that the protein megalin, which is known otherwise primarily for its function in the kidneys,
it remains a very serious illness when it reaches later stages with spreading. In a best case scenario, this discovery can pinpoint those patients who will experience a relapse,
#Fruit fly studies shed light on adaptability of nerve cells An international team of researchers at German Center for Neurodegenerative Diseases (DZNE)
little was known about the signalling underlying such ynaptic plasticity Now, investigations of fruit flies by researchers at the German Center for Neurodegenerative Diseases (DZNE), Tokyo Tech, the National Institute of Genetics in Japan,
offers new opportunities for many brain diseases that remain difficult to treat at this time a
#Yale scientists apply new tool to explore mysteries of the immune system Why do infected some individuals with the West nile virus develop life-threatening infections
deepening their understanding of cell biology and human disease. SPADE analysis showing the multiple subsets of immune and nonimmune cells that Cytof technology can detect from a single sample.
The research may help explain differences in immune response to infection that could potentially benefit those most harmed by the illness, notes Montgomery.
Similarly, in his lab, Hafler applies Cytof to the study of cellular complexities at the root of diseases such as a multiple sclerosis and cancer.
and profile whole populations of immune cells for the study of cancer and other complex diseases.
diseases and higher temperatures and droughts expected to accompany climate change. Cotton growers have experienced a plateau in yields since the early 1990s
and breeders in the years ahead develop cotton varieties with improved fiber qualities, higher yields and more tolerance to heat, drought and diseases anticipated due to climate change.
but for several other diseases as well. Shapiro, Canada Research Chair in Transplantation Surgery and Regenerative medicine in the University of Alberta Faculty of medicine & Dentistry,
For any area of regenerative medicine that requires replacing old cells with newnd there lots of different disease states where there just one gene defect that could be corrected by a cell transplanthis opens up an incredible future possibility for successful engraftment beneath the skin.
Structures with these well-defined, atomic-sized gaps could be used to detect single molecules associated with certain diseases
particularly those that are characteristic of certain diseases. When light is shined upon structures with extremely small gaps,
This enhanced electromagnetic field, in turn, increases the signal produced by any molecule within the gap. f some disease marker comes in and bridges the gap between the nanostructures
whether the disease was present or not, said Lipomi. While the technique reported in this study can produce nanostructures suitable for optical applications,
a disease which affects 300 million people worldwide. The team used mouse models of asthma and human airway tissue from asthmatic and non-asthmatic people to reach their findings.
the identification of Casr in airway tissue means that the potential for treatment of other inflammatory lung diseases beyond asthma is immense.
It is predicted that by 2020 these diseases will be the third biggest killers worldwide. Professor Riccardi and her collaborators are now seeking funding to determine the efficacy of calcilytic drugs in treating asthmas that are especially difficult to treat,
whether plexin B2 and the semaphorins also play a role in the repair of other organisms and in diseases such as cancer
Arizona State university engineering professor Jeffrey La Belle use of biomarkers measurable indicators of wellness or disease in body fluids to diagnose
Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin,
The School of Biomedical sciences team was able to observe the presence of the receptors as part of their ongoing research into the growth of human hearts during disease.
The research team primary focus is on how the heart grows normally as well as abnormally in disease. fter hypertension or a heart attack
Stanford university and Washington University has discovered that neuronal activity augments the accumulation of amyloid ß that is observed in the brains of patients with Alzheimer disease (AD).
This next generation of UC Berkeley Cellscope technology could help revive efforts to eradicate debilitating filarial diseases in Africa by providing critical information to health providers in the field. e previously showed that mobile phones can be used for microscopy,
where health officials have been battling the parasitic worm diseases onchocerciasis (river blindness) and lymphatic filariasis. The video Cellscope,
but treatable, diseases. Battling parasitic worms River blindness is transmitted through the bite of blackflies and is the second-leading cause of infectious blindness worldwide.
or IVM, can be used to treat these diseases, but mass public health campaigns to administer the medication have been stalled because of potentially fatal side effects for patients co-infected with Loa loa,
whether it is safe to administer IVM. he availability of a point-of-care test prior to drug treatment is a major advance in the control of these debilitating diseases,
developed by the Public health Agency of Canada and manufactured by the American pharmaceutical company Merck Sharp & Dome, was shown just to confer 100%protection against the disease,
because organs that are affected not by the disease are exposed to radiation. It also makes the exact localization of the tumor in the body more difficult
in order to recognize and eliminate diseases. Lillemeier team is working to identify new principles that determine
#Nanoparticles used to breach mucus barrier in lungs Proof-of-concept study conducted in mice a key step toward better treatments for lung diseases Nanotechnology could one day provide an inhaled vehicle to deliver targeted therapeutic genes
asthma and other life-threatening lung diseases. o our knowledge, this is the first biodegradable gene delivery system that efficiently penetrates the human airway mucus barrier of lung tissue,
Suk says their work with nanoparticles grew out of failed efforts to deliver treatments to people with lung diseases.
Most of the existing drugs for CF help clear infections but do not solve the disease underlying problems.
microsatellites are known for their role in certain diseases such as Fragile X and Huntington disease. Garner group has shown that these regions can be informative about diseases ranging from cancer to autism spectrum disorder.
With more study, researchers believe interrelated hereditary and genetic traits of certain cancers can be traced to their common origin at the neural crest,
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