It is designed to detect antigens in samples of blood with an ELISA test used to detect a number of bacteria,
Blood samples are tested after specific antibodies that bind to antigens meet the blood in the embedded well portion of the plate.
The introduced antibodies contain enzymes whose substrates react chemically and cause a distinct change in color.
Any antigens that may be present can be detected from analyzing the color changes. So how does the handheld ELISA diagnostic tool work?
Graphene is a biocompatible material with low toxicity that has already been suggested as an external coating for biomedical applications.
and Toxic Gases RMIT University researchers have created wearable sensor patches that detect harmful UV radiation and dangerous, toxic gases such as hydrogen and nitrogen dioxide.
If you place antibodies to certain viruses on the cantilever, it'll capture the viral particles in the analyzed environment.
then affix the nanoparticles to antibodies targeting malignant tumors and put them in a liquid that cancer patients could take via a single injection.
while the other is toxic and does not relieve pain. The optical activity is considered to be an important indicator of chiral environment.
The researchers developed a drug carrier that consists of polymeric nanoparticles coated with specialized antibodies that target a small conserved (i e.
minimizing the toxicity and circumventing resistance mechanisms caused by mutations in surface transporters.""The implication of this proof-of-concept study of a novel technology for reversing transporter-related drug resistance,
or antibody fragments and allow its passage into the eye. Once inside it releases the drugs.
which rely heavily on antibodies. These antibodies are expensive to produce, subject to degeneration when exposed to environmental changes (such as high temperatures
or UV LIGHT) and more importantly, have a high rate of false-positive readings. Professor Paula Mendes said,
The findings, published in the journal Chemical science, show how the rate of false readings that come with antibody based diagnosis can be reduced by the smart technology that focuses on the carbohydrate part of the molecule.
and so we need technology that can discriminate between these subtle differences-where antibodies are not able to."
Other students have used MOFS to create a mask and hood capable of trapping toxic gases in a selective manner.
Staphylococcus epidermis, bacteria that form toxic biofilms on plastics such as catheters in the human body; and Ralstonia, a genus of bacteria that contains various soil-borne pathogens.
Brandl says. hen we came up with the idea to use our particles to remove toxic chemicals, pollutants,
minimizing the risks of leaving toxic secondary products to persist in, say, a body of water. nce they switch to this macro situation where theye big clumps,
#Coral-Like Nanoplates Help Remove Toxic Heavy metals from Water A new material that mimics coral could help remove toxic heavy metals like mercury from the ocean,
Toxic heavy metal ions like mercury, lead and arsenic are released into the water through human activity, including manufacturing and industrial processes.
One major source of toxic metal contamination is the ocean. When mercury pollutes the water
The mercury builds up in the food chain, ultimately resulting in toxic fish. According to THE WHO, between 1. 5 and 17 in every thousand children living in selected subsistence fishing populations showed cognitive impacts caused by the consumption of fish containing mercury.
Heavy metals are also toxic to corals: even at low concentrations, small amounts of heavy metal pollution can kill corals.
This heightened toxicity is due to coral being very efficient at collecting, or adsorbing, heavy metals. The researchers behind the new study have taken inspiration from this
However, current methods for production currently require toxic chemicals and lengthy and cumbersome processes that result in low yield that is not scalable for commercial applications.
The process is relatively faster, safer and green devoid of any toxic substances (just graphite plus concentrated light.
a potent narcotic pain reliever that was selected for the project because it tops the list of the most commonly abused prescription drugs.
Experts have called for tight control of organisms genetically modified to produce narcotics. If you brew beer at home,
But there are concerns these latest advances could allow a DIY drug lord to brew illegal narcotics in their home."
During a virus infection, your immune system generates antibodies designed to fight the virus. Each antibody recognises a tiny fragment of the virus
Virus-specific antibodies can be long-lived; often persisting many years after an infection has disappeared. So, your antibody repertoire represents a historical record of all of the viruses that have infected you.
This immunological catalogue has been used for years to identify past virus exposure, but the diagnostic tests routinely used have been limited to one,
Antibodies present in a drop of human blood could then be used as bait to go fishing in this phage pool-only bacteriophage that express protein fragments recognised by the antibodies in the blood sample will be caught.
"said Jonathan Kipnis, Phd, professor in the UVA Department of Neuroscience and director of UVA's Center for Brain Immunology and Glia (BIG)."
#Scientists find molecular switch that creates long-term immunity Melbourne researchers have identified a protein responsible for preserving the antibody-producing cells that lead to long-term immunity after infection or vaccination.
Dr Kim Good-Jacobson, Professor David Tarlinton and colleagues from the Walter and Eliza Hall Institute discovered the presence of a protein called Myb was essential for antibody-producing plasma cells to migrate into bone marrow,
it can create plasma cells that secrete antibodies to specifically prevent future infections, generating immunity, "she said."
"Our bone marrow is like a long-term storage facility for plasma cells, allowing them to continue producing antibodies to protect against future infections.
Until now, it was known not why some plasma cells moved into the bone marrow, while others remained in the blood stream
plasma cells were no longer able to move into the bone marrow to provide long-term immunity.""Myb is a type of protein called a transcription factor,
we might be able to encourage the immune system to create long-term immunity for a range of infections."
improving the design of antibodies to better recognise invading pathogens in the future, "she said.""The Myb protein marks the plasma cells that produce high-quality antibodies for preservation."
"Professor Tarlinton said the discovery would mean researchers could now search for the trigger of Myb production
"Now that we know Myb is critical in creating long-term immunity, we can begin dissecting the pathways it uses to mark plasma cells for storage
we don't develop lasting immunity to the disease. If we can trigger the expression of Myb in plasma cells responding to pathogens
-either by infection or by immunisation-we might be able to convince the immune system to store these plasma cells in the bone marrow to offer protection against future infections
"Screening for drug toxicity To test the potential of the system as a drug-screening tool,
"We chose drug cardiac developmental toxicity screening to demonstrate a clinically relevant application of the cardiac microchambers,
and other UC Berkeley researchers publicly debuted a system of beating human heart cells on a chip that could be used to screen for drug toxicity.
can detect the toxic effect of over a dozen drugs with greater than 97%accuracy."
and is likely to critically improve our ability to predict drug toxicity, which was limited previously by the unavailability of liver cells.
That true of both conventional and antibody therapy. e inject drugs into the bloodstream and they go absolutely everywhere,
They then deliver a third drop containing fluorescent antibodies that stick only to the proteins modified in the cascade.
Looking at the antibodies in a microscope provides a snapshot of what has changed and what hasn't. By building up a series of snapshots at different time intervals,
Then, they developed antibodies that specifically recognize these stable phosphohistidine analogues, but also detect authentic phosphohistidine in proteins.
the team added their phosphohistidine antibodies to a collection of different mammalian cells grown on slides
and observed where in the cell the antibodies bound, which indicates parts of cells that have high levels of proteins with phosphohistidines. he thing that surprised us most is that
when we stained the cells with the new antibodies, we saw discrete areas within the cells that had high levels of histidine phosphorylation,
The team expects these antibody tools to be useful to other labs aiming to determine
immunology and molecular genetics and a director of the signal transduction and therapeutics program at the Jonsson Cancer Center. his demonstrates the effectiveness of our treatment
Screening for drug toxicity To test the potential of the system as a drug-screening tool,
problems with muscle contraction and lower beat rates compared with heart tissue that had not been exposed to thalidomide. e chose drug cardiac developmental toxicity screening to demonstrate a clinically relevant application of the cardiac microchambers,
and other UC Berkeley researchers publicly debuted a system of beating human heart cells on a chip that could be used to screen for drug toxicity.
In the clinical study, patientst-cells were engineered to express an affinity-enhanced T-cell receptor (TCR) specific for a type of tumor antigen,
or protein, known as a cancer-testis antigen (CT antigen). The target CT antigens were NY-ESO-1
and LAGE-1. Up to 60 percent of advanced myelomas have been reported to express NY-ESO-1 and/or LAGE-1,
which have been associated with another type of genetically engineered T-cells (chimeric antigen receptors, or CARS) used to treat other cancers.
professor in Microbiology-Immunology and Medicine-Infectious disease. hese findings lay the foundation for future studies to further understand the mechanisms for how the escape to the bloodstream occurs.
Immune cells in the brain that are exposed to increasing concentrations of the toxic protein fragment deteriorate
contributing to harmful inflammation and becoming toxic to the neurons. During the course of the disease, cells that support the brain's structure and function also fail at the cellular and molecular levels,
and reducing harmful inflammation through the secretion of chemicals that regulate immunity at the molecular level,
immunization prevents an estimated 2 million to 3 million deaths every year. The continued threat of pandemics such as H1n1 swine flu and emerging infectious diseases such as Ebola makes vaccine development and mass vaccination a priority for global healthcare.
or ELISA, is a diagnostic tool that identifies antigens such as viruses and bacteria in blood samples.
followed by small amounts of fluid containing specific antibodies that bind to antigens in the samples.
These antibodies are linked to enzymes, so when a substance containing the enzyme substrate the molecule the enzyme acts upon is added,
and quantify any antigens that may be present. The new device which is created with a 3d printer
#Soon, a single flu shot may offer universal immunity! A single vaccine that immunizes against all types of influenza may soon be a reality,
after a team of scientists from Australia and China have discovered how the body's immunity cells remember flu viruses. The study published in the journal Nature Communications elaborated that body's CD8 cells can memorize strains of influenza
Professor Elizabeth Hartland, head of the department of Microbiology and Immunology at the University of Melbourne added that the international collaboration has brought together the immunological expertise in Melbourne
"It exemplifies the approach we are taking at the Peter Doherty Institute for Infection and Immunity,
But state-of-the-art processes are expensive result in a significant reduction in a power plant's output and yield toxic byproducts.
#Medical cannabis DOESN'T ease pain, nausea, vomiting, sleep disorders or Tourette's By Lizzie Parry for Mailonline Published:
14:51 GMT, 24 june 2015 There is very little evidence to suggest cannabis can help ease the symptoms of a raft of illnesses,
Medicinal cannabis has been legalised in 23 US states as a therapy to treat disease or alleviate symptoms,
500 volunteers, found the evidence supporting the use of medical cannabis is weak. It found moderate-quality evidence to support the use of cannabinoids-chemical compounds that are the active principles in marijuana-for the treatment of chronic pain.
and her team evaluated the evidence for benefits and adverse events, related to medicinal cannabis use.
In addition, Dr Whiting and her team found weak evidence to support the claim that medicinal cannabis has no effect on psychosis,
'Further studies evaluating cannabis itself are required also because there is very little evidence on the effects and adverse effects of cannabis.'
'In an editorial linked to the study, Dr Deepak Cyril and Dr Mohini Ranganathan, of Yale university, said:'
'We chose drug cardiac developmental toxicity screening to demonstrate a clinically relevant application of the cardiac microchambers,
and other UC Berkeley researchers publicly debuted a system of beating human heart cells on a chip that could be used to screen for drug toxicity.
#New antibody fights several flu strains at once, could make flu shot obsolete Influenza is no longer the scourge it once was thanks to modern medicine,
An international team of researchers has identified a new antibody that might give us the edge in this yearly arms race.
Basically, you don have antibodies that recognize the new patterns on the virus (known as antigens) until youe encountered the new strain.
Each antibody can only detect a single antigen. But when it does find its match
The antibody binds to the surface of the virus particle, marking it for destruction by the immune system,
As the immune response picks up, more antibodies are pumped out and other immune cells swing into action to clear virus-infested cells and combat the infection.
A vaccine provides a template of antigens to train the immune response to recognize the new strains of influenza each year.
The newly isolated antibody, known as CT149, could vastly improve treatment. It bypasses the mixed-up pattern of proteins on the surface of virus particles.
This antibody was isolated from the blood of patients infected with the pandemic H1n1 influenza virus in 2009.
says lead author Satya Dandekar, who chairs the department of medical microbiology and immunology at University of California,
posing the risk of long-term toxicity. ee made great progress, but at the end of the day you still have more than 30 million people walking around with HIV,
and showed low toxicity. However, HIV is complicated a virus and, as clinicians have discovered with HAART,
says medical entomologist Gregory Lanzaro, professor in the pathology, microbiology and immunology department at University of California,
These polymeric discs are coated on one side with a single layer of an antibody that can bind to receptors on the monocyte surface.
leading to considerable toxicities. This outcome is partially because cells in any one tumor have chromosomes with different telomere lengths
"Using telomerase to incorporate toxic products into telomeres is remarkably encouraging at this point, "said Dr. Wright.
But the reaction is toxic and destroys the animal's motor neurons, Dr. Parker explained. Is the same scenario at work with people?
particularly in light of the huge disease burden of malaria,"explained senior author Manoj Duraisingh, Ph d.,professor of Immunology and Infectious diseases at the T. H. Chan School of Public health."
it is effective without causing weight loss, liver toxicity, or inflammation, pointed out Dr. Burris.
According to the World health organization, immunization prevents an estimated 2 million deaths every year. The continued threat of pandemics such as H1n1 swine flu and emerging infectious diseases such as Ebola makes vaccine development and mass vaccination a priority for global healthcare.
Vaccinated individuals have been shown to develop antibodies against the Ebola virus, but the significance and durability of this immune response have not been determined. rvsv-ZEBOV was engineered initially with support from the Public health Agency of Canada
the Walter reed Army Institute of Research, the Canadian Immunization Research Network, and the U s army Medical Research Institute of Infectious diseases.
and often include toxic lead, while polymers are lighter, more flexible, and more durable, but not very efficient.
Additionally, narcotic painkillers like Oxycontin are acquired frequently by prescription but then sold for recreational use. In the case of the Johns Hopkins dispenser, medication is added by the pharmacist via a lockable opening in the bottom the pharmacist has a key to that opening,
and had no toxic effects on living cells in the lab. The team also discovered that mixing the gel with silica nanoparticles gave it the ability to more effectively prevent bleeding,
which is strong enough to stabilize various types of compounds, such as antibodies, enzymes, nanoparticles, antibiotics and growth factors, by acting as a protective"cocoon"."
His nearly eight years of research centered around antibodies in the blood that had interacted previously with toxins during food poisoning.
The antibodies are able to squeeze past the barrier not just because of their size (these are fragments that consist of one molecule)
The single domain antibodies are exploiting the same mechanism that allows nutrients into the brain,
But before these nanoparticles get to the clinic there is still work to be done testing their toxicity
you can prevent toxic mining waste from being poured into the environment, according to the company. And by keeping electronics out of the garbage dump, you also prevent the toxic materials found inside these devices (things like mercury and cadmium) from leaking into the ground.
Of course, not all of the electronics that find their way into the ecoatm are taken actually apart and used for parts.
and then multiplies, producing proteins that are toxic to humans and cause watery diarrhea. That in turn can cause severe dehydration and an imbalance of electrolytes.
Humans can build immunity to some strains of cholera. But sometimes, new strains appear, and the transfer of genes from other species of bacteria (including other kinds of cholera) might be one reason these new strains arrive."
The Virscan test uses these engineered viruses to look for antibodies to each of these viruses in a sample of a person's blood.
Antibodies are immune system molecules that zero in on the proteins of a virus's coat and stick to it,
They found that the study participants had antibodies to an average of 10 virus species. In two people,
they found antibodies to 84 virus species. To see how well the scan could work as a test,
more often than not, showed antibodies to the same or similar viruses."We thought it would be a lot more individual than that,"
"Maybe antibodies have more similarity than we've been thinking.""Kula said this finding showcased one of the big advantages of this method of testing for a person's viral infection history:
Collagen has been considered a good candidate for such work due to its low toxicity and biocompatibility, but it been hard to shape it into formations that are structurally strong enough for many applications.
non-biodegradable and potentially toxic materials-are discarded at an alarming rate in consumers'pursuit of the next best electronic gadget.
However, gallium arsenide can be environmentally toxic, particularly in the massive quantities of discarded wireless electronics.
says the new process greatly reduces the use of such expensive and potentially toxic material."
because the materials can assemble in water instead of more toxic organic solutions that are used widely today. nce you make the materials,
because the materials can assemble in water instead of more toxic organic solutions that are used widely today. nce you make the materials,
The prostate specific-antigen antigen (PSA) test was recommended once the screening tool for detecting prostate cancer, but there is now disagreement over the use of this test
Few studies explore toxicity of cellulose nanocrystals March 10th, 2015superconductivity Electrons in slow motion: Here's how to see the'fastest slow process'--to understand superconductors March 9th, 2015strength in numbers:
Few studies explore toxicity of cellulose nanocrystals March 10th, 2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Researchers synthesize new thin-film material for use in fuel cells:
Few studies explore toxicity of cellulose nanocrystals March 10th, 2015thin films Graphene meets heat waves March 9th, 2015ciqus researchers obtain high-quality perovskites over large areas by a chemical method March 4th,
Few studies explore toxicity of cellulose nanocrystals March 10th, 2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Researchers snap-shot fastest observations of superconductivity yet March 10th,
Nanobodies are very similar to antibodies, which recognize and bind to antigens.""However, nanobodies are much smaller, more stable, easier to produce,
and cost-effective than traditional monoclonal antibodies, "says Hansman. Interestingly, Nano-85 was able to recognize the VLPS from a variety of different norovirus strains.
and occasionally clusters using antibodies that stick to special proteins found on the surface of some tumor cells.
and at the same time absence of toxicity and flammability, and the possibility to recover oil. The creation of this graphene-based oil-adsorbent product, commercialized as Grafysorber,
Iranian researchers produced biocompatible and biodegradable nanocomposite scaffolds by using a type of natural silk with no cellular toxicity observed in the experiments.
In addition, no sign of toxicity has been observed at the laboratorial scale. Results of the research have been published in RSC Advances,
In addition to its high speed, this sensor minimizes environmental pollution due to the use of very low concentration of quantum dots in the production of the sensor and the lack of the need for toxic and organic solvents.
2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015announcements Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd,201 0
#Physicists fine-tune control of agile exotic materials: Tunable hybrid polaritons realized with graphene layer on hexagonal boron nitride Abstract:
to Detect Cyanogen Toxic Gas June 23rd, 2015imaging Robust new process forms 3-D shapes from flat sheets of graphene June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015materials/Metamaterials n-tech Research Issues Report on Smart Coatings Market
to Detect Cyanogen Toxic Gas June 23rd, 2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers n-tech Research Issues Report on Smart Coatings Market
2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015military Iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd,
2015scientists Create Synthetic Membranes That Grow Like Living Cells June 22nd, 2015discovery paves way for new kinds of superconducting electronics June 22nd,
bio-inspired process unlike current approaches that rely on high temperatures, pressures, toxic solvents and expensive precursors,
In particular, current chemical synthesis methods use high temperatures and toxic solvents, which make environmental remediation expensive and challenging.
2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015materials/Metamaterials Physicists fine-tune control of agile exotic materials:
This method is based on the standards of green chemistry due to the use of biological and green reactants instead of toxic chemicals and contaminants.
use of biological reactant and elimination of toxic and polluting materials and solvents are among the most important advantages of the proposed method.
its high concentration causes digestive malfunctions and results in the related diseases due to its toxicity.
reducing pollution caused by large consumption of toxic solvents due to the high surface area, and high sorption capacity.
which rely heavily on antibodies. These antibodies are expensive to produce, subject to degeneration when exposed to environmental changes (such as high temperatures
or UV LIGHT) and more importantly, have a high rate of false-positive readings. Professor Paula Mendes said,
The findings, published in the journal Chemical science, show how the rate of false readings that come with antibody based diagnosis can be reduced by the smart technology that focuses on the carbohydrate part of the molecule.
and so we need technology that can discriminate between these subtle differences-where antibodies are not able to."
ranging from gas leakage, toxic and explosive gas sensing, and contaminants in water to DNA and proteins.
High-throughput bioactivity screening did not reveal increased toxicity of the particles when compared to an equivalent mass of metallic silver nanoparticles or silver nitrate solution.
and also toxicity, made for a good attachment point. That means the drug was inactivated as it flowed through the circulatory system until it reached the tumor.
These so-called artificial antigen-presenting cells (aapcs) were pioneered by Schneck's lab and have shown promise in activating laboratory animals'immune systems to attack cancer cells.
and"present"them with distinctive proteins called antigens. This process activates the T cells to ward off a virus, bacteria or tumor,
humans with magnetic aapcs bearing antigens from tumors. They then ran the plasma through a magnetic column.
The researchers found that the technique also worked with a mixture of aapcs bearing multiple antigens,
While the team initially tested the new method only on cancer antigens, Schneck says it could also potentially work for therapies against chronic infectious diseases, such as HIV.
and decreasing the alkaline and acidic solubility without creating the cellular toxicity. Results of the research have applications in textile, polymer,
However, current methods for production currently require toxic chemicals and lengthy and cumbersome processes that result in low yield that is not scalable for commercial applications.
The process is relatively faster, safer and green--devoid of any toxic substances (just graphite plus concentrated light.
But many of the advances rely on petroleum-based plastics and toxic materials. Yu-Zhong Wang, Fei Song and colleagues wanted to seek a greener way forward.
#Freshly squeezed vaccines (Nanowerk News) MIT researchers have shown that they can use a microfluidic cell-squeezing device to introduce specific antigens inside the immune systems B cells,
and implementing antigen-presenting cell vaccines. Such vaccines, created by reprogramming a patients own immune cells to fight invaders,
a class of antigen-presenting cells with broad functionality in the immune system, the researchers demonstrate in a study published in Scientific Reports("Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells")that B cells can be engineered to serve as an alternative.
As a result, large molecules antigens, in the case of this study can enter before the membrane reseals.
Courtesy of SQZ Biotech) We wanted to remove an important barrier in using B cells as an antigen-presenting cell population,
A new vaccine-preparation approach Dendritic cells are the most naturally versatile antigen-presenting cells.
In the body, they continuously sample antigens from potential invaders which they process and present on their cell surface.
or, targeting the specific antigens that are ingested and presented. Despite their critical role in the immune system, dendritic cells have used drawbacks
B cells are also antigen-presenting cells, but in contrast to dendritic cells, they can proliferate
Whereas dendritic cells constantly sample antigens they encounter, A b cell is programmed genetically only to bind to a specific antigen that matches the receptor on its surface.
As such, A b cell generally will not ingest and display an antigen if it does not match its receptor.
Using a microfluidic device, MIT researchers were able to overcome this genetically programmed barrier to antigen uptake by squeezing the B cells.
Cellsqueezes microfluidic channels are etched on silicon chips and sealed with a glass layer. The channels temporarily deform cells
the researchers pass a suspension of B cells and target antigen through tiny, parallel channels etched on a chip.
temporary holes in their membranes, allowing the target antigen to enter by diffusion. This process effectively loads the cells with antigens to prime a response of CD8 or killer T cells,
which can then kill cancer cells or other target cells. The researchers studied the squeezed B cells in culture
and found that they could expand antigen-specific T cells at least as well as existing methods using antibody-coated beads.
and antigen-specific T cells into mice, observing that the squeezed B cells could expand T cells in the spleen and in lymph nodes.
The researchers also say that this is the first method that decouples antigen delivery from B-cell activation.
when ingesting its antigen or when encountering a foreign stimulus that forces it to ingest nearby antigen.
This activation causes B cells to carry out very specific functions, which has limited options for B-cell-based vaccine programming.
Gail Bishop, a professor of microbiology at the University of Iowa Carver School of medicine and director of the schools Center for Immunology and Immune-Based Diseases, says that this paper presents a creative new approach with considerable
potential in the development of antigen-presenting cell vaccines. The antigen-presenting capabilities of B cells have often been underestimated,
but they are being appreciated increasingly for their practical advantages in therapies, says Bishop, who was involved not in this research.
This new technical approach permits loading B cells effectively with virtually any antigen and has the additional benefit of targeting the antigens to the CD8 T-cell presentation pathway
thus facilitating the activation of the killer T cells desired in many clinical applications. Main squeeze Armon Sharei, now a visiting scientist at the Koch Institute, developed Cellsqueeze while he was a graduate student in the laboratories of Klavs Jensen, the Warren K. Lewis Professor of Chemical engineering and a professor of materials science and engineering,
While nucleic acids can code a cell for a target antigen, these indirect methods have drawbacks:
They have limited ability in coding for difficult-to-identify antigens, and using nucleic acids bears a risk for accidental genome editing.
These methods are also toxic, and can cause cell damage and death. By delivering proteins directly into cells with minimal toxicity,
Cellsqueeze avoids these shortcomings and, in this new study, demonstrates promise as a versatile platform for creating more effective cell-based vaccines.
run it through a bedside device that has the antigen you want to vaccinate against, and then youd have the vaccine,
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