#Whole-Exome Sequencing Technology Identifies Drug Resistance Gene in Testicular cancer A study, funded by the Movember Foundation and conducted by scientists at The Institute of Cancer Research (ICR) in London,
in addition to uncovering a gene that may aid tumors in promoting resistance to existing drug therapies.
about 3%of patients develop resistance to platinum-based drugs, which consequently is associated with a diminished long-term survival rate.
as Johnson & johnson leadership in this area now extends from sharing its drug data to sharing its device
Eleven drug developers have committed to sharing clinical trial data through clinicalstudydatarequest. com and allow an independent review panel to decide data requests:
but not the open-access sought by Europe chief drug regulator and Glaxosmithkline. The European Medicines Agency in October issued a more expansive data sharing policy last October,
including live cells and drugs, according to the researchers. Thousands of times thinner than the average human hair, nanofibers are used by medical researchers to create advanced wound dressings and for tissue regeneration
drug testing, stem cell therapies, and the delivery of drugs directly to the site of infection."
"The process we have developed makes it possible for almost anyone to manufacture high-quality nanofibers without the need for expensive equipment,
and officials to negotiate drug prices with developers. Now years of talk is finally translating into action on bringing down the price of cancer drugs.
The payer won say which drugs or companies are the subject of discussions, first reported last month by The Wall street journal. Brian Henry, Express Scriptsvp,
Cancer was the third most expensive category of specialty drugs last year measured per-member-per year, according to Express Scripts;
and is among a handful of key drivers of rising costs here are drugs in cancer that may give five months of life in one indication and 12 days of life in another.
Henry said June 3. hen you get to the point where you have orphan drug pricing for non-orphan drugs,
Express Scripts sees similar cost-reduction opportunity for inflammatory and MS drugs, he added. Drug makers have resisted traditionally value-based pricing,
arguing they need to recoup R&d costs. The about-face reflects the convulsive changes wrought by U s. healthcare reform
and Europe embrace of government-led value-based drug pricing. In the U k.,the National Institute for Health and Care Excellence (NICE) makes formulary determinations through a ost-effectivenessthreshold assessing estimated costs of treatments or services in relation to their expected health benefits.
setting reimbursements for new drugs at the same level as the best existing comparator unless the new drugs show superiority to that comparator;
not just important new drugs. Theye also a new idea. I also think it true for Gleevec.
which are the sole buyers of drugs for state-run healthcare systems, numerous U s. payers exist.
Ph d.,research associate professor with the Tufts Center for the Study of Drug Development, told GEN. Having numerous payers,
the U s is less likely to see drug developers offer the extent of free trials or money-back guarantees,
or rebates for new drugs, as many have done in Europe to gain market access. Numerous payers is one reason why prices set by U s. payers will likely be more palatable to drug developers than
as payer cut prices for less-effective treatmentsven after developers invest in IT systems, drug utilization programs,
the company immediately added Abbvie Viekira Pak to its National Preferred Formulary as the exclusive option for patients with genotype 1 hepatitis Cust three days after the FDA approved the drug.
Henry said the lower price is consistent with discounts given for the drug in Europe for Sovaldi,
Express Scriptsindependent Pharmacy & Therapeutics Committee concluded that Viekira Pak was at least clinically equivalent to two Gilead sciences drugs, Harvoni (ledipasvir and sofosbuvir) and Sovaldi (sofosbuvir.
000-a-pill pricing by noting that the cost of Sovaldi is lower than the cost of complications associated with hepatitis C treatment, such as liver damage or liver failure.
and drug developerss well as pooling and sharing of resources. Institutions, developers, and patient groups should be encouraged to form consortia capable of assembling subpopulations large enough to speed up development,
Cancer treatments marketed by eight companies accounted for six of the Top 25 Best-selling Drugs of 2014 as listed by GEN,
000 uninsured or underinsured patients in the U s. annually for the past six-and-a-half yearsore than $1 billion in free medicine. ecause the cost of drugs is one of the few transparent healthcare costs,
drugs get much public attention, yet are only a small percentage of spending and demonstrate remarkable rewards,
such rules may require treatment with a cheaper drug whose patent protection will expire soon,
The scientists believe their research paves the way to an entirely new approach for finding a drug that can cure
which can be blocked by existing drugs. Dr. Parker's team is already testing drugs that have been approved previously by the FDA for treatment of such disorders as rheumatoid arthritis
to see if they work with ALS. Obstacles still remain, however, before finding a remedy for curing
the drug-treated mice showed a six-day-faster reconstitution of hematopoiesis after bone marrow transplantation. tudying mouse models,
The new technique holds the promise of a potent new tool to offset the growing challenge of antibiotic resistance by bacterial pathogens, according to the team.
and antibiotic resistance. The research team employed the Pacbio RS II system, which can collect data on base modifications simultaneously as it collects DNA sequence data.
assistant professor of genetics and genomics at the Icahn School of medicine at Mount sinai and senior author of the study. iven that phenotypic heterogeneity within a bacterial population can increase its advantage of survival under stress conditions such as antibiotic treatment,
This may have contributed to the increasing rate of antibiotic resistance of H. pylori. he application of this new technique will enable a more comprehensive characterization of the functions of DNA methylation and their impact on bacterial physiology.
such as RNA and protein expression, will help resolve regulatory relationships that govern higher order phenotypes such as drug resistance,
"There is a need to more fully understand the long-term molecular changes in the brain involved in drug craving and relapse."
"There are changes in the brain caused by drug use that occur and persist, but are unmasked only after withdrawal from a drugn this case, cocaine,"notes Dr. Dietz."
and gene therapies to prevent drug relapses, "explains Dr. Dietz.""If we can control this pathway,
Implications for nsp5 regulation and the development of antivirals, June 8 in the Journal of Biological Chemistry.
which provides the map to design potent new drugs to fight MERS, "said Dr. Mesecar,
#New Drug Prevents Cancer cells from Staging Last Stand Unlike many last stands in human history,
one that would include a new drug, a small molecule called SBI-0206965 that inhibits autophagy.
The new drug targets ULK1, an enzyme that initiates autophagy. The drug, which was developed by scientists at Salk Institute
and Sanford Burnham Prebys Medical Discovery Institute (SBP), was described June 25 in Molecular Cell, in an article entitled, mall Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1
"This allowed us to find a drug that targeted ULK1 not just in a test tube but also in tumor cells.
Our work provides the basis for a novel drug that will treat resistant cancer by cutting off a main tumor cell survival process. i
Moreover, the rate of resistance to current drug therapies is growing exponentially and scientists are always on the hunt for novel targets that have the potential to not only treat symptoms of infected patients,
"As drug resistance is a major problem for malaria control and eradication, it is critical that that we continue to develop new antimalarials that act against previously unexploited targets in the parasite to keep priming the drug pipeline."
"The findings from this study were published recently in Cell Host Microbe through an article entitled"Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans."
"In addition to a possible drug target, calcineurin underlies a very basic aspect of parasite biology. l
and in human tumor cells in the lab, showed that a specific drug can stop cancer cells without causing damage to healthy cells or leading to other severe side effects.
which started as an anti-cholesterol drug candidate, turns down fat synthesis so that cells can't produce their own fat.
The drug also has a good safety profile; it is effective without causing weight loss, liver toxicity,
The challenge for researchers in this scenario will be to find a way to allow the drug to cross this barrier, the body's natural protection for the brain,
When SR9243 is used in combination with existing chemotherapy drugs, it increases their effectiveness, in a mechanism apart from SR9243's own cancer fighting ability, added Dr. Burris B
drugs that modify LSD1 levels could provide a new approach to treating glioblastoma, according to the researchers.
"For instance, glioblastomas can escape the killing effects of a drug targeting MYC by simply shutting it off epigenetically
and turning it on after the drug is no longer present. Ultimately, strategies addressing this dynamic interplay will be needed for effective glioblastoma therapy."
and whether drugs could be developed to stop it from happening
#Sperm RNA Test May Improve Evaluation of Male Infertility Many couples who struggle with infertility also suffer uncertainty.
Since the first biopharmaceutical drug Humulin was launched in 1982 to the beginning of this decade (between 1982 and 2009 27 year period),
It will be maintained as the source of all cells used to produce the company drug through preclinical and clinical testing and then into commercial sale.
2012, the U s. Food and Drug Administration approved the use of Flucelvax, which is the first U s.-licensed (trivalent inactivated) influenza vaccine manufactured using cell culture technology.
The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function, according to the researchers.
The hope is that this could lessen the side effects of pain relief drugs.""You don want to feel sleepy or unaware,
and required technology to actually test different drugs to find something that targets the peripheral nervous system and not the central nervous system in a patient specific, or personalized manner."
This step was all-important as it prevents the drug from replicating with normal healthy cells
Around 16 percent of those given T-VEC demonstrated durable responses of more than six months, compared to just over two percent of those given the control drug.
The researchers found the drug to be most effective when used in the less advanced stages of the cancer, suggesting that T-VEC could prove a valuable early treatment option for skin cancers that are unable to be removed by a surgeon.
The drug has been submitted to both the US Federal Drug and Food administration and the European Medicines Agency for consideration, with the scientists hopeful of winning approval later this year.
#Student-designed pill dispenser uses fingerprint scanner to avoid overdosing And you thought that regular pill bottles were hard to open...
When they're subsequently supposed to take a pill, the patient holds their finger pad to the dispenser's scanner.
picking up a pill from a loaded cartridge and dropping it into an exit channel.
the treatment doesn't carry the risk of side effects that are associated often with drug treatments."
It also houses four separate chambers for carrying drugs directly to the brain and cellular-scale inorganic light-emitting diode(-ILED) arrays, allowing it to shine light on targeted cells.
If we want to influence an animal behavior with light or with a particular drug, we can simply point the remote at the animal and press a button."
the researchers were able to negate this action by remotely releasing a drug that blocks the function of the dopamine neurotransmitter.
so that drugs can be drip-fed to targeted cells as needed over a long time.""Wee successfully produced
#Pill on a string pulls early signs of cancer As with every form of the deadly disease,
what they claim to be a more accurate tool for early-diagnosis. Billed as"a pill on a string,
The Cytosponge is around the same size as a multi vitamin pill but instead of nutrition it packs a tightly compressed sponge.
the implant received market approval from the Food and Drug Administration (FDA) in the US, for the treatment of Retinitis Pigmentosa (RP) a degenerative condition that affects the peripheries of patient vision.
which is strong enough to stabilize various types of compounds, such as antibodies, enzymes, nanoparticles, antibiotics and growth factors, by acting as a protective"cocoon"."
the word changed from blue to red. a plastic dish imprinted with BMP-2 proteins that stimulate bone growth to control the direction of tissue growth. sodium ampicillin printed on a bacterial culture printed to test the effectiveness of a topographical distribution of the antibiotic
Omenetto says the ability to print antibiotics in topographical patterns would enable"smart"bandages in
the researchers gave the men a drug called buspirone during the final four weeks of the 18-week study.
This drug mimics the neurotransmitter serotonin and it is known to induce walking motions in mice with spinal cord injuries.
But by the end of the study, after they had received the buspirone drug, they could all move their legs with no stimulation at all.
Drugs already exist that can deactivate those cells. They are known as calcilytics and are used to treat people with osteoporosis. Researchers found that,
when the drug is inhaled, it deactivates the cells and stops all symptoms. Go ahead and Let Dogs Lick You,
Scientists are hopeful that patients can take the drug to prevent asthma attacks before they start ending the need to constantly carry an inhaler to end symptoms once an attack has started.
and received $200 million from the Gates Foundation, is making RTS, S available as a nonprofit drug.
A vial of the drug Glycopyrrolate with a strength of 1mg/ML became the five-millionth RFID-tagged dose at UVMC tracked by Kit Check, a Washington, D c,
what the drug is, the quantity, the lot number and the expiration date. Then they print out the RIFD tag from that information and label the drugs with it."
"There's an independent double-check where a second person goes in and puts in the information to help prevent an error
what they refer to"critical inventory"used by hospitals high-cost medications in refrigerators and high-risk drugs in anesthesia kits and trays.
if RFID chips will ever displace barcodes on drug packages any more than on cereal boxes in grocery stores.
Other focus points include staying ahead of drug-resistant bacteria, finding cures to Alzheimer and other diseases, developing new clean energy technologies,
#Delivering drugs straight into the brain A team of Canadian scientists has found a way to inject the drugs directly into the brain,
such as disease fighting drugs from entering the nervous system. It only allows a selected few types of molecules to cross including water, some gases and lipid soluble molecules.
and get the drugs to where they are needed most to the human brain. Currently, researchers say they have found a way based on the so-called ingle domain antibodiessda.
The discovery follows years of scientific Work at the moment drugs are placed usually into the blood
This makes it much easier to home in on potential drug targets for therapy. Scientists also no longer have to solely rely on mouse models of human disorders.
Using the invention on carboplatin a common cancer treatment drug, used against ovarian and lung cancers has boosted the potency by almost five times.
"The tool can be used to take away the wastage in a drug, meaning that you need less of it to do the same work.
and could mean that the drugs treat tumours much more effectively. As well as helping with treatment, the tool could cut down the wastage created during the process of making drugs.
That could make the pharmaceutical much more sustainable and reduce their impact on the environment.
as well as how certain drugs affect babies before they are born. The team present their findings in a paper,
of which were told they had been given a"dumbing pill "which prevented them from talking before all three were asked which one was still able to speak.
#Researchers Develop 3d printing Method to Produce Shell Capsules That Can Be loaded with Therapeutic Drugs Researchers at the University of Minnesota have introduced a novel 3d printing based method to produce highly monodisperse core/shell capsules that can
be loaded with biomolecules such as therapeutic drugs. They expect that this platform of 3d-printed programmable release capsules will be useful in applications such as dynamic tissue engineering, 3d-printed drug delivery systems, synthetic/artificial tissues, programmable matter,
and bionic nanosystems. Another important application area could be combinatorial screening of biomolecular gradients drugs, toxins, pollutants,
etc. against cell types. ur method provides us with robust control over particle properties, passive release kinetics,
and Drug Administration approval next year to expand its use to men. n the U s,
As a Phase III clinical trial, this technology is in the last phase of testing needed to obtain U s. Food and Drug Administration (FDA) approval for use in clinical settings.
#Shaping Implantable Medical devices to Avoid Immune system Tiny medical implants that can ferry drugs, cells, or other therapies safely to sites of disease are already seeing the light of day.
Study in journal Restorative Neurology and Neuroscience: A new technique for modeling neuronal connectivity using human pluripotent stem cellsource:
So far the device has been able to identify drugs and certain metabolites in animal tissue, hopefully soon moving on to trials with human samples.
Food and Drug Administration
#Optical Probe to Help Remove Only Cancerous Tissues in Brain Surgeries Neurosurgeons removing a tumor have to be obsessive about resecting just enough
#Electromagnetic field Activated Drug Loadded Nanowires Drug releasing implants can be of great benefit for conditions requiring long term treatment in a targeted area of the body.
Researchers at Purdue University have come up with a new way of releasing drugs into the body in a controlled manner using tiny injectable nanowire implants.
Applying an electromagnetic field over the wires caused them to release the drug. Turning off the EM field immediately stopped the drug release process.
The team tested the technology on mice with compression injuries, demonstrating that the drug reduced inflammation in the areas where the EM field was applied.
This worked over a period of weeks, pointing to this approach being applicable in long-term clinical applications.
Implantable Drug Releasing Microchips Over the past few years wee covered Microchips Biotech, an MIT spin out company that developed an implantable technology to release drugs inside the body in a controlled manner.
Wireless Implantable Microchips Deliver Drugs When Needed Continuous Microchips Glucose Monitoring Shows Promiseompany homepage: Microchips Biotechource:
#Tiny Remote Controlled Implant Releases Drugs Into Brain The blood-brain barrier is a picky bouncer, preventing most therapeutic compounds from crossing its barricades.
researchers from Washington Universityin St louis and the University of Illinois at Urbana-Champaign have developed a wireless implant that can be controlled remotely to release drugs right into the brain.
and contains four tiny drug chambers. It also HAS LED a tiny built-in that can deliver light to the implantation site
The drug delivery component is particularly interesting for clinical research, since optogenetics is only practical for researchers studying biological processes.
Yet, in laboratory studies, the combination of the two factors can help identify which compounds are promising neurological drug candidates.
The device reacts to infrared light to open up its drug chambers. Since such frequencies of light are able to penetrate a patient skull
the infrared light source can be used as a simple remote control to open up the drug chambers as necessary s
The patients also received the drug buspirone that acts like serotonin and which in the past has demonstrated considerable benefits for mice with spinal cord injuries.
enabling researchers to test drugs and cosmetics without using animals. The organs-on-chips tand to significantly reduce the need for animal testing by providing a faster
whether new drug compounds will be successful in human clinical trials, the university said in a news release.
and often it because the animal models being used to develop these drugs are not predictive of the human situation,
showed applying small quantities of antibiotic to the surface of medical devices, from small dental implants to hip replacements, could protect patients from serious infection.
the risk of deep bone infection is reduced substantially. ur research shows that applying small quantities of antibiotic to a surface between the polymer layers
chemicals and drugs any substance that someone wants to track closely and then detected using an optical readout device.
and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin,
greener and safer nanotechnology and could lead to enhanced efficiency of antimicrobial products used in agriculture and personal care.
"People have been interested in using silver nanoparticles for antimicrobial purposes, but there are lingering concerns about their environmental impact due to the long-term effects of the used metal nanoparticles released in the environment,
and environmentally responsible method to make effective antimicrobials with biomaterial cores.""The researchers used the nanoparticles to attack E coli, a bacterium that causes food poisoning;
"We may include less of the antimicrobial ingredient without losing effectiveness while at the same time using an inexpensive technique that has a lower environmental burden.
and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin,
greener and safer nanotechnology and could lead to enhanced efficiency of antimicrobial products used in agriculture and personal care.
"People have been interested in using silver nanoparticles for antimicrobial purposes, but there are lingering concerns about their environmental impact due to the long-term effects of the used metal nanoparticles released in the environment,
and environmentally responsible method to make effective antimicrobials with biomaterial cores.""The researchers used the nanoparticles to attack E coli, a bacterium that causes food poisoning;
"We may include less of the antimicrobial ingredient without losing effectiveness while at the same time using an inexpensive technique that has a lower environmental burden.
minimally invasive device for controlling brain cells with drugs and lighta study showed that scientists can wirelessly determine the path a mouse walks with a press of a button.
Typically, scientists who study these circuits have to choose between injecting drugs through bulky metal tubes
and can simultaneously deliver drugs and lights.""We used powerful nanomanufacturing strategies to fabricate an implant that lets us penetrate deep inside the brain with minimal damage,
or cannulas, scientists typically use to inject drugs. When the scientists compared the implant with a typical cannula they found that the implant damaged
The scientists tested the device's drug delivery potential by surgically placing it into the brains of mice.
they made mice walk in circles by injecting a drug that mimics morphine into the ventral tegmental area (VTA), a region that controls motivation and addiction.
when the scientists directed the device to simultaneously inject a drug that blocks neuronal communication.
It has room for up to four drugs and has four microscale inorganic light-emitting diodes. They installed an expandable material at the bottom of the drug reservoirs to control delivery.
When the temperature on an electric heater beneath the reservoir rose then the bottom rapidly expanded
and pushed the drug out into the brain.""We tried at least 30 different prototypes before one finally worked,
Scientists used soft materials to create a brain implant a tenth the width of a human hair that can wirelessly control neurons with lights and drugs.
Nanotechnology shows promise for more accurate prostate cancer screening and prognosis March 17th, 2015'Additive manufacturing'could greatly improve diabetes management March 17th, 2015nanotechnology Drug Delivery Market in the US 2012-2016:
2015nanomedicine'Additive manufacturing'could greatly improve diabetes management March 17th, 2015nanotechnology Drug Delivery Market in the US 2012-2016:
NC State Industrial & Systems Engineering Research Team Arms Implants With Battery-Activated Nanotechnology March 14th, 2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th,
2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th, 2015discovery demystifies origin of life phenomenon:
2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th, 2015is US immigration policy'STEMMING'innovation?
2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th, 2015nobel Laureate Martin Chalfie to Address International Nanomedicine Conference March 11th,
2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th, 2015silk could be new'green'material for next-generation batteries March 11th,
this could be a very promising lead in developing norovirus antiviral therapy. This could be especially beneficial to immunosuppressed individuals such as cancer patients.
However, if he or she has the option of receiving an antiviral to eliminate the infection,
including live cells and drugs. Many thousands of times thinner than the average human hair, nanofibers are used by medical researchers to create advanced wound dressings--and for tissue regeneration
drug testing, stem cell therapies and the delivery of drugs directly to the site of infection.
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011