#Nanoparticles provide novel way to apply drugs to dental plaque Therapeutic agents intended to reduce dental plaque
Their findings have been published in the journal ACS Nano("ph-Activated Nanoparticles for Controlled Topical Delivery of Farnesol To Disrupt Oral Biofilm Virulence".
"Farnesol is released from the nanoparticle carriers into the cavity-causing dental plaque. Graphic by Michael Osadciw/University of Rochester.
referred to as a nanoparticle carrier. They constructed the outer layer out of cationicor positively chargedsegments of the polymers.
the same is true of the nanoparticles and HA. Because teeth are coated with saliva, the researchers werent certain the nanoparticles would adhere.
But not only did the particles stay in place, they were also able to bind with the polymeric matrix
Since the nanoparticles could bind both to saliva-coated teeth and within plaque, Benoit and colleagues used them to carry an antibacterial agent to the targeted sites.
In other words, the nanoparticles release the drug when exposed to cavity-causing eating habitsprecisely when it is needed most to quickly stop acid-producing bacteria.
When the drug was administered without the nanoparticle carriers, there was no effect on the number of cavities and only a very small reduction in their severity.
But when it was delivered by the nanoparticle carriers, both the number and severity of the cavities were reduced.
Their soft nanoparticles stick to the plane where oil and water meet, but do not stick to one another.
effectively acting as a 2-D liquid("Interactions and Stress Relaxation in Monolayers of Soft Nanoparticles at Fluid-Fluid Interfaces".
"The researchers created a 2-D liquid consisting of nanoparticles at the interface between a drop of oil and the surrounding water.
The researchers created a 2-D liquid consisting of nanoparticles at the interface between a drop of oil and the surrounding water.
The teams technique for surmounting this problem hinged on decorating their gold nanoparticles with surfactant, or soap-like, ligands.
#Multimetal nanoframes improve catalyst performance (Nanowerk News) A team of researchers has synthesized a highly active and durable class of electrocatalysts by exploiting the structural evolution of solid Pt-Ni bimetallic nanocrystals into porous
and the University of Wisconsin synthesized a highly active and durable class of electrocatalysts by exploiting the structural evolution of solid Pt-Ni bimetallic nanocrystals into porous cage-like structures or nanoframes.
The material was synthesized by exploiting the structural evolution of platinum-nickel (Pt-Ni) bimetallic nanocrystals into cage-like structures with a self-assembled Pt skin structure on the interior and exterior surfaces.
crystalline Ptni3 nanoparticles, are transformed in solution and at mild temperatures into Pt3ni nanoframes with surfaces that have three-dimensional molecular accessibility.
The Pt-rich edges of the starting Ptni3 nanoparticles are maintained in the final Pt3ni nanoframes.
The HER activity for highly crystalline Pt3nit-skin nanoframe surface was enhanced by almost one order of magnitude relative to Pt/C. Utilizing the spontaneous structural evolution of a bimetallic nanoparticle from solid polyhedra to hollow nanoframes with controlled size, structure,
Published in NANO Letters("Real-time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells), "the study was led by Zhi Sheng and Deborah Kelly, both assistant professors at the institute,
#Lanthanide-organic framework nanothermometers prepared by spray-drying A work in Advanced Functional Materials shows how spray-drying prepared MOF nanoparticles containing lanthanide metals may be used as nanothermometers operative over a wide range of temperatures
The article also shows that spray-drying prepared MOF nanoparticles may be used as ratiometric luminescent nanothermometers operative over a wide range of temperatures, in particular, in the cryogenic range.
Prof Maspoch and Dr Imaz have contributed in the synthesis of the MOF nanoparticles of Tb (III) and Eu (III),
They sprayed a fine dusting of silica nanoparticles onto the stainless steel mesh to create a randomly bumpy surface
"He explained that certain combinations of layers yield nanoparticles that bind to oil instead of repelling it.
#Nanoparticles could make big impact for patients in need of cornea transplant There are about 48,000 corneal transplants done each year in the U s,
Johns Hopkins Medicine researchers may have discovered a way to prevent rejection by using biodegradable nanoparticles that release needed medication into the eye after surgery.
In an animal study being published in the March 10 issue of the Journal of Controlled Release("Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats),
biodegradable nanoparticle loaded with corticosteroids for timed release of medicine. The other three groups received weekly injections of saline, placebo nanoparticles and free dexamethasone sodium phosphate aqueous solution after surgery, respectively.
Treatments were given until the graft was deemed clinically as failed or until the nine-week test period concluded.
For rats that received the nanoparticle loaded with corticosteroids, 65 percent of the treatment remained in the eye
Two weeks after surgery, rats that received the placebo nanoparticle and saline injections had severe swelling, opaque corneas and unwanted growth of new blood vessels, all indicating graft failure.
The only group that showed successful corneal transplant was the group of rats that received the corticosteroid-loaded nanoparticle injections.
The steroid-loaded nanoparticle treatment group showed no signs of corneal transplant rejection. Thats 100 percent efficacy, a very promising finding, says Justin Hanes, Ph d.,director of the Center for Nanomedicine.
while making medicine adherence much easier on patients and their families The nanoparticle loaded with medication could eliminate the need for a patient to remember to take their medicine often multiple doses per hour after a surgery,
Scientists curve nanoparticle sheets into complex forms (Nanowerk News) Scientists have been making nanoparticles for more than two decades in two-dimensional sheets, three-dimensional crystals and random clusters.
But they have never been able to get a sheet of nanoparticles to curve or fold into a complex three-dimensional structure.
This highly magnified image of a folded gold nanoparticle scroll shows that even though researchers can fold the membrane,
the team got membranes of gold nanoparticles coated with organic molecules to curl into tubes when hit with an electron beam.
The scientists coat gold nanoparticles of a few thousand atoms each with an oil-like organic molecule that holds the gold particles together.
But its a very thin membrane made of a single layer of nanoparticles. To their surprise,
so they end up distributing themselves in a nonuniform way across the top and bottom layers of the nanoparticle sheet.
Argonne researchers are able to fold gold nanoparticle membranes in a specific direction using an electron beam
to analyze the surface of the nanoparticles. They discovered that the amount of surface covered by the organic molecules
In principle, scientists could use this method to induce folding in any nanoparticle membrane that has an asymmetrical distribution of surface molecules.
The results were published online in Nature Communications on August 4, 2015("A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models".
forming a water-soluble nanoparticle with the drug hidden in its core. These nanoparticles are highly soluble in blood
and are the perfect size to penetrate and accumulate in tumors where they take advantage of a tumor's acidic environment."
#Integration of quantum dots and photonic crystals produce brighter, more efficient light Recently, quantum dots (QDS) ano-sized semiconductor particles that produce bright, sharp,
developing a new method to extract more efficient and polarized light from quantum dots (QDS) over a large-scale area.
an ECE graduate student and the lead author of the research reported this week in Applied Physics Letters("Polarized quantum dot emission in electrohydrodynamic jet printed photonic crystals),
See explained. f you put the photonic crystal-enhanced quantum dot into a device like a phone or computer,
The device is made of thousands of quantum dots, each measuring about six nanometers. e made a tiny device,
These microcapsules, in turn, are packed with nanoparticles that can be filled with drugs. Heres how it works:
The drugs leak slowly out of the nanoparticles and are stored in the microcapsules. When the elastic film is stretched,
the microcapsule is recharged by the drugs that continue to leak out of the nanoparticles. This can be used to apply drugs directly to sites on the skin,
colloidal nanoparticles may play a role in digital technologies of the future. Nanoparticles can be displaced rapidly,
require little energy and their small footprint offers large storage capacity all these attributes make them well suited to new data storage applications or high-resolution displays.
These nanoparticles are constantly in motion due to the principle of Brownian motion. Since the particles are charged electrically,
In a new study, she and her colleagues have demonstrated now that it is not only possible to spatially confine nanoparticles,
"Nanoparticles possess properties that are very useful for digital technologies, and each individual particle can now be used to store
The targeted manipulation of individual nanoparticles opens up new options for their application, including in future data storage media
#Quantum dot solar cell exhibits 30-fold concentration We've achieved a luminescent concentration ratio greater than 30 with an optical efficiency of 82-percent for blue photons,
Luminescent solar concentrators featuring quantum dots and photonic mirrors suffer far less parasitic loss of photons than LSCS using molecular dyes as lumophores.
Alivisatos and Ralph Nuzzo of the University of Illinois are the corresponding authors of a paper in ACS Photonics describing this research entitled Quantum dot Luminescent Concentrator Cavity Exhibiting 30-fold Concentration.
We replaced the molecular dyes in previous LSC systems with core/shell nanoparticles composed of cadmium selenide (Cdse) cores
The Cdse/Cds nanoparticles enabled us to decouple absorption from emission energy and volume, which in turn allowed us to balance absorption
and scattering to obtain the optimum nanoparticle, he says. Our use of photonic mirrors that are matched carefully to the narrow bandwidth of our quantum dot lumophores allowed us to achieve waveguide efficiency exceeding the limit imposed by total internal reflection.
In their ACS Photonics paper, the collaborators express confidence that future LSC devices will achieve even higher concentration ratios through improvements to the luminescence quantum yield, waveguide geometry,
The success of this Cdse/Cds nanoparticle-based LSC system led to a partnership between Berkeley Lab, the University of Illinois, Caltech and the National Renewable energy Lab (NREL) on a new solar
acids, solid metal nanoparticles, and large protein molecules or enzymes in human bodies. Ninety percent of industrially important chemicals are made using catalysts.
and have been published in the leading British journal Nature Nanotechnology("Evolution of a Designless Nanoparticle Network into Reconfigurable Boolean logic").
They have used networks of gold nanoparticles for the execution of essential computational tasks. Contrary to conventional electronics, they have moved away from designed circuits.
#Quantum dots light up under strain Semiconductor nanocrystals, or quantum dots, are sized tiny, nanometer particles with the ability to absorb light
and re-emit it with well-defined colors. With low-cost fabrication, long-term stability and a wide palette of colors, they have become a building blocks of the display technology,
Exciting quantum dot applications are also emerging in the fields of green energy, optical sensing, and bio-imaging.
Prospects have become even more appealing after a publication was published in the journal Nature Communications last July("Band structure engineering via piezoelectric fields in strained anisotropic Cdse/Cds nanocrystals".
the IBM research lab Zurich (Switzerland) and the University of Milano-Bicocca (Italy) demonstrated a radically new approach to manipulate the light emission of quantum dots.
The traditional operating principle of quantum dots is based on the so-called quantum confinement effect, where the particle size determines the color of the emitted light.
a strain induced electrical field inside the quantum dots. It is created by growing a thick shell around the dots.
The result is a new generation of quantum dots whose properties are enabled beyond those by quantum confinement alone.
"Our findings add an important new degree of freedom to the development of quantum dot-based technological devices,
"For example, the elapsed time between light absorption and emission can be extended to be more than 100 times longer compared to conventional quantum dots,
#Nanoparticles could boost effectiveness and reduce side effects of allergy shots Whether triggered by cats, bees, pollen or mites,
researchers have developed nanoparticles that envelop an allergen and deliver it to specific cells. But these carriers degrade too slowly,
made with bioadhesive nanoparticles, that stays on the surface of the skin. Results of the research appear in the Sept. 28 online edition of the journal Nature Materials. e found that
and our nanoparticles are so adhesive that they don even go into hair follicles, which are relatively open.
UV exposed skin vs nanoparticle-treated, UV exposed skin. The merged images from rows two and three of this figure show two images of skin cells showing DNA damage in the form of double-strand breaks in sunscreen-treated, UV
exposed skin vs nanoparticle-treated, UV exposed skin. Girardi, who specializes in skin cancer development and progression, said little research has been done on the ultimate effects of sunblock usage and the generation of ROS, ut obviously,
the researchers developed a nanoparticle with a surface coating rich in aldehyde groups, which stick tenaciously to the outer skin layer.
The nanoparticle hydrophilic layer essentially locks in the active ingredient, a hydrophobic chemical called padimate O. Some sunscreen solutions that use larger particles of inorganic compounds, such as titanium dioxide or zinc oxide,
By using a nanoparticle to encase padimate O an organic chemical used in many commercial sunscreens,
#Brightness-equalized quantum dots improve biological imaging Researchers at the University of Illinois at Urbana-Champaign have introduced a new class of light-emitting quantum dots (QDS) with tunable and equalized fluorescence brightness
"In this work, we have made two major advances--the ability to precisely control the brightness of light-emitting particles called quantum dots,
"Brightness-Equalized Quantum dots,"published this week in Nature Communications. According to the researchers, these new materials will be especially important for imaging in complex tissues
Previously, nanoparticle walkers were only able to walk on precise and programmed one-and two-dimensional paths.
and a cathode based on Fes2 nanocrystals. ACS) Today, lithium-ion batteries are the storage technology of choice for many applications, from electric cars to smartphones.
Using a combination of gold and silver nanoparticles and Raman-active dyes, SERS substrates also can target specific DNA and RNA sequences."
"This work demonstrates the unique capability of micro-to-nanoscale topographies of the crumpled graphene-Au nanoparticles--higher density,
bringing the nanoparticles closer, "explained Juyoung Leem, a graduate student and first author of the study published in Nano Letters("Mechanically Self-Assembled, Three-dimensional Grapheneold Hybrid Nanostructures for Advanced Nanoplasmonic Sensors").
This process enables precise control and optimization of the size and spacing of integrated Au nanoparticles on crumpled graphene for higher SERS enhancement."
"According to Nam, the 3d crumpled graphene-Au nanostructure exhibits at least one order of magnitude higher SERS detection sensitivity than that of conventional, flat graphene-Au nanoparticles.
and the 3d integration of gold nanoparticle/graphene hybrid structures r
#Facebook M Is trained and Monitored by Humans, Facebook Reveals Facebook has entered the virtual digital assistant space with a new service for its millions of Messenger users,
#Clumps of gold nanoparticles can evolve to carry out computing Move over, microchip. A random assembly of gold nanoparticles can perform calculations normally reserved for neatly arranged patterns of silicon.
Traditional computers rely on ordered circuits that follow preprogrammed rules, but this strategy limits how efficient they can be. he best microprocessors you can buy in a store now can do 1011 operations per second
either using more nanoparticles or more electrodes. he electrodes are probably more important, so that you can have more inputs and outputs. o
#Clump of gold nanoparticles can evolve to carry out computing MOVE OVER, microchip. A random assembly of gold nanoparticles can perform calculations normally reserved for neatly arranged patterns of silicon.
Traditional computers rely on ordered circuits that follow preprogrammed rules, but this limits their efficiency. he best microprocessors you can buy in a store now can do 1011 operations per second,
"and"nanoparticle"are probably not terms you find yourself using in day-to-day interactions, but for the Univ. of Cincinnati (UC)' s Yoonjee Park, assistant professor in the College of Engineering and Applied science biomedical engineering professor, these words are central to every conversation relating to her cutting edge research on drug delivery vehicles.
"Usually I use nanoparticles for drug delivery vehicles, and we can attach image and contrast agents to the nanoparticle to track the particle.
Or the nanoparticle itself is the image and contrast agent which makes a complex of the image and contrast agent with the drug itself."
"In the course of time Park began to focus her efforts on those parts of the body that posed a significant challenge
Her Phd at Purdue University and her research at Boston's Massachusetts institute of technology were dedicated both to studying particle stabilization to avoid clogging arteries with the nanoparticles and drug delivery vehicles;
the scientists had to add platinum nanoparticles and an electron donor to their powder polymer."
"The platinum nanoparticles work as microelectrodes on which the electrons are transferred from the COF to the protons to form hydrogen,
according to the researchers. hat unique about this paper is that we show not the use of metal particles, not the use of metal nanoparticles,
he said. here are so many atoms inside the nanoparticle that never do anything. But in our process the atoms driving catalysis have no metal atoms next to them.
They then filled this mould with a suspension containing aluminium oxide platelets and glass nanoparticles as mortar.
they use a flexible polymer substrate covered in gold nanoparticles to which the VOCS attach. By applying electrodes and a voltage to the resulting film,
#One dollar blood test using gold nanoparticles outperforms PSA screen for prostate cancer, study suggests The simple test developed by University of Central Florida scientist Qun"Treen"Huo holds the promise of earlier detection of one of the deadliest cancers among men.
Huo's test detects that immune response using gold nanoparticles about 10,000 times smaller than a freckle.
When a few drops of blood serum from a finger prick are mixed with the gold nanoparticles, certain cancer biomarkers cling to the surface of the tiny particles,
Among researchers, gold nanoparticles are known for their extraordinary efficiency at absorbing and scattering light. Huo and her team at UCF's Nanoscience Technology Center developed a technique known as nanoparticle-enabled dynamic light scattering assay (Nanodlsay) to measure the size of the particles by analyzing the light they throw off.
That size reveals whether a patient has prostate cancer and how advanced it may be. And although it uses gold,
A small bottle of nanoparticles suspended in water costs about $250, and contains enough for about 2, 500 tests."
#Researchers deliver large particles into cells at high speed The researchers created a highly efficient automated tool that delivers nanoparticles, enzymes, antibodies, bacteria and other"large-sized"cargo into mammalian cells at the rate
"The device uses gold nanoparticles (microscopic particles) and glowing quantum dots. The researchers developed a novel approach for rapid and sensitive detection of surface proteins of viruses from blood samples of turkeys.
#Efficient method of producing metallic nanoparticles VTT's aerosol technology reactor for nanoparticle production can generate a variety of pure metal particles, particles of various alloys and carbon-coated particles.
The reactor can efficiently produce hundreds of grammes or even kilogrammes of nanoparticles per day."
"Demand has outstripped supply in the nanoparticle markets. This has been an obstacle to the development of product applications;
In most cases, industrial production of metallic nanoparticles involves chemical reduction in liquid solutions which requires the design of product-specific solutions.
Nanoparticles have also been tested in the manufacture of magnetic inks and inks that conduct electricity in printed electronics.
The silicon nanoparticles it produces may even enable lithium battery capacity to be boosted by a factor of 10.
The laser's cavity is made up of an array of reflective gold nanoparticles, where the light is concentrated around each nanoparticle
and then amplified. In contrast to conventional laser cavities, no mirrors are required for the light to bounce back and forth.
the nanoparticle cavity stays fixed and does not change; only the liquid gain around the nanoparticles changes.
The main advantages of very small lasers are: Some technical backgroundplasmon lasers are promising nanoscale coherent sources of optical fields
Odom's research team has found a way to integrate liquid gain materials with gold nanoparticle arrays to achieve nanoscale plasmon lasing that can be tuned dynamical, reversibly and in real time.
Thus, the same fixed nanocavity structure (the same gold nanoparticle array) can exhibit lasing wavelengths that can be tuned over 50 nanometers, from 860 to 910 nanometers,
Four new atomic structures for gold nanoparticle clusters Led by University of Nebraska-Lincoln chemistry professor Xiao Cheng Zeng,
and former UNL visiting professor Yi Gao, new research has revealed four atomic arrangements of a gold nanoparticle cluster.
Knowing the nanoparticle's most stable configurations, Zeng said, could allow biomedical engineers to identify appropriate binding sites for drugs used to treat cancer and other diseases.
The findings could also optimize the use of gold nanoparticles in catalyzing the oxidation process that transforms dangerous carbon monoxide emissions into the less noxious carbon dioxide,
The group developed a sensitive biosensing platform that detects E coli by the aggregation of nanoparticles on cellulose Paper gold nanoparticles are covered with surface molecules that bind to E coli bacteria.
When the test fluid containing bacteria is mixed with the nanoparticles and transferred to the cellulose paper, the aggregation results in a blue spot.
creating an electrode made of nanoparticles with a solid shell, and a"yolk"inside that can change size again and again without affecting the shell.
The use of nanoparticles with an aluminum yolk and a titanium dioxide shell has proven to be"the high-rate champion among high-capacity anodes"
That's where the idea of using confined aluminum in the form of a yolk-shell nanoparticle came in.
what are called"core-shell"and"yolk-shell"nanoparticles. The former have a shell that is bonded directly to the core,
#New research may enhance display, LED lighting technology Recently, quantum dots (QDS)--nano-sized semiconductor particles that produce bright, sharp,
developing a new method to extract more efficient and polarized light from quantum dots (QDS) over a large-scale area.
"If you put the photonic crystal-enhanced quantum dot into a device like a phone or computer,
The device is made of thousands of quantum dots, each measuring about six nanometers.""We made a tiny device,
Scientists unveil new technique for spotting quantum dots to make high performance nanophotonic devices A quantum dot should produce one and only one photon--the smallest constituent of light--each time it is energized,
which will enable control of the photons that the quantum dot generates. However finding the quantum dots--they're just about 10 nanometers across--is no small feat.
Now, researchers working at the National Institute of Standards and Technology (NIST) in the United states,
Array"This is a first step towards providing accurate location information for the manufacture of high performance quantum dot devices,
--but our camera-based imaging technique instead seeks to map the location of the quantum dots first,
One LED activates the quantum dots when it flashes (you could say this LED gives the quantum dots red eye).
At the same time, a second, different color LED flash illuminates metallic orientation marks placed on the surface of the semiconductor wafer the dots are embedded in.
Their coordinates in hand, scientists can then tell the computer-controlled electron beam lithography tool to place any structure the application calls for in its proper relation to the quantum dots,
which they were able to collect 50 per cent of the quantum dot's emitted photons, the theoretical limit for this type of structure.
Such high purity is partly due to the fact that the location technique helps the researchers to quickly survey the wafer (10,000 square micrometers at a time) to find regions where the quantum dot density is especially low-only about one per 1
This makes it far more likely that each grating device contains one--and only one--quantum dot.
or photons, using an artificially constructed atom, known as a semiconductor quantum dot. Thanks to the enhanced optical properties of this system and the technique used to make the measurements,
In the Cambridge experiment, the researchers achieved this by shining a faint laser beam on to their artificial atom, the quantum dot.
This excited the quantum dot and led to the emission of a stream of individual photons.
By scattering faint laser light from the quantum dot the noise of part of the electromagnetic field was reduced to an extremely precise and low level, below the standard baseline of vacuum fluctuations.
#Ideal single-photon source developed With the help of a semiconductor quantum dot, physicists have developed a new type of light source that emits single photons.
However, quantum dots made of semiconductor materials are offering new hope. A quantum dot is a collection of a few hundred thousand atoms that can form itself into a semiconductor under certain conditions.
Single electrons can be captured in these quantum dots and locked into a very small area. An individual photon is emitted
when an engineered quantum state collapses. Noise in the semiconductor A team of scientists led by Dr. Andreas Kuhlmann and Prof.
Richard J. Warburton from the University of Basel have shown already in past publications that the indistinguishability of the photons is reduced by the fluctuating nuclear spin of the quantum dot atoms.
Wave-particle dualism with large molecules The virtual laboratories provide an insight into the fundamental understanding and into the applications of quantum mechanics with macromolecules and nanoparticles.
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