Gastrointestinal diseases

Celiac disease (12)
Colitis (15)
Crohn's disease (11)
Diarrhea (28)
Gastroenteritis (15)
Irritable bowel syndrome (10)
Liver diseases (92)
Nausea (13)
Pancreatitis (10)

Synopsis: Health: Illness: Gastrointestinal diseases:

People with irritable bowel syndrome, obesity, Alzheimer's disease, Parkinson's and depression have been shown to have differences in gut bacteria

##Noroviruses are intestinal viruses that cause violent vomiting and diarrhea. People ill with the virus remain contagious up to three days after they seem to recover.

They then grew a pure culture of this single organism in the lab. An early guess is that this particular microbe may be linked to obesity and fatty liver disease

The company is currently studying the device for treating Hepatitis C with patients on chronic dialysis,

a mysterious type of equine hepatitis that is linked to blood products and causes liver failure in up to 90%of afflicted animals.

which eight horses had developed suddenly hepatitis after being injected with an antitoxin to prevent them from developing botulism.

and one later showed rising levels of liver enzymes that suggested liver disease. Although the researchers did not purify the virus before injecting it into the horses, Pablo Murcia, a virologist from the University of Glasgow,

After all, human hepatitis can be caused by at least five viruses. TDAV belongs to the family Flaviviridae,

dengue fever and hepatitis C. It is associated most closely with a genus of newly discovered viruses called Pegivirus,

which is used to treat hepatitis. The law enforcement has to ship it by express mail to a lab that then has to process the drug and run a series of tests.

This could help diagnose viruses like hepatitis C which people often don know they have u

and Crohn s disease suffer from chronic inflammation of the digestive tract and experience severe diarrhea pain fatigue

and weight loss. IBD is known to have a strong link to the microbiome according to Alm:

and Crohn s disease and translated that knowledge into descriptions of the underlying biological processes a critical step in the development of rationally designed drugs.

also known as subunit vaccines, have been successful against a few diseases, such as hepatitis and diphtheria. To develop subunit vaccines for other diseases,

and colitis but the drugs have never been tested as possible cancer treatments. What our study really says is that these drugs could have an entirely new second life in combination with chemotherapy says Yaffe who is a member of MIT s Koch Institute for Integrative Cancer Research.

The researchers found that a sealant they had developed previously worked much differently in cancerous colon tissue than in colon tissue inflamed with colitis. The finding suggests that for this sealant

However, it performed worse in tissue inflamed with colitis than in healthy tissue. Further studies of the molecular interactions between the adhesive

Upon autopsytheir fatty liver disease resembled that of an alcoholic. However the culprit was excess sugar

and gastrointestinal infections, including pneumonia, sepsis, gastritis, and Legionnairesdisease. One advantage of the engineered phages is that unlike many antibiotics,

an infection of Cryptosporidium parvum may mean nothing more than a few days of bad diarrhea. For someone with a compromised immune system,

it can mean death, following an excruciating, protracted bout of watery diarrhea. Recently, researchers at Fudan University's Institute of Biomedical sciences in Shanghai developed a lab-on-a-chip device that can rapidly diagnose cryptosporidium infections from just a finger prickotentially bringing point-of-care diagnosis to at-risk areas in rural China

In addition to diabetes, the researchers also think that interfering with pyruvate transport may help patients with nonalcoholic fatty liver disease, a condition common in people with obesity y

while not usually fatal, can lead to a slew of unpleasant symptoms such as excessive vomiting and diarrhea.

#Definitive tests for irritable bowel syndrome developed at Cedars-Sinai Millions of people afflicted by irritable bowel syndrome can now be diagnosed quickly

and bouts of relentless diarrhea, constipation, or both. Fatigue and the stress of trying to plan one's life around visits to the bathroom can be debilitating.

A multicenter study validating the accuracy of the new blood tests,"Development and Validation of a Biomarker for Diarrhea-Predominant Irritable bowel syndrome in Human Subjects"

comparing IBS patients to those diagnosed with inflammatory bowel disease, celiac disease and those with no GI disease.

developed by Pimentel to detect both anti-Cdtb and anti-vinculin antibodies in the diagnosis of irritable bowel syndrome and inflammatory bowel disease.

MURATA Yoji at the Kobe University Graduate school of Medicine Division of Molecular and Cellular Signaling, were the first to demonstrate the role of stomach cancer-associated protein tyrosine phosphatase (SAP)- 1 in the pathogenesis and prevention of Crohn's disease, ulcerative colitis,

are expected to accelerate the development of targeted therapies for inflammatory gastrointestinal diseases. Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, are disorders of unknown etiology that are characterized often by abdominal pain, diarrhea, bloody stool, fever,

and weight loss. These symptoms frequently interfere with activities of daily living and place patients at an elevated risk of mortality.

In Japan, there are an estimated 200,000 patients with Crohn's disease and ulcerative colitis, who qualify for the special Government-led medical assistance system for intractable diseases.

suggesting that SAP-1 plays a protective role against colitis. In addition, carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 20,

Suppression of CEACAM20 functions via dephosphorylation was suggested to contribute to preventing colitis. By shedding light on the anti-inflammatory mechanism of the intestinal epithelial cells, Prof.

kidney damage, hearing loss, nausea and vomiting.""It is extremely rare to discover anticancer agents that can selectively kill cancer cells

-and distinguish between this cancer and the inflammatory condition chronic pancreatitis, which can be hard to tell apart.

192 from patients known to have pancreatic cancer, 92 from patients with chronic pancreatitis and 87 from healthy volunteers.

while patients suffering from chronic pancreatitis had significantly lower levels than cancer patients. When combined, the three proteins formed a robust panel that can detect patients with stages I-II pancreatic cancer with over 90 per cent accuracy.

which is meant to identify everything in wheat's DNA sequences that can trigger a reaction in people suffering from celiac disease, an autoimmune disorder in

The only known treatment for celiac disease is a gluten-free diet free of any foods that contain wheat, rye, and barley."

Though celiac disease is four to five times more common now than 50 years ago, only about 1 per cent of the world's population is believed to suffer from it,

Understanding the causes of celiac disease and gluten intolerance is the goal of a lot of research around the world;

An expert on celiac disease who reviewed Miller's plan online worries that it may prove"too simplistic,

Armin Alaedini, assistant professor of medical sciences at Columbia University and a researcher at the New york-based school's Celiac disease Center, said the project may end up with a less toxic wheat product that isn't completely safe for all celiac disease patients."

The medical advisory board for the Celiac disease Foundation, a nonprofit based in Woodland Hills, California, could not reach a consensus on the viability of Miller's research.

Her son had been sick his entire life before being diagnosed with celiac disease at age 15, Geller said,

If these research efforts can keep celiac disease in the public eye, more doctors will be aware of it and more federal research dollars may flow,

It's often used to treat nausea associated with HIV or cancer therapies but this new process could offer a less expensive,

It's often used to treat nausea associated with HIV or cancer therapies, but this new process could offer a less expensive,

But drugs designed to block Notch have caused serious side effects such as severe diarrhea or skin cancers. Now a team from the University of Michigan Comprehensive Cancer Center offers a potential new target to block Notch without the toxic effects.

These changes in bacterial expression triggered chronic colitis in mice genetically prone to this disorder,

10.1038/nature14232#Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome#Authors: Benoit Chassaing, et a e

Alternately, riders prone to the malady could always take anti-nausea medications, though this is not a particularly practical solution for various reasons.

300,000 cases of hepatitis C and 35,000 new cases of HIV each year, as well as other infections. t was one of the proudest days in my life,

Moreover, it readily distinguishes between pancreatic cancer and chronic pancreatitis, conditions that are mistaken easily for each other.

92 from patients with chronic pancreatitis, 87 from healthy volunteers, and 117 samples from patients with other benign and malignant liver and gall bladder conditions.

Patients suffering from chronic pancreatitis had significantly lower levels than cancer patients. Combining the three proteins

cholera (Vibrio cholera), septicemia or gastroenteritis from eating infected raw oysters (Vibrio vulnificus) and gastric illnesses that threaten people with weakened immune systems (Aeromonas hydrophila.

If the glasses shift, for instance, optical aberrations disrupt the viewing, potentially causing headache, fatigue, and nausea.

a drug used to treat hepatitis C, while other individuals did not. A side effect of ribavirin is that it causes anemia--a condition characterized by a decrease in red blood cell levels--in approximately 8 to 10 percent of patients."

The most common complaints with high doses of Vitamin c are diarrhea, nausea, abdominal cramps and other gastrointestinal disturbances.

"and refers to its ability to bore through a person's intestines and into the liver and other organs, causing ulcers, internal bleeding and chronic diarrhea.

"and refers to its ability to bore through a person's intestines and into the liver and other organs, causing ulcers, internal bleeding and chronic diarrhea.

hepatitis and cancer. The research, led by Yury Stebunov, a scientist at the MIPT, was published in the ACS Applied materials & Interfaces.

targeting lymphoma and a form of autoimmune hepatitis.""The spherical nucleic acids always win from potency and speed standpoints,

This observation has significant implications for treating liver cancer and cirrhosis patients.""The beauty of the approach is that a very small amount of drug does a tremendous amount of work,

hepatitis and cancer. The research, led by Yury Stebunov, a scientist at the MIPT, was published in the ACS Applied materials

for example, can show up cirrhosis. It is more difficult to measure the elasticity of the brain.

with symptoms ranging from severe diarrhea to intestinal lesions to death. Bogyo's team has developed ways of conducting high-throughput screens of small molecules to speedily test their ability to inhibit

What's more, they have demonstrated the practicality of this approach by identifying a novel molecule that blocks a key enzyme used by the hepatitis C virus."Our dream is to provide a do-it-yourself method--one that can be applied by anyone,

Hepatitis C, and influenza using a strategy called lethal mutagenesis. This strategy seeks to extinguish viruses by forcing their already high mutation rates above an intolerable threshold.

Viruses responsible for 50 percent of gastroenteritis Noroviruses, a group of viruses responsible for over 50%of global gastroenteritis cases, can spread by air up to several meters from an infected person

suggests that measures applied in hospitals during gastroenteritis outbreaks may be insufficient to effectively contain this kind of infection.

and long-term care facilities affected by gastroenteritis outbreaks. Researchers gathered air samples at a distance of 1 meter from patients, at the doors to their rooms,

The viruses were detected in 54%of the rooms housing patients with gastroenteritis, 38%of the hallways leading to their rooms,

A dose of 20 norovirus particles is usually enough to cause gastroenteritis. According to Professor Duchaine

this previously unknown mode of norovirus propagation could explain why gastroenteritis outbreaks are so hard to contain:"

Use of mobile air filtration units or the wearing of respiratory protection around patients with gastroenteritis are measures worth testing. i

--and distinguish between this cancer and the inflammatory condition chronic pancreatitis, which can be hard to tell apart.

while patients suffering from chronic pancreatitis had significantly lower levels than cancer patients. When combined, the three proteins formed a robust panel that can detect patients with stages I-II pancreatic cancer with over 90 per cent accuracy.

which has frequently been observed in autistic children, its association with gastrointestinal diseases --which often accompany autistic disorders

and hepatitis C. What they have in common is that the genome does not consist of DNA, but RNA.

which infects 50 million people and causes 40,000-110,000 deaths via severe diarrhea worldwide.""Chelsea is a fearless experimenter.

some reports have linked Crohn's disease to the presence of certain strains of E coli.""We'd like to be able to remove specific members of the bacterial population

and gastrointestinal infections, including pneumonia, sepsis, gastritis, and Legionnaires'disease. One advantage of the engineered phages is that unlike many antibiotics,

Interferon infection-fighting power is accompanied by severe side effects most commonly associated with its former use as a treatment for Hepatitis C that include, not surprisingly,

Of all major organs, the liver has the highest capacity to regenerate that why many liver diseases,

including cirrhosis and hepatitis, can often be cured by transplanting a piece of liver from a healthy donor.

leading the researchers to conclude that these cells don contribute to liver cancer caused by obesity-induced hepatitis

the researchers successfully used their sequencing kit to detect Hepatitis C in the blood of an infected UCSF patient,

which cause severe diarrhea, vomiting, dehydration and potential long-term growth and cognition deficiencies. These pathogens are particularly devastating to children and people with AIDS.

This unique medication could mean a dramatic reduction of the difficult side-effects of traditional cancer treatments like hair loss, nausea, anemia and neuropathy.

which included varying degrees of flu-like symptoms with high fevers nausea and muscle pain.

#Immune cells in liver drive fatty liver disease, liver cancer Fatty liver disease--alongside fatty liver due to massive alcohol consumption--is caused mainly by excessive consumption of fat

This is referred to as nonalcoholic fatty liver disease (NAFLD. If NAFLD becomes chronic--e g. through the constant uptake of high lipids

This can lead to nonalcoholic steatohepatitis (NASH)--a liver disease with clear detectable pathologic alteratons of the tissue.

These liver diseases (NAFLD and NASH) along with chronic viral infections are the most common causes of liver cancer or hepatocellular carcinoma (HCC.

T cells involved in the development of fatty liver disease NASH and HCC The mechanisms that cause diseases such as fatty liver disease steatohepatitis and HCC are still not widely understood.

However immune cells particularly CD8+T cells and NK T cells seem to play an important role.

Our results provide completely new insights into the development of these serious liver diseases. Building on this knowledge we now want to develop new preventive

#Defective gene renders diarrhea vaccine ineffective Acute diarrheal illnesses cause nearly one-fifth of all child deaths in developing countries.

and develop fatty liver disease and abnormal blood lipid levels. All of these increase the risk of developing diabetes and cardiovascular disease.

and animals FGF21 levels are elevated in association with obesity insulin resistance and nonalcoholic fatty liver disease.

It quickly became clear to the investigators that Strain 115 could produce a potent antibiotic that targets a large number of medically relevant bacteria including those that cause staph infections strep throat and severe gastrointestinal diseases.

if certain child care centers are reporting the beginning of stomach flu (vomiting and diarrhea), other centers can start taking steps to thoroughly clean to kill any viruses before symptoms occur

fever, influenza-like illness, pink eye, stomach illnesses (gastroenteritis), cold or respiratory symptoms, ear infections and rash.

The most common illnesses reported were gastroenteritis (37 percent), fever (31 percent), cold (17 percent) and influenza (3 percent.

Data also revealed an unusually large increase in gastroenteritis cases during a two-day period,

Things moved so fast he was septic before he was symptomatic for appendicitis Kinch said.

and Eliza Hall Institute scientists have discovered a small molecule that blocks a form of cell death that triggers inflammation opening the door for potential new treatments for inflammatory disease such as rheumatoid arthritis Crohn's disease

The material is used widely as a passive structural support for abdominal wall hernias, breast reconstruction, and chest wall defects.

including HIV and hepatitis C. The method, called Virscan, is an efficient alternative to existing diagnostics that test for specific viruses one at a time.

#Copper and its alloys destroy'stomach flu'virus Metal surfaces containing copper can destroy human norovirus, one of the causes of gastroenteritis or'stomach flu,

including copious vomiting and diarrhea. It is a major problem on cruise ships, in restaurants, and in elder care homes, where the disease is transmitted easily by environmental contamination,

hepatitis Researchers have developed a highly sensitive nanomechanical sensor that can detect cancerous tumours as well as viral disease markers for HIV,

hepatitis and herpes. Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.

including HIV, hepatitis, herpes, and many others. The sensor will also enable doctors to identify tumour markers,

hepatitis and herpes. Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.

including HIV, hepatitis, herpes, and many others. The sensor will also enable doctors to identify tumour markers,

hepatitis and herpes. Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.

including HIV, hepatitis, herpes, and many others. The sensor will also enable doctors to identify tumour markers,

At age 18, Erik Gatenholm started his first medical device company, manufacturing meniscus implants and other implants, such surgical meshes for ventral hernia repairs and wound dressings.

a tensionless urethral sling, a hernia repair piece, and artificial skin, blood vessels and ligament, many of which rely on the exact same 3d printing technique.

and gastroenteritis all of which can be deadly unless the patient is given immediate and appropriate treatment.

including HIV, hepatitis, herpes, and many others. The sensor will enable doctors to identify tumor markers,

For example, primary biliary cirrhosis (PBC) has been reported, controversially, to arise from viral infection, so it would be great to compare the virome of PBC patients with those without the disease.

#Medical cannabis DOESN'T ease pain, nausea, vomiting, sleep disorders or Tourette's By Lizzie Parry for Mailonline Published:

And weaker evidence still that the drug eased nausea and vomiting in chemotherapy patients, sleep disorders,

But researchers discovered weak evidence that medical marijuana was associated with improvements in nausea and vomiting due to chemotherapy

Notably, cannabinoids were found to cause dizziness, dry mouth, nausea, fatigue, euphoria, vomiting, disorientation, drowsiness, confusion, a loss of balance and hallucination.

Schoellhammer sees this being helpful for the 1 million people in the United states who have irritable bowel syndrome (IBS) as well as other conditions.

If an individual has a condition like celiac disease Chef Watson can pull up gluten-free recipes.

would complement Shire existing stable of drugs for gastrointestinal diseases.""The acquisition of NPS Pharma is a significant step in advancing Shire's strategy to become a leading biotechnology company, Shire CEO Flemming Ornskov, M d,

a life sciences and healthcare industry consultant, told GEN. Express Scripts is hoping to repeat the success it enjoyed last year in hepatitis C. In December 2014,

the company immediately added Abbvie Viekira Pak to its National Preferred Formulary as the exclusive option for patients with genotype 1 hepatitis Cust three days after the FDA approved the drug.

and only covers Sovaldi for non-genotype 1 hepatitis C. ur clients will save more than $1 billion this year on hepatitis C medications,

000-a-pill pricing by noting that the cost of Sovaldi is lower than the cost of complications associated with hepatitis C treatment, such as liver damage or liver failure.

and patients with colitis may benefit from this approach, "stated co-author James Willson, M d, . associate dean of oncology programs at UT Southwestern Medical center and co-author on the current study."

and may also be a treatment for colitis."The findings from this study were published recently in Science through an article entitled"Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration."

#Smart capsule keeps hold of payload until reaching its target We have drugs to treat nasty conditions like irritable bowel syndrome and Crohn's disease,

#World First Blood test To Diagnose Irritable bowel syndrome World First Blood test To Diagnose Irritable bowel syndrome Newshealthby Good News Network-May 21,

whether a person actually has developed irritable bowel syndrome a common disorder that includes bouts of relentless diarrhoea,

and then multiplies, producing proteins that are toxic to humans and cause watery diarrhea. That in turn can cause severe dehydration and an imbalance of electrolytes.

the group ran the scan on people known to be infected with hepatitis C and HIV.

Hepatitis C, Kula said, is detected often not for months or years, because few people think to ask about it.

May 6th, 2015improving Clinical Care and Patient Quality of life in Advanced Liver disease, d-LIVER Workshop, Milan, 27 may 2015 May 6th, 201 0

including Hepatitis C, SARS or MERS, could also benefit from the user friendly chip and its rapid results. is award is truly helping our lab become translational,

including HIV, hepatitis, herpes, and many others. The sensor will enable doctors to identify tumor markers,

"A lot of people have hepatitis C, for example, without realising,"says Elledge. You could imagine routinely screening people in this way,

Raghu Kalluri of the University of Texas MD Anderson Cancer Center in Houston found that there is so much more glypican-1 in people with pancreatic cancer that a blood test can be used to accurately distinguish them from both healthy controls and people with the disease pancreatitis."

"We've failed so far to find drugs to treat diarrhea using cell culture models

together with HIV and hepatitis C. The method is an efficient substitute to diagnostics available at present.

#More clues to how drug reverses obesity diabetes fatty liver disease In addition to illuminating how the drug amlexanox reverses obesity diabetes

and fatty liver disease the findings suggest a new pathway for future treatments. The research was published Jan 12 in Nature Communications.

This combination results in multiple health risks including high blood sugar and fatty liver disease. For years to gain insight into this phenomenon researchers focused on the role of altered insulin action in the liver in the production of triglycerides.

but instead reduces fatty liver disease in patients with type 2 diabetes. These results provide new insights into the pathogenesis of nonalcoholic liver disease

and provides new approaches to treat fatty liver disease which is now the most common liver disease in the world said Shulman.

Shulman and his team plan to apply similar methodology to translate their findings to insulin-resistant patients with type 2 diabetes hyperlipidemia and fatty liver disease e

#'Crispr'science: Newer genome editing tool shows promise in engineering human stem cells In a recent online report on the work in Molecular Therapy the Johns Hopkins team says the findings could streamline

and speed efforts to modify and tailor human-induced pluripotent stem cells (ipscs) for use as treatments

SERPINA1 a gene that when mutated causes alpha1-antitrypsin deficiency an inherited disorder that may cause lung and liver disease;

including HIV and hepatitis C."It turns out that it works really well,""Elledge says."

and gastroenteritis--all of which can be deadly unless the patient is given immediate and appropriate treatment.

We found that it significantly reduced inflammation in the fat tissues and improved kidney and liver disease.

"Our ultimate hope would be to use these findings to create a lipoxin-based drug for obese people to help protect them against associated illnesses, such as kidney and liver disease,

#Vitamin d shows promise for treating Crohn's disease Crohn's disease (CD) is a lifelong chronic relapsing and remitting gastrointestinal condition, characterised by inflammation,

CD is associated with abdominal pain, diarrhea, fatigue and in many cases can result in a reduction of quality of life, time off work, hospitalisations and surgery.

"This is an exciting development in the treatment of Crohn's disease and we welcome anything new that could potentially help patients with this debilitating condition

Infection with rotavirus is the most common cause of diarrhea in children around the world.

which cause vomiting and diarrhea. Rotavirus infection is the most frequent cause of diarrhea in children

and is responsible for more than 500,000 deaths around the world each year. It attacks the epithelial cells that coat the intestine and damages them."

Interferons are used, for example, in the immunotherapy of often refractory chronic viral infections such as hepatitis. The researchers postulate that the innovative mechanism in which two components of the innate immune system collaborate effectively in the epithelial cells may have developed in the course of evolution as a secondary line of immune defense in an environment in

#Risk of hepatitis E outbreak'very high'in earthquake-ravaged Nepal During the coming monsoon season, survivors of the recent earthquake that destroyed parts of Nepal face a"very high

"risk of a hepatitis E outbreak that could be especially deadly to pregnant women, according to a consensus statement from a group of infectious disease experts from around the world.

There are an estimated 20 million hepatitis E infections in the world annually. While the virus can lead to liver disease,

it mostly runs its course with few long-term complications. Yet pregnant women have a mortality rate of 25 percent

"Hepatitis E is neglected a virus that isn't well understood but we are now seeing that it is likely a major cause of maternal deaths in countries where it is common,

#Gel that can make drugs last longer A drug-delivering hydrogel has been developed to treat chronic diseases such as hepatitis C a liver disease that kills around 500,000 people worldwide every year.

Researchers at the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR have developed a drug-delivering hydrogel to treat chronic diseases such as hepatitis C a liver disease that kills around 500,000 people worldwide every year."

and well-being of patients suffering from chronic diseases such as hepatitis C,"said IBN Executive director Professor Jackie Y. Ying.

The standard treatment for chronic hepatitis C infections includes a weekly injection of a protein drug called PEGYLATED interferon.

"Our hydrogels can significantly extend the half-life of hepatitis C drugs by up to 10 times longer than current treatment.

Up to 150 million people globally suffer from chronic hepatitis C infections according to the World health organization.""I believe that our method can pave the way for more effective and safe treatment of hepatitis C. We are also testing the microstructured gel for the treatment of other chronic diseases besides hepatitis C,"added Dr Kurisawa.

Story Source: The above post is reprinted from materials provided by The Agency for Science, Technology and Research (A*STAR.

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