Sclerosis

Atrophy (14)
Bleeding (66)
Disability (104)
Fever (40)
Fibrosis (56)
Headache (11)
Malignancy (12)
Preeclampsia (11)
Sclerosis (17)
Sickness (10)
Ulcer (28)

Synopsis: Health: Illness: Signs and symptoms: Sclerosis:

#Scientists find off switch for scleroderma Researchers have identified a signaling pathway that switches on scleroderma,

chairperson of the department of pharmacology and toxicology in the College of Osteopathic Medicine at Michigan State. here are two kinds of scleroderma, localized and systemic,

Localized scleroderma affects the skin and causes a loss of flexibility. Systemic sclerosis can spread throughout the body,

hardening organs such as the lungs, heart, gut, and kidneys. Scleroderma is an autoimmune disorder. It estimated 300,000 Americans suffer from the disease with about one-third of those having the systemic form.

Localized scleroderma patients usually live normal lifespans. Yet about half of systemic patients especially with widespread skin involvement and internal organ fibrosis, will see their lives cut short.

Scleroderma many pathways he majority of drug treatments that exist today for fibrosis basically look at reducing just the inflammation,

says Dinesh Khanna, associate professor of internal medicine at the University of Michigan. here are other drugs that block one or two of the signaling pathways that cause the disease,

but scleroderma has many of these pathways. Published in the Journal of Pharmacology and Experimental Therapeutics, the new research could significantly change the quality of life for scleroderma patients

and greatly increase the lifespan of systemic patients, Neubig says. ur research shows promise for the development of a new drug that can reverse the fibrosis process by flipping the main switch on all of the signaling pathways.

A donation from Jon and Lisa Rye, a Michigan family who has experienced the effects of scleroderma,

and the family crowdfunding site, the Scleroderma Cure Fund, helped support the research h

#Anticancer drug reverses schizophrenia symptoms in teen mice An experimental anticancer drug appears to reverse schizophrenia-related behavior

Scleroderma Foundation, and core funds from instem and IFOM r

#Discovery Could Lead to Better Recovery After Stroke UCLA researchers have identified a molecule that, after a stroke,

and tuberous sclerosis 1 and 2). They discovered that a cellular calcium signaling process involving the inositol trisphosphate receptor was altered very much.

and tuberous sclerosis 1 and 2). They discovered that a cellular calcium signaling process involving the inositol trisphosphate receptor was altered very much.

10.1038/ncomms8319abstractneurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neuronsamyotrophic lateral sclerosis (ALS) is a neurodegenerative disease thought to employ cell nonautonomous

tuberous sclerosis and Hirschsprung disease. hese observations may help to explain certain human disease syndromes in which abnormalities of the nervous system appear to be associated, for previously unclear reasons,

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